LOCUS       NM_174923               1264 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens coiled-coil domain containing 107 (CCDC107),
            transcript variant A, mRNA.
ACCESSION   NM_174923
VERSION     NM_174923.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1264)
  AUTHORS   Ghanizade,P., Oroujalian,A. and Peymani,M.
  TITLE     Differential expression analysis of CCDC107 and RMRP lncRNA as
            potential biomarkers in colorectal cancer diagnosis
  JOURNAL   Nucleosides Nucleotides Nucleic Acids 40 (12), 1144-1158 (2021)
   PUBMED   34669559
  REMARK    GeneRIF: Differential expression analysis of CCDC107 and RMRP
            lncRNA as potential biomarkers in colorectal cancer diagnosis.
REFERENCE   2  (bases 1 to 1264)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1264)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   4  (bases 1 to 1264)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC410699.1, BC018758.1,
            AL357874.13 and BM973388.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_174923.2.
            
            Summary: This gene encodes a membrane protein which contains a
            coiled-coil domain in the central region. Multiple alternatively
            spliced transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (A) represents the longest
            transcript and encodes the longest isoform (A).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018758.1, ERR279832.1220.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000426546.7/ ENSP00000414964.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                DC410699.1         3-24
            23-745              BC018758.1         1-723
            746-746             AL357874.13        69102-69102
            747-940             BC018758.1         725-918
            941-1256            BM973388.1         15-330              c
            1257-1264           AL357874.13        69613-69620
FEATURES             Location/Qualifiers
     source          1..1264
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..1264
                     /gene="CCDC107"
                     /gene_synonym="PSEC0222"
                     /note="coiled-coil domain containing 107"
                     /db_xref="GeneID:203260"
                     /db_xref="HGNC:HGNC:28465"
     exon            1..194
                     /gene="CCDC107"
                     /gene_synonym="PSEC0222"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..940
                     /gene="CCDC107"
                     /gene_synonym="PSEC0222"
                     /note="isoform A precursor is encoded by transcript
                     variant A; coiled-coil domain-containing protein 107"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 107
                     isoform A precursor"
                     /protein_id="NP_777583.2"
                     /db_xref="CCDS:CCDS6583.1"
                     /db_xref="GeneID:203260"
                     /db_xref="HGNC:HGNC:28465"
                     /translation="MAGAVSLLGVVGLLLVSALSGVLGDRANPDLRAHPGNAAHPGSG
                     ATEPRRRPPLKDQRERTRAGSLPLGALYTAAVAAFVLYKCLQGKDETAVLHEEASKQQ
                     PLQSEQQLAQLTQQLAQTEQHLNNLMAQLDPLFERVTTLAGAQQELLNMKLWTIHELL
                     QDSKPDKDMEASEPGEGSGGESAGGGDKVSETGTFLISPHTEASRPLPEDFCLKEDEE
                     EIGDSQAWEEPTNWSTETWNLATSWEVGRGLRRRCSQAVAKGPSHSLGWEGGTTAEGR
                     LKQSLFS"
     exon            195..346
                     /gene="CCDC107"
                     /gene_synonym="PSEC0222"
                     /inference="alignment:Splign:2.1.0"
     exon            347..407
                     /gene="CCDC107"
                     /gene_synonym="PSEC0222"
                     /inference="alignment:Splign:2.1.0"
     exon            408..498
                     /gene="CCDC107"
                     /gene_synonym="PSEC0222"
                     /inference="alignment:Splign:2.1.0"
     exon            499..1264
                     /gene="CCDC107"
                     /gene_synonym="PSEC0222"
                     /inference="alignment:Splign:2.1.0"
     regulatory      921..926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC107"
                     /gene_synonym="PSEC0222"
                     /note="hexamer: AACAAA"
     polyA_site      940
                     /gene="CCDC107"
                     /gene_synonym="PSEC0222"
                     /note="major polyA site"
     regulatory      1232..1237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC107"
                     /gene_synonym="PSEC0222"
                     /note="hexamer: AATAAA"
     polyA_site      1264
                     /gene="CCDC107"
                     /gene_synonym="PSEC0222"
ORIGIN      
        1 gctcgcgtgc gcgtgcgcgt tggggcggcc ggccaatgcc ggaccgcttc ggcaccgccc
       61 gcccgatccc tccacccgtg ggccggcaat ggcgggcgca gtttcgctct tgggtgtggt
      121 ggggctgctg cttgtgtctg cgctgtccgg ggtcctagga gaccgcgcca atcccgacct
      181 ccgggcacac ccagggaacg cagcccaccc cggctctgga gccacggaac cccggcggcg
      241 accaccgctc aaggatcaac gcgagcggac ccgggccggg tcgctgcctc tgggggcgct
      301 gtacaccgcg gccgtcgcgg cttttgtgct gtacaagtgt ttgcagggga aagatgaaac
      361 tgcggttctc cacgaggagg caagcaagca gcagccactg cagtcagagc aacagctggc
      421 ccagttgaca caacagctgg cccagacaga gcagcacctg aacaacctga tggcccagct
      481 ggaccccctt tttgagcgtg tgactactct ggctggagcc cagcaggagc ttctgaacat
      541 gaagctatgg accatccacg agctgctgca agatagcaag ccggacaagg atatggaggc
      601 ttcagaacca ggtgaaggct cgggaggcga gtctgctgga ggtggagaca aagtctctga
      661 aactggaaca ttcctgatct ctccccacac agaggccagc agacctcttc ctgaggactt
      721 ctgtttaaag gaggacgagg aggagattgg tgacagtcag gcctgggagg agcccacaaa
      781 ctggagcaca gagacatgga acctagctac ttcctgggag gtggggcggg gactacggag
      841 aaggtgcagc caggctgtgg caaagggccc cagtcacagc cttggctggg aaggagggac
      901 gacagctgaa ggtcgactaa aacaaagtct gttttcatga tggagtgctc ctgtgtgttt
      961 tttcgatcct agttggttgt acacacccat actaggtgcc taaggacaac tgggccttct
     1021 tgaagagctg tccttattag gacaaaaaga ggctgccttc cagtgtgaca gcagagaaga
     1081 tagagggagc tccagctctt ttcctcgtat tcctgaggcc accagcatgc ccgcgttcag
     1141 ggcccaaaaa tcccttttct catagcaaaa ctgagacaga agggtctttc ccaaaaaaaa
     1201 gaaaaaaaac tttactcaaa tccagtggaa aaataaatga tagaaactat acacaacata
     1261 aaaa
//
