LOCUS       NM_022742               4246 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens coiled-coil domain containing 136 (CCDC136),
            transcript variant 1, mRNA.
ACCESSION   NM_022742
VERSION     NM_022742.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4246)
  AUTHORS   Adams,A.K., Smith,S.D., Truong,D.T., Willcutt,E.G., Olson,R.K.,
            DeFries,J.C., Pennington,B.F. and Gruen,J.R.
  TITLE     Enrichment of putatively damaging rare variants in the DYX2 locus
            and the reading-related genes CCDC136 and FLNC
  JOURNAL   Hum Genet 136 (11-12), 1395-1405 (2017)
   PUBMED   28866788
  REMARK    GeneRIF: Missense variant in CCDC136 gene is associated with
            reading disability.
REFERENCE   2  (bases 1 to 4246)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 4246)
  AUTHORS   Gialluisi,A., Newbury,D.F., Wilcutt,E.G., Olson,R.K., DeFries,J.C.,
            Brandler,W.M., Pennington,B.F., Smith,S.D., Scerri,T.S.,
            Simpson,N.H., Luciano,M., Evans,D.M., Bates,T.C., Stein,J.F.,
            Talcott,J.B., Monaco,A.P., Paracchini,S., Francks,C. and
            Fisher,S.E.
  CONSRTM   SLI Consortium
  TITLE     Genome-wide screening for DNA variants associated with reading and
            language traits
  JOURNAL   Genes Brain Behav 13 (7), 686-701 (2014)
   PUBMED   25065397
  REMARK    GeneRIF: CCDC136 locus showed association with a comparable
            reading/language measure.
REFERENCE   4  (bases 1 to 4246)
  AUTHORS   Zhang,X.M., Sheng,S.R., Wang,X.Y., Bin,L.H., Wang,J.R. and Li,G.Y.
  TITLE     Expression of tumor related gene NAG6 in gastric cancer and
            restriction fragment length polymorphism analysis
  JOURNAL   World J Gastroenterol 10 (9), 1361-1364 (2004)
   PUBMED   15112360
  REMARK    GeneRIF: Data suggest that NAG6 may represent a candidate tumor
            suppressor gene at 7q31-32 loci associated with gastric carcinoma.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC024952.4 and AC025594.5.
            
            On Nov 24, 2018 this sequence version replaced NM_022742.4.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150331.1, AB058696.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267773, SAMN03465402
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297788.9/ ENSP00000297788.4
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-460               AC024952.4         76425-76884
            461-715             AC024952.4         78805-79059
            716-790             AC024952.4         79151-79225
            791-1114            AC024952.4         85643-85966
            1115-1226           AC024952.4         89107-89218
            1227-1392           AC024952.4         89816-89981
            1393-1533           AC024952.4         90218-90358
            1534-1692           AC024952.4         90694-90852
            1693-1863           AC024952.4         91145-91315
            1864-2049           AC024952.4         91817-92002
            2050-2244           AC024952.4         93907-94101
            2245-2472           AC024952.4         94596-94823
            2473-2985           AC025594.5         951-1463
            2986-3207           AC025594.5         1859-2080
            3208-3489           AC025594.5         3789-4070
            3490-3807           AC025594.5         4765-5082
            3808-3914           AC025594.5         6909-7015
            3915-4246           AC025594.5         10950-11281
FEATURES             Location/Qualifiers
     source          1..4246
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.1"
     gene            1..4246
                     /gene="CCDC136"
                     /gene_synonym="NAG6"
                     /note="coiled-coil domain containing 136"
                     /db_xref="GeneID:64753"
                     /db_xref="HGNC:HGNC:22225"
                     /db_xref="MIM:611902"
     exon            1..460
                     /gene="CCDC136"
                     /gene_synonym="NAG6"
                     /inference="alignment:Splign:2.1.0"
     CDS             445..3909
                     /gene="CCDC136"
                     /gene_synonym="NAG6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 136; nasopharyngeal
                     carcinoma-associated gene 6 protein"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 136
                     isoform 1"
                     /protein_id="NP_073579.5"
                     /db_xref="CCDS:CCDS47704.1"
                     /db_xref="GeneID:64753"
                     /db_xref="HGNC:HGNC:22225"
                     /db_xref="MIM:611902"
                     /translation="MQAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLS
