LOCUS       NM_145265               9283 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens coiled-coil domain containing 127 (CCDC127), mRNA.
ACCESSION   NM_145265
VERSION     NM_145265.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9283)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 9283)
  AUTHORS   Saito,Y., Nakagawa,T., Kakihana,A., Nakamura,Y., Nabika,T.,
            Kasai,M., Takamori,M., Yamagishi,N., Kuga,T., Hatayama,T. and
            Nakayama,Y.
  TITLE     Yeast Two-Hybrid and One-Hybrid Screenings Identify Regulators of
            hsp70 Gene Expression
  JOURNAL   J Cell Biochem 117 (9), 2109-2117 (2016)
   PUBMED   26873636
  REMARK    GeneRIF: A luciferase reporter gene assay revealed that hsp70
            promoter activation is enhanced by the transcriptional co-activator
            AF9 and splicing mediator SNRPE, but suppressed by the coiled-coil
            domain-containing protein CCDC127.
REFERENCE   3  (bases 1 to 9283)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC015349.2 and AC021087.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_145265.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.154660.1,
                                           SRR1803613.91690.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296824.4/ ENSP00000296824.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1391              BC015349.2         30-1420
            1392-9283           AC021087.5         52458-60349         c
FEATURES             Location/Qualifiers
     source          1..9283
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.33"
     gene            1..9283
                     /gene="CCDC127"
                     /note="coiled-coil domain containing 127"
                     /db_xref="GeneID:133957"
                     /db_xref="HGNC:HGNC:30520"
     exon            1..61
                     /gene="CCDC127"
                     /inference="alignment:Splign:2.1.0"
     exon            62..192
                     /gene="CCDC127"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..854
                     /gene="CCDC127"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 127"
                     /protein_id="NP_660308.1"
                     /db_xref="CCDS:CCDS3852.1"
                     /db_xref="GeneID:133957"
                     /db_xref="HGNC:HGNC:30520"
                     /translation="MNNLNDPPNWNIRPNSRADGGDGSRWNYALLVPMLGLAAFRWIW
                     SRESQKEVEKEREAYRRRTAAFQQDLEAKYHAMISENRRAVAQLSLELEKEQNRTASY
                     REALISQGRKLVEEKKLLEQERAQVMQEKRQVQPLRSAYLSCLQREENWQRRARLLLK
                     EFEAVLTERQNIYCSLFLPRSKRLEIEKSLLVRASVDPVAADLEMAAGLTDIFQHDTY
                     CGDVWNTNKRQNGRLMWLYLKYWELVVELKKFKRVEEAILEK"
     exon            193..9283
                     /gene="CCDC127"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1170..1175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC127"
                     /note="hexamer: AATACA"
     polyA_site      1194
                     /gene="CCDC127"
                     /note="major polyA site"
