LOCUS       NM_001040440            2387 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens coiled-coil domain containing 112 (CCDC112),
            transcript variant 1, mRNA.
ACCESSION   NM_001040440
VERSION     NM_001040440.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2387)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2387)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2387)
  AUTHORS   Wang,M., Liu,X., Chang,G., Chen,Y., An,G., Yan,L., Gao,S., Xu,Y.,
            Cui,Y., Dong,J., Chen,Y., Fan,X., Hu,Y., Song,K., Zhu,X., Gao,Y.,
            Yao,Z., Bian,S., Hou,Y., Lu,J., Wang,R., Fan,Y., Lian,Y., Tang,W.,
            Wang,Y., Liu,J., Zhao,L., Wang,L., Liu,Z., Yuan,R., Shi,Y., Hu,B.,
            Ren,X., Tang,F., Zhao,X.Y. and Qiao,J.
  TITLE     Single-Cell RNA Sequencing Analysis Reveals Sequential Cell Fate
            Transition during Human Spermatogenesis
  JOURNAL   Cell Stem Cell 23 (4), 599-614 (2018)
   PUBMED   30174296
REFERENCE   4  (bases 1 to 2387)
  AUTHORS   Gupta,G.D., Coyaud,E., Goncalves,J., Mojarad,B.A., Liu,Y., Wu,Q.,
            Gheiratmand,L., Comartin,D., Tkach,J.M., Cheung,S.W., Bashkurov,M.,
            Hasegan,M., Knight,J.D., Lin,Z.Y., Schueler,M., Hildebrandt,F.,
            Moffat,J., Gingras,A.C., Raught,B. and Pelletier,L.
  TITLE     A Dynamic Protein Interaction Landscape of the Human
            Centrosome-Cilium Interface
  JOURNAL   Cell 163 (6), 1484-1499 (2015)
   PUBMED   26638075
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB451908.1, AJ580807.1, BM975079.1 and BM873447.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001040440.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.141754.1,
                                           SRR1803613.274560.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379611.10/ ENSP00000368931.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               DB451908.1         108-351
            245-1774            AJ580807.1         251-1780
            1775-1905           BM975079.1         498-628             c
            1906-2387           BM873447.1         13-494              c
FEATURES             Location/Qualifiers
     source          1..2387
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q22.3"
     gene            1..2387
                     /gene="CCDC112"
                     /gene_synonym="MBC1"
                     /note="coiled-coil domain containing 112"
                     /db_xref="GeneID:153733"
                     /db_xref="HGNC:HGNC:28599"
     exon            1..228
                     /gene="CCDC112"
                     /gene_synonym="MBC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1701
                     /gene="CCDC112"
                     /gene_synonym="MBC1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 112; mutated in
                     bladder cancer 1; mutated in bladder cancer protein 1"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 112
                     isoform 1"
                     /protein_id="NP_001035530.1"
                     /db_xref="CCDS:CCDS34213.1"
                     /db_xref="GeneID:153733"
                     /db_xref="HGNC:HGNC:28599"
                     /translation="MAALTTVVVAAAATAVAGAVAGAGAATGTGVGATPAPQQSDGCF
                     STSGGIRPFHLQNWKQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIE
                     HSMLEELENKLIHSRKTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMME
                     EIENAINTFKEEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSK
                     VPVDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVL
                     EHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPV
                     LFHNKQEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQ
                     RQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLE
                     LKILDRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRLYKPTKGWEERTKKIGPTGSG
                     PLLHIPHRAIPTWRQGIQRRV"
     exon            229..350
                     /gene="CCDC112"
                     /gene_synonym="MBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..472
                     /gene="CCDC112"
                     /gene_synonym="MBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..562
                     /gene="CCDC112"
                     /gene_synonym="MBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            563..638
