LOCUS       NM_176816               4283 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens coiled-coil domain containing 125 (CCDC125),
            transcript variant 1, mRNA.
ACCESSION   NM_176816 XM_005248457 XM_005276761
VERSION     NM_176816.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4283)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4283)
  AUTHORS   Araya,N., Arimura,H., Kawahara,K., Yagishita,N., Ishida,J.,
            Fujii,R., Aratani,S., Fujita,H., Sato,T., Yamano,Y., Higuchi,I.,
            Osame,M., Nishioka,K., Fukamizu,A., Arimura,K., Maruyama,I. and
            Nakajima,T.
  TITLE     Role of Kenae/CCDC125 in cell motility through the deregulation of
            RhoGTPase
  JOURNAL   Int J Mol Med 24 (5), 605-611 (2009)
   PUBMED   19787194
  REMARK    GeneRIF: These results suggest that the novel gene, Kenae/CCDC125,
            acts as a regulator of cell motility through RhoA, Rac1 and cdc42.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC145132.2, BC108715.1, AB024691.1 and AI141520.1.
            
            On May 17, 2019 this sequence version replaced NM_176816.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000396496.7/ ENSP00000379754.2
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AC145132.2         45222-45374
            154-497             BC108715.1         6-349
            498-1978            AB024691.1         413-1893
            1979-3233           AC145132.2         95544-96798
            3234-3766           AI141520.1         9-541               c
            3767-4283           AC145132.2         97332-97848
FEATURES             Location/Qualifiers
     source          1..4283
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     gene            1..4283
                     /gene="CCDC125"
                     /gene_synonym="KENAE"
                     /note="coiled-coil domain containing 125"
                     /db_xref="GeneID:202243"
                     /db_xref="HGNC:HGNC:28924"
                     /db_xref="MIM:613781"
     exon            1..153
                     /gene="CCDC125"
                     /gene_synonym="KENAE"
                     /inference="alignment:Splign:2.1.0"
     exon            154..497
                     /gene="CCDC125"
                     /gene_synonym="KENAE"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..1729
                     /gene="CCDC125"
                     /gene_synonym="KENAE"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 125"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 125
                     isoform 1"
                     /protein_id="NP_789786.2"
                     /db_xref="CCDS:CCDS4000.1"
                     /db_xref="GeneID:202243"
                     /db_xref="HGNC:HGNC:28924"
                     /db_xref="MIM:613781"
                     /translation="MSKVARSSSESDVQLWETEEDDMTEGDLGYGLGRKPGGIYEIEF
                     SHRSRKRSDGKNFSPPPFPRKGEERNEASFQYSKHKSQQDTFPQVSRISNYRRQSSTV
                     DSNSELSNEELRQCLNETLEEVEMLKTELEASQRQLRGKEEALKILQSMAILGKATSH
                     TQAVLQKTMEQNRSLEKEINALQWEIEFDHNRFKNIEESWIQKYDRLNCENAVLKENL
                     KVKTEEIKMLKSDNAVLNQRYLEALAMLDIKQQKMAQENMCCDKSGFAEASGLELAVL
                     GACLCHGPGGNPCSCARMAASTRKLLLQLKQELEILQKSKEEAYVMADAFRIAFEQQL
                     MRKNDQALQLTQMDKMHKKATKWMNWKHLKEDGFPSPRSKKTFGQRLLGMLPSENSSK
                     RMEDQDSPQEVLKMLIDLLNDKEEALAHQRKVSYMLARALEDKDTASNENKEKNPIKE
                     NFPFNNPWRKTSEFSVLGDPIHSSVCILNSVGCICSIQHSQIDPNYRTLKRSHSLPSS
                     IIF"
     exon            498..559