     regulatory      1368..1373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC127"
                     /note="hexamer: CATAAA"
     polyA_site      1389
                     /gene="CCDC127"
                     /note="major polyA site"
     polyA_site      1630
                     /gene="CCDC127"
     regulatory      4747..4752
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC127"
                     /note="hexamer: ATTAAA"
     polyA_site      4767
                     /gene="CCDC127"
     regulatory      7746..7751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC127"
                     /note="hexamer: AATAAA"
     polyA_site      7765
                     /gene="CCDC127"
     polyA_site      9283
                     /gene="CCDC127"
ORIGIN      
        1 aaagcggacc cgcggacggt ggcgttaagg gaacgctgag gtcccgcgct ccccgaccga
       61 ggtatatctc catgaataac ctaaatgatc ccccaaattg gaatatccgg cctaattcca
      121 gggcggatgg tggtgatgga agcaggtgga attatgccct gttggttcca atgctgggat
      181 tggctgcttt tcgttggatt tggtctaggg agtcccagaa agaagtagaa aaagagagag
      241 aagcctaccg tcggagaact gctgcttttc aacaggatct ggaagccaag taccacgcca
      301 tgatctcaga aaatcggcgt gctgtcgctc agttgtcctt ggaactcgaa aaggaacaaa
      361 acagaactgc tagttaccga gaagccctta tctctcaggg acgcaagttg gtagaagaaa
      421 agaagcttct ggaacaggaa cgggcccagg tgatgcaaga aaaaagacag gtgcagcctt
      481 tgagaagtgc gtatttgagc tgcctgcaaa gggaagaaaa ctggcaaagg agagccaggc
      541 ttttgctgaa agaatttgaa gctgttctca cagaaagaca gaatatctac tgcagtctgt
      601 ttcttcctcg cagcaagcgg ctggagatag agaagagctt actggtgcga gcgtccgtcg
      661 accccgtcgc cgctgaccta gagatggcag ccggtctcac cgacatattt cagcatgata
      721 catactgtgg tgatgtctgg aacaccaaca aacgccagaa tggcagactc atgtggctct
      781 atctcaaata ctgggaactc gttgtcgaac tgaagaagtt taagagagta gaggaagcca
      841 tactagaaaa gtaagacaag agtgaaatca aactgctttt agtgactcga ggccaggcag
      901 tcatgcgcct tctgggtctc cggcgtcttc cgttcccgtg ctgcccgtgt catggccaca
      961 ccgtcaccct tcagcagcga cctccactcc cgccaccgtc tgagcagaag tgcaccgaag
     1021 cctcagagac agagggtctc ctcccgatgc tctgccgctg ttggggatat ggtttcttga
     1081 agcattttta ggctgccagt attgtattaa gcagaacagt ataacctcgt attttagctc
     1141 cagggtaaaa atggtttttt aaaaagtcaa atacaatact ggtccttacc acaagtaatt
     1201 ttctgtctgt ttcatcactc cctaaatact ttctcctcaa attatttttc tctgtcacca
     1261 gattacatta agaatttgtc agataatgtg tagaactgca taacaggtaa taggaagtag
     1321 taatattata ttatcaaggg tttatatttt aaagatctct ctcactccat aaaggggaaa
     1381 taccaagtgt ttcttgtatc cagttgttac ttaatgtgtg tttgttgtat gcagttgtta
     1441 cctaatgtgt gtttgttgta tgcagttgtt acctaatgtg tgtgtgttgt atgcagttgt
     1501 tacctaatgt gtgtgtgttg tatccagttg ttacctaatg tgtgtttgga atttggcttg
     1561 tgtctgtatt cagcaagcag atacttatta gcaatgatat atactcaaaa tacttgccat
     1621 ttatgagtaa taatgccact ttttgtgtaa ttcttcactc tttacaaaat atttttatat
     1681 gtattatctc attgtttacc acagccaaca aggtagacag gcacttatca ccccatgtca
     1741 cacatagcta ctgggaattg agcctgtata cctgttcact catggaatcc tcagtcgaat
     1801 cctgtgaagt gagtattact attacgcttt gcggaggtgc cccaaggcca gcccccaggt
