LOCUS       NM_001370470            2093 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens coiled-coil domain containing 106 (CCDC106),
            transcript variant 5, mRNA.
ACCESSION   NM_001370470
VERSION     NM_001370470.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2093)
  AUTHORS   Zhi,W., Wei,Y., Lazare,C., Meng,Y., Wu,P., Gao,P., Lin,S., Peng,T.,
            Chu,T., Liu,B., Ding,W., Cao,C. and Wu,P.
  TITLE     HPV-CCDC106 integration promotes cervical cancer progression by
            facilitating the high expression of CCDC106 after HPV E6 splicing
  JOURNAL   J Med Virol 95 (1), e28009 (2023)
   PUBMED   35854676
  REMARK    GeneRIF: HPV-CCDC106 integration promotes cervical cancer
            progression by facilitating the high expression of CCDC106 after
            HPV E6 splicing.
REFERENCE   2  (bases 1 to 2093)
  AUTHORS   Zhao,N., Wang,C., Guo,P., Hou,J., Yang,H., Lan,T., Zhou,Y., Li,J.,
            Bhawal,U.K. and Liu,Y.
  TITLE     CCDC106 promotes the proliferation and invasion of ovarian cancer
            cells by suppressing p21 transcription through a p53-independent
            pathway
  JOURNAL   Bioengineered 13 (4), 10956-10972 (2022)
   PUBMED   35484984
  REMARK    GeneRIF: CCDC106 promotes the proliferation and invasion of ovarian
            cancer cells by suppressing p21 transcription through a
            p53-independent pathway.
REFERENCE   3  (bases 1 to 2093)
  AUTHORS   Cao,C., Hong,P., Huang,X., Lin,D., Cao,G., Wang,L., Feng,B., Wu,P.,
            Shen,H., Xu,Q., Ren,C., Meng,Y., Zhi,W., Yu,R., Wei,J., Ding,W.,
            Tian,X., Zhang,Q., Li,W., Gao,Q., Chen,G., Li,K., Sung,W.K., Hu,Z.,
            Wang,H., Li,G. and Wu,P.
  TITLE     HPV-CCDC106 integration alters local chromosome architecture and
            hijacks an enhancer by three-dimensional genome structure
            remodeling in cervical cancer
  JOURNAL   J Genet Genomics 47 (8), 437-450 (2020)
   PUBMED   33023834
  REMARK    GeneRIF: HPV-CCDC106 integration alters local chromosome
            architecture and hijacks an enhancer by three-dimensional genome
            structure remodeling in cervical cancer.
REFERENCE   4  (bases 1 to 2093)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2093)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2093)
  AUTHORS   Zhang,X., Zheng,Q., Wang,C., Zhou,H., Jiang,G., Miao,Y., Zhang,Y.,
            Liu,Y., Li,Q., Qiu,X. and Wang,E.
  TITLE     CCDC106 promotes non-small cell lung cancer cell proliferation
  JOURNAL   Oncotarget 8 (16), 26662-26670 (2017)
   PUBMED   28460455
  REMARK    GeneRIF: Our studies revealed that CCDC106 is associated with
            non-small cell lung cancer progression and unfavorable prognosis.
            CCDC106 enhanced Cyclin A2 and Cyclin B1 expression and promoted
            A549 and H1299 cell proliferation, which depended on AKT signaling.
            These results suggest that CCDC106 may be a novel target for lung
            cancer treatment.
REFERENCE   7  (bases 1 to 2093)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2093)
  AUTHORS   Zhou,J., Qiao,X., Xiao,L., Sun,W., Wang,L., Li,H., Wu,Y., Ding,X.,
            Hu,X., Zhou,C. and Zhang,J.
  TITLE     Identification and characterization of the novel protein CCDC106
            that interacts with p53 and promotes its degradation
  JOURNAL   FEBS Lett 584 (6), 1085-1090 (2010)
   PUBMED   20159018
  REMARK    GeneRIF: CCDC106 promotes the degradation of p53 protein and
            inhibits its transactivity.
REFERENCE   9  (bases 1 to 2093)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   10 (bases 1 to 2093)
  AUTHORS   Cheng,J., Kapranov,P., Drenkow,J., Dike,S., Brubaker,S., Patel,S.,
            Long,J., Stern,D., Tammana,H., Helt,G., Sementchenko,V.,
            Piccolboni,A., Bekiranov,S., Bailey,D.K., Ganesh,M., Ghosh,S.,
            Bell,I., Gerhard,D.S. and Gingeras,T.R.
