LOCUS       NM_020879               3335 bp    mRNA    linear   PRI 06-DEC-2024
DEFINITION  Homo sapiens coiled-coil domain containing 146 (CCDC146), mRNA.
ACCESSION   NM_020879 XM_003846699 XM_003846700
VERSION     NM_020879.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3335)
  AUTHORS   Ye,J.W., Abbas,T., Zhou,J.T., Chen,J., Yang,M.L., Huang,X.H.,
            Zhang,H., Ma,H., Ma,A., Xu,B., Murtaza,G., Shi,Q.H. and Shi,B.L.
  TITLE     Homozygous CCDC146 mutation causes oligoasthenoteratozoospermia in
            humans and mice
  JOURNAL   Zool Res 45 (5), 1073-1087 (2024)
   PUBMED   39245651
  REMARK    GeneRIF: Homozygous CCDC146 mutation causes
            oligoasthenoteratozoospermia in humans and mice.
REFERENCE   2  (bases 1 to 3335)
  AUTHORS   Muronova,J., Kherraf,Z.E., Giordani,E., Lambert,E., Eckert,S.,
            Cazin,C., Amiri-Yekta,A., Court,M., Chevalier,G., Martinez,G.,
            Neirijnck,Y., Kuhne,F., Wehrli,L., Klena,N., Hamel,V., De
            Macedo,L., Escoffier,J., Guichard,P., Coutton,C., Mustapha,S.F.B.,
            Kharouf,M., Bouin,A.P., Zouari,R., Thierry-Mieg,N., Nef,S.,
            Geimer,S., Loeuillet,C., Ray,P.F. and Arnoult,C.
  TITLE     Lack of CCDC146, a ubiquitous centriole and microtubule-associated
            protein, leads to non-syndromic male infertility in human and mouse
  JOURNAL   Elife 12, 86845 (2024)
   PUBMED   38441556
  REMARK    GeneRIF: Lack of CCDC146, a ubiquitous centriole and
            microtubule-associated protein, leads to non-syndromic male
            infertility in human and mouse.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3335)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3335)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3335)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3335)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   7  (bases 1 to 3335)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   8  (bases 1 to 3335)
  AUTHORS   Firat-Karalar,E.N., Sante,J., Elliott,S. and Stearns,T.
  TITLE     Proteomic analysis of mammalian sperm cells identifies new
            components of the centrosome
  JOURNAL   J Cell Sci 127 (Pt 19), 4128-4133 (2014)
   PUBMED   25074808
REFERENCE   9  (bases 1 to 3335)
  AUTHORS   Hart,A.B., Engelhardt,B.E., Wardle,M.C., Sokoloff,G., Stephens,M.,
            de Wit,H. and Palmer,A.A.
  TITLE     Genome-wide association study of d-amphetamine response in healthy
            volunteers identifies putative associations, including cadherin 13
            (CDH13)
  JOURNAL   PLoS One 7 (8), e42646 (2012)
   PUBMED   22952603
REFERENCE   10 (bases 1 to 3335)
  AUTHORS   Speliotes,E.K., Willer,C.J., Berndt,S.I., Monda,K.L.,
            Thorleifsson,G., Jackson,A.U., Lango Allen,H., Lindgren,C.M.,
            Luan,J., Magi,R., Randall,J.C., Vedantam,S., Winkler,T.W., Qi,L.,
            Workalemahu,T., Heid,I.M., Steinthorsdottir,V., Stringham,H.M.,
            Weedon,M.N., Wheeler,E., Wood,A.R., Ferreira,T., Weyant,R.J.,
            Segre,A.V., Estrada,K., Liang,L., Nemesh,J., Park,J.H.,
            Gustafsson,S., Kilpelainen,T.O., Yang,J., Bouatia-Naji,N., Esko,T.,
            Feitosa,M.F., Kutalik,Z., Mangino,M., Raychaudhuri,S., Scherag,A.,
            Smith,A.V., Welch,R., Zhao,J.H., Aben,K.K., Absher,D.M., Amin,N.,
            Dixon,A.L., Fisher,E., Glazer,N.L., Goddard,M.E., Heard-Costa,N.L.,
            Hoesel,V., Hottenga,J.J., Johansson,A., Johnson,T., Ketkar,S.,
            Lamina,C., Li,S., Moffatt,M.F., Myers,R.H., Narisu,N., Perry,J.R.,
            Peters,M.J., Preuss,M., Ripatti,S., Rivadeneira,F., Sandholt,C.,
            Scott,L.J., Timpson,N.J., Tyrer,J.P., van Wingerden,S.,
            Watanabe,R.M., White,C.C., Wiklund,F., Barlassina,C., Chasman,D.I.,
            Cooper,M.N., Jansson,J.O., Lawrence,R.W., Pellikka,N.,
