LOCUS       NM_001136203             987 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens coiled-coil domain containing 124 (CCDC124),
            transcript variant 2, mRNA.
ACCESSION   NM_001136203
VERSION     NM_001136203.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 987)
  AUTHORS   Hacibeyoglu,K., Tuzlakoglu Ozturk,M., Arslan,O. and Tazebay,U.H.
  TITLE     Live Cell Protein Imaging of Tandem Complemented-GFP11-Tagged
            Coiled-Coil Domain-Containing Protein-124 Identifies this Factor in
            G3BP1-Induced Stress-Granules
  JOURNAL   Protein J 43 (4), 834-841 (2024)
   PUBMED   39009911
  REMARK    GeneRIF: Live Cell Protein Imaging of Tandem
            Complemented-GFP11-Tagged Coiled-Coil Domain-Containing Protein-124
            Identifies this Factor in G3BP1-Induced Stress-Granules.
REFERENCE   2  (bases 1 to 987)
  AUTHORS   Cakirca,G., Ozturk,M.T., Telkoparan-Akillilar,P., Gullulu,O.,
            Cetinkaya,A. and Tazebay,U.H.
  TITLE     Proteomics analysis identifies the ribosome associated coiled-coil
            domain-containing protein-124 as a novel interaction partner of
            nucleophosmin-1
  JOURNAL   Biol Cell 116 (1), e202300049 (2024)
   PUBMED   38029384
REFERENCE   3  (bases 1 to 987)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 987)
  AUTHORS   Tuzlakoglu Ozturk,M. and Gullulu,O.
  TITLE     Dimerization underlies the aggregation propensity of intrinsically
            disordered coiled-coil domain-containing 124
  JOURNAL   Proteins 90 (1), 218-228 (2022)
   PUBMED   34369007
  REMARK    GeneRIF: Dimerization underlies the aggregation propensity of
            intrinsically disordered coiled-coil domain-containing 124.
REFERENCE   5  (bases 1 to 987)
  AUTHORS   Arslan,O., Soylu,N.K., Akillilar,P.T. and Tazebay,U.H.
  TITLE     Coiled-coil domain-containing protein-124 (Ccdc124) is a novel RNA
            binding factor up-regulated in endometrial, ovarian, and urinary
            bladder cancers
  JOURNAL   Cancer Biomark 31 (2), 149-164 (2021)
   PUBMED   33896821
  REMARK    GeneRIF: Coiled-coil domain-containing protein-124 (Ccdc124) is a
            novel RNA binding factor up-regulated in endometrial, ovarian, and
            urinary bladder cancers.
REFERENCE   6  (bases 1 to 987)
  AUTHORS   Wells,J.N., Buschauer,R., Mackens-Kiani,T., Best,K., Kratzat,H.,
            Berninghausen,O., Becker,T., Gilbert,W., Cheng,J. and Beckmann,R.
  TITLE     Structure and function of yeast Lso2 and human CCDC124 bound to
            hibernating ribosomes
  JOURNAL   PLoS Biol 18 (7), e3000780 (2020)
   PUBMED   32687489
  REMARK    GeneRIF: Structure and function of yeast Lso2 and human CCDC124
            bound to hibernating ribosomes.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 987)
  AUTHORS   Telkoparan,P., Erkek,S., Yaman,E., Alotaibi,H., Bayik,D. and
            Tazebay,U.H.