  TITLE     Transcriptional maps of 10 human chromosomes at 5-nucleotide
            resolution
  JOURNAL   Science 308 (5725), 1149-1154 (2005)
   PUBMED   15790807
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008735.9, BI755544.1 and GU354323.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.114733.1,
                                           SRR3476690.731275.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000586790.6/ ENSP00000465757.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-324               AC008735.9         27812-28135         c
            325-821             BI755544.1         34-530
            822-2093            GU354323.1         321-1592
FEATURES             Location/Qualifiers
     source          1..2093
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..2093
                     /gene="CCDC106"
                     /gene_synonym="HSU79303; ZNF581"
                     /note="coiled-coil domain containing 106"
                     /db_xref="GeneID:29903"
                     /db_xref="HGNC:HGNC:30181"
                     /db_xref="MIM:613478"
     exon            1..866
                     /gene="CCDC106"
                     /gene_synonym="HSU79303; ZNF581"
                     /inference="alignment:Splign:2.1.0"
     CDS             836..1678
                     /gene="CCDC106"
                     /gene_synonym="HSU79303; ZNF581"
                     /note="isoform 1 is encoded by transcript variant 5;
                     protein predicted by clone 23882; coiled-coil
                     domain-containing protein 106"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 106
                     isoform 1"
                     /protein_id="NP_001357399.1"
                     /db_xref="CCDS:CCDS33118.1"
                     /db_xref="GeneID:29903"
                     /db_xref="HGNC:HGNC:30181"
                     /db_xref="MIM:613478"
                     /translation="MNDRSSRRRTMKDDETFEISIPFDEAPHLDPQIFYSLSPSRRNF
                     EEPPEAASSALALMNSVKTQLHMALERNSWLQKRIEDLEEERDFLRCQLDKFISSARM
                     EAEDHCRMKPGPRRMEGDSRGGAGGEASDPESAASSLSGASEEGSASERRRQKQKGGA
                     SRRRFGKPKARERQRVKDADGVLCRYKKILGTFQKLKSMSRAFEHHRVDRNTVALTTP
                     IAELLIVAPEKLAEVGEFDPSKERLLEYSRRCFLALDDETLKKVQALKKSKLLLPITY
                     RFKR"
     exon            867..971
                     /gene="CCDC106"
                     /gene_synonym="HSU79303; ZNF581"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1148
                     /gene="CCDC106"
                     /gene_synonym="HSU79303; ZNF581"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1361
                     /gene="CCDC106"
                     /gene_synonym="HSU79303; ZNF581"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..2093
                     /gene="CCDC106"
                     /gene_synonym="HSU79303; ZNF581"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2063..2068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC106"
                     /gene_synonym="HSU79303; ZNF581"
                     /note="hexamer: ATTAAA"
     polyA_site      2093
                     /gene="CCDC106"
                     /gene_synonym="HSU79303; ZNF581"
                     /note="major polyA site"
ORIGIN      
        1 agacgctccc cggcgccggg catgggcgcc gccgccgtcg gtccccgagc cggattccgc
       61 gagcgggtgg gtgagcgcgg ggggcctcgg cccctcggac cccgggcacc cgcgggcggg
      121 ggatggtggc cgcgtttgca cccccgccct agtgcatgtt cccgctggaa tcgttccacg
      181 accgctcccc ctcccacccg cgggacaaag ggcgggggcg gggggggcgc acccccacgc
      241 gtgacctttc cccgtactgc gcacgcgccc agcccccacc accgggggac ggtccgcccg
      301 cccacgcgag tgcgggggag gggtgtgggg gccccgaagg tagaggaggc agcgcgcacg
      361 ggctggacct cctcctaccc tgggaagttg gggcagtttc cccctgcacc tgcctcttcc
      421 ttaggcctgg cagtggcccg cgatgagaga gggtccttcc ccttcaggct aggtgtccct
      481 ggtcaggcga ccccttgggg cacccagcaa tttagggctt cagcttcctt ttccttcgat
      541 acccaggagc ccacgtcccc agctcacttc tcccccagga cctaggcggc tgggccccct
      601 gcccctgact ccaggagccc aggagtttga agcccaggcg cgttttgcct cagtcctggg
      661 gtccaggctc cctcctccct cagaccaggg gtccaggcca gaaggtccct cctgtctcac
      721 ttcacctccc ccaggatgga ccctccagtc catctgcgtc tctccatttg tggctgccgt
      781 ttctgtccag tgcccctgag gccctcggct gctggggtcc gtaggaagcc gcgccatgaa
      841 tgaccggagc agtcggaggc ggacaatgaa ggacgatgag accttcgaga tctccattcc
      901 cttcgatgag gcaccccacc tagacccaca gatcttttac agtctgagcc cctctcggag
      961 aaacttcgag gagcctccgg aggctgcgtc ctccgccctg gctctgatga acagcgtcaa
     1021 gacccagctg cacatggctc tggagaggaa ctcctggctg cagaagcgca tcgaggacct
     1081 ggaggaagag agggacttcc tgcggtgcca gctggacaaa ttcatctctt ctgctcggat
     1141 ggaggcagag gaccactgcc ggatgaagcc tgggcccagg cggatggagg gggacagccg
     1201 tggtggggct gggggcgagg cctcggaccc tgagtcagca gcctcctccc tcagcggagc
     1261 gtccgaagaa ggcagcgcca gtgagaggag gcggcagaag cagaagggag gtgctagtcg
     1321 gaggcgcttt gggaagccca aggcccggga gaggcagcga gtgaaggacg ccgacggggt
     1381 cctctgccgg tacaagaaga tcctgggcac cttccagaag ctcaagagca tgtcgcgggc
     1441 cttcgagcac caccgcgtgg acaggaacac cgtggcgctg accacgccca tcgccgagct
     1501 gctcattgtg gcccccgaga agctggccga ggtgggcgag ttcgacccct ccaaggagcg
     1561 cctgctcgag tactcccgcc gctgctttct ggccctggac gacgagacgc tcaagaaggt
     1621 gcaggcgctc aagaagagca agctgctgct gcccatcacc taccgcttca agcggtgatc
     1681 gcaccacgcc tccgcgcctc cacccgggcc ttcctccccc gtggaccccg gtggatgacc
     1741 tgcccctctc cccgccgcgc ccctgcccct cctcctcgct ccctgggttg ggggctccct
     1801 tagccgggcc cccaagcgcg acggccccgg accggccgcg gccccttccc gaacgccggc
     1861 acccccttcc gcttgggctg cccagccctg tcctcgccgg gccccttcct cctggaaaac
     1921 caggcaggcg ggtgcccccc cctcgagtgg gggactgtac agaccccgtc tccgccctgg
     1981 ccccgcggag gagctgccca cctgattccc ggacagacct ccccaactcc gcgtgagaca
     2041 gagaattatt cagataattt aaattaaaaa acgacgtgaa aatttggaat aaa
//