            Prokopenko,I., Shi,J., Thiering,E., Alavere,H., Alibrandi,M.T.,
            Almgren,P., Arnold,A.M., Aspelund,T., Atwood,L.D., Balkau,B.,
            Balmforth,A.J., Bennett,A.J., Ben-Shlomo,Y., Bergman,R.N.,
            Bergmann,S., Biebermann,H., Blakemore,A.I., Boes,T.,
            Bonnycastle,L.L., Bornstein,S.R., Brown,M.J., Buchanan,T.A.,
            Busonero,F., Campbell,H., Cappuccio,F.P., Cavalcanti-Proenca,C.,
            Chen,Y.D., Chen,C.M., Chines,P.S., Clarke,R., Coin,L., Connell,J.,
            Day,I.N., den Heijer,M., Duan,J., Ebrahim,S., Elliott,P.,
            Elosua,R., Eiriksdottir,G., Erdos,M.R., Eriksson,J.G.,
            Facheris,M.F., Felix,S.B., Fischer-Posovszky,P., Folsom,A.R.,
            Friedrich,N., Freimer,N.B., Fu,M., Gaget,S., Gejman,P.V.,
            Geus,E.J., Gieger,C., Gjesing,A.P., Goel,A., Goyette,P.,
            Grallert,H., Grassler,J., Greenawalt,D.M., Groves,C.J.,
            Gudnason,V., Guiducci,C., Hartikainen,A.L., Hassanali,N.,
            Hall,A.S., Havulinna,A.S., Hayward,C., Heath,A.C., Hengstenberg,C.,
            Hicks,A.A., Hinney,A., Hofman,A., Homuth,G., Hui,J., Igl,W.,
            Iribarren,C., Isomaa,B., Jacobs,K.B., Jarick,I., Jewell,E.,
            John,U., Jorgensen,T., Jousilahti,P., Jula,A., Kaakinen,M.,
            Kajantie,E., Kaplan,L.M., Kathiresan,S., Kettunen,J., Kinnunen,L.,
            Knowles,J.W., Kolcic,I., Konig,I.R., Koskinen,S., Kovacs,P.,
            Kuusisto,J., Kraft,P., Kvaloy,K., Laitinen,J., Lantieri,O.,
            Lanzani,C., Launer,L.J., Lecoeur,C., Lehtimaki,T., Lettre,G.,
            Liu,J., Lokki,M.L., Lorentzon,M., Luben,R.N., Ludwig,B.,
            Manunta,P., Marek,D., Marre,M., Martin,N.G., McArdle,W.L.,
            McCarthy,A., McKnight,B., Meitinger,T., Melander,O., Meyre,D.,
            Midthjell,K., Montgomery,G.W., Morken,M.A., Morris,A.P., Mulic,R.,
            Ngwa,J.S., Nelis,M., Neville,M.J., Nyholt,D.R., O'Donnell,C.J.,
            O'Rahilly,S., Ong,K.K., Oostra,B., Pare,G., Parker,A.N., Perola,M.,
            Pichler,I., Pietilainen,K.H., Platou,C.G., Polasek,O., Pouta,A.,
            Rafelt,S., Raitakari,O., Rayner,N.W., Ridderstrale,M., Rief,W.,
            Ruokonen,A., Robertson,N.R., Rzehak,P., Salomaa,V., Sanders,A.R.,
            Sandhu,M.S., Sanna,S., Saramies,J., Savolainen,M.J., Scherag,S.,
            Schipf,S., Schreiber,S., Schunkert,H., Silander,K., Sinisalo,J.,
            Siscovick,D.S., Smit,J.H., Soranzo,N., Sovio,U., Stephens,J.,
            Surakka,I., Swift,A.J., Tammesoo,M.L., Tardif,J.C.,
            Teder-Laving,M., Teslovich,T.M., Thompson,J.R., Thomson,B.,
            Tonjes,A., Tuomi,T., van Meurs,J.B., van Ommen,G.J., Vatin,V.,
            Viikari,J., Visvikis-Siest,S., Vitart,V., Vogel,C.I., Voight,B.F.,
            Waite,L.L., Wallaschofski,H., Walters,G.B., Widen,E., Wiegand,S.,
            Wild,S.H., Willemsen,G., Witte,D.R., Witteman,J.C., Xu,J.,
            Zhang,Q., Zgaga,L., Ziegler,A., Zitting,P., Beilby,J.P.,
            Farooqi,I.S., Hebebrand,J., Huikuri,H.V., James,A.L., Kahonen,M.,
            Levinson,D.F., Macciardi,F., Nieminen,M.S., Ohlsson,C.,
            Palmer,L.J., Ridker,P.M., Stumvoll,M., Beckmann,J.S., Boeing,H.,
            Boerwinkle,E., Boomsma,D.I., Caulfield,M.J., Chanock,S.J.,
            Collins,F.S., Cupples,L.A., Smith,G.D., Erdmann,J., Froguel,P.,
            Gronberg,H., Gyllensten,U., Hall,P., Hansen,T., Harris,T.B.,
            Hattersley,A.T., Hayes,R.B., Heinrich,J., Hu,F.B., Hveem,K.,
            Illig,T., Jarvelin,M.R., Kaprio,J., Karpe,F., Khaw,K.T.,
            Kiemeney,L.A., Krude,H., Laakso,M., Lawlor,D.A., Metspalu,A.,
            Munroe,P.B., Ouwehand,W.H., Pedersen,O., Penninx,B.W., Peters,A.,
            Pramstaller,P.P., Quertermous,T., Reinehr,T., Rissanen,A.,
            Rudan,I., Samani,N.J., Schwarz,P.E., Shuldiner,A.R., Spector,T.D.,
