LOCUS       NM_001353453            2319 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens coiled-coil domain containing 160 (CCDC160),
            transcript variant 1, mRNA.
ACCESSION   NM_001353453 XM_005262409
VERSION     NM_001353453.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2319)
  AUTHORS   Zeng,Z., Feingold,E., Wang,X., Weeks,D.E., Lee,M., Cuenco,D.T.,
            Broffitt,B., Weyant,R.J., Crout,R., McNeil,D.W., Levy,S.M.,
            Marazita,M.L. and Shaffer,J.R.
  TITLE     Genome-wide association study of primary dentition pit-and-fissure
            and smooth surface caries
  JOURNAL   Caries Res 48 (4), 330-338 (2014)
   PUBMED   24556642
REFERENCE   2  (bases 1 to 2319)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004409.1 and KF459428.1.
            
            On Jun 15, 2021 this sequence version replaced NM_001353453.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1, 2 and 3 all encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.16042.1,
                                           SRR14372080.3097013.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000695460.1/ ENSP00000511932.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AC004409.1         28268-28429
            163-253             AC004409.1         29836-29926
            254-824             AC004409.1         35863-36433
            825-1172            KF459428.1         1-348
            1173-2319           AC004409.1         36782-37928
FEATURES             Location/Qualifiers
     source          1..2319
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.2"
     gene            1..2319
                     /gene="CCDC160"
                     /note="coiled-coil domain containing 160"
                     /db_xref="GeneID:347475"
                     /db_xref="HGNC:HGNC:37286"
     exon            1..162
                     /gene="CCDC160"
                     /inference="alignment:Splign:2.1.0"
     exon            163..253
                     /gene="CCDC160"
                     /inference="alignment:Splign:2.1.0"
     exon            254..2319
                     /gene="CCDC160"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..1255
                     /gene="CCDC160"
                     /note="UPF0625 coiled-coil domain-containing protein
                     ENSP00000359845"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 160"
                     /protein_id="NP_001340382.1"
                     /db_xref="CCDS:CCDS48171.1"
                     /db_xref="GeneID:347475"
                     /db_xref="HGNC:HGNC:37286"
                     /translation="MDARRKHWKENMFTPFFSAQDVLEETSEPESSSEQTTADSSKGM
                     EEIYNLSSRKFQEESKFKRKKYIFQLNEIEQEQNLRENKRNISKNETDTNSASYESSN
                     VDVTTEESFNSTEDNSTCSTDNLPALLRQDIRKKFMERMSPKLCLNLLNEELEELNMK
                     YRKIEEEFENAEKELLHYKKEIFTKPLNFQETETDASKSDYELQALRNDLSEKATNVK
                     NLSEQLQQAKEVIHKLNLENRNLKEAVRKLKHQTEVGNVLLKEEMKSYYELEMAKIRG
                     ELSVIKNELRTEKTLQARNNRALELLRKYYASSMVTSSSILDHFTGDFF"
     regulatory      1653..1658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC160"
                     /note="hexamer: AATAAA"
     polyA_site      1684
                     /gene="CCDC160"
                     /note="major polyA site"
     regulatory      2294..2299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC160"
                     /note="hexamer: AATAAA"
     polyA_site      2319
                     /gene="CCDC160"
ORIGIN      
        1 aaccgcgcgg cccgcgctgg cgctgcactg cggtggctca gcccggagcc ggcccggcgg
       61 ggtcgcggtg gccagagccg aacggggggc tgccgcgcgc gggtggtggt tgtctttgag
      121 gaagagaggt tcgggctctc cagacggcat ccacgcttcc agggagggag gcggaatttt
      181 cttttttcca gttcaaactg gagaaggagg gcagagatat ccagtagaca gaagatcttg
      241 gaccccagga agtatattgg aagaggtgcc tggagaaatg gatgctagaa gaaaacactg
      301 gaaggagaat atgtttactc ctttttttag tgcacaagat gttctagaag agacttctga
      361 gcctgaatct tcttctgaac aaacgactgc agatagcagc aagggaatgg aagaaattta
      421 taatttgtcc agtagaaagt ttcaggaaga aagtaaattt aagaggaaaa aatatatttt
      481 ccaactaaat gaaatagaac aagaacaaaa tttaagagag aacaagagaa acatttcaaa
      541 gaatgaaaca gacacaaatt ctgcatccta tgaatcatct aatgtggatg ttacaacaga
      601 agaaagcttt aacagcacag aagataactc tacctgcagt acagataact taccagctct
      661 actaagacaa gacataagaa agaaatttat ggaaagaatg tctccaaaac tttgcctgaa
      721 tcttttgaat gaagaactgg aagaacttaa tatgaaatac agaaaaatag aagaggaatt
      781 tgaaaatgct gaaaaagaac ttttgcacta caaaaaagaa atattcacaa aacccctaaa
      841 ttttcaagaa acagagacgg atgcttcaaa aagtgactat gaacttcaag ctttaagaaa
      901 tgacctgtct gaaaaagcaa caaatgtaaa aaacttaagt gaacagctcc agcaagccaa
      961 agaagtcatc cacaaattga acctagagaa cagaaattta aaagaagctg ttaggaagtt
     1021 aaagcatcaa accgaggttg gaaatgtgct cctaaaagaa gaaatgaaat catattatga
     1081 attagaaatg gcaaagatcc gcggagagct cagtgtcatc aagaatgaac tgagaactga
     1141 gaagacccta caagcaagaa ataacagagc cttggagttg cttagaaaat actatgcttc
     1201 ttcaatggta acatcatcaa gtatccttga ccactttact ggggattttt tttaaaactt
     1261 aaaaaaatcc ttccagtagg caagtcattg agccaaatca gtgtttattg tattttcttt
     1321 gcgtattact taaaatatat gtaataggat gttattttca ttttcagtaa atcacagtat
     1381 ctataaaaca tatacatgtt tccaagcttc tgctttctct ttctgatgaa gttattgcag
     1441 gaatacaaat ggaaacgaag ctttggaaat ctcatatcag agtgtgtgtg tgtgtgtgtg
     1501 tgtgtgtgtg tacacacaca catatattca ctcaaaaaca cataatgatt caccaaatca
     1561 tttatgaata caaatcagca attttgtgat ctcgtaagca aatatgtctt tggcacgtga
     1621 atatttttcc atctgtgttc attgatgtta acaataaaaa tcttgtttat gtgtataagc
     1681 ctaacatatg cctgtgggtc ttataactgc ctgttcaaac tcaatgggat accaaaaatg
     1741 tatctgctta ctttgggggt ctaactttaa ttcggtacat ataaacatct ctggaaaaaa
     1801 atgtagtttt tttcttcccc ctgctgtttt ccccaggctt tctcctttga cctggccacg
     1861 gttcccatag actacaagac gacttagaga cattgctgtg accttttgct agagccctgc
     1921 tcttgccagc agtggctttt gtgttttctt atgttgacca gtaaggggca ttgtttacac
     1981 agttcttcca aaactcgacc aggggaaaat ttcgaagctt cctccccggc ttacatcaca
     2041 agttggcggg gactgtggtg aagttggatg tcatctggat aaacttttag tgagctggct
     2101 tgatttttac agtaatccag ccctgtaagg gctccaggtg atgacaattt attttacact
     2161 tatacatggt aaaaatgtac tgcctcaatc cttgggtgga agtgatgggc cagttgactc
     2221 tttaccattt gtttgtatca gtcatcaaga tatcctgtaa taggagctct atttgcatgg
     2281 tgttttaaag cctaataaac caaatgtaat tgcacacta
//
