LOCUS       NM_001395273            6661 bp    mRNA    linear   PRI 17-MAR-2025
DEFINITION  Homo sapiens coiled-coil domain containing 149 (CCDC149),
            transcript variant 3, mRNA.
ACCESSION   NM_001395273
VERSION     NM_001395273.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6661)
  AUTHORS   Cai,D.C., Fonteijn,H., Guadalupe,T., Zwiers,M., Wittfeld,K.,
            Teumer,A., Hoogman,M., Arias-Vasquez,A., Yang,Y., Buitelaar,J.,
            Fernandez,G., Brunner,H.G., van Bokhoven,H., Franke,B.,
            Hegenscheid,K., Homuth,G., Fisher,S.E., Grabe,H.J., Francks,C. and
            Hagoort,P.
  TITLE     A genome-wide search for quantitative trait loci affecting the
            cortical surface area and thickness of Heschl's gyrus
  JOURNAL   Genes Brain Behav 13 (7), 675-685 (2014)
   PUBMED   25130324
REFERENCE   2  (bases 1 to 6661)
  AUTHORS   Satoh,J., Obayashi,S., Misawa,T., Sumiyoshi,K., Oosumi,K. and
            Tabunoki,H.
  TITLE     Protein microarray analysis identifies human cellular prion protein
            interactors
  JOURNAL   Neuropathol Appl Neurobiol 35 (1), 16-35 (2009)
   PUBMED   18482256
REFERENCE   3  (bases 1 to 6661)
  AUTHORS   Christoforou,A., Le Hellard,S., Thomson,P.A., Morris,S.W.,
            Tenesa,A., Pickard,B.S., Wray,N.R., Muir,W.J., Blackwood,D.H.,
            Porteous,D.J. and Evans,K.L.
  TITLE     Association analysis of the chromosome 4p15-p16 candidate region
            for bipolar disorder and schizophrenia
  JOURNAL   Mol Psychiatry 12 (11), 1011-1025 (2007)
   PUBMED   17457313
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116422.1, AL545064.3, DB500831.1, AK296454.1, AC006390.8 and
            CB243678.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.166601.1,
                                           SRR1803617.47400.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000635206.3/
                                                ENSP00000488929.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AC116422.1         43143-43206         c
            65-125              AL545064.3         1-61
            126-535             DB500831.1         38-447
            536-1205            AK296454.1         130-799
            1206-1238           AC006390.8         133095-133127       c
            1239-1898           AK296454.1         800-1459
            1899-3385           AC006390.8         118830-120316       c
            3386-3805           CB243678.1         271-690             c
            3806-3807           AC006390.8         118408-118409       c
            3808-4058           CB243678.1         18-268              c
            4059-6661           AC006390.8         115554-118156       c
FEATURES             Location/Qualifiers
     source          1..6661
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.2"
     gene            1..6661
                     /gene="CCDC149"
                     /note="coiled-coil domain containing 149"
                     /db_xref="GeneID:91050"
                     /db_xref="HGNC:HGNC:25405"
     exon            1..226
                     /gene="CCDC149"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1786
                     /gene="CCDC149"
                     /note="isoform 3 is encoded by transcript variant 3;
                     coiled-coil domain-containing protein 149"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 149
                     isoform 3"
                     /protein_id="NP_001382202.1"
                     /db_xref="CCDS:CCDS82914.2"
                     /db_xref="GeneID:91050"
                     /db_xref="HGNC:HGNC:25405"
                     /translation="MNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQQE
                     RDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGE
                     EIKELQQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIE
                     SLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHILSGHENRIIDVDALCMENRYL
                     QERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSED
                     HGCSLPATPQSISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLE
                     VSGLWSLPGLSYNVSVGFGRGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKADPKD
                     GEAQKQEEDESCAAAEALTAPEDAGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVN
                     SLGREIIKLTKEQAAAELEEVRRESPIEGQRSETGPAPPGLAIQGELPKSHLDSFEAS
                     RPAAKASTPEDGKGIPEGGGMRSTVKT"
     exon            227..388
                     /gene="CCDC149"
                     /inference="alignment:Splign:2.1.0"
     exon            389..427
                     /gene="CCDC149"
                     /inference="alignment:Splign:2.1.0"
     exon            428..535
                     /gene="CCDC149"
                     /inference="alignment:Splign:2.1.0"
     exon            536..652
                     /gene="CCDC149"
                     /inference="alignment:Splign:2.1.0"
     exon            653..825
                     /gene="CCDC149"
                     /inference="alignment:Splign:2.1.0"
     exon            826..898
                     /gene="CCDC149"
                     /inference="alignment:Splign:2.1.0"
     exon            899..983
                     /gene="CCDC149"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1128
                     /gene="CCDC149"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1205
                     /gene="CCDC149"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1238
                     /gene="CCDC149"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1355
                     /gene="CCDC149"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..6661
                     /gene="CCDC149"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1967..1972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC149"
                     /note="hexamer: ATTAAA"
     polyA_site      1985
                     /gene="CCDC149"
                     /note="major polyA site"
     regulatory      4036..4041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC149"
                     /note="hexamer: ATTAAA"
     polyA_site      4058
                     /gene="CCDC149"
                     /note="major polyA site"
     regulatory      6633..6638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC149"
                     /note="hexamer: AATAAA"
     polyA_site      6661
                     /gene="CCDC149"
ORIGIN      
        1 ggaggctgac gtggagtcaa cagcgctggc ggccgcgaga ggcggcggcg cagcggctcg
       61 gaggcgccgg gccctctcgg ggccgcgcgg ggcccgggcg gcggcggcga cgcgacgtcg
      121 cgaggaggag gaggcggcgg gggtccagga ggccggccag cgcatggagg aggaggccat
      181 gaacggcgac cggactgaga gcgactggca ggggctggtg agcgagtacc tggtgtgtaa
      241 gaggaagctg gagagtaaga aggaagccct gctgatcctc tccaaggagc tggacacctg
      301 tcaacaggaa agggaccagt acaaactcat ggccaatcag ctccgggagc gccaccagtc
      361 actgaagaag aagtaccgag agctgattga tggagatcca tcacttcctc ctgaaaaaag
      421 gaaacaggct aatcttgcac aactattgag agattctcag gaccgaaata aacatctggg
      481 agaagaaatt aaagaacttc agcaaaggct tggagaagtc cagggcgaca acaagctctt
      541 gaggatgacg attgccaaac aaaggctcgg agacgaagca atcggcgtgc gacactttgc
      601 agcccatgag cgtgaagact tggtgcagca gctagagcga gctaaggaac agattgagtc
      661 tctggagcac gacctgcagg cttctgtgga cgagcttcag gatgttaaag aagaacggtc
      721 ttcctaccag gacaaagtgg agaggctcaa ccaggagctg aaccatatcc tgagtgggca