            Tuomilehto,J., Uda,M., Uitterlinden,A., Valle,T.T., Wabitsch,M.,
            Waeber,G., Wareham,N.J., Watkins,H., Wilson,J.F., Wright,A.F.,
            Zillikens,M.C., Chatterjee,N., McCarroll,S.A., Purcell,S.,
            Schadt,E.E., Visscher,P.M., Assimes,T.L., Borecki,I.B.,
            Deloukas,P., Fox,C.S., Groop,L.C., Haritunians,T., Hunter,D.J.,
            Kaplan,R.C., Mohlke,K.L., O'Connell,J.R., Peltonen,L.,
            Schlessinger,D., Strachan,D.P., van Duijn,C.M., Wichmann,H.E.,
            Frayling,T.M., Thorsteinsdottir,U., Abecasis,G.R., Barroso,I.,
            Boehnke,M., Stefansson,K., North,K.E., McCarthy,M.I.,
            Hirschhorn,J.N., Ingelsson,E. and Loos,R.J.
  CONSRTM   MAGIC; Procardis Consortium
  TITLE     Association analyses of 249,796 individuals reveal 18 new loci
            associated with body mass index
  JOURNAL   Nat Genet 42 (11), 937-948 (2010)
   PUBMED   20935630
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007000.2, BC036053.1, DB099681.1 and AK056542.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020879.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036053.1, SRR1803611.174361.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285871.5/ ENSP00000285871.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC007000.2         99213-99214
            3-6                 BC036053.1         1-4
            7-574               DB099681.1         5-572
            575-755             BC036053.1         573-753
            756-1085            AK056542.1         531-860
            1086-2468           BC036053.1         1084-2466
            2469-3067           AK056542.1         2245-2843
            3068-3205           BC036053.1         3066-3203
            3206-3335           AK056542.1         2982-3111
FEATURES             Location/Qualifiers
     source          1..3335
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..3335
                     /gene="CCDC146"
                     /gene_synonym="MBO2; SPGF94"
                     /note="coiled-coil domain containing 146"
                     /db_xref="GeneID:57639"
                     /db_xref="HGNC:HGNC:29296"
                     /db_xref="MIM:619829"
     exon            1..118
                     /gene="CCDC146"
                     /gene_synonym="MBO2; SPGF94"
                     /inference="alignment:Splign:2.1.0"
     exon            119..285
                     /gene="CCDC146"
                     /gene_synonym="MBO2; SPGF94"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..2997
                     /gene="CCDC146"
                     /gene_synonym="MBO2; SPGF94"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 146"
                     /protein_id="NP_065930.2"
                     /db_xref="CCDS:CCDS34671.1"
                     /db_xref="GeneID:57639"
                     /db_xref="HGNC:HGNC:29296"
                     /db_xref="MIM:619829"
                     /translation="MEDSSTDTEKEEEEEKDEKDQEPIYAIVPTINIQDERFVDLSET
                     PAFIFLHELHAMGKLPGTRMAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQ
                     QFHLQQADNFPEAFSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVK
                     EFEKITKPGEMEKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELE
                     ELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKV
                     ENKVSAIVDEKENVIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDL
                     NLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEM
                     EAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQEN
                     MKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIY
                     RRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERK
                     LQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMV
                     QLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFL
                     KMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRA
                     RFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQD
                     TLLLAKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNSRIE
                     KGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLEADNRQLPNGVYTTAEQRPNAYI
                     PEADATLPLPKPYGALAPFKPSEPGANMRHIRKPVIKPVEI"
     exon            286..368
                     /gene="CCDC146"
                     /gene_synonym="MBO2; SPGF94"
                     /inference="alignment:Splign:2.1.0"
     exon            369..578
                     /gene="CCDC146"
                     /gene_synonym="MBO2; SPGF94"
                     /inference="alignment:Splign:2.1.0"
     exon            579..636
                     /gene="CCDC146"
                     /gene_synonym="MBO2; SPGF94"
                     /inference="alignment:Splign:2.1.0"
     exon            637..813
                     /gene="CCDC146"
                     /gene_synonym="MBO2; SPGF94"
                     /inference="alignment:Splign:2.1.0"
     exon            814..887
                     /gene="CCDC146"
                     /gene_synonym="MBO2; SPGF94"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1115
                     /gene="CCDC146"
                     /gene_synonym="MBO2; SPGF94"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1302
                     /gene="CCDC146"
                     /gene_synonym="MBO2; SPGF94"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1398
                     /gene="CCDC146"
                     /gene_synonym="MBO2; SPGF94"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1569
                     /gene="CCDC146"
                     /gene_synonym="MBO2; SPGF94"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1658
                     /gene="CCDC146"
                     /gene_synonym="MBO2; SPGF94"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1823
                     /gene="CCDC146"
                     /gene_synonym="MBO2; SPGF94"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..2048
                     /gene="CCDC146"
                     /gene_synonym="MBO2; SPGF94"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2277
                     /gene="CCDC146"
                     /gene_synonym="MBO2; SPGF94"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2406
                     /gene="CCDC146"
                     /gene_synonym="MBO2; SPGF94"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2544
                     /gene="CCDC146"
                     /gene_synonym="MBO2; SPGF94"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2793
                     /gene="CCDC146"
                     /gene_synonym="MBO2; SPGF94"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..3335
                     /gene="CCDC146"
                     /gene_synonym="MBO2; SPGF94"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3315..3320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC146"
                     /gene_synonym="MBO2; SPGF94"
                     /note="hexamer: AATAAA"
     polyA_site      3335
                     /gene="CCDC146"
                     /gene_synonym="MBO2; SPGF94"
                     /note="major polyA site"
ORIGIN      
        1 ggataccaag gacgcgactt cttgtttgga gagggtggag ctttggagtg agacccagga
       61 ggccaaatcc caaagagaaa aataggagcc taaataagga tcaggaccaa gggaagggaa
      121 tcgtgaaaaa tggaagacag tagcacagac acagaaaaag aagaggaaga ggagaaagat
      181 gaaaaggatc aagagcccat ttatgccata gtgcccacaa ttaacattca agatgagcgg
      241 tttgttgatt tatctgaaac tccagctttc atttttctgc atgagttaca tgctatggga
