LOCUS       NM_173510               3964 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens coiled-coil domain containing 117 (CCDC117),
            transcript variant 1, mRNA.
ACCESSION   NM_173510
VERSION     NM_173510.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3964)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3964)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3964)
  AUTHORS   Horton,A.J., Brooker,J., Streitfeld,W.S., Flessa,M.E., Pillai,B.,
            Simpson,R., Clark,C.D., Gooz,M.B., Sutton,K.K., Foley,A.C. and
            Lee,K.H.
  TITLE     Nkx2-5 Second Heart Field Target Gene Ccdc117 Regulates DNA
            Metabolism and Proliferation
  JOURNAL   Sci Rep 9 (1), 1738 (2019)
   PUBMED   30742009
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3964)
  AUTHORS   Wu,C., Wang,Z., Song,X., Feng,X.S., Abnet,C.C., He,J., Hu,N.,
            Zuo,X.B., Tan,W., Zhan,Q., Hu,Z., He,Z., Jia,W., Zhou,Y., Yu,K.,
            Shu,X.O., Yuan,J.M., Zheng,W., Zhao,X.K., Gao,S.G., Yuan,Z.Q.,
            Zhou,F.Y., Fan,Z.M., Cui,J.L., Lin,H.L., Han,X.N., Li,B., Chen,X.,
            Dawsey,S.M., Liao,L., Lee,M.P., Ding,T., Qiao,Y.L., Liu,Z., Liu,Y.,
            Yu,D., Chang,J., Wei,L., Gao,Y.T., Koh,W.P., Xiang,Y.B., Tang,Z.Z.,
            Fan,J.H., Han,J.J., Zhou,S.L., Zhang,P., Zhang,D.Y., Yuan,Y.,
            Huang,Y., Liu,C., Zhai,K., Qiao,Y., Jin,G., Guo,C., Fu,J., Miao,X.,
            Lu,C., Yang,H., Wang,C., Wheeler,W.A., Gail,M., Yeager,M.,
            Yuenger,J., Guo,E.T., Li,A.L., Zhang,W., Li,X.M., Sun,L.D.,
            Ma,B.G., Li,Y., Tang,S., Peng,X.Q., Liu,J., Hutchinson,A.,
            Jacobs,K., Giffen,C., Burdette,L., Fraumeni,J.F. Jr., Shen,H.,
            Ke,Y., Zeng,Y., Wu,T., Kraft,P., Chung,C.C., Tucker,M.A., Hou,Z.C.,
            Liu,Y.L., Hu,Y.L., Liu,Y., Wang,L., Yuan,G., Chen,L.S., Liu,X.,
            Ma,T., Meng,H., Sun,L., Li,X.M., Li,X.M., Ku,J.W., Zhou,Y.F.,
            Yang,L.Q., Wang,Z., Li,Y., Qige,Q., Yang,W.J., Lei,G.Y., Chen,L.Q.,
            Li,E.M., Yuan,L., Yue,W.B., Wang,R., Wang,L.W., Fan,X.P., Zhu,F.H.,
            Zhao,W.X., Mao,Y.M., Zhang,M., Xing,G.L., Li,J.L., Han,M.,
            Ren,J.L., Liu,B., Ren,S.W., Kong,Q.P., Li,F., Sheyhidin,I., Wei,W.,
            Zhang,Y.R., Feng,C.W., Wang,J., Yang,Y.H., Hao,H.Z., Bao,Q.D.,
            Liu,B.C., Wu,A.Q., Xie,D., Yang,W.C., Wang,L., Zhao,X.H.,
            Chen,S.Q., Hong,J.Y., Zhang,X.J., Freedman,N.D., Goldstein,A.M.,
            Lin,D., Taylor,P.R., Wang,L.D. and Chanock,S.J.