      781 cgagaaccgc atcattgacg tggacgccct gtgtatggag aacaggtacc ttcaagagag
      841 attaaagcaa ctccatgaag aggtcaacct cttgaaatca aacattgcca aatacaagaa
      901 tgctctggag agacggaaaa actcgaaggg ccagggtaaa tccagcagca gtgctctgac
      961 aggagtcctg tctgcaaagc aagttcagga tctgctatct gaggatcatg gatgcagcct
     1021 cccagctact ccgcagtcca tttctgacct gaaatctctg gcaacagccc tgttggaaac
     1081 aatccacgag aaaaacatgg tcattcagca ccagaggcaa accaacaaaa tcctagggaa
     1141 tcgggtggct gagctggaaa aaaaattaag aactctggaa gtttctggtt tgtggagtct
     1201 tccaggcctg agctacaatg tttcagtagg atttgggagg ggcaaggaca ccatactgtt
     1261 cagcgacccc actcttccta gtggacagag gtcgagatcc ccactgctga agtttgtcga
     1321 gcagcccact gagaacaaag cagatcccaa ggatggggag gctcagaagc aagaagaaga
     1381 tgaaagttgt gccgctgctg aggcgttgac agcgcctgag gatgctggga ggcccgctgt
     1441 caactcccca gcaaatcaga gccgcgggaa ccaatgcaag ctctttcatc cttcattacc
     1501 ccagttacct tctgaggaag aagtaaacag ccttgggagg gaaataatta aactgacaaa
     1561 ggaacaggca gctgcagaac tggaagaggt cagaagagag agtcccatag aaggtcagag
     1621 gagtgagacg gggccagccc cgccaggcct ggccatccag ggggagctcc ctaaatctca
     1681 cctggactcc ttcgaggcca gccggccagc agccaaagct tccacaccgg aagacggcaa
     1741 agggatccca gagggcggag gcatgaggag caccgtgaaa acctgaaggg gagagggatc
     1801 tgacacaatg acacattgaa agccccagag agggtcaaga atgaagcatc ggaatggtgc
     1861 gctcacgtcg ccttctcctg aaatacctcc gagtctgcaa gtgagaaaac gcactgatcc
     1921 tgttgcaaac tgtgaatatt ctgatgatgc cagtacagtt tgatttatta aatgtaggtc
     1981 ctcaagcttc tcagtgtcat ctcttttctg ccagagagtg ctactgtgaa cagggccagg
     2041 cccaggaatc gtgtccacca tatggctggt tttcagcatc cgtctttctg tcagcttttg
     2101 ttttatcaga gataagatgt ttttgtatta gcatttaatg ttgtcaatca aaattatggg
     2161 aagagctaga aactgatggg gtttttaatc aggtccccat cttggtcaag gttaggcagc
     2221 tggagaggaa ggtataattg agcaaaacgt gtccagagga cccatggctg caccccatca
     2281 agtcagggcc caggaggact gcctggcatg ggtgtgcttg gcattgtgcc cacagcactg
     2341 ctgtcgtggt acagactggc agttggaagg ggccttaagc cggctgagaa gtttgggctt
     2401 ctgggttgaa atccacagcc ccggttgagg cctgtgtgct gagtgccaga gctggagttt
     2461 tctagcttgt aaatctggag aattaactga tctgaagtga ctgggagggg tgagcataaa
     2521 agccggggaa caggactccc agtggtggtc tggttttttt tgtgagatga gatgagagct
     2581 accacctgga aatgctcatt ctctgcattc agcctgtctc acatacagga ttgtatggcc
     2641 atttcaggtt tgggaaagat ctacctgctg ggagccagtc tagtttcctg caccacctgg
     2701 aacttccaaa cccttcactc cttcaacaga atgttgaggc tgcctcattt gtgccaccaa
     2761 gtacgggaat cttaaagaca gaaacagagc tcatgacctt ttatgggaaa gagagaggaa
     2821 aacaaaacaa cttcacaaca gcatggcaag gggggatgtg gaaccaagga catgatacag
     2881 ggatgggaaa ggagggcatg ctcaattcta gctggttctt tcctttcaga taaaaatgag
     2941 cttttctagt tggcatccgg cactgcagaa aactaaaagt catccagcca tagctttttc
     3001 cttccctgga aagcctgaga ctagatccca aagctcagaa tgcctctgag aaccagaatc
     3061 actcctttga gaggcgctcc ttgcaggaaa aagagaggct cccagagtgg tagcctctca
     3121 gtgaaaatgc atcctaaaaa ttcaatgttt ataccaggct catgacacta agatgtgaca
     3181 tctggacacg aggggtcagc cacgtggata catccctccc agattgcatc tccaggaatc
     3241 actctgctag cagaatgggc gccccatccc ttactatgct gctcctcctc aaagtgcagc
     3301 ccagaaggac ccaggccttt gatgcacatt gggtgggtct cccactactt tagttgaaat
     3361 gggagcatgc tggagtcggc gttctgttgc ttctggtgag aaggacatcc cattgacccc
     3421 tggccaccag gtccagtatt ccatccttcc ttctgtccca gcctatcgcc ctccccacca
     3481 ggcccacccc cacaacttct cctcaaggga ggttgctccc gcagctggag ggcttgcaca
     3541 gaccagcagt cacagaaatc attcttcctg ctgtactggg ccttaactgc ctgcaaatgt
     3601 ccagcactac tgcataggat gccagagcca ccgaaggaaa acacagccaa gtttaataat
     3661 aataaaagga aaaatctcag cctgcagaac tctggttttg acccaccatc ggccagatgc