      301 aaacttcctg gaaccagaat ggcagcgtta aaagccaagt ataccttgct gcatgacgcc
      361 gtgatgagca cacaagagtc agaggtccaa ctgctacaga atgccaaacg tttcactgag
      421 caaatacaac agcagcagtt tcacctgcag caagctgata attttccaga agcattctcc
      481 acggaggtct ccaaaatgag agaacaactt ctcaagtatc aaaatgaata taatgcagtg
      541 aaggaaagag agttccataa tcagtacaga ttaaatagct taaaggaaga aaaaatcatc
      601 atagtaaaag aatttgagaa gataacaaag ccaggagaaa tggagaagaa gatgaaaata
      661 ttgagagaaa gcactgaaga attacgtaaa gaaataatgc agaagaaatt agaaattaaa
      721 aatttacgag aagatttggc atctaaacaa aagcaattat taaaagagca gaaggaacta
      781 gaagaattgt tgggacatca ggtcgtccta aaggatgaag tggcccacca tcaaaccatt
      841 ccagtacaaa ttggaaaaga gatagaaaaa ataacacgca aaaaagtaga aatggaaaag
      901 aaaaaaattg tcttggaaca agaagtcaaa acgctaaatg actccctaaa gaaagttgaa
      961 aacaaggtta gtgctatagt ggatgagaag gaaaatgtaa taaaggaagt tgaaggcaaa
     1021 cgagccttac ttgaaatcaa agaacgagaa cataaccaat tggtcaagct attggaatta
     1081 gccagagaga atgaagcaac ttcattaact gaaagaggga tcttggatct caatttacgc
     1141 aacagtctca ttgacaagca gaactaccat gatgaacttt ctcgtaagca aagagagaaa
     1201 gaacgagatt ttcgaaattt aagaaagatg gaactgctct tgaaagtgtc ctgggatgca
     1261 cttaggcaaa ctcaagcact gcatcaaagg cttctattag agatggaagc tatccccaaa
     1321 gatgattcta cattatctga gagaaggcga gagcttcaca aggaagttga agtagctaag
     1381 aggaatttgg cccaacagaa aattatatca gaaatggagt ctaagttagt agaacaacaa
     1441 cttgcagaag aaaacaagct tttaaaggag caagaaaaca tgaaagagct agtagtcaac
     1501 cttctccgca tgactcaaat caaaattgat gaaaaggaac aaaagtccaa ggatttcctg
     1561 aaagctcagc aaaaatacac caacattgtt aaagaaatga aagcaaagga tcttgaaatc
     1621 aggatacaca agaagaaaaa atgtgaaatt tatcggagac tgagagagtt tgctaaactg
     1681 tatgacacca ttcgaaatga aagaaacaaa tttgttaact tactccacaa agctcatcag
     1741 aaagtaaatg aaataaaaga aaggcataaa atgtcattaa atgaacttga aattctgaga
     1801 aatagtgccg ttagtcaaga aagaaagcta caaaattcca tgctgaaaca cgccaacaat
     1861 gttaccatca gagagagcat gcaaaacgat gtgcgcaaaa ttgtatcaaa acttcaggaa
     1921 atgaaagaaa agaaggaagc ccagttaaat aacattgaca gacttgccaa cacgatcaca
     1981 atgatcgaag aggagatggt gcagcttcgc aaaagatacg aaaaagctgt tcagcatcga
     2041 aatgaaagtg gcgttcagct gatagagcgg gaagaagaaa tatgcatttt ttatgaaaaa
     2101 ataaatatcc aagagaagat gaaactaaat ggagaaattg aaatacatct actggaagaa
     2161 aagatccaat tcctgaaaat gaagattgct gagaagcaaa gacaaatttg tgtgacccag
     2221 aaattactgc cagccaagag gtccctggat gccgacctag ctgtgctcca aattcagttt
     2281 tcacagtgta cagacagaat taaagacctg gagaaacagt tcgtaaagcc tgatggtgag
     2341 aatagagctc gcttccttcc agggaaagat ctgaccgaaa aagaaatgat ccaaaaatta
     2401 gacaagctgg aactacaact ggccaagaag gaggagaagc tgctggagaa ggatttcatc
     2461 tatgagcagg tctccaggct cacagacagg ctctgcagca aaactcaggg ctgcaagcag
     2521 gacacactgc tcttagccaa gaagatgaat ggctatcaaa gaaggatcaa aaatgcaact
     2581 gagaaaatga tggctcttgt tgctgagctg tccatgaaac aagccctaac cattgaactc
     2641 caaaaggaag tcagggagaa agaagacttc atcttcactt gcaattccag gatagaaaaa
     2701 ggtctgccac tcaataagga aattgagaaa gaatggttga aagtccttcg agatgaagaa
     2761 atgcacgcct tggccatcgc tgaaaagtct caggagttct tggaagcaga taatcgccag
     2821 ctgcccaatg gtgtttacac aactgcagag cagcgtccga atgcctacat cccagaagca
     2881 gatgccactc ttcctttgcc aaaaccttat ggtgctttgg ctccttttaa acccagtgaa
     2941 cctggagcca atatgaggca cataaggaaa cctgttataa agccagttga aatctgaata
     3001 tgtgaacaaa tccaggcctc tcaaggaaaa gacttcaacc aggcttcctt gtacccacag
     3061 gtgaaaaatg tgagcataat acttctaata ttattgataa gtaaggtaac cacaattagt
     3121 cagcaacaga gtacaacagg gtttctattt acccaccaac tactatacct ttcatgacgt
     3181 tgaatgggac atagaactgt cctacattta tgtcaaagta tatatttgaa tcgcttatat
     3241 tttctttttc actctttata ttgagtacat tccagaaatt tgtagtaggc aaggtgctat
     3301 aaaaatgcac taaaaataaa tctgttctca atgaa
//
