LOCUS       NM_001394954            3778 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens coiled-coil domain containing 158 (CCDC158),
            transcript variant 1, mRNA.
ACCESSION   NM_001394954 XM_006714204
VERSION     NM_001394954.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3778)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3778)
  AUTHORS   Kottgen,A., Pattaro,C., Boger,C.A., Fuchsberger,C., Olden,M.,
            Glazer,N.L., Parsa,A., Gao,X., Yang,Q., Smith,A.V., O'Connell,J.R.,
            Li,M., Schmidt,H., Tanaka,T., Isaacs,A., Ketkar,S., Hwang,S.J.,
            Johnson,A.D., Dehghan,A., Teumer,A., Pare,G., Atkinson,E.J.,
            Zeller,T., Lohman,K., Cornelis,M.C., Probst-Hensch,N.M.,
            Kronenberg,F., Tonjes,A., Hayward,C., Aspelund,T., Eiriksdottir,G.,
            Launer,L.J., Harris,T.B., Rampersaud,E., Mitchell,B.D.,
            Arking,D.E., Boerwinkle,E., Struchalin,M., Cavalieri,M.,
            Singleton,A., Giallauria,F., Metter,J., de Boer,I.H.,
            Haritunians,T., Lumley,T., Siscovick,D., Psaty,B.M.,
            Zillikens,M.C., Oostra,B.A., Feitosa,M., Province,M., de
            Andrade,M., Turner,S.T., Schillert,A., Ziegler,A., Wild,P.S.,
            Schnabel,R.B., Wilde,S., Munzel,T.F., Leak,T.S., Illig,T.,
            Klopp,N., Meisinger,C., Wichmann,H.E., Koenig,W., Zgaga,L.,
            Zemunik,T., Kolcic,I., Minelli,C., Hu,F.B., Johansson,A., Igl,W.,
            Zaboli,G., Wild,S.H., Wright,A.F., Campbell,H., Ellinghaus,D.,
            Schreiber,S., Aulchenko,Y.S., Felix,J.F., Rivadeneira,F.,
            Uitterlinden,A.G., Hofman,A., Imboden,M., Nitsch,D.,
            Brandstatter,A., Kollerits,B., Kedenko,L., Magi,R., Stumvoll,M.,
            Kovacs,P., Boban,M., Campbell,S., Endlich,K., Volzke,H.,
            Kroemer,H.K., Nauck,M., Volker,U., Polasek,O., Vitart,V.,
            Badola,S., Parker,A.N., Ridker,P.M., Kardia,S.L., Blankenberg,S.,
            Liu,Y., Curhan,G.C., Franke,A., Rochat,T., Paulweber,B.,
            Prokopenko,I., Wang,W., Gudnason,V., Shuldiner,A.R., Coresh,J.,
            Schmidt,R., Ferrucci,L., Shlipak,M.G., van Duijn,C.M., Borecki,I.,
            Kramer,B.K., Rudan,I., Gyllensten,U., Wilson,J.F., Witteman,J.C.,
            Pramstaller,P.P., Rettig,R., Hastie,N., Chasman,D.I., Kao,W.H.,
            Heid,I.M. and Fox,C.S.
  TITLE     New loci associated with kidney function and chronic kidney disease
  JOURNAL   Nat Genet 42 (5), 376-384 (2010)
   PUBMED   20383146
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC096743.3 and AC034139.7.