                     VNKHRGLSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQ
                     QAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDS
                     ATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSD
                     YSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLS
                     MTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVS
                     EEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQ
                     LQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEEL
                     QCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQD
                     LLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCE
                     LLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEE
                     QKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLM
                     EQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMS
                     LESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASE
                     AYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKV
                     LIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMA
                     PQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRP
                     SVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQRKL
                     DGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEE
                     EKEEDSEEEEDDADSSLESPEENNPLRLSESKKSSPTPNPPIFSLPLVGLVVISALLW
                     CWWAETSS"
     exon            461..715
                     /gene="CCDC136"
                     /gene_synonym="NAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            716..790
                     /gene="CCDC136"
                     /gene_synonym="NAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            791..1114
                     /gene="CCDC136"
                     /gene_synonym="NAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1226
                     /gene="CCDC136"
                     /gene_synonym="NAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1392
                     /gene="CCDC136"
                     /gene_synonym="NAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1533
                     /gene="CCDC136"
                     /gene_synonym="NAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1692
                     /gene="CCDC136"
                     /gene_synonym="NAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1863
                     /gene="CCDC136"
                     /gene_synonym="NAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2049
                     /gene="CCDC136"
                     /gene_synonym="NAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2244
                     /gene="CCDC136"
                     /gene_synonym="NAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2472
                     /gene="CCDC136"
                     /gene_synonym="NAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2985
                     /gene="CCDC136"
                     /gene_synonym="NAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..3207
                     /gene="CCDC136"
                     /gene_synonym="NAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..3489
                     /gene="CCDC136"
                     /gene_synonym="NAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3490..3807
                     /gene="CCDC136"
                     /gene_synonym="NAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3808..3914
                     /gene="CCDC136"
                     /gene_synonym="NAG6"
                     /inference="alignment:Splign:2.1.0"
     exon            3915..4246
                     /gene="CCDC136"
                     /gene_synonym="NAG6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4225..4230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC136"
                     /gene_synonym="NAG6"
                     /note="hexamer: ATTAAA"
     polyA_site      4246
                     /gene="CCDC136"
                     /gene_synonym="NAG6"
                     /note="major polyA site"
ORIGIN      
        1 ctccatctgt aggccacctc agcctttcag cctcttcttc actggctccc gccctctttc
       61 agtcttggcc ctctcctccc tgtccccccg gactaaatac gcacaccccc tctttctttc
      121 tgtgcaagca agagggtcct ggaacagcgg gttctgagga ggctgggagg cagggctgag
      181 aggtggccga gagagaggag tcgcagagcc gccagagtga gtcaggcacc tccactggga
      241 ttacagatcc cagagcctcg aggagctgga agacatgtcc ccttctttcc tctgcacccc
      301 agcccgcagc cagcccccca ccccccagcc cctcctttct ccctgctctc aggacccaca
      361 gtgaccactc taggctccta tgaggcttcc gagggctgtg agaggaagaa gggccaacgc
      421 tgggggtccc tggaacgacg ggggatgcaa gctatggagg gggaggtgtt actcccagct
