LOCUS       NM_001017437            4478 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens coiled-coil domain containing 157 (CCDC157),
            transcript variant 2, mRNA.
ACCESSION   NM_001017437 XM_496523
VERSION     NM_001017437.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4478)
  AUTHORS   Zheng,H., Gong,C., Li,J., Hou,J., Gong,X., Zhu,X., Deng,H., Wu,H.,
            Zhang,F., Shi,Q., Zhou,J., Shi,B., Yang,X. and Xi,Y.
  TITLE     CCDC157 is essential for sperm differentiation and shows
            oligoasthenoteratozoospermia-related mutations in men
  JOURNAL   J Cell Mol Med 28 (7), e18215 (2024)
   PUBMED   38509755
  REMARK    GeneRIF: CCDC157 is essential for sperm differentiation and shows
            oligoasthenoteratozoospermia-related mutations in men.
REFERENCE   2  (bases 1 to 4478)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4478)
  AUTHORS   Bassaganyas,L., Popa,S.J., Horlbeck,M., Puri,C., Stewart,S.E.,
            Campelo,F., Ashok,A., Butnaru,C.M., Brouwers,N., Heydari,K.,
            Ripoche,J., Weissman,J., Rubinsztein,D.C., Schekman,R.,
            Malhotra,V., Moreau,K. and Villeneuve,J.
  TITLE     New factors for protein transport identified by a genome-wide
            CRISPRi screen in mammalian cells
  JOURNAL   J Cell Biol 218 (11), 3861-3879 (2019)
   PUBMED   31488582
  REMARK    GeneRIF: The CCDC157 is localized along the secretory pathway and
            was found to interact with resident proteins of ER-Golgi membranes.
REFERENCE   4  (bases 1 to 4478)
  AUTHORS   Yuan,X., Zheng,H., Su,Y., Guo,P., Zhang,X., Zhao,Q., Ge,W., Li,C.,
            Xi,Y. and Yang,X.
  TITLE     Drosophila Pif1A is essential for spermatogenesis and is the
            homolog of human CCDC157, a gene associated with idiopathic NOA
  JOURNAL   Cell Death Dis 10 (2), 125 (2019)
   PUBMED   30741974
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4478)
  AUTHORS   Wojczynski,M.K., Li,M., Bielak,L.F., Kerr,K.F., Reiner,A.P.,
            Wong,N.D., Yanek,L.R., Qu,L., White,C.C., Lange,L.A.,
            Ferguson,J.F., He,J., Young,T., Mosley,T.H., Smith,J.A., Kral,B.G.,
            Guo,X., Wong,Q., Ganesh,S.K., Heckbert,S.R., Griswold,M.E.,
            O'Leary,D.H., Budoff,M., Carr,J.J., Taylor,H.A. Jr., Bluemke,D.A.,
            Demissie,S., Hwang,S.J., Paltoo,D.N., Polak,J.F., Psaty,B.M.,
            Becker,D.M., Province,M.A., Post,W.S., O'Donnell,C.J., Wilson,J.G.,
            Harris,T.B., Kavousi,M., Cupples,L.A., Rotter,J.I., Fornage,M.,
            Becker,L.C., Peyser,P.A., Borecki,I.B. and Reilly,M.P.
  TITLE     Genetics of coronary artery calcification among African Americans,
            a meta-analysis
  JOURNAL   BMC Med Genet 14, 75 (2013)
   PUBMED   23870195
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004997.2.