                     /gene="CCDC125"
                     /gene_synonym="KENAE"
                     /inference="alignment:Splign:2.1.0"
     exon            560..646
                     /gene="CCDC125"
                     /gene_synonym="KENAE"
                     /inference="alignment:Splign:2.1.0"
     exon            647..724
                     /gene="CCDC125"
                     /gene_synonym="KENAE"
                     /inference="alignment:Splign:2.1.0"
     exon            725..810
                     /gene="CCDC125"
                     /gene_synonym="KENAE"
                     /inference="alignment:Splign:2.1.0"
     exon            811..893
                     /gene="CCDC125"
                     /gene_synonym="KENAE"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1009
                     /gene="CCDC125"
                     /gene_synonym="KENAE"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1117
                     /gene="CCDC125"
                     /gene_synonym="KENAE"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1292
                     /gene="CCDC125"
                     /gene_synonym="KENAE"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1423
                     /gene="CCDC125"
                     /gene_synonym="KENAE"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..4283
                     /gene="CCDC125"
                     /gene_synonym="KENAE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3741..3746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC125"
                     /gene_synonym="KENAE"
                     /note="hexamer: AATAAA"
     polyA_site      3766
                     /gene="CCDC125"
                     /gene_synonym="KENAE"
                     /note="major polyA site"
ORIGIN      
        1 agcggcgcac gcgcacggag aggaggctac ttgccaggtg agcgagctga gtggggcgcc
       61 ggggcggtag gagggtgctg ttcgctgagc tggagtccgg gctccggtcc ccgccacgga
      121 ccttgagagg gtacccgggg tcagacctgg cagacagccc attttttctt atgataaaga
      181 cggcatttgg ctcatgagca aggtggcaag atcatcaagt gagtcagacg tgcagctctg
      241 ggaaacagaa gaggatgaca tgacagaagg tgatttaggg tatggcctcg gaaggaaacc
      301 tggtgggatt tatgaaatag aattttcaca taggtctaga aaaagatcag atggaaagaa
      361 ctttagccct cctccatttc cgagaaaggg agaagaaaga aatgaagcga gttttcagta
      421 ttccaagcat aagagccagc aagatacatt ccctcaagtg tccagaattt ccaattacag
      481 acgacaaagt agcactgtag attcgaattc agaattgtca aatgaagaat taaggcaatg
      541 tcttaatgaa actttagagg aggtagaaat gttaaaaact gaacttgagg catctcaaag
      601 acaactcaga ggtaaagagg aagcattgaa aattcttcaa agcatggcaa tactgggcaa
      661 agccacaagt catacgcagg cagtgcttca aaaaactatg gaacaaaaca gatccttgga
      721 gaaggaaata aatgccttgc agtgggaaat agaatttgat cataatagat ttaaaaatat
      781 agaggaatct tggatccaaa aatatgacag gctaaactgt gaaaatgcag tcctcaaaga
      841 gaatttgaaa gtgaaaacag aagaaattaa aatgctgaag tctgacaatg cagttttgaa
      901 tcaacggtat ttggaggccc tcgccatgct tgatatcaaa cagcagaaga tggctcagga
      961 aaacatgtgc tgtgataaaa gtggctttgc agaggcttca ggtcttgagc ttgcggtcct
     1021 cggagcctgc ctttgtcatg ggcccggagg gaacccctgt tcttgtgcca gaatggcagc
     1081 atccactcgg aaactgcttc ttcagctcaa acaagagttg gaaattttgc agaagagtaa
     1141 agaagaagct tacgtgatgg cagatgcttt cagaattgca tttgagcaac aattaatgag
     1201 aaaaaatgac caggcactac aattgacaca aatggataaa atgcataaaa aagcaacaaa
     1261 atggatgaat tggaagcacc ttaaagagga tggatttcca tcaccaagga gtaagaagac
     1321 cttcgggcag agactgttgg gtatgctccc ttcagaaaac agttctaaga ggatggaaga
     1381 ccaggacagt cctcaagagg tccttaagat gctcatagat ttgcttaatg ataaagaaga