  TITLE     Joint analysis of three genome-wide association studies of
            esophageal squamous cell carcinoma in Chinese populations
  JOURNAL   Nat Genet 46 (9), 1001-1006 (2014)
   PUBMED   25129146
REFERENCE   5  (bases 1 to 3964)
  AUTHORS   Wolpin,B.M., Rizzato,C., Kraft,P., Kooperberg,C., Petersen,G.M.,
            Wang,Z., Arslan,A.A., Beane-Freeman,L., Bracci,P.M., Buring,J.,
            Canzian,F., Duell,E.J., Gallinger,S., Giles,G.G., Goodman,G.E.,
            Goodman,P.J., Jacobs,E.J., Kamineni,A., Klein,A.P., Kolonel,L.N.,
            Kulke,M.H., Li,D., Malats,N., Olson,S.H., Risch,H.A., Sesso,H.D.,
            Visvanathan,K., White,E., Zheng,W., Abnet,C.C., Albanes,D.,
            Andreotti,G., Austin,M.A., Barfield,R., Basso,D., Berndt,S.I.,
            Boutron-Ruault,M.C., Brotzman,M., Buchler,M.W.,
            Bueno-de-Mesquita,H.B., Bugert,P., Burdette,L., Campa,D.,
            Caporaso,N.E., Capurso,G., Chung,C., Cotterchio,M., Costello,E.,
            Elena,J., Funel,N., Gaziano,J.M., Giese,N.A., Giovannucci,E.L.,
            Goggins,M., Gorman,M.J., Gross,M., Haiman,C.A., Hassan,M.,
            Helzlsouer,K.J., Henderson,B.E., Holly,E.A., Hu,N., Hunter,D.J.,
            Innocenti,F., Jenab,M., Kaaks,R., Key,T.J., Khaw,K.T., Klein,E.A.,
            Kogevinas,M., Krogh,V., Kupcinskas,J., Kurtz,R.C., LaCroix,A.,
            Landi,M.T., Landi,S., Le Marchand,L., Mambrini,A., Mannisto,S.,
            Milne,R.L., Nakamura,Y., Oberg,A.L., Owzar,K., Patel,A.V.,
            Peeters,P.H., Peters,U., Pezzilli,R., Piepoli,A., Porta,M.,
            Real,F.X., Riboli,E., Rothman,N., Scarpa,A., Shu,X.O.,
            Silverman,D.T., Soucek,P., Sund,M., Talar-Wojnarowska,R.,
            Taylor,P.R., Theodoropoulos,G.E., Thornquist,M., Tjonneland,A.,
            Tobias,G.S., Trichopoulos,D., Vodicka,P., Wactawski-Wende,J.,
            Wentzensen,N., Wu,C., Yu,H., Yu,K., Zeleniuch-Jacquotte,A.,
            Hoover,R., Hartge,P., Fuchs,C., Chanock,S.J.,
            Stolzenberg-Solomon,R.S. and Amundadottir,L.T.
  TITLE     Genome-wide association study identifies multiple susceptibility
            loci for pancreatic cancer
  JOURNAL   Nat Genet 46 (9), 994-1000 (2014)
   PUBMED   25086665
REFERENCE   6  (bases 1 to 3964)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   7  (bases 1 to 3964)
  AUTHORS   Gano,J.J. and Simon,J.A.
  TITLE     A proteomic investigation of ligand-dependent HSP90 complexes
            reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein
  JOURNAL   Mol Cell Proteomics 9 (2), 255-270 (2010)
   PUBMED   19875381
REFERENCE   8  (bases 1 to 3964)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   9  (bases 1 to 3964)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK289516.1, BC053874.1, AK091133.1 and HY224937.1.