     1861 gcgtgacctg ctgggagatc tcacaggact cagcacaggg ttggactcag cacagagcag
     1921 aatcagcaaa gggagagggt gtgtgggtgg cgctcagagg agccacgtgt ggacacccca
     1981 ggatccactc cctggagtca tacaggacac acctaactat taagaataag ctcactggag
     2041 actcagcacc tggggctttt gctaagggct ggtcatgtgg taccccctgc ctggcctgtg
     2101 tgggaattcc ccacttgtcc agaaggaggg tgggtttggt gtggtctgtg ccgtgagcac
     2161 aagtactgtg gtcacagagc cacgcgtagg agttaatggt gctgggaagt ctcccagaat
     2221 ccgagttccc agatgtcagt caagggccag ccttgcacac aggccctggt aggacacagc
     2281 cttgggcctg ctgtgtgaat tcgtcaccac gcacctcact ttacggagat gtggaagagc
     2341 taacctgcct gaggtcacgc aggtagtagt gttggagcca gtctgagccc gggcaccttt
     2401 tctccagaac cgcgagtaac ctgtgtgcag tgatttgata gtgtgtggcc aggcaggagc
     2461 gggagcaggt tgtccatctg ctttcaaggg ccatgttctc ccctcctgcc cgtctgtacg
     2521 ggagtaggag caactgttaa aaatcctaag ctcatagagc ccacgtggca gtatgagagc
     2581 cactattcat ggagtgcatg ttccaccctg agctgtacac gctttacacg catgcgttgt
     2641 ttgaaatccg tggaacccct tgagcgcggc ggaggcgggc tcagagccaa catgcgctgc
     2701 ctgcaacaga cacgggcccc ctgccatgct ctgctctcgg cacccacgcc ctgctaaggg
     2761 tgctcagatg cttcacccag gcaggagtgc agtggtgtga tggctaaggg tgctcagatg
     2821 cttctcttct tcagtggctg ctagcgtgcc tctctgctct accaccatcg ctttatctga
     2881 gaaaaagtca cttttatttt cattttttat tttttttgag agggaatctc tgtcacccag
     2941 gcaggagtgc agtggtgtga tctcagctca ctacagcctc cgcctcctgg gttcaagcga
     3001 ttctcctgcc tcagcctcct gggtagctgg gattacaggc gtgcgctacc acacccagct
     3061 aatttttgtt ttgttagtag agacggggtt tcaccatgtt ggccaggctg gtctcgaact
     3121 gctgacctca ggtgatccac cgcccccacc tcggcctccc acagcactgg gattacaggt
     3181 gtgggccacg gcacccggcc cctaaaaagt cattttttcg gtaaatctgg acaaaactct
     3241 tcctgttgtt gtttgtactt cctgatgcat caagaccctt gcctaaagag cggtgcaggc
     3301 tccattcctg cggcaatccg gtctgctggg tgtccctgtg tgaaccactc cacgtttgtc
     3361 tttaaatgaa gaaaacacag tcagctgctt tgtaggtgaa tgattttcga ggcaaattgt
     3421 taatcctcat cctgtttcta atgtccagtg tgctgtcagc ctagcttcct tctatagtga
     3481 gatagatatg ttcagagcct tcaagctggt gtggacactg acccgctgac ccggtcctgc
     3541 agagttagga agacgagcat tttttttttg agacagtctc gttctgttgc caggcgggag
     3601 tgcagtggca caatctcgcc tcactgcaag ctctgcctcc cgggttcgag tagtttgcct
     3661 gcctcagcct cccgagtagc tgggactaca ggtgcctgcc accatgcctg gctaattttt
     3721 gtatgtttag tagagacagg gtttcaccat gttggccagg atggcctcaa acttctgatc
     3781 tcaggtgatc cacctgcctc agcctcccaa agtgctggga ttaggggcgt gagccaccgt
     3841 gcctggccgg aagatgctct ttccacaggg ttgatattag ttcgtgtttg tgtggcgtgg
     3901 ctgccttcca tcagcaagtt tgagtgttga tgtgaggcca ccctcttttg aaatggattg
     3961 tggtcggttt ggaatagtta cacggtgctg tgccatttgg taactccaca catgtaccga
     4021 aaggtgagcc cacagtggaa cgctcctcaa ccaaagtggt ttaaagttgc agaaaagggt
     4081 aattgtgctg gttggtgtgt gtgctgaatt tgtagcgaca tcagagtcaa gcattatttg
     4141 tcctgctgct ttcttggagg tcacagtaac tataaaaccg tgagccagca aggcagagag
     4201 gaccctttgg ggtaaggagt ggagctctgg gagatcctag gtttcggaag caggtccagt
     4261 ttccttgggg aggggagggc tcgctgcagg gcggaggagg ggcagccact gtaatccttg
