LOCUS       NM_144978               2375 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens coiled-coil domain containing 138 (CCDC138),
            transcript variant 1, mRNA.
ACCESSION   NM_144978
VERSION     NM_144978.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2375)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2375)
  AUTHORS   Drew,K., Lee,C., Huizar,R.L., Tu,F., Borgeson,B., McWhite,C.D.,
            Ma,Y., Wallingford,J.B. and Marcotte,E.M.
  TITLE     Integration of over 9,000 mass spectrometry experiments builds a
            global map of human protein complexes
  JOURNAL   Mol Syst Biol 13 (6), 932 (2017)
   PUBMED   28596423
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2375)
  AUTHORS   Volik,S., Raphael,B.J., Huang,G., Stratton,M.R., Bignel,G.,
            Murnane,J., Brebner,J.H., Bajsarowicz,K., Paris,P.L., Tao,Q.,
            Kowbel,D., Lapuk,A., Shagin,D.A., Shagina,I.A., Gray,J.W.,
            Cheng,J.F., de Jong,P.J., Pevzner,P. and Collins,C.
  TITLE     Decoding the fine-scale structure of a breast cancer genome and
            transcriptome
  JOURNAL   Genome Res 16 (3), 394-404 (2006)
   PUBMED   16461635
REFERENCE   4  (bases 1 to 2375)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010095.6 and AC073415.6.
            
            On Nov 24, 2018 this sequence version replaced NM_144978.2.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.268930.1,
                                           SRR5189661.124590.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295124.9/ ENSP00000295124.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AC010095.6         171538-171682
            146-203             AC010095.6         172799-172856
            204-318             AC010095.6         173619-173733
            319-446             AC010095.6         176442-176569
            447-628             AC010095.6         179307-179488
            629-787             AC073415.6         114547-114705
            788-907             AC073415.6         121008-121127
            908-985             AC073415.6         128750-128827
            986-1093            AC073415.6         128939-129046
            1094-1258           AC073415.6         132060-132224
            1259-1375           AC073415.6         155304-155420
            1376-1568           AC073415.6         162857-163049
            1569-1745           AC073415.6         172913-173089
            1746-1884           AC073415.6         189570-189708
            1885-2375           AC073415.6         192207-192697
FEATURES             Location/Qualifiers
     source          1..2375
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q13"
     gene            1..2375
                     /gene="CCDC138"
                     /note="coiled-coil domain containing 138"
                     /db_xref="GeneID:165055"
                     /db_xref="HGNC:HGNC:26531"
     exon            1..145
                     /gene="CCDC138"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..2050
                     /gene="CCDC138"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 138"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 138
                     isoform 1"
                     /protein_id="NP_659415.1"
                     /db_xref="CCDS:CCDS2080.1"
                     /db_xref="GeneID:165055"
                     /db_xref="HGNC:HGNC:26531"
                     /translation="MEPRVVKPPGQDLVVESLKSRYGLGGSCPDEYDFSNFYQSKYKR
                     RTLTSPGDLDIYSGDKVGSSLKYSDESKHCRTPLGSLFKHVNVNCLDDELDSFHDLKK
                     QETEEELIENDYRVSTSKITKQSFKEIEKVALPTNTTSSRPRTECCSDAGDSPLKPVS
                     CPKSKASDKRSLLPHQISQIYDELFQIHLKLQCETAAQQKFAEELQKRERFLLEREQL
                     LFRHENALSKIKGVEEEVLTRFQIIKEQHDAEVEHLTEVLKEKNKETKRLRSSFDALK
                     ELNDTLKKQLNEASEENRKIDIQAKRVQARLDNLQRKYEFMTIQRLKGSSHAVHEMKS
                     LKQEKAPVSKTYKVPLNGQVYELLTVFMDWISDHHLSKVKHEESGMDGKKPQLKFASQ
                     RNDIQEKCVKLLPLMTEQLQWMPFVNIKLHEPFVKFIYWSLRQLDAGAQHSTMTSTLR
                     RLGEDIFKGVVTKGIQDNSPQHSVENKPKTAAFFKSSNLPLRFLSTLIVLKTVTQADY
                     LAQAFDSLCLDLKTEEGKTLFLEYQAVPVILSHLRISSKGLLSNVIDSLLQMTVESKS
                     LQPFLEACSNSLFFRTCSVLLRAPKLDLQILEKLSIILQKLSKIKSNKKLFELFTIHL
                     MLQEIQRTTNPEHAFLCINLNSTLFNLGLTKCNSLVSSASP"
     exon            146..203
                     /gene="CCDC138"
                     /inference="alignment:Splign:2.1.0"
     exon            204..318
                     /gene="CCDC138"
                     /inference="alignment:Splign:2.1.0"
     exon            319..446
                     /gene="CCDC138"