     1441 agctttggct catcaaagaa aagttagcta catgcttgct cgggcattgg aagacaaaga
     1501 cactgcttca aacgagaata aagaaaaaaa tcctataaaa gagaatttcc ctttcaacaa
     1561 cccctggcgt aagacttcag aattctctgt tttgggtgat cctatacatt caagtgtctg
     1621 cattttaaat tctgtgggct gcatttgttc aatccagcac tctcaaatag atccaaacta
     1681 tagaactctt aaaagatccc attctttgcc atcaagtatc atattttaaa gacaagccag
     1741 ttgaaattgg aactgagagt tgtttatatc gagatacttt gaaaaatgat tttgtaaatt
     1801 ttgctgcatc ttgagaagtt gtatgtttcc taggtatttc taaattttag gaggtcactt
     1861 aaatcaaata ttttctacat tttctttttc ttcttttgag atggagtctt gctctgtcac
     1921 ccaggttgga gtgcagtggt gtgatctcgg ttcactgcaa cctccgcctc ccggttcaag
     1981 caattctcct gcctcagcct cccgagtaac tcggattaca ggcatgtgcc accacgccca
     2041 gctaattttt gtatttttag tagagacggg gttttaccat gttagccagg ctgatcttga
     2101 actcctgacc tcaagtgatc cgcctgcctt ggcctccgaa agtgctggga ttacaggcgt
     2161 gagccaccac acccagccta ttttctacat tttctacaag aaattagtat tctgtgttga
     2221 cattttattt ataaattaca ttactgtatt tataaattac attacaggct gggcatggtg
     2281 gctcatgctt ataaatccca gcactttggg aggccaaggt gggtgggtca cctgaggctg
     2341 gagttcaaga ccagtctgac caacatggag aaaccccatc tctactaaaa atacaaaaaa
     2401 ttagctaggc ctagtggcgc atgcctgtaa tcccagctac ttgggaggct gaggtaggag
     2461 aatcgcttga acctgggagg cgggggttgt ggtaagccga gactgtgtca ttgcactcca
     2521 gcctgggcga caagagcgaa actctgtctc aaaaaaaaaa aaaaacacat tacagtgttt
     2581 gccaacatcc taaaacaaaa aataatgatt tttgggaaaa acaaaaaatt atttaactat
     2641 tttgattgac tatagggatc ttagcttggc taaatcaaca atatagcaat gtatcttaat
     2701 gctctaaaaa gtaacaatac ctaggactga ctgaatgtta atttctggaa ttcatttatc
     2761 ttgttttatt tgccttgttc agtatttttc atttaccata tgaagtttag aaataacaat
     2821 ttccttaagt taacttcaat aagacagttt tgatggtggg accttggcag aagtatattg
     2881 agtcagtgcc ggctgcgttc atggcttctt gtcagggtag taacattttg caaccaaatc
     2941 tgcacagatt tgtagccaag tctacaaagt gcttaacagc tcttttcatt gcatcctgtg
     3001 agatggttgt gatgatccag gaaatggggt ctcaggaatc tgaagaagct gcctgagcca
     3061 aggtgatttc taggagtttt tttgtttgtg gtatgtgaat tggggtgtgt gggggtgggg
     3121 tgtgtgtgta gacagggtcc cactgtgttg ctcaggctgg tgccaaactc ctggcctcaa
     3181 gggatcctcc tgcctcagcc tctcaaagtg ctgggattac aggcataaac cacaactcaa
     3241 taaaaaagtt tttaaaaatt tacaaagctc atatttgatc cagctaggat tttaccctgt
     3301 acatttgtat ttcttgtagg ctggcgcaca gatatcttaa atggctacta attgctgctg
     3361 tgtatgaaaa caaatggcta tcaaggccgg gtgcagtggc ttacagatct ggtctgaatc
     3421 tcaagtccag accagtccag agttcaagac cagcctgggc aacatggtga aaccccatct
     3481 atacaaaaac tcggcaaggc atggtggcat gcacctgttg tcccagctac tcaggggctg
     3541 aggcaggagg atggcatgag cccaggagct tgaggctgca gtgagctgtg attgtgccac
     3601 tgcactccag cctgagtgac agagtgagac ccccatctcc aaaagaaaag gctatcaata
     3661 caaaagttta tctaaattac tgtacagcta tacaatggaa tactctacaa aatggagaga
     3721 tccataagat aaagcaaatg aataaagcaa aatgcatgtg ttgacagctg ttgtgatacc
     3781 tcagttcttg tcttcttggt ttaaaagaat ttaaatgaga cagcaaagga gatgcagcat
     3841 aatttattgc aaaagaaaag gagtattttg aaagttaggt gcagaacaga cagtacacct
     3901 gagagagaga attcagggcc ggctgctcgt aagggtgaga cagcattgat tattgctgga
     3961 gaaactccct ttatgggagt tttgcattat tattcataag gaggtgaggt gttgcagtaa
     4021 tcatgtcctg ggtggtcctc tgcacaggtg cagtagctgt taatgcttgt tcatacacca
     4081 catgtctcag tagcatctta aatttccacc tagaggtgtg ttttttatta ttatcatgtg
     4141 caaaggatca gtttgaggac aggtaaaatc aaaatgtgta tgctctctag aagggaaagt
     4201 ccctactgaa gatagctttg cttaaatgag ctcaattaca atgtgaatgc tgaggtttat
     4261 tgtgttggct gtatggtcat gag
//
