LOCUS       NM_001114938            2245 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens coiled-coil domain containing 17 (CCDC17), transcript
            variant 1, mRNA.
ACCESSION   NM_001114938
VERSION     NM_001114938.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2245)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2245)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK303939.1, DC359257.1, AL355480.22 and BU677500.1.
            
            On Nov 24, 2018 this sequence version replaced NM_001114938.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK303939.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158569, SAMN03267780
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000528266.6/ ENSP00000432172.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               AK303939.1         4-368
            366-366             DC359257.1         369-369
            367-1202            AK303939.1         370-1205
            1203-1203           AL355480.22        101177-101177       c
            1204-1883           AK303939.1         1207-1886
            1884-2245           BU677500.1         18-379              c
FEATURES             Location/Qualifiers
     source          1..2245
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     gene            1..2245
                     /gene="CCDC17"
                     /note="coiled-coil domain containing 17"
                     /db_xref="GeneID:149483"
                     /db_xref="HGNC:HGNC:26574"
     exon            1..319
                     /gene="CCDC17"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..2014
                     /gene="CCDC17"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 17"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 17 isoform
                     1"
                     /protein_id="NP_001108410.2"
                     /db_xref="CCDS:CCDS44131.2"
                     /db_xref="GeneID:149483"
                     /db_xref="HGNC:HGNC:26574"
                     /translation="MDSHSGEPALLPCGTCDMVFRSSALLATHTQRFCIGHPTQEMTF
                     GAQASVATEPQRAAVVPQEHQGVPQEPQGLPDQQASRSALKRLTEEVQWLRLSLQEMR
                     PWITEVPRVFAGPWTRSEARPQSPMSEAVGSPSERLRALFRTRARRVAEMEAQSRALQ
                     LRGEELSRRLQVVACTRGGMSRLFGLEQEIRELQAEAGRTRGALEVLGARIQELQAEP
                     GNPLSSRREAELYSPVQKANPGTLAAEIRALREAYIRDGGRDPGVLGQIWQLQVEASA
                     LELQRSQTRRGRAGATSGELPVVEAENRRLEAEILALQMQRGRAPLGPQDLRLLGDAS
                     LQPKGRRDPPLLPPPVAPPLPPLPGFSEPQLPGTMTRNLGLDSHFLLPTSDMLGPAPY
                     DPGAGLVIFYDFLRGLEASWIWVQLRTGLARDGRDTGRTTALPPALCLPPPPAPGPMG
                     NCAILASRQPVPRLPPSSSVSLVCELQVWQGLAWARAPQPKAWVSLGLFDQDQRVLSG
                     RWRLPLRALPLDPSLSLGQLNGIPQAGQAELFLRLVNARDAAVQTLAEINPASVHEYQ
                     YPPPVSSTSSLEASFLTPAVGFADPPPRTEEPLSGVKDRDEGLGPHHSSDLPPVSF"
     exon            320..415
                     /gene="CCDC17"
                     /inference="alignment:Splign:2.1.0"
     exon            416..638
                     /gene="CCDC17"
                     /inference="alignment:Splign:2.1.0"
     exon            639..801
                     /gene="CCDC17"
                     /inference="alignment:Splign:2.1.0"
     exon            802..885
                     /gene="CCDC17"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1004
                     /gene="CCDC17"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1112
                     /gene="CCDC17"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1231