            
            On Nov 22, 2018 this sequence version replaced NM_173510.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053874.1, BC040488.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000249064.9/ ENSP00000249064.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AK289516.1         22-40
            20-1876             BC053874.1         1-1857
            1877-3657           AK091133.1         1824-3604
            3658-3964           HY224937.1         7-313               c
FEATURES             Location/Qualifiers
     source          1..3964
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.1"
     gene            1..3964
                     /gene="CCDC117"
                     /gene_synonym="dJ366L4.1"
                     /note="coiled-coil domain containing 117"
                     /db_xref="GeneID:150275"
                     /db_xref="HGNC:HGNC:26599"
     exon            1..340
                     /gene="CCDC117"
                     /gene_synonym="dJ366L4.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..995
                     /gene="CCDC117"
                     /gene_synonym="dJ366L4.1"
                     /note="isoform a is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 117"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 117
                     isoform a"
                     /protein_id="NP_775781.1"
                     /db_xref="CCDS:CCDS13846.1"
                     /db_xref="GeneID:150275"
                     /db_xref="HGNC:HGNC:26599"
                     /translation="MAALGRPFSGLPLSGGSDFLQPPQPAFPGRAFPPGADGAELAPR
                     PGPRAVPSSPAGSAARGRVSVHCKKKHKREEEEDDDCPVRKKRITEAELCAGPNDWIL
                     CAHQDVEGHGVNPSVSGLSIPGILDVICEEMDQTTGEPQCEVARRKLQEIEDRIIDED
                     EEVEADRNVNHLPSLVLSDTMKTGLKREFDEVFTKKMIESMSRPSMELVLWKPLPELL
                     SDKPKPSSNTKNYTGESQAKHVAAGTAFPQRTELFSEPRPTGMSLYNSLETATSTEEE
                     MEL"
     exon            341..394
                     /gene="CCDC117"
                     /gene_synonym="dJ366L4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..619
                     /gene="CCDC117"
                     /gene_synonym="dJ366L4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..757
                     /gene="CCDC117"
                     /gene_synonym="dJ366L4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            758..3964
                     /gene="CCDC117"
                     /gene_synonym="dJ366L4.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3940..3945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC117"
                     /gene_synonym="dJ366L4.1"
                     /note="hexamer: AATAAA"
     polyA_site      3964
                     /gene="CCDC117"
                     /gene_synonym="dJ366L4.1"
                     /note="major polyA site"
ORIGIN      
        1 gagcggcctg aggtggaggg ttctagaagg cgtgacgtgg ggtcgagagc gggatccgag
       61 gctggcgggt tttggcagta gctgtggctg cggctgccgg gcctggggac gcgggcggcc
      121 gaggccgccg tcgcagcctc ctcgtctcgc cggctatggc tgcgctcggc cggcccttca
      181 gcggcctccc tctgagcggc ggctcggact tcctgcagcc gccgcagccg gccttccccg
      241 gccgggcctt cccgccgggg gctgacggcg ccgagttggc cccgcggccg ggacctcgcg
      301 cagtccctag cagtcccgct gggagtgcgg cgcgcggacg tgtttctgtt cactgtaaaa
      361 agaaacacaa gcgagaggag gaggaggatg atgattgtcc agtaagaaag aaaaggataa
      421 ctgaagcaga gctctgtgct ggtcctaatg actggattct ttgtgcacat caggatgtag
      481 aggggcatgg agtaaatccc agtgttagtg gcctttccat acctgggata ttagatgtta
      541 tttgtgaaga aatggatcag acaactggag aaccacagtg tgaagttgcc cgaaggaagc
      601 ttcaggagat tgaggacagg ataattgatg aagatgaaga agttgaagct gacagaaatg
      661 ttaaccatct ccccagtctt gtcctttctg ataccatgaa aacaggtttg aagagggaat
      721 ttgatgaagt ttttacaaag aaaatgattg agtctatgag ccgtccttcc atggagcttg
      781 ttctctggaa acccctccct gaactccttt ctgataagcc aaagccatcc tctaatacta
