LOCUS       NM_001366335            4131 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens coiled-coil domain containing 14 (CCDC14), transcript
            variant 3, mRNA.
ACCESSION   NM_001366335 XM_005247710
VERSION     NM_001366335.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4131)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 4131)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4131)
  AUTHORS   Gupta,G.D., Coyaud,E., Goncalves,J., Mojarad,B.A., Liu,Y., Wu,Q.,
            Gheiratmand,L., Comartin,D., Tkach,J.M., Cheung,S.W., Bashkurov,M.,
            Hasegan,M., Knight,J.D., Lin,Z.Y., Schueler,M., Hildebrandt,F.,
            Moffat,J., Gingras,A.C., Raught,B. and Pelletier,L.
  TITLE     A Dynamic Protein Interaction Landscape of the Human
            Centrosome-Cilium Interface
  JOURNAL   Cell 163 (6), 1484-1499 (2015)
   PUBMED   26638075
REFERENCE   4  (bases 1 to 4131)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   5  (bases 1 to 4131)
  AUTHORS   Kodani,A., Yu,T.W., Johnson,J.R., Jayaraman,D., Johnson,T.L.,
            Al-Gazali,L., Sztriha,L., Partlow,J.N., Kim,H., Krup,A.L.,
            Dammermann,A., Krogan,N.J., Walsh,C.A. and Reiter,J.F.
  TITLE     Centriolar satellites assemble centrosomal microcephaly proteins to
            recruit CDK2 and promote centriole duplication
  JOURNAL   Elife 4, e07519 (2015)
   PUBMED   26297806
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4131)
  AUTHORS   Firat-Karalar,E.N., Rauniyar,N., Yates,J.R. 3rd and Stearns,T.
  TITLE     Proximity interactions among centrosome components identify
            regulators of centriole duplication
  JOURNAL   Curr Biol 24 (6), 664-670 (2014)
   PUBMED   24613305
REFERENCE   7  (bases 1 to 4131)
  AUTHORS   Chen,S., Lu,F.F., Seeman,P. and Liu,F.
  TITLE     Quantitative proteomic analysis of human substantia nigra in
            Alzheimer's disease, Huntington's disease and Multiple sclerosis
  JOURNAL   Neurochem Res 37 (12), 2805-2813 (2012)
   PUBMED   22926577
REFERENCE   8  (bases 1 to 4131)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   9  (bases 1 to 4131)
  AUTHORS   Camargo,L.M., Collura,V., Rain,J.C., Mizuguchi,K., Hermjakob,H.,
            Kerrien,S., Bonnert,T.P., Whiting,P.J. and Brandon,N.J.
  TITLE     Disrupted in Schizophrenia 1 Interactome: evidence for the close
            connectivity of risk genes and a potential synaptic basis for
            schizophrenia
  JOURNAL   Mol Psychiatry 12 (1), 74-86 (2007)
   PUBMED   17043677
REFERENCE   10 (bases 1 to 4131)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117381.5.
            
            On Oct 1, 2018 this sequence version replaced XM_005247710.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1460398.1,
                                           SRR1803615.88778.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409697.8/ ENSP00000386866.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AC117381.5         130077-130162       c
            87-142              AC117381.5         125673-125728       c
            143-215             AC117381.5         125288-125360       c
            216-285             AC117381.5         124979-125048       c
            286-408             AC117381.5         124776-124898       c
            409-645             AC117381.5         117829-118065       c
            646-740             AC117381.5         117624-117718       c
            741-1257            AC117381.5         115736-116252       c
            1258-1399           AC117381.5         113782-113923       c
            1400-1482           AC117381.5         102606-102688       c
            1483-1701           AC117381.5         100241-100459       c
            1702-1834           AC117381.5         100035-100167       c
            1835-4131           AC117381.5         82355-84651         c
FEATURES             Location/Qualifiers
     source          1..4131
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.1"
     gene            1..4131
                     /gene="CCDC14"
                     /note="coiled-coil domain containing 14"
                     /db_xref="GeneID:64770"
                     /db_xref="HGNC:HGNC:25766"
                     /db_xref="MIM:617147"
     exon            1..86
                     /gene="CCDC14"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..2774
                     /gene="CCDC14"
                     /note="isoform 3 is encoded by transcript variant 3;