            
            On Oct 19, 2020 this sequence version replaced NM_001017437.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.215158.1,
                                           SRR14372080.1815703.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338306.8/ ENSP00000343087.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               AC004997.2         74722-74847
            127-280             AC004997.2         79676-79829
            281-539             AC004997.2         83705-83963
            540-711             AC004997.2         87147-87318
            712-1336            AC004997.2         88041-88665
            1337-1414           AC004997.2         89365-89442
            1415-1626           AC004997.2         89790-90001
            1627-1794           AC004997.2         91312-91479
            1795-1963           AC004997.2         91638-91806
            1964-2148           AC004997.2         93194-93378
            2149-2237           AC004997.2         93974-94062
            2238-4478           AC004997.2         94148-96388
FEATURES             Location/Qualifiers
     source          1..4478
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..4478
                     /gene="CCDC157"
                     /note="coiled-coil domain containing 157"
                     /db_xref="GeneID:550631"
                     /db_xref="HGNC:HGNC:33854"
                     /db_xref="MIM:619391"
     exon            1..126
                     /gene="CCDC157"
                     /inference="alignment:Splign:2.1.0"
     exon            127..280
                     /gene="CCDC157"
                     /inference="alignment:Splign:2.1.0"
     exon            281..539
                     /gene="CCDC157"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..2550
                     /gene="CCDC157"
                     /note="isoform 1 is encoded by transcript variant 2;
                     coiled-coil domain-containing protein 157"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 157
                     isoform 1"
                     /protein_id="NP_001017437.3"
                     /db_xref="CCDS:CCDS33632.2"
                     /db_xref="GeneID:550631"
                     /db_xref="HGNC:HGNC:33854"
                     /db_xref="MIM:619391"
                     /translation="MAHLLGSQACMESLRTDLTDLQGAIVDVFSRAGPVRFPSWKFPD
                     RMACDLDMVALLEHYDHVPGDPEFTQLSHAVLLELVIDRLLLLLQSCMSYLENLGSEQ
                     MMPPAQAAGPCMSVGLTVRRFWDSLLRLGTLHQQPLPQKGANQRETPTSKPTTKGEPA
                     RSPEYLTTKLIKPSSPVLGLPQTCQEPESIPVRASLQFPATTFKNTRSVHSQTIETAL
                     VPCDACASVQGSLQKVGKVVISLCQSQNLPSSLGQFQQLVQDSMGLRPLPAATVGRWA
                     AEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQ
                     CLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAE
                     RQVQQLEEQVQQLEAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAK
                     QRALLKQLDSLDQEREELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQ
                     REKQGLEQATTDLRLTILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSVES
                     QITCPTDSGNVTDHMERQVQSNDIRIRVLQEENGRLQSMLSKIREVAQQGGLKLIPQD
                     RLWSPSSKGTQGATPPVQAKSTSPGPLGRQHLPSSRTGRTLLGQPCTSPPRQPCTSPP
                     RQPCTSPPRQPCTSPSRQPCSQPSKSLLEGVTHLDTCTQNPIKVLVRLRKRLSPGRGQ
                     ASSAHQPQERPM"
     exon            540..711
                     /gene="CCDC157"
                     /inference="alignment:Splign:2.1.0"