     3721 acatcttcag ggcctgttga gcaccttctg aaaagcaggg ctcgtaatag actccagcac
     3781 attccatcag agtcaggaaa actgcagtga gtcccagaga atctagggtg cagggcaggg
     3841 agcaggagtc ataaggagtg ataacctaaa ctgtgtgtag tcagcgggga gggtcttatg
     3901 ttatcaggtg aaatgagagc cagtaagtta gttgatcctg tcacagatat aaccctgata
     3961 acaccccata gatacgcgac acgtgtgtcc tgcccctgct ttccccatcc aacatggttc
     4021 ttctgttcca cagacattaa aggggctttc tgcaattact tacagctgtc ttttgtcttt
     4081 tttaggatca aagtttaagg ttgtggcatt ctgtccccta cttcactaga taaccctgca
     4141 tcagtcatgg tcctctcagc ttcaagccac acttaacaga aacttaagcg gtagggaaat
     4201 gaattatgtt gtataacagg aacttcgaaa gtaaggcatt ccagggctat acattcaaga
     4261 aagttgtcaa ggttctaggt ttccatcttc ctgctcttcc tgctgtgtca gctgctttct
     4321 catgataacg aggtggctgc aacagctcca gataacacct gttcaaaggc agaaggaagt
     4381 ttcttcccac atacgtgtgt gtgtgtgttt caagagcgag aaacccagtt cctatcacat
     4441 tttattggtc agaatgatca cctggggctt gtggtcgcat gagaccttgt cacatgatga
     4501 tgtcacatgg caatgtctta accatttctt agcaagggag atggtattac catgatctgt
     4561 ttaggttcac caagattcac ccttaagaac tgaagaaggg ccctgtcgct agacattcag
     4621 actctaaaag gctgaacacc aaaacagaat catatcttgg gatgtgtaag agagttggga
     4681 atagacaacc aatggtgctg tctctgaacc ccatgtcttt ttgttgctgc ataaaaagcc
     4741 agaaaatcat gtttccgatg agtttggagt taaggggagg ggctatggtt gtttgctcag
     4801 aaaaaagcca tctcatcccc cctccctggc atctttctga tctgtcctgt tctgtaggtg
     4861 gaatgttccc acctttgttt gcctgttcag acgtgtttgt ccttccatta tttttccggc
     4921 tggattgcca gcagaatgca gagcagcctg gagaaatgaa acagagctga caggtctctt
     4981 aatgaaagct tgtttgcaca ctctgcctct cctgtgatcg ctctgtgcct gagagcctct
     5041 aggtgtggat ttttacatga gcgtttgtct ttcttttgat taaggcctgt agaagtggat
     5101 tggtttttgt aaaccaggca tttctcatcc ctcactcttg ctcttcctcc ttccacacct
     5161 tctctgccca ccttcttctc ccctccccgt tccttctctt gctcccacag ctattcccaa
     5221 agcctctcta gctgggaggc tcctgatggc ctcagctcaa tgccggctgg accctcccag
     5281 cttttggcaa tcttaagcaa gctaaattag tttgcccatc gttgctcctc ttctgtgacc
     5341 tccctcccaa acatgcacca ccatcacgat gcaaagtgct agaaaagggc tctgctatca
     5401 attattcaca tgttggagta aattttttga tgtgttattc ctaccgggag cctttgcacc
     5461 ccggttcacg atatggcatg aaaagttctg tctcctcttt aaggaatgac aaagaccagc
     5521 tgcttactca ctgaggtgat cttctctgtc tctttaaaat tacagcatgc ctttgcccct
     5581 gttggttttc actccaaaaa aatggggtgc cctcttggct ttgttgtttt cccacagcct
     5641 tgtggatgac ttggtaccct acttcttttt tttttttttt ttttttttga gagtctcact
     5701 ctgtcaccca gggtggagtg cagtggcatg atctcggctc actgcaacct ccacttcccg
     5761 agttcaagcg attctcctgc ctcagcctcc cgagtaactg ggactacagg catgcaccac
     5821 catgcctggc taatttttgt atttttagta gagacggggt ttcactatgt tgaccaggct
     5881 ggtctcaaac tcccaacctc gtgatctgcc ttcctcggcc tcccaaagtg ctgggattgc
     5941 aggcgtgagc cactgcgccc ggcctgtacc ctccttcttt ttgaaaaaga gagtaccttc
     6001 ttcctctgct ttcattctga agcctccatt taaaacactc ctcctcctta gcaatagtga
     6061 gggtcccttc agactagata ggatgtcaaa aggccaaagc attgccccca acacactcct
     6121 ttaatgtagt cccttctttc caggtgtctt cctgaagaga gaaaaatttg tagatcagag
     6181 agatgcaatt gggagctccg tagtgaatct agttagaaat gagtagcaga aaaaatagga
     6241 aagacccgtc tctcaatatt atggttgctt cccaaaacaa aaccagttga tacagcatga
     6301 aggcaattta aaatgataga tatggacatg ctgccttaca tttcatatca cctctttact
     6361 aaatgagaat tttttggatg catagggaaa gtttgcataa tattgaaaag tttgactttc
     6421 tggaatctat gtgagctcag gaatatattt ggggatctta gcagaggcca gtggtagcct
     6481 attaaatcta aaacaattgg ctttgttttt aaaaccagct gctattttgt agtttcattt
     6541 aaagaaaaag taccttctat tcatttgcag aagttgcttt attggattct atggtcattg
     6601 tatatcataa ctatatcttt tttgttacct gaaataaaca tgtggcaatt ttcctgatag
     6661 a
//