                     /gene="CCDC17"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1329
                     /gene="CCDC17"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1533
                     /gene="CCDC17"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1744
                     /gene="CCDC17"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1855
                     /gene="CCDC17"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..2245
                     /gene="CCDC17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2225..2230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC17"
                     /note="hexamer: ATTAAA"
     polyA_site      2245
                     /gene="CCDC17"
                     /note="major polyA site"
ORIGIN      
        1 caaacttgaa gatctcacag acctaataga cacggccttt cctctctgcc tctggcttta
       61 tgtctctttc atcctcctct gcctttcccc tgcccttgat cccttctgca ggtcttggct
      121 ggtttcagga aacgggtccc atcccatgga ctcccactct ggggagcctg cgctcctgcc
      181 ctgtgggacc tgtgacatgg ttttccgctc ctcagctctg ttagccaccc atactcagcg
      241 cttctgcatt ggccacccga cccaagagat gacatttgga gcacaggcat cagttgccac
      301 tgaaccccag cgggccgcgg ttgtgccaca agaacaccag ggcgtgccac aagaacccca
      361 gggcctccca gaccagcagg ccagtagatc tgctctaaag aggttaacag aggaggtgca
      421 gtggctgcgg ctatccctac aggaaatgcg gccctggata acagaggtcc ccagggtgtt
      481 cgcggggccc tggacacgtt ccgaggcgcg gcctcagagt cccatgtccg aggcggtggg
      541 aagccccagc gagcggctgc gggcgctgtt caggactcgc gcgaggcgcg tggcggagat
      601 ggaagcgcag agccgggccc tgcagctacg cggcgaggaa ctgagccgac gcctccaagt
      661 tgtggcctgt acgcggggcg ggatgtcccg cctcttcggc ctggagcagg agattcgaga
      721 actacaagct gaggccggga ggacgcgggg agctctagag gtgttggggg cccgcattca
      781 ggagctgcag gcggagccag ggaacccgct gagctcccgg cgagaggcag aactttattc
      841 tccagtgcaa aaggccaacc cgggaactct ggctgccgaa atccgggcgc tgcgggaggc
      901 ctacattcga gacgggggcc gggaccccgg cgtgctgggc cagatatggc agttgcaggt
      961 ggaggcgtct gcactggagc tgcagcggtc gcagacccgc agaggaaggg caggtgccac
     1021 ctcaggggag cttccagtag tggaggctga aaaccggcgc ttggaggcag aaatcttggc
     1081 cttgcaaatg cagaggggtc gggcaccctt ggggccccag gatctgcgac tcctggggga
     1141 tgccagccta caaccgaagg ggaggagaga tcccccactc ctcccgccac cggtggcacc
     1201 accgctgcca ccacttccag gcttctcgga gccacagctt cctggaacaa tgaccagaaa
     1261 cctgggcctg gactcacact tcctcctgcc cacatcggac atgctgggcc ctgcacccta
     1321 tgatcctggg gctggcctgg tcattttcta tgatttcctg cggggccttg aggcttcctg
     1381 gatttgggtg caactaagga ctggcttggc acgcgatgga cgggatacag gaaggaccac
     1441 agcgttgccc ccagcccttt gcctgccccc acctcctgct cccgggccca tgggcaactg
     1501 tgccatcctt gccagcaggc agcctgtgcc cagactacca ccctcatcat cagtatcttt
     1561 ggtctgtgag ctgcaggtct ggcaggggct agcatgggct agggcaccac agccaaaggc
     1621 ttgggtctca cttggactat ttgaccaaga tcagcgggtg ctaagtggcc gctggcgcct
     1681 cccacttcgg gcccttcctc tggaccccag ccttagcctt gggcagctga atgggattcc
     1741 tcaggcaggt caggctgagc tctttctgcg gctggtgaat gcaagagatg cagctgtaca
     1801 gacactggca gagatcaatc cagcaagtgt ccatgagtac cagtacccac ctccggtgtc
     1861 cagcacatct tcactggaag ccagcttcct cacccccgca gttggctttg ctgatccccc
     1921 acctcgtaca gaagagcccc tcagtggagt caaggataga gatgagggtt tgggccctca
     1981 ccacagttct gacttgcccc cagtgagttt ctgaacccaa gtgaatgtgg agatgagcat
     2041 ctgaacatgc acaggactgg ggcctatttc cagacctaca ggtttactac tccatgttct
     2101 gacattgggt ctagaagcat ctagcagttg agtacagaaa accagttcca accacagctt
     2161 taccacctcc cgttaagtcc ttaacttttc tgtacctctt ctgtttttgt aaaacagatt
     2221 aaggattaaa tgagtttgtc aggta
//