  TITLE     Coiled-coil domain containing protein 124 is a novel centrosome and
            midbody protein that interacts with the Ras-guanine nucleotide
            exchange factor 1B and is involved in cytokinesis
  JOURNAL   PLoS One 8 (7), e69289 (2013)
   PUBMED   23894443
  REMARK    GeneRIF: Ccdc124 is a novel factor operating both for proper
            progression of late cytokinetic stages in eukaryotes.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 987)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB503140.1, BQ669035.1, BC013949.2 and BM998230.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001136203.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.975842.1,
                                           SRR3476690.906662.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000445755.7/ ENSP00000408730.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DB503140.1         1-16
            17-508              BQ669035.1         17-508
            509-750             BC013949.2         571-812
            751-987             BM998230.1         18-254              c
FEATURES             Location/Qualifiers
     source          1..987
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..987
                     /gene="CCDC124"
                     /gene_synonym="Lso2; oxs1"
                     /note="coiled-coil domain containing 124"
                     /db_xref="GeneID:115098"
                     /db_xref="HGNC:HGNC:25171"
     exon            1..34
                     /gene="CCDC124"
                     /gene_synonym="Lso2; oxs1"
                     /inference="alignment:Splign:2.1.0"
     exon            35..204
                     /gene="CCDC124"
                     /gene_synonym="Lso2; oxs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..717
                     /gene="CCDC124"
                     /gene_synonym="Lso2; oxs1"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 124"
                     /protein_id="NP_001129675.1"
                     /db_xref="CCDS:CCDS12369.1"
                     /db_xref="GeneID:115098"
                     /db_xref="HGNC:HGNC:25171"
                     /translation="MPKKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDK
                     HVMRKEQRKEEKEKRRLDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIED
                     TLRRDHQLREAPDTAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEA
                     ADRHPERRMRAAFTAFEEAQLPRLKQENPNMRLSQLKQLLKKEWLRSPDNPMNQRAVP
                     FNAPK"
     exon            205..394
                     /gene="CCDC124"
                     /gene_synonym="Lso2; oxs1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..509
                     /gene="CCDC124"
                     /gene_synonym="Lso2; oxs1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..987
                     /gene="CCDC124"
                     /gene_synonym="Lso2; oxs1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      956..961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC124"
                     /gene_synonym="Lso2; oxs1"
                     /note="hexamer: AATAAA"
     polyA_site      987
                     /gene="CCDC124"
                     /gene_synonym="Lso2; oxs1"
                     /note="major polyA site"
ORIGIN      
        1 ggaggcgcga ccgggccggc gctggggtaa gaagcctgct gagggatgcc caagaagttc
       61 cagggtgaga acaccaagtc ggcagcggcc cgggcacgta gggcagaggc caaggcggcc
      121 gctgatgcca agaagcagaa ggagctggag gatgcctact ggaaggacga cgacaaacac
      181 gtcatgagga aggagcagcg caaggaggag aaggagaagc ggcgcctcga ccagctggaa
      241 cgtaagaagg agacgcagcg cctactggag gaggaggact ccaagctcaa gggcggcaag
      301 gcgccgcggg tggccacgtc cagcaaggtc acccgggccc agatcgagga cacgctgcgc
      361 cgagaccatc agctcaggga ggccccggac acagccgaga aagccaagag ccatctggag
      421 gtgccgctgg aggagaacgt gaaccgccgc gtgctggagg agggcagcgt ggaggcgcgc
      481 accatcgagg acgccattgc agtgctcagc gtggcggagg aggcggccga ccggcaccca
      541 gaaagacgca tgcgggcagc cttcacagcc tttgaggaag cccagctgcc gcggctcaaa
      601 caagagaacc ccaacatgcg gctgtcgcag ctgaaacagc tgctcaagaa ggagtggctc
      661 cgctctcctg acaaccccat gaaccagcgg gccgtgccct tcaatgcccc caagtgagcc
      721 cagaacttgg ggagccagtt cacccacggg tggtccaggt cacgactctg cacgccctta
      781 ggccaggtca gctgcgaggg tcacagagcg ttccgggggc caaggcgccg ggccccgggg
      841 ccatgctctt atcaccagcc acccgtcctc ccgccagagg gtccctgccc cgagtgacac
      901 cccatcccct cccatccccc ggcgcgtgtg tgtagagcct cagggctgag tgcccaataa
      961 aggtggcggc aaggctgcgg tgaggca
//