                     /gene="CCDC112"
                     /gene_synonym="MBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            639..1029
                     /gene="CCDC112"
                     /gene_synonym="MBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1443
                     /gene="CCDC112"
                     /gene_synonym="MBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1539
                     /gene="CCDC112"
                     /gene_synonym="MBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1658
                     /gene="CCDC112"
                     /gene_synonym="MBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..2387
                     /gene="CCDC112"
                     /gene_synonym="MBC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2198..2203
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC112"
                     /gene_synonym="MBC1"
                     /note="hexamer: AATAAA"
     polyA_site      2222
                     /gene="CCDC112"
                     /gene_synonym="MBC1"
                     /note="major polyA site"
     regulatory      2364..2369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC112"
                     /gene_synonym="MBC1"
                     /note="hexamer: TATAAA"
     polyA_site      2387
                     /gene="CCDC112"
                     /gene_synonym="MBC1"
ORIGIN      
        1 atcccggcca agcccgcagc gcagggagct gtctgcagag gccagggtgc gcctgccacg
       61 aatccccagg caccggtggc cgccgcggcc cgagtagctc ggcgggtaaa catggccgca
      121 ctgacgacgg ttgtggtagc ggctgcggcc accgcggtag ccggggctgt ggcaggggcg
      181 ggcgcggcca ccgggaccgg cgtgggagcg acgccagcgc ctcaacagag tgatggctgt
      241 tttagtactt caggtggaat tcgtcctttt catcttcaga actggaagca gaaagttaat
      301 cagactaaga aagcagaatt tgtacgcaca gcagaaaaat ttaaaaatca agtaattaac
      361 atggaaaaag ataaacacag tcatttctac aaccaaaaaa gtgacttcag aattgagcat
      421 agtatgctag aagaattgga aaataaattg attcacagca ggaaaacaga aagagcaaaa
      481 atccagcaac aattggccaa aatacataat aatgtaaaga aacttcagca tcaattaaaa
      541 gatgtgaagc ctacacctga ttttgttgag aagctcagag aaatgatgga agaaattgaa
      601 aatgcaatta acacttttaa agaagagcag aggttgatat atgaagagct aattaaagaa
      661 gagaagacaa ctaataatga gttgagtgcc atatcaagaa aaattgacac atgggctttg
      721 ggtaattcag aaacagagaa agctttcaga gcaatctcaa gcaaagttcc tgtagacaaa
      781 gtaacaccaa gtactcttcc agaagaggta ctagattttg aaaaattcct tcagcaaaca
      841 ggagggcgac aaggtgcctg ggatgattat gatcaccaga actttgtaaa ggtgagaaac
      901 aaacataaag ggaagccaac atttatggaa gaagttctag aacaccttcc tggaaaaaca
      961 caagatgaag ttcaacagca tgaaaaatgg tatcaaaagt ttctggctct agaagaaaga
     1021 aaaaaagagt caattcagat ttggaaaact aaaaagcagc aaaaaaggga ggaaattttc
     1081 aagttaaagg aaaaggcaga caacacacct gtgctttttc ataataaaca agaggataat
     1141 caaaagcaaa aagaggaaca aagaaagaaa cagaaattgg cagttgaagc ttggaagaaa
     1201 cagaaaagta tagaaatgtc aatgaaatgt gcttcccagt taaaagaaga agaagagaaa
     1261 gagaaaaaac atcagaaaga acgccagcgc cagtttaagt taaaattact actagaaagt
     1321 tatacccagc agaagaaaga acaggaagaa tttttgaggc ttgaaaagga gataagggaa
     1381 aaggcagaaa aggcagaaaa aaggaaaaat gctgctgatg aaatttccag atttcaagaa
     1441 agagatttac ataaacttga actgaaaatt ctagatagac aggcaaagga agatgaaaag
     1501 tcacaaaaac aaagaagact ggcaaaatta aaagaaaagg ttgaaaacaa tgttagtaga
     1561 gatccctcta ggctttacaa acccaccaaa ggttgggaag aacgaaccaa aaagatagga
     1621 ccaacaggct ctgggccact tctacatatc ccacataggg ctattccaac ctggagacaa
     1681 ggaatacaga gaagagtatg agataatcaa attgctactc agttgataag aatgttaaca
     1741 tactaagtta taccagggag agagtgacta accacattct ttaaatatca atagcttagt
     1801 cagattgatt attgtgctat attgtgaatt gagaggtatt aagtttcatg aggctttgtc
     1861 attagtattc ctgcttctac caagaaggta tttaatatat gtgttggcct attattgatg
     1921 taaaagttat ttaaataagt taatgttaga aacattattc aatttaaata ctgaaaacat
     1981 ttcaaagaga ttttgttttt gttatagcat agcaaagtaa attggaacaa tcatacaatg
     2041 acatttttta aaccaaaatt ttgtaacttt tataacttgg agttaagtta gcttgagtaa
     2101 caaaaaggta aagtggtttt tgtttagagt tacgaaatgt tagtactttt tctatgttta
     2161 acaaattggc agtttgtcag ttatgacatt tttgtgtaat aaatattttg tatttgtttg
     2221 aagcatgctt tgttttatat agagaatatt tattttaaaa atatgtctct catataccct
     2281 attaattgta ttattgatat aatctttttg gtttccttca gcaattccaa attttccttc
     2341 agcctttctg gatttcacag atttataaaa tctttgtgtc tttcaca
//
