LOCUS       NM_001277074             841 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens coiled-coil domain containing 12 (CCDC12), transcript
            variant 2, mRNA.
ACCESSION   NM_001277074
VERSION     NM_001277074.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 841)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 841)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 841)
  AUTHORS   Ke,J., Lou,J., Zhong,R., Chen,X., Li,J., Liu,C., Gong,Y., Yang,Y.,
            Zhu,Y., Zhang,Y., Chang,J. and Gong,J.
  TITLE     Identification of a Potential Regulatory Variant for Colorectal
            Cancer Risk Mapping to 3p21.31 in Chinese Population
  JOURNAL   Sci Rep 6, 25194 (2016)
   PUBMED   27120998
  REMARK    GeneRIF: It was suggested that rs1076394 served as an expression
            Quantitative Trait Loci (eQTL) for gene CCDC12 and NME6, while
            NME6's expression was obviously higher in colorectal cancer
            tissues.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 841)
  AUTHORS   Fan,C., Dong,L., Zhu,N., Xiong,Y., Zhang,J., Wang,L., Shen,Y.,
            Zhang,X. and Chen,M.
  TITLE     Isolation of siRNA target by biotinylated siRNA reveals that human
            CCDC12 promotes early erythroid differentiation
  JOURNAL   Leuk Res 36 (6), 779-783 (2012)
   PUBMED   22269669
  REMARK    GeneRIF: CCDC12 is a new participant that promotes early erythroid
            differentiation.
REFERENCE   5  (bases 1 to 841)
  AUTHORS   Hegele,A., Kamburov,A., Grossmann,A., Sourlis,C., Wowro,S.,
            Weimann,M., Will,C.L., Pena,V., Luhrmann,R. and Stelzl,U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
REFERENCE   6  (bases 1 to 841)
  AUTHORS   Behrends,C., Sowa,M.E., Gygi,S.P. and Harper,J.W.
  TITLE     Network organization of the human autophagy system
  JOURNAL   Nature 466 (7302), 68-76 (2010)
   PUBMED   20562859
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC094020.2 and AC109583.2.
            
            On Aug 13, 2020 this sequence version replaced NM_001277074.1.
            
            Transcript Variant: This variant (2) uses an alternate internal
            promoter and uses a downstream in-frame start codon, compared to
            variant 1. The encoded isoform (2) is shorter at the N-terminus,
            compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096749.1, BU189853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683445.1/ ENSP00000508011.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AC094020.2         135268-135376       c
            110-177             AC094020.2         99629-99696         c
            178-257             AC109583.2         171708-171787       c
            258-319             AC109583.2         169859-169920       c
            320-354             AC109583.2         169581-169615       c
            355-431             AC109583.2         168488-168564       c
            432-841             AC109583.2         167982-168391       c
FEATURES             Location/Qualifiers
     source          1..841
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..841
                     /gene="CCDC12"
                     /note="coiled-coil domain containing 12"
                     /db_xref="GeneID:151903"
                     /db_xref="HGNC:HGNC:28332"
     exon            1..109
                     /gene="CCDC12"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..514
                     /gene="CCDC12"
                     /note="isoform 2 is encoded by transcript variant 2;
                     coiled-coil domain-containing protein 12"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 12 isoform
                     2"
                     /protein_id="NP_001264003.1"
                     /db_xref="CCDS:CCDS2748.3"
                     /db_xref="GeneID:151903"
                     /db_xref="HGNC:HGNC:28332"
                     /translation="MEATTAGVGRLEEEALRRKERLKALREKTGRKDKEDGEPKTKHL
                     REEEEEGEKHRELRLRNYVPEDEDLKKRRVPQAKPVAVEEKVKEQLEAAKPEPVIEEV
                     DLANLAPRKPDWDLKRDVAKKLEKLKKRTQRAIAELIRERLKGQEDSLASAVDAATEQ
                     KTCDSD"
     exon            110..177
                     /gene="CCDC12"
                     /inference="alignment:Splign:2.1.0"
     exon            178..257
                     /gene="CCDC12"
                     /inference="alignment:Splign:2.1.0"
     exon            258..319
                     /gene="CCDC12"
                     /inference="alignment:Splign:2.1.0"
     exon            320..354
                     /gene="CCDC12"
                     /inference="alignment:Splign:2.1.0"
     exon            355..431
                     /gene="CCDC12"
                     /inference="alignment:Splign:2.1.0"
     exon            432..841
                     /gene="CCDC12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      821..826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC12"
                     /note="hexamer: AGTAAA"
     polyA_site      841
                     /gene="CCDC12"
                     /note="major polyA site"
ORIGIN      
        1 gtacgcgggc aagatggagg caactacggc tggtgtgggc cggctagagg aagaggcgtt
       61 gcggcgaaag gaacggctga aggccctacg ggagaaaacc gggcgcaagg acaaggaaga
      121 tggggagcca aagaccaagc atctcagaga agaggaggaa gaaggcgaga agcacaggga
      181 acttaggctg cggaactatg tcccggagga tgaggacctg aagaagagga gggtgcccca
      241 ggccaaaccg gttgcagtgg aggagaaggt gaaggagcag ctggaggccg ccaagcccga
      301 gcccgtcatc gaggaggtgg acctggccaa cctcgctcct cggaagcctg actgggacct
      361 caagagagat gtggccaaga agctggagaa actaaaaaag cggactcaga gggccattgc
      421 cgagctgatc cgtgaaaggc tgaaaggcca ggaagacagc ctagcctctg cagtggatgc
      481 tgccaccgaa caaaagacct gtgactccga ctgaggcatg ccctgcccca ccactcgccc
      541 atcaggcctg tcctgcagag gatggtcttg ggcagggatg ggggctaggc ttgccatcac
      601 ctccagtttg gcttctgagc agagactccc tgcccatcaa gtctgaaacc cccatggatg
      661 aggtcagctc cttgtctgct gggtggcccc tgccattctg aatggaggca gaaccagcaa
      721 caactctggg cgtgcctgtg tctgcacatg tggatgtaca tatgtctgta tatatgtata
      781 tattttgaac tttctaaaaa aaaatctgga aatagaaaca agtaaacccc tgtgtgtggc
      841 a
//