                     coiled-coil domain-containing protein 14"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 14 isoform
                     3"
                     /protein_id="NP_001353264.1"
                     /db_xref="CCDS:CCDS93358.1"
                     /db_xref="GeneID:64770"
                     /db_xref="HGNC:HGNC:25766"
                     /db_xref="MIM:617147"
                     /translation="MVRSGARPGQVLSSGRHTGPAKLTNGKKATYLRKIPRFNADSGY
                     SIHSDSESQAETVHGLDGCASLLRDILRNEDSGSETAYLENRSNSRPLESKRYGSKKK
                     RHEKHTIPLVVQKETSSSDNKKQIPNEASARSERDTSDLEQNWSLQDHYRMYSPIIYQ
                     ALCEHVQTQMSLMNDLTSKNIPNGIPAVPCHAPSHSESQATPHSSYGLCTSTPVWSLQ
                     RPPCPPKVHSEVQTDGNSQFASQGKTVSATCTDVLRNSFNTSPGVPCSLPKTDISAIP
                     TLQQLGLVNGILPQQGIHKETDLLKCIQTYLSLFRSHGKETHLDSQTHRSPTQSQPAF
                     LATNEEKCAREQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLGE
                     LKALVAEQEDSEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQL
                     RILNQQLREQQKTQKPSGAVDCNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELL
                     KVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELEEALVNVKSSQFKLET
                     AEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKLLSDLSVDSARCKPGNNLTKSLL
                     NIHDKQLQHDPAPAHTSIMSYLNKLETNYSFTHSEPLSTIKNEETIEPDKTYENVLSS
                     RGPQNSNTRGMEEASAPGIISALSKQDSDEGSETMALIEDEHNLDNTIYIPFARSTPE
                     KKSPLSKRLSPQPQIRAATTQLVSNSGLAVSGKENKLCTPVICSSSTKEAEDAPEKLS
                     RASDMKDTQLLKKIKEAIGKIPAATKEPEEQTACHGPSGCLSNSLQVKGNTVCDGSVF
                     TSDLMSDWSISSFSTFTSRDEQDFRNGLAALDANIARLQKSLRTGLLEK"
     exon            87..142
                     /gene="CCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            143..215
                     /gene="CCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            216..285
                     /gene="CCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            286..408
                     /gene="CCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            409..645
                     /gene="CCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            646..740
                     /gene="CCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            741..1257
                     /gene="CCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1399
                     /gene="CCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1482
                     /gene="CCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1701
                     /gene="CCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1834
                     /gene="CCDC14"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..4131
                     /gene="CCDC14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3213..3218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC14"
                     /note="hexamer: ATTAAA"
     polyA_site      3234
                     /gene="CCDC14"
     regulatory      3809..3814
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC14"
                     /note="hexamer: ATTAAA"
     polyA_site      3833
                     /gene="CCDC14"
                     /note="major polyA site"
     regulatory      4104..4109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC14"
                     /note="hexamer: AATAAA"
     regulatory      4114..4119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC14"
                     /note="hexamer: AATAAA"
     polyA_site      4122
                     /gene="CCDC14"
     polyA_site      4131
                     /gene="CCDC14"
ORIGIN      
        1 ctttttaccg tgaggcttca cttccctcgg tctgggcttc tctgaggcgg cgagagatgg
       61 tcaggtctgg agctcgaccg ggccaggtgt tatcttcagg aaggcacact ggacctgcta
      121 aattaacaaa tggaaagaaa gcgacctatt taagaaaaat accacgtttt aatgcagatt
      181 ctggctattc catccattct gattcagaaa gtcaggctga aactgtacac gggcttgatg
      241 gttgtgcttc tttgctgagg gacattttga gaaatgaaga ttcaggttca gaaacagcat
      301 atttagaaaa cagatctaat tctagacctt tagaaagcaa aagatacgga tcaaaaaaga
      361 aaagacatga aaaacatact attcctttgg tagtccagaa agaaacatca tcttcagata
      421 ataagaaaca gatacctaat gaagcttctg ctagaagtga aagagacaca tcagacctag
      481 agcaaaactg gtcattgcaa gatcattata gaatgtattc acccataata taccaagccc
      541 tctgtgagca cgtgcagact cagatgtcac tgatgaatga cttgacttca aagaacatcc