      841 agaactatac aggagagagc caagctaagc atgtagctgc tggcactgcc ttccctcaga
      901 gaactgaact gttttcggaa cctcggccaa cagggatgtc tctttataat agtttggaga
      961 cagctactag cacagaagaa gagatggaac tctagaaacc aatttctaca ctaaagttgt
     1021 caaatgttag aagaatcctg tgttcagtta tgagactctt tgcatagtat agggacttga
     1081 aagttttatg agacgggtgt aataatatct ccacctgtga tttgggggtg ggactcttat
     1141 tttgggtagc catttattga cttcaccttt ttgccaagga cgtttgtctc aagggaaaag
     1201 cagttttctg tggggcttat taaaggaatg ttggtttaca ttgtcttcaa agacaagtat
     1261 agaagctgta tgtgtaaggg tgacttaaat catatgtcac attgtctaaa ctattcagac
     1321 acttggagaa tattctcctt gaattaaaaa agatgattaa gaaggatgct cctacaactg
     1381 tatcctgaca gttaagtcac agcttaatgt gtagatatga gctgtttaca gtggtgacta
     1441 tatataattg gggagaagaa gggaagagag cagcagtagc ttaagcctgt tgctaagaaa
     1501 tttaatttct tagcaacttg taatttagtt atcaattcaa tatagctctg ttgattaaat
     1561 agccgatagt attgtggctc tcctctttga ctatgaaaat atagagaaag ttttttcttt
     1621 aaggcttttt tgccttgtgc cactgttgct ccttggtttc ccttgcgtaa ttgataagcc
     1681 cagttattca gtaatgttta caaattaatt gactttgata gttaaaagat tatgaggtaa
     1741 cccatctgca atttgcctgt gggagaagca tcctttagtt catcttaagg aagtgcttta
     1801 tcagctaaac ccaacattga taactttggt aattttttta aaaagttata cttgtattag
     1861 caagtttttt tttttttccc ccaccgcaac ctccatctcc cgggttcaag caattctcct
     1921 gcctcaccct cccaagtagc tgggattaca ggtgcccacc tccacgccca gctaattttt
     1981 gtatttttaa tagagaccgg ttttgccatg ttggccaggc tggtctcgaa ctcctgacct
     2041 caggtgatct gcccacccca gcctcccaaa atgctgggat tacaggcgtg agccacggca
     2101 cgcagccagc aagttgtttt taaatgttaa tatagaaaac agtgaaggat tagctgaaaa
     2161 tatatgagca ggtgacattg aggtttactg aaatagccaa tttgactggt gcttagacta
     2221 ttgtgcagta aacctaaaag gtagtggaga attgcttcct gctagcagga agccttcatc
     2281 ttcttgagta cccaaaccag gcttcaggtg tcctttgagg atagccaggt ttgaaatttt
     2341 tagtttctca ggaagagctc ttctatgtgg caggggctga tagggcaaaa taaaatgaca
     2401 atttctttat tgctacagag tatcctctat aagttattaa acgagtgtaa tggtataatg
     2461 cccttccatc acacaacagg acaccacccc agttttgttt tctgggtttc ttcccccttt
     2521 gtaggaatca gatacctttt gtagaaaaaa atggcttatg ccacgtaaag gtgaattttt
     2581 agaaaccacc ttctaggcgt ttttggaacc cttactgaaa tccctcccct tgttacagat
     2641 ggcgtagaag tcacaagtct gttaattgga ctgttgcttc tttgcctgtt cctgctttct
     2701 ctttctgtct ggatagtcag gaaaagattt aatgtttaat atttaaacaa aatatttaat
     2761 gtctatacag taaaattatt caaacttcaa accagtattg aaagcagttg gaaaccagct
     2821 aatagtttct taatctcaga tttcgagatg aatgtaaact gtattctttt gaaatgtgca
     2881 agtgtttgat tcatgccatt tgataaactt ctgccttgta gtcattgttt gatgggacca
     2941 acttgtaaag tatgagcctt aaataaatct ccatgctgaa aaatgtgttc taatgcaaca
     3001 caaaaacatg aagtgactgc ccagaggtag agttagtgtt taggtggaaa gggagatgac
     3061 agctttccaa agaaggacct aaaacacacc aagattgtct tctacaggaa ttgctgggca
     3121 ggtctccgac taaaggtctt atgatgaaaa ggaagaaaca agcccccaac acaaggctct
     3181 gatactactg gtaaatgtag gagagaatta agaatctgtt aattaaaatc caaacagagc
     3241 ttatttcagt agtcaagtta cctgacatga taattatttc tgcaggataa ttgatgtttt
     3301 atgttctttt ttggacttta tcttcttgca aaaatttcta caaaaattgt tttcttcatc
     3361 cttgtggtgc ttattcatct gagccgtctc cacagtccca atgcctctgc tttttgtttt
     3421 acttttgtag cataaggttt ttgcttttgc tttgccttaa gagttcccta gggagttacc
     3481 agggcttttc gttttgtgta gcttttgcag catggatcaa acattggctt actgtgctaa
     3541 tgtgtgaaga gaaaaaattc tctaaagcag gtgagcttta atgaacaaat gtgtatttta
     3601 tctgagtttg agtagggtgc gttgtggatt ttgttttttg ggtttttttt ttttttttgt
     3661 aattatatga agaaagtcca gttctcataa atattgatca cttaaaaaac ttactctttc
     3721 ttgaaaaggt acacatgtaa aatttaggaa aataactaaa gtaggggctg gaaccataag
     3781 aagaatgttt atcagcacgt tcatttatta ttttggattt ggaacttggc tttgtttttc
     3841 aatagtgaca agaatggttc agttctagga atgttctgga agatgctgtt aattttactt
     3901 taaaatgaga atctggtgtt actgtatttt atcgttttca ataaaacttc ttaagtgttt
     3961 tgga
//