            
            On May 11, 2021 this sequence version replaced XM_006714204.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000682701.1/ ENSP00000507278.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               AC096743.3         33734-33910         c
            178-220             AC096743.3         24859-24901         c
            221-363             AC096743.3         15907-16049         c
            364-581             AC096743.3         9038-9255           c
            582-691             AC034139.7         171736-171845       c
            692-1019            AC034139.7         171268-171595       c
            1020-1096           AC034139.7         170842-170918       c
            1097-1207           AC034139.7         169790-169900       c
            1208-1322           AC034139.7         166470-166584       c
            1323-1442           AC034139.7         158597-158716       c
            1443-1640           AC034139.7         156606-156803       c
            1641-2123           AC034139.7         154474-154956       c
            2124-2313           AC034139.7         149306-149495       c
            2314-2466           AC034139.7         144554-144706       c
            2467-2579           AC034139.7         142504-142616       c
            2580-2738           AC034139.7         140303-140461       c
            2739-2831           AC034139.7         138900-138992       c
            2832-2957           AC034139.7         138176-138301       c
            2958-3115           AC034139.7         121190-121347       c
            3116-3175           AC034139.7         119612-119671       c
            3176-3235           AC034139.7         118524-118583       c
            3236-3303           AC034139.7         116080-116147       c
            3304-3462           AC034139.7         113037-113195       c
            3463-3570           AC034139.7         110482-110589       c
            3571-3778           AC034139.7         100219-100426       c
FEATURES             Location/Qualifiers
     source          1..3778
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.1"
     gene            1..3778
                     /gene="CCDC158"
                     /note="coiled-coil domain containing 158"
                     /db_xref="GeneID:339965"
                     /db_xref="HGNC:HGNC:26374"
     exon            1..177
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     exon            178..220
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     exon            221..363
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..3647
                     /gene="CCDC158"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 158"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 158
                     isoform 1"
                     /protein_id="NP_001381883.1"
                     /db_xref="CCDS:CCDS93551.1"
                     /db_xref="GeneID:339965"
                     /db_xref="HGNC:HGNC:26374"
                     /translation="MESKAWESNNEDLLSSSGVTSNGGSSSSFFVSSIRGTIIENTSS
                     AGTLTQVPFFPKYEVELDSPRKIIPSPGKEHFERVLEEYSHQVKDLQRRLNESNELHE
                     KQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCL
                     KEDMLKDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASGKKICEHDSMSTLHFRSL
                     GSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEH
                     EVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELR
                     EAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKE
                     LSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQM
                     AAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEK
                     ERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEI
                     LRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELE
                     ARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRN
                     FRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKR
                     GQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQ
                     ERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSN
                     SSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSV
                     INEEPAVSLSKTEEDGRTSLGALYVAVEDRVRDCITESSLRSDMCHRSNNSLRDSTEG
                     SKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKKSPVHSLLT
                     SSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQTLVEDLQ
                     LKNQAMSSMIRNQEKRIQKVKDQEKMLLK"
     exon            364..581
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     exon            582..691
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     exon            692..1019
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1096
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1207
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1322
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1442
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1640
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..2123
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2313
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2466
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2579
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2738
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2831
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2957
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..3115
