LOCUS       NM_024584               2343 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens coiled-coil domain containing 121 (CCDC121),
            transcript variant 3, mRNA.
ACCESSION   NM_024584
VERSION     NM_024584.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2343)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2343)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2343)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   4  (bases 1 to 2343)
  AUTHORS   Kraja,A.T., Vaidya,D., Pankow,J.S., Goodarzi,M.O., Assimes,T.L.,
            Kullo,I.J., Sovio,U., Mathias,R.A., Sun,Y.V., Franceschini,N.,
            Absher,D., Li,G., Zhang,Q., Feitosa,M.F., Glazer,N.L.,
            Haritunians,T., Hartikainen,A.L., Knowles,J.W., North,K.E.,
            Iribarren,C., Kral,B., Yanek,L., O'Reilly,P.F., McCarthy,M.I.,
            Jaquish,C., Couper,D.J., Chakravarti,A., Psaty,B.M., Becker,L.C.,
            Province,M.A., Boerwinkle,E., Quertermous,T., Palotie,L.,
            Jarvelin,M.R., Becker,D.M., Kardia,S.L., Rotter,J.I., Chen,Y.D. and
            Borecki,I.B.
  TITLE     A bivariate genome-wide approach to metabolic syndrome: STAMPEED
            consortium
  JOURNAL   Diabetes 60 (4), 1329-1339 (2011)
   PUBMED   21386085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK125354.1, BC066936.1 and AC074091.6.
            
            On May 21, 2020 this sequence version replaced NM_024584.4.
            
            Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon, compared to variant 2. The encoded isoform
            (3) is shorter than isoform 2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK125354.1, BC066936.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324364.4/ ENSP00000339087.2
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2263              AK125354.1         1-2263
            2264-2264           BC066936.1         2236-2236
            2265-2342           AK125354.1         2265-2342
            2343-2343           AC074091.6         154595-154595
FEATURES             Location/Qualifiers
     source          1..2343
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..2343
                     /gene="CCDC121"
                     /note="coiled-coil domain containing 121"
                     /db_xref="GeneID:79635"
                     /db_xref="HGNC:HGNC:25833"
     exon            1..63
                     /gene="CCDC121"
                     /inference="alignment:Splign:2.1.0"
     exon            64..2343
                     /gene="CCDC121"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..1018
                     /gene="CCDC121"
                     /note="isoform 3 is encoded by transcript variant 3;
                     coiled-coil domain-containing protein 121"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 121
                     isoform 3"
                     /protein_id="NP_078860.2"
                     /db_xref="CCDS:CCDS1759.1"
                     /db_xref="GeneID:79635"
                     /db_xref="HGNC:HGNC:25833"
                     /translation="MTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLT
                     NKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKR
                     KLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEP
                     DRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTA
                     TQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQDVPKTTPSLPQGTKSRIN
                     PK"
     regulatory      2300..2305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC121"
                     /note="hexamer: ATTAAA"
     regulatory      2317..2322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC121"
                     /note="hexamer: AATAAA"
     polyA_site      2324
                     /gene="CCDC121"
     polyA_site      2343
                     /gene="CCDC121"
                     /note="major polyA site"
ORIGIN      
        1 agagaaactt ccgcaatgtt ctgggctgcg aacgaaaacc accacagcgt cagaaaggag
       61 cgggtttgct gagggcccca gaaggctcct tccaccgtat catagtctaa taaataattt
      121 tgtcaagcca gagaagctaa caaaggtaga gacaaggctt aaagaaaaga tagtggcgga
      181 aatgacggat ctgaacaagc atataaaaca agctcaaacc cagcggaaac agctactgga
      241 ggaatccagg gagctacacc gagaaaagtt acttgtccag gctgaaaaca gattctttct
      301 ggaatacctg actaacaaaa ctgaagagta cacagagcaa cctgagaagg tatggaacag
      361 ctatttacaa aaaagtggag agattgaacg aagaagacaa gaatcagcct ccagatatgc
      421 agaacaaatt tcagtgctta aaacagcgct cttgcaaaag gaaaatatcc aatccagttt
      481 gaagcggaag ttgcaggcaa tgagggacat tgctatatta aaggaaaagc aggagaaaga
      541 aatacagaca ttacaggagg agacaaagaa agtccaagct gagacagctt caaagacacg
      601 ggaagtacag gcccagctcc tccaggagaa aagattactg gagaaacaac tgagcgagcc
      661 agacaggagg ctactgggaa agagaaaaag aagagagctt aatatgaagg cccaggcctt
      721 gaagttggca gcaaagcggt ttatttttga atactcctgt ggcatcaaca gagagaacca
      781 gcagttcaag aaggaattac tgcagctaat tgagcaagcc cagaaactaa cggctactca
      841 aagccactta gaaaacagga agcagcagct gcagcaggaa cagtggtatc tggagtcctt
      901 aatccaggcg aggcagagac tgcaaggaag tcataatcag tgcctaaata gacaggatgt
      961 tccaaagacc acacccagtc ttccccaagg caccaaatca aggattaatc caaagtaact
     1021 tctaaaataa cactgattaa ataagaactg gagcaagtac tcttaagtgc tacattaacc
     1081 tggttagaaa ggctgttgga ttccagattg ctattgtaaa atctccatca tgatgtgttg
     1141 gagtgaagga ttagatggtt ttatccaaca gtcctactag atatttggta accagcttcc
     1201 cttaactagc tttttcttta aatactcgtt aataagctat tccacaaacc tccagttaac
     1261 ctaacacatg accctaacct agccatttac catacatcaa actagctaaa ggaaaccaac
     1321 ctaaggaagt gaaaacagtt gtgatttatt tcatctagct aaattgtatt tctttataga
     1381 gaaagtacct ttaaggatag cattccaaat agactttgaa tagcgttctg ccagtttatc
     1441 ctcattcctt ttgaccaact tagcagacaa aagcagtttt tacaagctct ttgtgagttt
     1501 gtgccagtga ccaggtagct ccttctagtt ttctcatgag tgaaaaagca ttctgataac
     1561 agcaagtcca gtaagtgcta ggcagagtga cctttcatct gatgctaagc ccctacaagt
     1621 ttgagaaggt aagaaaagat gaaggagaca tatattaggt cagctcttac ttttgaaaat
     1681 gttttatttg aagaaacacc tgtagcattg aggtgactga atgcctccac ttatttcagg
     1741 aaaacgtatc caaaaaaagt tgaaatattt ggacaacttt ttttttaagt gccatcgatt
     1801 tccctagcag cattctaaaa gatagcaagt aaaatgatgt ttgttatcct aaatgcttta
     1861 gttttaggtc atttattaat tttcttacag gtgcactttc tagtacatga agtatccttt
     1921 gtaattaatg tgtgccatat gtttattccc atttagtata actataaatt atattttaaa
     1981 ttatatattt ttaggatagt tatatttttt ttgggttcta cgacattgaa gttggactag
     2041 tgatttattt gaatgctgaa tcctagtata ggggaatata atcttatatt ttaacagggg
     2101 tcctctatgg gaaaatagga tgaactttgt ttcccagaaa ttgttaagtg atgaaaaact
     2161 tcaaaataat tttcctgcat tttctgcttt atttacatgt aaagtgaatt ccctgaaaat
     2221 tggatttaaa aagcattctc cttcaatgtg cctttacctt gtagctttaa caacttttct
     2281 gttaaatatg tagtttttta ttaaacaatg ttattaaata aaaacattta tccactgatt
     2341 tta
//