      601 ctaatggaat tcctgctgta ccatgccatg ctccctctca ttctgaatct caggcaactc
      661 ctcattctag ttatggctta tgtacctcca ccccagtctg gtcacttcag cggccaccct
      721 gccctccaaa ggttcattct gaagttcaaa ctgatggcaa cagtcagttt gcatcacaag
      781 gtaaaacagt ttctgcaacc tgtactgatg ttctacggaa ttcatttaat accagtcctg
      841 gagttccatg tagcctgccc aaaactgaca tatcagctat tccaacattg cagcaactgg
      901 gccttgttaa tggaattctg ccacaacaag gaattcataa ggaaacagac ctactaaaat
      961 gtattcaaac atatttgtct ctttttcgat ctcatggaaa agaaacgcat ctggacagtc
     1021 agacacaccg aagccctact cagtcacaac cagctttctt ggccactaat gaagaaaaat
     1081 gtgccagaga gcaaattaga gaggccacaa gtgaaagaaa ggatttaaac atacatgtgc
     1141 gagatacaaa aacagtgaag gatgtacaga aggcaaaaaa tgtgaacaag acagctgaaa
     1201 aagttagaat tataaaatat ttgttgggag agctcaaggc cctggtagca gaacaagagg
     1261 attcagaaat tcagaggttg attacagaaa tggaggcatg tatatctgta cttccaacag
     1321 taagtggaaa cacagatatt caagttgaga tagcactggc catgcaacca ttaagaagtg
     1381 agaatgctca gttacgaagg cagttgagaa ttttgaacca gcaactcaga gaacaacaga
     1441 aaactcaaaa accatctggt gctgtggatt gcaaccttga attgttttct cttcagtcat
     1501 tgaatatgtc actgcaaaat caattggagg agtcactaaa gagccaggaa ttactgcaga
     1561 gtaaaaatga agagctgtta aaagtgattg aaaatcagaa agatgaaaac aaaaaattta
     1621 gtagtatatt taaagacaaa gatcaaacta tacttgaaaa taaacagcaa tatgatattg
     1681 agataacaag aataaaaatt gaattggagg aagccctagt caatgtgaaa agctcccagt
     1741 ttaagttaga aactgctgaa aaggaaaacc agatattggg gataacatta cgtcagcgtg
     1801 atgctgaggt gactcgacta agagaattaa ccagaacttt acagactagc atggcaaagc
     1861 ttctctccga tcttagtgtg gacagtgctc gctgcaagcc tgggaataac cttaccaaat
     1921 cactcttgaa cattcatgat aaacaacttc aacatgaccc agctcctgct cacacttcca
     1981 taatgagcta tctaaataag ttagaaacaa attacagttt tacacattca gagccacttt
     2041 ctacaattaa aaatgaggaa accatagagc cagacaaaac ctatgaaaat gttctgtcct
     2101 ccagaggccc tcaaaatagt aacactaggg gcatggagga agcatctgca cctggaatta
     2161 tttctgccct ttcaaaacag gattctgatg aagggagtga aactatggct ttaatagaag
     2221 atgagcataa tttggataat acaatttaca ttccttttgc tagaagcact cctgaaaaga
     2281 aatcaccact ttctaagaga ctatcccctc agccacaaat aagagcagct acaacacagc
     2341 tagtcagcaa cagcggactt gctgtctctg gaaaagaaaa taaactgtgt acacctgtaa
     2401 tctgttcctc ttcaacaaag gaagcagaag atgcacctga aaaactttcc agagcatctg
     2461 atatgaagga cacacagctc ctcaagaaaa taaaggaagc aattggtaag atccctgctg
     2521 ccaccaagga gccagaggaa caaactgcat gtcatggccc atcaggttgt cttagcaaca
     2581 gccttcaagt gaaaggcaat actgtctgtg atggtagtgt tttcacttct gacttgatgt
     2641 ctgactggag catctcttcg ttttcaacgt tcacttctcg tgatgaacaa gacttcagaa
     2701 atggccttgc ggcattagat gccaacatag ctagactcca gaagtcttta aggactggtc
     2761 ttctggagaa atgaattcag aagaaaactc atcaggtgct tctttttaaa actagaactt
     2821 ggctatattg aatgtgtatt tttctttagt gaaatgatgt tttatgttat tatgtgtgaa
     2881 gtaatatatt gtacaagtaa taaatgtatt gttgagatat attgacactg aggagcttat
     2941 aaaaacaagt catcttaagt tcacaattgc tacaagaaga aagttgtgga taactaggaa
     3001 attattgtaa gtaatgtttt atttcagtac ttagcaatta gagttctttt attaagatgt
     3061 atctgctgga ttaagggtac aggttgaaat agttctgtgg ctgtcctaag aaataatggg
     3121 aaaagaatct ctggatgtaa gtttttctgt tgaaactaga gggttttttt tttctgttta
     3181 catatacttt tttttaatag caatgtgttt ttattaaaca tgctgtgtgc cacaggccag
     3241 tgttgttggt gaaatatata aacatttatt taaagagaaa agttaccagt atctacacct
     3301 cttaaaaaac attgattggt ctaaaaaata tatagataac atcctaagtt aacatatggc
     3361 ttcttaaaac ttgggcactt ttatttgttt ttatcccaaa ttcatgtttt aaggccttta
     3421 aagaatagtc agactgataa agaagtgcta acagataagc tatagttggg gaaatttgtg
     3481 ggtttttttt aaataagaaa tgtttatttt tgtccttata tttaaacatg atggaatttg
     3541 taaatcttgg cattgattgt aattctgcct ttttggaaga attttttctc ccagcatgtt
     3601 agctgagaat attctctatt ttataaataa tatgaagtag gttggtctct ctgcttctct
     3661 ataccaggac ttcttagctc agtatcatct cccttcatgt aagcagcacg ttttaactct
     3721 taggaagctg aatgttgtgt tatcactaat actttgtaca ggtcacctgc ctactctaat
     3781 tgtccttagt acttggacag gctttatcat taaagagtgt tctcctaatc ccagaacctc
     3841 ctcgtgtttt ttgttttttt ggtggttttt tttttttttt taggtgttag tgctacagcg
     3901 tttgaaggag ccagctgtag tctctttgat atgttcagat tttccagata gagatttaag
     3961 tctaaaaatt tattaagtga attctaaact atttcacaca agagtccatt agcatcttta
     4021 attttattta gtattcatga attaatttat tggcatctta tttggaggta ataggccaca
     4081 actctttaac aaataagttc agaaataaaa aataataaaa aaggaaaaaa a
//