                     /inference="alignment:Splign:2.1.0"
     exon            447..628
                     /gene="CCDC138"
                     /inference="alignment:Splign:2.1.0"
     exon            629..787
                     /gene="CCDC138"
                     /inference="alignment:Splign:2.1.0"
     exon            788..907
                     /gene="CCDC138"
                     /inference="alignment:Splign:2.1.0"
     exon            908..985
                     /gene="CCDC138"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1093
                     /gene="CCDC138"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1258
                     /gene="CCDC138"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1375
                     /gene="CCDC138"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1568
                     /gene="CCDC138"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1745
                     /gene="CCDC138"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1884
                     /gene="CCDC138"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2375
                     /gene="CCDC138"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2170..2175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC138"
                     /note="hexamer: AATAAT"
     polyA_site      2193
                     /gene="CCDC138"
     regulatory      2351..2356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC138"
                     /note="hexamer: AATAAA"
     polyA_site      2375
                     /gene="CCDC138"
                     /note="major polyA site"
ORIGIN      
        1 gcgggtttga tgaacgcggt tcccggggag actggtacgg ttgctgtgtg ctatggagcc
       61 gagggtcgtc aagccaccgg ggcaggattt agtagtggag agtctcaaaa gccgctacgg
      121 actcgggggc agctgccccg acgagtatga tttttcaaat ttttatcagt ctaagtataa
      181 gagaagaact ctaacctccc caggtgattt ggatatctac tctggagata aagttggttc
      241 atcgttaaaa tattctgatg aaagcaagca ttgtagaaca ccattgggca gcttattcaa
      301 gcacgtaaat gtgaattgcc tagatgatga actggattct ttccatgatt tgaagaaaca
      361 ggaaacagaa gaagagttaa ttgaaaatga ttatagagtt agtacctcga aaataaccaa
      421 gcagtctttt aaagaaatag aaaaagttgc cttgccaact aatacgacct catcgagacc
      481 tcggactgag tgttgtagtg atgcaggtga ctctcctttg aaacctgtca gctgtccaaa
      541 atctaaagca tcagacaagc ggagtttact tccacatcag atcagtcaga tatatgacga
      601 attatttcag atacatctga aattgcagtg tgaaactgca gcacaacaga aatttgctga
      661 agaacttcaa aagcgagaac gttttttact tgaaagagaa caactgcttt tcagacatga
      721 aaatgccttg agtaaaatta aaggtgttga agaagaggtt cttacaagat ttcaaattat
      781 aaaagagcag catgatgcag aagttgaaca cttaaccgaa gttcttaagg aaaagaataa
      841 agaaaccaag agactgaggt cctcttttga tgcattgaaa gaattgaatg ataccttaaa
      901 aaaacagtta aatgaagcaa gtgaagaaaa caggaagata gacattcagg ctaaaagagt
      961 tcaagctcgt ttagataatt tacagaggaa gtacgagttt atgacaatac agagattgaa
     1021 aggaagttcc catgctgttc atgaaatgaa aagtttaaaa caagaaaaag caccagtttc
     1081 aaaaacttac aaggtaccac ttaatgggca agtttatgaa cttttaactg tcttcatgga
     1141 ctggatttcg gatcatcatc ttagcaaagt gaaacatgaa gaatctggaa tggatggtaa
     1201 aaaaccacaa ctcaaatttg cttcccagag aaatgatatt caggagaagt gtgtaaagct
     1261 tttgcctcta atgacagagc agctacagtg gatgccattt gtgaatatca aacttcacga
     1321 gccttttgta aaatttatat attggtccct aaggcagcta gatgctggag cacagcactc
     1381 gactatgaca tcaacattga ggagattggg tgaagacatt tttaaaggag tggtaactaa
     1441 aggaattcag gataattctc cacagcattc tgtggagaat aaaccaaaga cagctgcttt
     1501 ctttaagagc tccaatttgc cattgagatt tttatcaacc ttaattgttc tcaaaacagt
     1561 cactcaagct gattacctgg ctcaggcatt tgattctctt tgtttggact tgaagacaga
     1621 agaaggaaaa accttgtttt tggagtatca ggctgttcca gtaatattaa gtcatctaag
     1681 aatatccagt aaaggactcc tgtctaatgt tattgatagt ttgctccaga tgacggtgga
     1741 atctaaatcc ttgcagcctt tcctggaagc ctgtagcaac tctttatttt ttcgtacttg
     1801 ctctgtgctg cttcgagccc ctaagcttga tcttcaaata ctagaaaaac tcagtattat
     1861 tttacagaaa ctttccaaaa tcaagagtaa taagaagctc tttgaacttt ttacgattca
     1921 tctgatgctt caagaaatac aaaggacaac aaacccagag catgcatttc tctgtattaa
     1981 tctaaattca actctgttca atctgggttt aacaaaatgt aactccctgg tctccagtgc
     2041 aagcccttag actggctaat tttttaatat agtatatgtg gtgcttattt ataaacatgt
     2101 agaaattacc aaagtaacta caattctacc aagtaaagtt atcagtagca tcatttatca
     2161 tgaaaaataa ataatttttt tgaactgtaa aaatgaaatc tgtagaaggt attggaactt
     2221 ttggaatgtt tcagttcagg taaggtaata ctaatataca agatggcgtt tctagaatgt
     2281 atgacactga agtgactttt tgtaaaaata tattaggaaa attatttctt aaaattatgt
     2341 gattatttgg aataaaattg gtgcttatgt gagaa
//