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     exon            3116..3175
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     exon            3176..3235
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3303
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     exon            3304..3462
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     exon            3463..3570
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     exon            3571..3778
                     /gene="CCDC158"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3749..3754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC158"
                     /note="hexamer: AATAAA"
     polyA_site      3778
                     /gene="CCDC158"
                     /note="major polyA site"
ORIGIN      
        1 agcttccggc gccgcagccg aggaggagga gccgccccgc agcctccgcg gggcctaggg
       61 gcgaagagtg gggagccgcc ccgtcccagc cgccaggtcg acgtaggtgg ggccgctgcg
      121 cccgccggcg ccccgcggag atgtggccgg tgtcttagga ttaggtgttg gttgcagata
      181 ttaatagaat aagtgaaaat aagaatatcc agaagttaag acaggaacca aaagaaccaa
      241 agagggaacc attcatactt caagatctct aataagaagt agcaatattt aatatggaat
      301 caaaagcttg ggaatcaaat aatgaagatc ttttatcaag tagtggtgtc acatctaatg
      361 gaggttcttc aagttcattt tttgtgtcat ctattcgtgg tacaataatt gaaaacacat
      421 cttcagctgg gactttgaca caggttcctt ttttccctaa atatgaagtg gaacttgatt
      481 ctcctagaaa aatcatccca tctcctggaa aggaacactt tgaacgtgtt ttggaagaat
      541 attcacatca agtcaaagat ttacagagaa gactaaatga aagcaatgaa ttgcatgaga
      601 aacaaaagtt ttatttgagg cagtcagtca ttgatttgca aacaaaactt caggagatgc
      661 aaatggagag agatgctatg gctgacatca gacgaaggga gagtcagtcc caggaggatt
      721 taagaaatca gcttcaaaat acagttcatg aacttgaagc tgccaaatgc cttaaagagg
      781 acatgctgaa agacagcaac acacagatag agcaactacg aaaaatgatg cttagtcatg
      841 agggagtgct tcaagaaatc cggtcaatcc tagttgactt tgaagaagcc tcaggcaaaa
      901 aaatatgtga acatgacagc atgtctactc tgcacttccg cagcttgggc tcagctatta
      961 gtaaaatact aagagaatta gacacagaga tttcttatct taaagggagg atatttccag
     1021 tagaggatca acttgaagca ctgaaatctg aatcacagaa caaaatagaa ctacttctgc
     1081 aacaacacca agataggatt gagcagttaa taagtgaaca tgaagttgaa ataacaggac
     1141 ttactgagaa agctagcagt gctcgaagcc aagccaatag tatccagagt caaatggaaa
     1201 tcattcaaga gcaagcaaga aaccaaaact ctatgtatat gcgtcagctc agcgatctgg
     1261 aatctactgt ttctcagcta cgttctgaat taagggaagc caaaaggatg tatgaagaca
     1321 agacagaaga gctggaaaag cagttagtcc ttgccaactc agagctaact gaagcccgga
     1381 cagagcgtga tcaattcagt caggaatctg gaaatttaga tgatcaactt caaaagctgt
     1441 tggctgatct acacaaaagg gagaaggagc tgagtctgga gaaggagcag aataagcgtc
     1501 tgtgggaccg agacacaggc aacagcatca ccattgacca cctgcggcgg gaactggaca
     1561 accggaacat ggaggtgcag cgcctggaag ccctgctcaa ggccttgaag agcgagtgtc
     1621 agggccagat ggagcggcag atggcagcaa ttcaaggaaa gaatgaaagt ctagaaaaag
     1681 tatcctcctt gactgctcag cttgaatcca ccaaagagat gctgcgcaaa gtagtagaag
     1741 agttgacagc caagaaaatg actctggaga gctcagagag gacaatatcg gacctgacaa
     1801 cttctctcca ggaaaaagag agagccatcg aggctaccaa tgcagagatc acaaagctcc
     1861 gctcccgggt ggacttgaaa ttgcaggagc tgcaacactt gaaaaatgaa ggggatcatc
     1921 tcagaaatgt gcagacagaa tgtgaggccc tcaaactgca gatgacagag aaggacaagg
     1981 tgatcgagat tctgcgacag cagattgaga acatgacaca gctggtgggc cagcatggac
     2041 gaactgctgg agctatgcaa gtagaaaaag ctcaactgga gaaagaaatt aatgataggc
     2101 ggatggaact aaaggaactt aagatattaa aagataaaaa agatgcaaag atccgggagc
     2161 ttgaggccag agtgagtgac ttggagctgg aaaaggtgaa gctggtgaat gcaggctctg
     2221 agcggctccg tgcagtgaag gacatcaaac aagagagaga tcaattatta aatgaggtga
     2281 aaacaagtag gagtgaatta aacaatcttt cagaggagta tgaagtctta aaaaggaatt
     2341 tccgaaacaa aagtgaagaa atggaaatga ctacaaataa gttgaaaatg caattaaaat
     2401 ctgcacagtc tgaactagaa cagacaagaa atacattaaa gtcaatggaa ggatctgatg
     2461 gtcatgctat gaaagtggca atggggatgc aaaagcaaat cacagccaaa agaggtcaga
     2521 tagatgccct tcagagcaag atacagtttt tggaagaggc aatgacaaat gcaaataagg
     2581 agaaacattt tctgaaagaa gagaaaagta aactcagtca ggaattgagt actgttgcca
     2641 cagaaaaaaa caagatggct ggggagttgg aagttctgcg atctcaggaa cgccgtttga
     2701 aagaaaaggt tactaatatg gaagtggctc tggataaggc atctttgcag tttgcagaat
     2761 gtcaagatat aatacagcgt caggagcaag aatcagtgcg cttaaaactt caacacactt
     2821 tggatataaa agaacttcag ggccctggat acacctcaaa ttcttcattg aaaccacgcc
     2881 ttctccagcc agcatctgtt actcgttctc attctaatgt accatcttcg cagtctacag
     2941 ccagcttcct gtctcatcac tctacaaaag ctaacacact gaaggaagat ccaacaaggg
     3001 acctgaaaca gcttctccaa gagttgagaa gcgtgatcaa tgaggagcca gctgtgtctc
     3061 tgagcaagac agaggaagat ggaagaacat ctctgggagc cttgtatgtg gctgtagagg
     3121 atagggtaag agattgcatt actgaatcca gcctgagatc agacatgtgc catagaagca
     3181 acaactcgtt gagggactcc actgaaggaa gcaaatcaag tgaaactctt agtagagagc
     3241 cagtcacatt acacgcagga gacagggaag atccctctgg ttgcttcaca ttcacatctg
     3301 cagcaagtcc atctgtgaaa aactcagctt ctcgttcatt caattcttct cctaagaagt
     3361 ctccagtgca ctcactccta actagttcag ttgaaggttc aataggttcc acatcacagt
     3421 atagatctgc caaacctatt cattcatctg attctgttaa agattcacag tctccgccaa
     3481 tagaaacaac aggaaaaaca tgcaggaagc ttcagaacag actagaaagc ttgcaaactc
     3541 tggtagaaga tttacagctg aagaaccaag caatgtcttc aatgatcaga aatcaagaaa
     3601 agaggataca gaaagtaaaa gaccaggaaa aaatgttact aaaatgactc gttgcttgcc
     3661 tattctttac agaggaatga ggcccaatta attgtggtgt tactcgtaat tagtgccctg
     3721 tgtacttttt ctttttatgt gaaaatttaa taaaagatac cctgtcttgt aaactcta
//