      481 ctctatgagg aggaagagga agaggaagag gaggaagaag aggtggaaga agaagaagaa
      541 caagtgcaga aaggtggcag tgttggctct ctgtcagtca acaagcaccg gggactgagc
      601 ctcacggaga cagagctgga ggagctgcgg gctcaggtgc tgcagctggt ggcagaactg
      661 gaggagaccc gggaactggc agggcagcat gaggatgact ccttggagct acaggggctc
      721 ctggaggatg aacggctagc cagcgcccag caggcagagg tgttcaccaa gcagatccag
      781 cagctccaag gtgagctgcg ttctctacgg gaggagattt ccctgttaga gcatgagaaa
      841 gaaagcgaac ttaaggaaat agaacaggaa ttgcatttgg cccaggctga gatccagagt
      901 ctgcggcaag cagcagagga ttccgcaact gaacatgaga gtgacatagc atccctgcag
      961 gaggatctct gccggatgca gaatgaactt gaagacatgg aacgcattcg gggagattat
     1021 gagatggaga tcgcctccct ccgtgcagaa atggaaatga agagctctga accatccggt
     1081 agtttaggtc tctcagatta ctctgggtta caagaagaac tgcaggagct gcgggaacgc
     1141 taccatttcc tgaatgagga ataccgggcc ctgcaggaga gcaacagcag cctcacgggg
     1201 cagcttgcag atctggagag tgagaggaca cagagagcaa cagagagatg gctgcagtcc
     1261 caaacactga gtatgacgtc agcagagtct cagacttcag aaatggattt cttagagcct
     1321 gatcctgaaa tgcagttgtt acggcagcag ctacgggatg ctgaagagca gatgcatggc
     1381 atgaagaaca agtgtcagga attgtgttgt gagttggaag agctacagca tcatcgccag
     1441 gtcagtgagg aggagcagag gcggctgcag agggagctca agtgtgctca gaatgaggtg
     1501 cttcggtttc agacctccca cagtgtcacc cagaatgagg agctgaagtc cagactctgt
     1561 accctgcaga aaaaatatga tactagccag gatgagcaga acgagctctt gaagatgcag
     1621 ctgcaacttc agactgagct ccggcagctc aaagtcatga aatccacact tgtagaaaac
     1681 cagagtgaga aggagttact gtgccggctg cagaagctgc acctccagca ccagaacgtc
     1741 acatgtgaga aggaaaagct gctggaacgg cagcagcagc tgcaggagga gctgcagtgc
     1801 catgaggcag agctgcagca cctcagggat acggtggcct ccttcaaaga gagcaatgag
     1861 aaggacacag agacgcacgc tcagcttcag gagatgaagc agctgtacca ggccagcaag
     1921 gacgagctgg agcggcagaa gcacatgtat gaccagctgg agcaggacct cctgctctgc
     1981 cagctggagc tgaaagagct caaggcctcc caccccattc cggaggacaa aggaaagtgt
     2041 gctaataagt gtgacacact gctgtccaga ctgacagaat tgcaggaaaa gtacaaggcc
     2101 agccagaagg agatggggca gctgcagatg gagcagtgtg agctcctgga ggatcagagg
     2161 aggatgcagg aggagcaggg ccagctgcag gaagagctgc acaggctcac actgccactg
     2221 ccaaagagtg gcctcttact caagagtcag gagctactca ccaagttaga agacctgtgt
     2281 gagctgcagc tgctctacca aggcatgcag gaggaacaga agaagctgat acagaaccaa
     2341 gactgtgtat taaaagaaca attagagatc cacgaagagc tgcgacgttt caaagagtct
     2401 catttccagg aagtgttgga gaatcccgat gattccaaat tggctaagtc ctccaaatgt
     2461 aatcgaaaca agcaatccaa gctgctcatg gagcagatgc aggccctgca ggtgatgtat
     2521 gacgccggtc aggcgaagca ggagctcttg cagcaagagc aagggaggct cctagaggag
     2581 cggaagaggc tgcaggcaga cttgcagctc tgcctggaag aaatgcagct gcttcaagtc
     2641 cagtcccctt ctataaaaat gagccttgag tcctacggga agagctatgg tagcatggtc
     2701 cccagcaatg agaactgtcg caagacttat gataccactg tggatgacaa tgagagctat
     2761 tacaagagtt acaccagcac ccagaccagc agcaagagct ttctcaagag ctatgacagc
     2821 agcaccagtg ccagtgaggc ctatgggaag agttactgca ctaccagcaa cagcagcatt
     2881 acctataaga agagttacgg cagcaccagt agctctgaca cctgccagaa gagttttgtc
     2941 agcagctgca ctgacgagga acctgctgag cctgaagaca tggagcgctt tgaggaaatg
     3001 gttgtgaaag tgctgatcaa gctgcaggcg gtgcaggcca tgtaccagat aagccaggag
     3061 gaacacagcc agctgcaaga gcagatggaa aagttactgg ccaagcagaa agacctgaag
     3121 gaagagctgg atgcctgtga aagggagttc aaggagtgca tggaatgcct tgaaaagccc
     3181 atggcccccc agaacgacaa gaatgagatc aaagaactgc agaccaagct gcgggagctg
     3241 cagctgcaat accaggctag catggatgag caggggcggc ttctggtagt gcaggagcag
     3301 ctggaggggc agctgcagtg ctgccaggag gagctccgcc agctcaggga gaagaggcct
     3361 tctgttgtca aagaagcccg ggggaagaat gctaataaga acatgaacaa gaatgccaat
     3421 ggggttaaaa tgaaaaaggt gaccaagcca tgctcggata cttctgagag cgaccttgag
     3481 accagaaaga gtctggaggt agtgctgtac tacaaggcca gccagaggaa attagatgga
     3541 ctagcaaaag aggaggaaaa gaaagaggag atggaggagg aaaaaaagca agtgaaagag
     3601 gaagcaaagg agcagtgtgg ggatgagcta gttgctgagc cagcagatcc tgaggaagct
     3661 aaatccacag aagatcagga ggaaaatgaa gaggacaaag aggaagagga gaaggaagaa
     3721 gacagtgaag aggaggagga tgacgccgac tcttcccttg aaagtcccga agaaaataac
     3781 cccctcagac tttccgagag caaaaagtca tcccctaccc ccaatccccc catcttctcc
     3841 ttgcctcttg taggcctggt ggtcatctcg gctttgctct ggtgctggtg ggctgagacg
     3901 tcgtcctaat gcagaacatg tttgggttgt ggaagcctat ggtattcttg gctattgcag
     3961 ctgtggctct gtatgtgtta cccaacatgc gacagcagga gtcagagttc tgcctcatgg
     4021 agtgatggca gaccttggcc agcgcgaggg cagatcccca gtggccacca ccctcagctt
     4081 tgggcaggac acactgtgcc agaaccctcc ccatatgttc catgtgtccc catctcctca
     4141 gcctcagtca cccaggctga aaaggcttgt ggggagcggc tgacttccat ctcctgcctt
     4201 gtgtaagaac ctgagttcct tgtaattaaa tatcaactga attaca
//
