LOCUS       NM_199287               2095 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens coiled-coil domain containing 137 (CCDC137), mRNA.
ACCESSION   NM_199287 XM_290771
VERSION     NM_199287.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2095)
  AUTHORS   Dai,W., Wu,J., Peng,X., Hou,W., Huang,H., Cheng,Q., Liu,Z.,
            Luyten,W., Schoofs,L., Zhou,J. and Liu,S.
  TITLE     CDK12 orchestrates super-enhancer-associated CCDC137 transcription
            to direct hepatic metastasis in colorectal cancer
  JOURNAL   Clin Transl Med 12 (10), e1087 (2022)
   PUBMED   36254394
  REMARK    GeneRIF: CDK12 orchestrates super-enhancer-associated CCDC137
            transcription to direct hepatic metastasis in colorectal cancer.
REFERENCE   2  (bases 1 to 2095)
  AUTHORS   Bai,L., Yang,Z.X., Liu,J.S., Wang,D.S. and Yu,H.C.
  TITLE     Prognostic Significance of CCDC137 Expression and Its Association
            with Immune Infiltration in Hepatocellular Carcinoma
  JOURNAL   Dis Markers 2022, 5638675 (2022)
   PUBMED   36061359
  REMARK    GeneRIF: Prognostic Significance of CCDC137 Expression and Its
            Association with Immune Infiltration in Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2095)
  AUTHORS   Zhang,F. and Bieniasz,P.D.
  TITLE     HIV-1 Vpr induces cell cycle arrest and enhances viral gene
            expression by depleting CCDC137
  JOURNAL   Elife 9, e55806 (2020)
   PUBMED   32538781
  REMARK    GeneRIF: HIV-1 Vpr induces cell cycle arrest and enhances viral
            gene expression by depleting CCDC137.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2095)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 2095)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 2095)
  AUTHORS   Um,S.J., Youn,H. and Kim,E.J.
  TITLE     Negative regulation of ERRalpha by a novel nucleolar protein
  JOURNAL   Biochem Biophys Res Commun 418 (2), 290-295 (2012)
   PUBMED   22266318
  REMARK    GeneRIF: These data suggest that RaRF sequesters ERRalpha in the
            nucleolus through a specific interaction, thereby inhibiting its
            transcriptional activity.
REFERENCE   7  (bases 1 to 2095)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   8  (bases 1 to 2095)
  AUTHORS   Ohta,S., Bukowski-Wills,J.C., Sanchez-Pulido,L., Alves Fde,L.,
            Wood,L., Chen,Z.A., Platani,M., Fischer,L., Hudson,D.F.,
            Ponting,C.P., Fukagawa,T., Earnshaw,W.C. and Rappsilber,J.
  TITLE     The protein composition of mitotic chromosomes determined using
            multiclassifier combinatorial proteomics
  JOURNAL   Cell 142 (5), 810-821 (2010)
   PUBMED   20813266
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139530.3.
            
            On Nov 23, 2018 this sequence version replaced NM_199287.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ649645.1, BC009369.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329214.13/ ENSP00000329360.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               AC139530.3         62788-62951         c
            165-298             AC139530.3         61826-61959         c
            299-527             AC139530.3         59235-59463         c
            528-610             AC139530.3         57862-57944         c
            611-690             AC139530.3         57533-57612         c
            691-2095            AC139530.3         55789-57193         c
FEATURES             Location/Qualifiers
     source          1..2095
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..2095
                     /gene="CCDC137"
                     /gene_synonym="RaRF"
                     /note="coiled-coil domain containing 137"
                     /db_xref="GeneID:339230"
                     /db_xref="HGNC:HGNC:33451"
                     /db_xref="MIM:614271"
     exon            1..164
                     /gene="CCDC137"
                     /gene_synonym="RaRF"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..900
                     /gene="CCDC137"
                     /gene_synonym="RaRF"
                     /note="hepatocellular carcinoma related protein 2;
                     retinoic acid resistance factor"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 137"
                     /protein_id="NP_954981.1"
                     /db_xref="CCDS:CCDS42400.1"