     exon            712..1336
                     /gene="CCDC157"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1414
                     /gene="CCDC157"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1626
                     /gene="CCDC157"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1794
                     /gene="CCDC157"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1963
                     /gene="CCDC157"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2148
                     /gene="CCDC157"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2237
                     /gene="CCDC157"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..4478
                     /gene="CCDC157"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2605..2610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC157"
                     /note="hexamer: AATAAA"
     polyA_site      2634
                     /gene="CCDC157"
                     /note="major polyA site"
     regulatory      4444..4449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC157"
                     /note="hexamer: AATAAA"
     regulatory      4457..4462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC157"
                     /note="hexamer: AATAAA"
     polyA_site      4463
                     /gene="CCDC157"
     polyA_site      4478
                     /gene="CCDC157"
ORIGIN      
        1 gttgccaagg cagcggcctg agcgcccggc tagggctttt cggggatccc ggtggccgca
       61 ggcgcaccgg gggcagttcc gggagccgac cagacacgaa ggctgaagcc gcgacgccga
      121 agacagggtc tgaagagcta ctcagagcca accctgcact ggagacagga agccgggcac
      181 ctggatgagc ctctgaccca gagccctgga gcccataggc tcgtctgaga actagacaca
      241 ctcagtcact ccagctccac gggcagacac ctgcacagag gatctgtgag gatggcgcac
      301 ctgctgggca gccaggcctg catggagagc ctgcgcacag acctcaccga cctgcagggt
      361 gccatcgtag acgtcttctc ccgcgccggg cctgtgcgct tcccctcctg gaagttccct
      421 gaccgcatgg cctgtgacct cgacatggtg gccctgctgg agcactatga ccatgttccg
      481 ggtgaccccg agttcacgca gctgtcccat gccgtgctgc tggagctggt catcgacagg
      541 ctcctgctgc tgcttcaaag ctgtatgagc tacttggaga accttggctc agagcagatg
      601 atgccccctg cacaggctgc ggggccctgc atgtccgtgg ggctcacggt gcggcgcttc
      661 tgggacagcc tgctgaggct gggcacgctc caccagcagc cactccccca gaaaggggca
      721 aaccaaaggg agactcccac ctccaagccc accaccaagg gcgagccagc caggagccct
      781 gaatatctga ctaccaagtt aatcaagccc tcctccccag tgctaggctt gccccagacc
      841 tgccaagagc cagagagcat ccctgtcaga gcctccctgc agttcccagc cacgaccttc
      901 aagaacacca ggagtgtcca ctcccagacc attgagacgg ccctggtgcc ctgtgacgca
      961 tgcgccagcg tccagggaag cctgcagaag gtgggcaagg tggtcatcag cctgtgtcag
     1021 agccagaacc tgccctcgtc cttaggccag ttccagcaac tggtgcagga cagcatgggg
     1081 ctcaggccac tgccggctgc caccgtgggc cgctgggcag cagagcagag gaaagacctg
     1141 acgcgcctca gtaagcatgt ggaggccctc agggcccagc tggaggaggc tgaagggcag
     1201 aaggatggcc tgaggaagca ggcgggcaag ctggagcagg cgctgaaaca ggagcagggg
     1261 gcacggcggc gacaggcgga ggaggatgag cagtgcctgt ctgagtggga gcacgacaaa
     1321 cagcagctgc tcacagaaac aagtgaccta aagacaaaga tggccaccct ggagagagaa
     1381 ctgaaacagc agcgggagtc cacacaggct gtggaggcaa aggcccagca gctgcaggag
     1441 gaaggtgagc gcagggcggc agcggagagg caggtgcagc agctggagga gcaggtgcag
     1501 cagttggagg cgcaggtgca gctgttggtg ggtcggctgg agggcgctgg ccagcaggtc
     1561 tgctgggcca gcacggagct ggataaggag aaggcccgtg tcgacagcat ggtccgccac
     1621 caggagtctc tgcaggccaa gcagcgagcc ctgctaaagc agctggacag cctggaccag
