LOCUS       NM_025004               3812 bp    mRNA    linear   PRI 17-MAR-2025
DEFINITION  Homo sapiens coiled-coil domain containing 15 (CCDC15), mRNA.
ACCESSION   NM_025004
VERSION     NM_025004.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3812)
  AUTHORS   Arslanhan,M.D., Cengiz-Emek,S., Odabasi,E., Steib,E., Hamel,V.,
            Guichard,P. and Firat-Karalar,E.N.
  TITLE     CCDC15 localizes to the centriole inner scaffold and controls
            centriole length and integrity
  JOURNAL   J Cell Biol 222 (12) (2023)
   PUBMED   37934472
  REMARK    GeneRIF: CCDC15 localizes to the centriole inner scaffold and
            controls centriole length and integrity.
REFERENCE   2  (bases 1 to 3812)
  AUTHORS   Deng,X., Sabino,E.C., Cunha-Neto,E., Ribeiro,A.L., Ianni,B.,
            Mady,C., Busch,M.P. and Seielstad,M.
  CONSRTM   REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology
            Donor Study-II Component International
  TITLE     Genome wide association study (GWAS) of Chagas cardiomyopathy in
            Trypanosoma cruzi seropositive subjects
  JOURNAL   PLoS One 8 (11), e79629 (2013)
   PUBMED   24324551
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3812)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003501.2, BC018540.1, AK023277.1, BU569785.1, DB516555.2 and
            AW339835.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_025004.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1965299, SAMEA1968540
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344762.6/ ENSP00000341684.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AP003501.2         89282-89286
            6-2061              BC018540.1         1-2056
            2062-2247           AK023277.1         2143-2328
            2248-2566           BC018540.1         2243-2561
            2567-2858           BU569785.1         210-501
            2859-3137           DB516555.2         393-671
            3138-3459           AP003501.2         175895-176216
            3460-3812           AW339835.1         5-357               c
FEATURES             Location/Qualifiers
     source          1..3812
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..3812
                     /gene="CCDC15"
                     /note="coiled-coil domain containing 15"
                     /db_xref="GeneID:80071"
                     /db_xref="HGNC:HGNC:25798"
     exon            1..169
                     /gene="CCDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            170..355
                     /gene="CCDC15"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..3034
                     /gene="CCDC15"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 15"
                     /protein_id="NP_079280.2"
                     /db_xref="CCDS:CCDS44756.1"
                     /db_xref="GeneID:80071"
                     /db_xref="HGNC:HGNC:25798"
                     /translation="MLGSMARKKPRNTSRLPLALNPLKSKDVLAVLAERNEAIVPVGA
                     WVEPASPGSSEIPAYTSAYLIEEELKEQLRKKQEALKHFQKQVKYRVNQQIRLRKKQQ
                     LQKSYERAQKEGSIAMQSSATHLTSKRTSVFPNNLNVAIGSSRLPPSLMPGDGIEDEE
                     NQNELFQQQAQALSETMKQARHRLASFKTVIKKKGSVFPDDGRKSFLTREEVLSRKPA
                     STGINTGIRGELPIKVHQGLLAAVPYQNYMENQELDYEEPDYEESSSLVTDEKGKEDL
                     FGRGQQDQQAIHSEDKNKPFSRVQKVKFKNPLFVLMEEEEQKQLHFEGLQDILPEAQD
                     YFLEAQGDLLETQGDLTGIQSVKPDTQAVEMKVQVTEPEGQAIEPEGQPIKTETQGIM
                     LKAQSIELEEGSIVLKTQDFLPTNQALLTKNQDVLLKDHCVLPKDQSILLKYQDQDFL
                     PRDQHVLHKDQDILPKYQDQNFLPKDQNFLSRDQHVLPKDQDILPKYQDQNFLPKDQN