     4321 tctggagtga acattgtata tgaggttgca gtggcttaaa aaggaaggac ttttgcgggg
     4381 aggggttgag attgtacttt ctaatttcgc ttgcttcaga cttgactttg gaatgaagtt
     4441 cgaaggcatc acaattgacc tggacattcc aaaaacaaaa ctgaagaggc agcatttctc
     4501 ttccgtagtc cagtcagctc atttggtaga tgcgcttttt cctcctttgc gcttattcat
     4561 ccataaggat atataatttg catatatatt tcatatgcgt gcatatgtgt gtgtatgtgt
     4621 gaactggcag gtgttgattt cataaggaca aaattgttct gcaaaccttg caccaattat
     4681 ggggtgtttc aacggaaaaa cttcaccaaa tgatctgtgt gttctttcaa agagaagtta
     4741 tgtctaatta aaatgtgtaa cggactattt ctgtgttgga ttgtttaaaa agtgattgct
     4801 tcatagtgta ctaagatcat ctctttaagc agaagggaga aaacagcttt ctagttactt
     4861 tcacatatta ggtttgctac ataaaagcaa gtctgaagac tacacctgtg acattgcaga
     4921 gaccaaactg cagtgtgtgc agccatgagt ggcagctgct tcctcctcga ggtgtcttgt
     4981 tccagcatga ggacagcccg tgcgatgttg ggaggagcca gggtgtttgg gggggcagct
     5041 gccctagaca ctggctggct gtgatggggg gcagcctgct gtgtagacac tggctggctg
     5101 tgatgggggg cagcctgctg tgtagacact ggctggctgt gatgggggca gcctgctgtg
     5161 tagacgctgg ctgtgatggg ggcagcctgc tgtgtagacg ctggctggct gtgatggggg
     5221 cagcctgctg tgtagacgct ggctagctgt gatgggggca gcctgctgtg tagacgctgg
     5281 ctggctgtga tgggggcagc ctgctgtgta gaaagtgctg ggcttgctcc gtctgccttg
     5341 acttgtgtga gtaactgcgc tgggttttat aggttgaggc tgaaaaggct cctctttcta
     5401 tgctgggttt gacgaaacag ttgctgtatt tctctattaa tttaggattc tgtttgcaag
     5461 cagcagagat ggatttgtgc tagcctagaa agttaaagag ggatttaagg ctgtctcgtg
     5521 aaacttcagg tcaagaatgg agaacacagg ttagatgtca gagaagaacc agaaagacaa
     5581 ataagggact ctcaggggcc tcggagtact tgtcactctg tgtcatatct ctgcatagcc
     5641 gcgccaatcc ccaaaccagc ttctctggcc acacggtggg acagggcggt tcccacagct
     5701 cctgagcctg ccccctgcct ggcctgctcc agcgggcggc cgagttaggg aagcgctggg
     5761 ctccaccata ccgcggtgtt ctaaaggagt gggaacaatg aagatcaggg ttgcagagcc
     5821 tgtggccttt gctagcttca tgggaaatct tgaaaagaga aaacgaaggg cttcagtaag
     5881 ccacccatgg acagcaggca tgcggtggaa ggcggagggc ttctgtggca gcttcgcagg
     5941 tctctcatct gctgcagacc ccctgacagg ctgagggtct tgctgtcggg tagcgggacc
     6001 agatgagcct gaatgtggct ctgcggctca caggacaagt gtaccttgag agctgctgcc
     6061 gccgcctgga tgtttgctgg gtgagctcca gattcacggg agccctttgt gccagcatgg
     6121 ccgccccaac cccatgggga aagcagatct ccctcacctg ggaatctggc agagacctca
     6181 ggcagtgccc catctttcat gacctgcctg gtccaggtag aggagtcaag tcctgctcca
     6241 ggagcaggtg cagggcctgg cctgggtgcc gagagtgggg tgaggaggga ggagtaacga
     6301 agaaaggcag atgggcagaa agtgccacat tggggcactc aagtggctct gtttaatatt
     6361 ccagcaggga cactgagacc gagcccatcc ctgctgggag agcttctcga agctggttgg
     6421 tggctgacag gcagggagtg gggtgctggg gcctcctcgg gaggtagggg tgctggggcc
     6481 ctgctcttga cagcactgtg ccatagctcc gaggtggctg ctccccatgg gccagggctg
     6541 gtggtgccag aaaatgggat ctgggctgag gggctctggg ctggcagagg tggggcgggg
     6601 ggtgactggc aggcatcaag atgggggggg acaagcacgg tgcccccacc catggggccg
     6661 tgtggggctg atggatagtg ggactccagc atgcagcaga tgatggagcc ttgctcaact
     6721 cagaagagga agagcaggag agcgctggtg gatgagagca accctgatgt tccagggccc
     6781 ttggccacgt ccaccacaca gaggggccac gtccacacag aggggccacg tccaccacac