     1681 gaacgtgagg agctgcgggg cagcctggac gaggctgagg cccagcgggc ccgcgtggag
     1741 gagcagctgc agagcgagcg ggagcagggg caatgccagc tcagggccca gcaggagctg
     1801 ctgcagagcc tgcagaggga gaagcaaggc ctggagcagg cgactacgga cctgcggcta
     1861 accatcctgg agctagaacg ggagctggag gagctgaagg agcgggagcg gctgctggtg
     1921 gccttcccag acctgcacag gcccaccgag acccagatcc atggaggcag atccagcagc
     1981 gtggaatccc agataacatg tcccacagac tctggcaacg tcacagatca catggagagg
     2041 caagtgcagt ccaacgacat ccgcatccgg gtcctacagg aggagaacgg gcggctccaa
     2101 tcaatgctgt ccaaaatccg ggaagtggcc cagcagggtg gcctcaagct gatcccgcag
     2161 gaccggctct ggtccccttc cagcaaggga acccagggag caacaccacc agtccaggcc
     2221 aagagcacat ccccagggcc tctgggcaga cagcaccttc ctagcagcag gacgggtagg
     2281 accctgctgg gccagccctg cacatcccca cctcggcagc cctgcacatc cccacctcgg
     2341 cagccctgca catccccacc tcggcagccc tgcacatccc catctcggca gccctgcagc
     2401 cagcccagca agtccttgct ggagggtgtg acccacttgg acacctgcac ccagaacccc
     2461 atcaaggtct tggtcaggct gagaaagaga ctgtcacctg gccggggaca ggccagctct
     2521 gcacaccagc cccaggagcg gcccatgtag cctgtggccc agggctgagg ctggatggga
     2581 ggtggctggc agcccaccca ctgtaataaa gccccagcca ttggcccaca gcaatctttg
     2641 cctcacagta tgactgagcc aaggaaagaa cccttccttc cctgtcctgg gcaggggcca
     2701 ctgagtcccc agccatgtag ttcagtcagt cagcagagtc ctggcactat gggccctcag
     2761 taaaaggggc cttcctgctt ccctcccgac agaggctgtg ggataggaga gtacacccag
     2821 ggcagaggaa gctcctaaga cctgggccag gtgaaggtcc gtttttctat ccccagagca
     2881 agggtcgagg ggtgaacctt ggctcagtgg cccgcactga ctcaggaagg ggtcaggtgg
     2941 gagtggacag aggaagggcc ggtgaggatg tctgaagcag gcagagggca gcaacgcctt
     3001 cagcctccca ccctggctct ggacctgcgc tgggcacatt aaggacccaa gaggtcaggc
     3061 ctcctttcac tgaggaactc cttgccttta ggaaatggtg accgtcatga aggtttctct
     3121 aaatcctgga gatcatagcc ccaggaggcc actgaaggcg gggcaaggcc tccaccaagc
     3181 agaggacacc ctgccagccc tggctttccc atccctgtcc cttgggggtc tcttcagccc
     3241 agggtgccat gcggccaagc atctggggct ctggttttcc tcatgaagcc accagcctac
     3301 cctgagccac ctcacctgtg aaggacaatc tccaaaaact tgctgaggcc ttctcagggc
     3361 gcacgctccc aaatgcctga agcattttcc cttggtgaag aggccgtcag gtagagcacc
     3421 tcagttcaca gagaagggtc aagaggggcc atgtatatag ctgagctacc acagctttgg
     3481 tcagcccaac ttcctgcttc tgaggggcct gggagttcct gagggaggct ggggtgcccc
     3541 gggcaccccc ctcacagggg agcaccatcc ctcagcaccc tgagccagaa ggcctgtgct
     3601 caagtccagg ggaaggacct cacagctgag tagctctctc aggcgcccac caactccgtg
     3661 ccatgtattc attagctccc agttctggca gtcagaagtc caggttctgt gtggctgggt
     3721 ttttttgctc cgggtcccag agggctgaaa ttgaggcatc taccaggttg cgttcctttc
     3781 tgccggttct ggggaagaat tggcttccaa gctccacttg ttggcagaat tccgatcctt
     3841 gcggctgtgg gactgaggtc cccatgtcct cgctggctgg ctgtaagcca ggtcctctca
     3901 cggctcctag aggccgtcca ccttccttgc catggggctc cctccatctt caagtcaaca
     3961 acagaggatt tctcatgtgc tgaatccccc acatgcttca aatccctgac ttcctcctct
     4021 tctaccagca gaaaactact ttgaataggc tcatgtggtt agggcaaggc tcacactcaa
     4081 atactttccc tatcttcagg tcagcttgct ataagacaga acccaaccat gggcataaaa
     4141 tccctttgag aagccaggcg cagtggctca cgtctgtaat cccagcactt tgggaggccg
     4201 aggcaggcgg atcacctgag atcgggagtt cgagaccagc ctgaccaaca tggagaaacc
     4261 ccgtctctac taaaaataca aaattagccg ggcgtggtgg cgcatgtctg taatcccagc
     4321 tacttgggag gctgagacag gagaattgct tgaacccggg aggcggaggt tgcagtgagg
     4381 cgagatcacg ccattgcact ccagcctggg caacaagagt gaaactccat ctcaagaaat
     4441 aaaaataaaa taaataaata aaatccctct gagtccca
//