                     FLSRDQHVLPKDQNILPKYQGQDFLPKDQDFLSRDQHVLPKDWNILPKCQDQDFLPRD
                     QGVLPKDQNILPICQDQDFLPRDQGYLPKDQNILPICQDRDFLPRDLHVLSNDQNILP
                     KCQDQDFLPKYQKVHFKEPYSDMTDEKGREDFSLADYQCLPPKSQDQDDIKNQQPASF
                     MREERVREELPLDYHQYVVPKIQDQDSPREQNKHIKLPSSFEKWEIARGNTPGVPLAY
                     DRYQSGLSTEFQAPLAFQSDVDKEEDKKERQKQYLRHRRLFMDIEREQVKEQQRQKEQ
                     KKKIEKIKKKREQECYAAEQRILRMNFHEDPYSGEKLSEILAQLQLQEIKGTREKQQR
                     EKEYLRYVEALRAQIQEKMQLYNITLPPLCCCGPDFWDAHPDTCANNCIFYKNHRAYT
                     RALHSFINSCDVPGGNSTLRVAIHNFASAHRRTLKNL"
     exon            356..505
                     /gene="CCDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            506..694
                     /gene="CCDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            695..808
                     /gene="CCDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            809..931
                     /gene="CCDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1078
                     /gene="CCDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..2086
                     /gene="CCDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2209
                     /gene="CCDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2317
                     /gene="CCDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2392
                     /gene="CCDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2485
                     /gene="CCDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2589
                     /gene="CCDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2763
                     /gene="CCDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2912
                     /gene="CCDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3812
                     /gene="CCDC15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3640..3645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC15"
                     /note="hexamer: AATAAA"
     polyA_site      3661
                     /gene="CCDC15"
                     /note="major polyA site"
     regulatory      3786..3791
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC15"
                     /note="hexamer: AATAAA"
     polyA_site      3812
                     /gene="CCDC15"
ORIGIN      
        1 agactgagtc tgtggcgagc tgcgggccga ttcctggcca gtgccatctc agccggagca
       61 ggcctcgggg cctcagaagc aggcttttat ctggcccgag gctcccagcc gttcagcgcg
      121 tcttcccata acctataccg attattggga ctctcggctg cagacacagg agtcacagat
      181 gctgggaagt atggcccgaa agaaacctcg aaatacctca aggttgcccc tggctttaaa
      241 ccccctgaag agcaaggacg tgttggcagt gctggctgag aggaacgagg ctatagtacc
      301 agttggggca tgggtggaac ctgcctcacc aggtagttcg gaaatcccag catatacatc
      361 agcatattta attgaagaag aactaaagga acagctaaga aaaaaacaag aagctttgaa
      421 acattttcag aaacaagtta aataccgagt aaatcaacaa attaggttga gaaaaaagca
      481 acagcttcag aagtcttatg aaagagcaca aaaagaaggc tccatagcca tgcagtcttc
      541 agcaacacac ttaacttcca aaaggacaag tgtttttcca aacaatttga atgttgctat
      601 tggaagttct aggttacctc cttccctgat gcctggggat ggaatagagg atgaagagaa
      661 tcagaacgaa ttattccaac aacaagccca ggctcttagt gaaactatga aacaggcacg
      721 tcaccggcta gcatccttta aaaccgtgat taaaaaaaag ggatcagtgt ttccagatga
      781 tggaaggaaa agctttctta ccagagagga agtgctttcc aggaaaccag catccactgg
      841 gataaataca ggaataagag gagagttgcc cattaaggtc catcaaggtc ttttagctgc
      901 tgtaccttac cagaattata tggaaaatca ggaacttgac tatgaggaac ctgactatga