                     /db_xref="GeneID:339230"
                     /db_xref="HGNC:HGNC:33451"
                     /db_xref="MIM:614271"
                     /translation="MAGAGRGAAVSRVQAGPGSPRRARGRQQVQPLGKQRPAPWPGLR
                     SKEKKKVNCKPKNQDEQEIPFRLREIMRSRQEMKNPISNKKRKKAAQVTFRKTLEKEA
                     KGEEPDIAVPKFKQRKGESDGAYIHRMQQEAQHVLFLSKNQAIRQPEVQAAPKEKSEQ
                     KKAKKAFQKRRLDKVRRKKEEKAADRLEQELLRDTVKFGEVVLQPPELTARPQRSVSK
                     DQPGRRSQMLRMLLSPGGVSQPLTASLARQRIVEEERERAVQAYRALKQRQQQLHGER
                     PHLTSRKKPEPQL"
     exon            165..298
                     /gene="CCDC137"
                     /gene_synonym="RaRF"
                     /inference="alignment:Splign:2.1.0"
     exon            299..527
                     /gene="CCDC137"
                     /gene_synonym="RaRF"
                     /inference="alignment:Splign:2.1.0"
     exon            528..610
                     /gene="CCDC137"
                     /gene_synonym="RaRF"
                     /inference="alignment:Splign:2.1.0"
     exon            611..690
                     /gene="CCDC137"
                     /gene_synonym="RaRF"
                     /inference="alignment:Splign:2.1.0"
     exon            691..2095
                     /gene="CCDC137"
                     /gene_synonym="RaRF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2071..2076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC137"
                     /gene_synonym="RaRF"
                     /note="hexamer: ATTAAA"
     polyA_site      2095
                     /gene="CCDC137"
                     /gene_synonym="RaRF"
                     /note="major polyA site"
ORIGIN      
        1 ggcttcgcta gggagcctcc cggcgtggag atggcgggag ctggtcgcgg agcagcggtg
       61 tccagggtgc aggcgggtcc tgggagtccc cggcgagcgc gggggcggca gcaagtgcag
      121 ccgctgggga agcagcgccc agccccgtgg cccgggcttc gcagcaaaga gaagaagaaa
      181 gtgaactgca agcccaagaa ccaggacgaa caggagattc ctttccggct ccgggagatt
      241 atgaggagcc gccaagagat gaaaaacccg atcagtaaca agaagaggaa gaaagcagcc
      301 caggtgacct tcagaaagac attggagaag gaagcaaagg gagaggagcc cgacatcgca
      361 gtccccaagt tcaaacagag gaagggggag tctgacgggg cctatatcca ccgcatgcag
      421 caagaggccc agcatgtgct gttcctcagc aagaaccagg ccatccggca gccagaggtg
      481 caggcagctc ccaaggagaa gtctgagcag aaaaaagcaa aaaaagcgtt ccagaagcgg
      541 cgactagata aagtccgacg gaaaaaggag gaaaaggcgg cagacaggct ggagcaggag
      601 ttgctccgag acacggtgaa gtttggtgag gttgtcctgc agcccccaga gctgactgcc
      661 aggccccaga ggagcgtaag caaggaccag cctggcagga gatcgcagat gctgcggatg
      721 cttctgagcc ccggtggtgt gtcccagcct ctgaccgcct ccctggcccg ccagcggatt
      781 gtggaggagg agagagagcg ggccgtgcag gcctacagag cgttgaagca gcggcagcag
      841 cagctgcacg gggagcgacc ccacctcact tcccggaaga agccagagcc gcagctgtga
      901 tggagagaca cccggggcct ggccacgctc tggggcaact ggcaccagga gctgctacac
      961 ctgggtagga gagaggcagg ccatgccagc agtgtggggt gaggcctcca gctacttgtt
     1021 cacacgttgg gcactagtgg gtccacatct tgcagggggt gagtgcccga tggactaggg
     1081 ccaaggcctg gttgacagac ggcccgtggg gcccggtgtc actcacagct ccatctcttt
     1141 gttttgaacg tccattctga gtctcagccc aggtggacct taggaagggc tggatccctg
     1201 tccctgaaca ccaaataccg agacagctga tgaggctggc tcagtgtgtg acggaggccc
     1261 ccgggagtca gcagagccga gcgtacagtg cacatcaggc agagcaggcc acgggcaggg
     1321 acgacgcatc gggacagggc tctgcagggg accgtgacta caggccagct gtgagtggtc
     1381 ccctacagag gctgcccacc caaggtttgg ttggggtgaa acatgatgac aacacataca
     1441 cttaagaagg tgggaaccgg gggccgggcg cggtggctca cacctgtaat gccagcactt
     1501 tgggcagctg aggcgagtgg atcacctgag gtcaggagtt cgaaccagcc tggccaacat
     1561 ggtgaaactg catctctact aaaaatacac gaagaaaaaa aaaacagtgg gaacagagtt
     1621 gtcacctacc taacagggct ctgagagagc cgggaggccc aaagtggctg gaagaaggta
     1681 aaggaaaaat cctgtcttgg gctcaaggtc acagagtggg gcccaggggg agttcctgct
     1741 gagggcaggg ccttgccagg cttcagtctc cagtgccaaa ggaggaaatg cccaggctgt
     1801 cagcatttcc agatgagagc agaagggaga agcttaaacc caagtcacac atccagcaat
     1861 ggagtccgac agcccagcac catctgggaa ctgagaagca cctctgcccg gcccccacac
     1921 cgtgtggaaa gtgaggagca cctctgcctg gccgccaccc cgtctggcaa gtgaggagcg
     1981 cctctgcccg gccgctgtgc aaccttccaa gtgtgaagtg acagccttgt gtgtgatgtt
     2041 ttctgccttc cccaagtttg cactttcgac attaaagttt actttttagt taaaa
//
