LOCUS       NM_138493                572 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens coiled-coil domain containing 167 (CCDC167), mRNA.
ACCESSION   NM_138493 XM_166346
VERSION     NM_138493.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 572)
  AUTHORS   Chen,P.S., Hsu,H.P., Phan,N.N., Yen,M.C., Chen,F.W., Liu,Y.W.,
            Lin,F.P., Feng,S.Y., Cheng,T.L., Yeh,P.H., Omar,H.A., Sun,Z.,
            Jiang,J.Z., Chan,Y.S., Lai,M.D., Wang,C.Y. and Hung,J.H.
  TITLE     CCDC167 as a potential therapeutic target and regulator of cell
            cycle-related networks in breast cancer
  JOURNAL   Aging (Albany NY) 13 (3), 4157-4181 (2021)
   PUBMED   33461170
  REMARK    GeneRIF: CCDC167 as a potential therapeutic target and regulator of
            cell cycle-related networks in breast cancer.
REFERENCE   2  (bases 1 to 572)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 572)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 572)
  AUTHORS   Need,A.C., Attix,D.K., McEvoy,J.M., Cirulli,E.T., Linney,K.L.,
            Hunt,P., Ge,D., Heinzen,E.L., Maia,J.M., Shianna,K.V., Weale,M.E.,
            Cherkas,L.F., Clement,G., Spector,T.D., Gibson,G. and
            Goldstein,D.B.
  TITLE     A genome-wide study of common SNPs and CNVs in cognitive
            performance in the CANTAB
  JOURNAL   Hum Mol Genet 18 (23), 4650-4661 (2009)
   PUBMED   19734545
REFERENCE   5  (bases 1 to 572)
  AUTHORS   Chapuis,J., Hot,D., Hansmannel,F., Kerdraon,O., Ferreira,S.,
            Hubans,C., Maurage,C.A., Huot,L., Bensemain,F., Laumet,G.,
            Ayral,A.M., Fievet,N., Hauw,J.J., DeKosky,S.T., Lemoine,Y.,
            Iwatsubo,T., Wavrant-Devrieze,F., Dartigues,J.F., Tzourio,C.,
            Buee,L., Pasquier,F., Berr,C., Mann,D., Lendon,C., Alperovitch,A.,
            Kamboh,M.I., Amouyel,P. and Lambert,J.C.
  TITLE     Transcriptomic and genetic studies identify IL-33 as a candidate
            gene for Alzheimer's disease
  JOURNAL   Mol Psychiatry 14 (11), 1004-1016 (2009)
   PUBMED   19204726
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC108655.1.
            
            On Nov 22, 2018 this sequence version replaced NM_138493.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC108655.1, SRR1163658.518522.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373408.4/ ENSP00000362507.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-572               BC108655.1         5-576
FEATURES             Location/Qualifiers
     source          1..572
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.2"
     gene            1..572
                     /gene="CCDC167"
                     /gene_synonym="C6orf129; HSPC265"
                     /note="coiled-coil domain containing 167"
                     /db_xref="GeneID:154467"
                     /db_xref="HGNC:HGNC:21239"
     exon            1..72
                     /gene="CCDC167"
                     /gene_synonym="C6orf129; HSPC265"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..324
                     /gene="CCDC167"
                     /gene_synonym="C6orf129; HSPC265"
                     /note="transmembrane and coiled-coil domain-containing
                     protein C6orf129"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 167"
                     /protein_id="NP_612502.1"
                     /db_xref="CCDS:CCDS34441.1"
                     /db_xref="GeneID:154467"
                     /db_xref="HGNC:HGNC:21239"
                     /translation="MTKKKRENLGVALEIDGLEEKLSQCRRDLEAVNSRLHSRELSPE
                     ARRSLEKEKNSLMNKASNYEKELKFLRQENRKNMLLSVAIFILLTLVYAYWTM"
     exon            73..167
                     /gene="CCDC167"
                     /gene_synonym="C6orf129; HSPC265"
                     /inference="alignment:Splign:2.1.0"
     exon            168..220
                     /gene="CCDC167"
                     /gene_synonym="C6orf129; HSPC265"
                     /inference="alignment:Splign:2.1.0"
     exon            221..572
                     /gene="CCDC167"
                     /gene_synonym="C6orf129; HSPC265"
                     /inference="alignment:Splign:2.1.0"
     regulatory      553..558
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC167"
                     /gene_synonym="C6orf129; HSPC265"
                     /note="hexamer: AATAAA"
     polyA_site      572
                     /gene="CCDC167"
                     /gene_synonym="C6orf129; HSPC265"
                     /note="major polyA site"
ORIGIN      
        1 agtgatgact gggggatccc ggcaagtaac atgactaaaa agaagcggga gaatctgggc
       61 gtcgctctag agatcgatgg gctagaggag aagctgtccc agtgtcggag agacctggag
      121 gccgtgaact ccagactcca cagccgggag ctgagcccag aggccaggag gtccctggag
      181 aaggagaaaa acagcctaat gaacaaagcc tccaactacg agaaggaact gaagtttctt
      241 cggcaagaga accggaagaa catgctgctc tctgtggcca tctttatcct cctgacgctc
      301 gtctatgcct actggaccat gtgagcctgg cacttcccca caaccagcac aggcttccac
      361 ttggcccctt gatcaggatc aagcaggcac ttcaagcctc aataggacca aggtgctggg
      421 gtgttcccct cccaacctag tgttcaagca tggcttcctg gcggcccagg ccttgcctcc
      481 ctggcctgct ggggggttcc gggtctccag aaggacatgg tgctggtccc tcccttagcc
      541 caagggagag gcaataaaga acacaaagct gt
//