      961 ggaatcttca tctcttgtaa ctgatgagaa agggaaagaa gatttgtttg ggagaggcca
     1021 gcaggaccag caggctatcc attctgaaga taagaacaaa cctttcagca gagttcagaa
     1081 agtaaaattc aaaaatccat tatttgttct gatggaagag gaagaacaaa agcagttaca
     1141 ttttgagggc cttcaggata ttctgccaga agcccaggat tattttctag aagcccaagg
     1201 tgatttgctg gaaacccagg gtgatttgac aggaatccag agtgttaagc cagataccca
     1261 ggctgttgaa atgaaggttc aggttactga gccagaaggc caggccattg agccagaagg
     1321 ccagcctatt aagacagaaa ctcagggtat tatgctgaaa gcccagagta ttgagctaga
     1381 agaagggagt attgtgttga aaacccagga ttttctaccc acaaatcagg ctcttctaac
     1441 gaaaaaccag gatgttttac tcaaagacca ctgtgttctc cctaaagacc agagtattct
     1501 actcaaatat caggaccagg acttcctacc cagagaccag catgttctcc acaaagacca
     1561 agatattctg ccaaaatatc aggaccagaa ttttctacct aaggaccaga attttttatc
     1621 tagagaccag catgttctcc ccaaagacca agatattctg ccaaaatatc aggaccagaa
     1681 ttttctacct aaggaccaga attttttgtc tagagaccag catgttctcc ccaaagacca
     1741 gaatattcta cctaaatatc aaggccagga ttttctacct aaagaccagg actttttatc
     1801 tagagaccag catgttctcc ccaaagactg gaatattcta cccaaatgtc aggaccagga
     1861 ttttctaccc agagaccaag gtgttcttcc caaagaccaa aatattctac ccatatgtca
     1921 ggaccaggat tttctaccca gagaccaagg ttatcttcct aaagaccaaa atattctacc
     1981 catatgtcag gaccgggatt ttctacccag agacctgcat gttctctcca acgaccagaa
     2041 tattctaccc aaatgtcagg accaagattt tctaccaaaa tatcagaaag tacactttaa
     2101 ggagccatac tctgatatga cagatgagaa agggagagaa gacttttctc tggcagacta
     2161 tcagtgtttg cctcccaaat cccaggacca ggatgacatc aaaaatcagc aacctgcatc
     2221 ttttatgaga gaagaaagag tgagagaaga attgcctctg gactatcatc aatatgttgt
     2281 acctaaaatc caggaccaag actcccctag agaacagaac aagcatatca aactaccctc
     2341 atcttttgag aaatgggaga ttgcaagagg aaatactcct ggagtgccct tggcttatga
     2401 taggtatcaa tcaggattga gcactgaatt ccaagctcca ctggcatttc agtctgacgt
     2461 ggataaagaa gaagataaga aagagcgtca aaagcagtac ctgagacata gacgactttt
     2521 catggatatt gagagagaac aagttaaaga acaacaaagg caaaaagaac aaaagaagaa
     2581 aattgaaaaa attaagaaaa agagagagca agaatgttat gctgcagagc agaggatcct
     2641 aagaatgaac tttcatgaag atccatattc aggagagaag ttgagtgaga tattagccca
     2701 gttacaactt caagaaataa aaggaaccag agaaaaacaa cagagagaaa aagaatacct
     2761 gagatatgta gaagctttac gagcccaaat ccaggagaaa atgcagctgt ataatattac
     2821 tttacctcca ctatgctgtt gtggtcctga tttttgggat gctcatcctg atacctgtgc
     2881 caacaactgt attttctata aaaaccacag agcatatact cgggcactac attcattcat
     2941 caattcctgt gatgtccctg ggggtaattc aactcttcga gtcgcaattc ataattttgc
     3001 ttctgcacac aggcggactt tgaaaaatct ataataagaa tctgaaatta actggtagta
     3061 ttttggcttt tacttaaaat catccctgag agagtattta agaaaagctg ttcaagttat
     3121 aaaatatata atctgggaag aaatactgtc tcatataata attagattgt aatcattgtt
     3181 ttaatctctg tctgggaacc aagattgaaa gctgacttac ttctctcttc tgtcttgtga
     3241 accatacgga gcctattatt ttaaaatatg atcagacaag taaggcttct cttactttgc
     3301 tctgctctga tcagaagagc tcatgtgaag tctttgagat tctcttattt atcatctttc
     3361 taaaactgtg tttttgagct tgacagtact gaaaatgtct ggatgaagca gaaaagaaag
     3421 tgatgaaatg tgtttctgag catcagagac catctatatt gccattacct tttctagttg
     3481 tatataagaa ttcaagatta gaagaattta gatttgttgc acattttttt cctcagcatt
     3541 ttttcctctt gttttttaaa atgtattgcc tctttcccca ttcagtgaca ctggacatag
     3601 gaatttttaa ttgtgtaatt ttctgttgca aaaagggtaa ataaatcctt tgtcttttga
     3661 atatcttcta tgtgaaataa ttgtgagtga catttgaaaa agtgaatctg aagtcaaagt
     3721 gagtaaattc cttatttccc tattttttaa aaacctggta tatgacatgg ctacagggca
     3781 aatgaaataa aaattgccat agttggtatg aa
//