     6841 agaggggcca cgtccaccac acaggggcca ctgggcctgc gtatatctcc ttggcctgcg
     6901 agggtatcat catttcctga cctgtggaac aagtcattaa gccaggaagg acttgagttg
     6961 gagcccctaa aacggccccc actccttgcc aggatggtgg acaggaagca gtgccatgtt
     7021 ctgaaggagc tgcaccagcc catgctgctg tggaagaccc aagggaggca aagacggtgg
     7081 ctccagatgg cggcccccat tgggaccctg ctcacatcac ccactggccc tggaaagccg
     7141 gggtgggcct gggcaggtga accctgaggc tccgccagga gcagccccag ctacagccac
     7201 catggatgtt tgctgggttg gatcagcact ctcacctgct gaatggtttt gcctgattcc
     7261 cactagcttg tcttgtgtgg gaggccgtgt tttctgcggt agagaagtgc tctccataaa
     7321 aacccagcag gcgtgctcct gggccctgca gacgccggat gtgtggccac agacgccatg
     7381 cgacccagga ctggagtcac aagattgggc gaggacaaag acccagcgaa tggtgaacgg
     7441 ccatgcagga tggggccgat cagttcagta ggagcaagtg cgagacctgc acaggacggg
     7501 cgagggaggc gttggtcccc agcctctgct ggccttatca gaatgggctg ttcttgggaa
     7561 gcccctgggt gtctgtggag ctggagatgt tgggagcttg tgccctcagc accgcccact
     7621 gacaccagtg ggctcctgtg tgccctgccc aatcccaggc ctcaggacac ccagcaccct
     7681 gggcccttct ccactgccac aggccttaag gttggtcatc atgccgccca gcggctgagt
     7741 cttacaataa aaattcagac acaaagcagt ggcagccact ctgtgcttta gagttagaag
     7801 taagtcatta aaaatgttgg cccagcacct tccctgcctg tttccaaaag ctggccgcaa
     7861 tatcaaattc atgtccctgg acaaggctcc agtaaggcac tgcctgcagt gtgcagagag
     7921 cacttaggtg gttgcagagc aggcagagac gaatgtgggg agtggaagtc accatatctg
     7981 cccactcggc aggaggccgt ccattcctga gacgcccccg ggaggcaggc tcctgtacgg
     8041 cactcatgct gggtacccaa cccctacaac ccaggcaaac ccctaccctg ggcagagaag
     8101 ggcctggaca caccaggggc agaaggagaa aggggatgga gacaaacctg ggtgggggtg
     8161 acctgggggc agctggggtg gggtgacacg gggaccattg gggtggggac acactccggg
     8221 agggggagac acggggcagc aggggtgggg gcacacctgg agtggggtga catgggggcc
     8281 cctggggtgg ggacacactc ggggaggggg tgacacaggg accactgggg tggggacaca
     8341 ctccgggagg gggtgatacg gggcagcggt gtagggaaaa gagagatcag actgtcactg
     8401 tgtctatgta gaaagggaag acatgagact ccgttttgaa aaagacctgt actttaaata
     8461 attgctttgc tgagatgatg ttaatgtgta gctttgcccc agccactttg ccccaacctg
     8521 gagctcacaa aaacatgtgt tgtatgaaat caaggtttaa gggatctagg gctgtgcagg
     8581 acgtgccttg ttaacaaaat gtttacaagc agtatgcttg gtaaaagtca tcgctattct
     8641 ctagtctcaa taaaccagag gcacaatgca ctgcggaaag ccgcagggac ctctgccctt
     8701 gaaagccggg tattgtccac ggtttctccc catgtgatag tctgaaatat ggcctcgtgg
     8761 aatgagaaag acctgaccgt cccccagccc gacacccgta aagggtctgt gctgacatgg
     8821 gttagtaaaa gacgaaagcc tcttgcagtt gagagagaga agtccactgt ctcctgctcg
     8881 ccgctgggaa ctgaatgtcg cggtgtaaaa cccgattgta catttgttca actctgagac
     8941 aggagaaaag ccgccttgtg gcgggaggcg agacatgttt gcggcaatgc tgccttgtta
     9001 ttctttactc tgctgagatg tttgggtgga gagaaacata aatctggcct acgtgcacgt
     9061 ccaggcatag taccttccct tgaacttaat tacgacatag attcttttgc tcacacgttt
     9121 ttgctgacct cctccttatt atcaccctgc tctcctacta cattcctttt tgctgaaata
     9181 atgaaaataa taataaaaac tgagggaact cagaggccgg tgccagtgca ggtccttggt
     9241 atgctgagcg ccggtcccct gggcccactg ttgtttctct ata
//
