LOCUS       NM_033212               2432 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens coiled-coil domain containing 102A (CCDC102A), mRNA.
ACCESSION   NM_033212
VERSION     NM_033212.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2432)
  AUTHORS   Wang,T., Fan,G., Xia,Y., Zou,Y., Liu,Y., Wang,J., Hu,Y., Teng,J.,
            Huang,N. and Chen,J.
  TITLE     Dual roles of CCDC102A in governing centrosome duplication and
            cohesion
  JOURNAL   Cell Rep 43 (2), 113696 (2024)
   PUBMED   38280197
REFERENCE   2  (bases 1 to 2432)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2432)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 2432)
  AUTHORS   Lin,H.J., Huang,Y.C., Lin,J.M., Liao,W.L., Wu,J.Y., Chen,C.H.,
            Chou,Y.C., Chen,L.A., Lin,C.J. and Tsai,F.J.
  TITLE     Novel susceptibility genes associated with diabetic cataract in a
            Taiwanese population
  JOURNAL   Ophthalmic Genet 34 (1-2), 35-42 (2013)
   PUBMED   23137000
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004382.1, BC009941.2 and CA449463.1.
            
            On Nov 24, 2018 this sequence version replaced NM_033212.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009941.2, ERR3218379.718530.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258214.3/ ENSP00000258214.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC004382.1         186331-186336       c
            7-504               BC009941.2         1-498
            505-518             AC004382.1         178644-178657       c
            519-1976            BC009941.2         513-1970
            1977-2311           CA449463.1         19-353              c
            2312-2432           BC009941.2         2306-2426
FEATURES             Location/Qualifiers
     source          1..2432
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..2432
                     /gene="CCDC102A"
                     /note="coiled-coil domain containing 102A"
                     /db_xref="GeneID:92922"
                     /db_xref="HGNC:HGNC:28097"
     exon            1..72
                     /gene="CCDC102A"
                     /inference="alignment:Splign:2.1.0"
     exon            73..804
                     /gene="CCDC102A"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..1872
                     /gene="CCDC102A"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 102A"
                     /protein_id="NP_149989.2"
                     /db_xref="CCDS:CCDS10784.1"
                     /db_xref="GeneID:92922"
                     /db_xref="HGNC:HGNC:28097"
                     /translation="MSHGPSPRLAESPQLSKGSLLTILGSPSPERMGPADSLPPTPPS
                     GTPSPGPPPALPLPPAPALLADGDWESREELRLRELEEARARAAQMEKTMRRWSDCTA
                     NWREKWSKVRAERNRAREEVRQLRQRLDALTKELAGARRERQEAQGECEARGRELARL
                     RGARGVADQTRDGPEPEAEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEAR
                     SLGAGGPRGSSGRQERSRLPWEDTAATEEEASKLTALRLRLDESQKVLLKEREDKLAL
                     SRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARS
                     SMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARR
                     RRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHE
                     AEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSR
                     LRRQQQNAPLFGKIRSARFGTEEAEDGTSDLDEDEDLQIQVA"
     exon            805..1031
                     /gene="CCDC102A"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1140
                     /gene="CCDC102A"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1257
                     /gene="CCDC102A"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1467
                     /gene="CCDC102A"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1638
                     /gene="CCDC102A"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1742
                     /gene="CCDC102A"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..2432
                     /gene="CCDC102A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2292..2297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC102A"
                     /note="hexamer: AATAAA"
     polyA_site      2311
                     /gene="CCDC102A"
                     /note="major polyA site"
     regulatory      2413..2418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCDC102A"
                     /note="hexamer: AATAAA"
     polyA_site      2432
                     /gene="CCDC102A"
                     /note="major polyA site"
ORIGIN      
        1 gcagctgcac ggtgcccgct ctaccccgcc gcagcggctg ggacgtacgg agcccgcaag
       61 tcccggcccg aggtccgagg aggcgtcctc cgcccggtgg cccagaggga agcggggcac
      121 ggcgtcatca tgcacagttg tatcgcgccc gccgcgcgtc cccggagccg cccctgagcc
      181 cgaccgcgag ttcgagctca gggcccgccc ggccgcacca tgagccacgg gcccagcccc
      241 cggctggccg agtccccgca gctgtccaag ggcagcctcc tgaccatcct gggcagcccg
      301 tcgccggagc gcatggggcc tgccgactcc ttgccgccca cgccgcccag cggcacgccc
      361 tcgcccgggc cgccgcccgc actgcccctg ccccccgcgc ccgcgctgct ggccgacggc
      421 gactgggaga gccgcgagga gctgcggctg cgggagctgg aggaggcgcg ggcgcgggcg
      481 gcgcagatgg agaagaccat gcgccggtgg tcggactgca ctgccaattg gcgcgagaaa
      541 tggagcaagg tgcgcgctga gcgcaaccgc gcgcgcgagg aggtgcgcca gctgcgccag
      601 cgcctggacg cgctcaccaa ggagctggcg ggcgcacggc gcgagcgcca agaggcgcag
      661 ggcgagtgcg aggcacgggg ccgcgagctg gcgcggctga ggggcgcccg gggggtcgcc
      721 gaccagacgc gcgacggccc cgagccggaa gcggagcgcg agccagtgcg tgacgtcggg
      781 tccgagaggc cgccaggcag ccaggaactg gagctggtgg agagcctgct gaagagcatg
      841 ccagaggagt ctgaggactg ctgggaggcg cgcagcctgg gggctggggg cccgcggggc
      901 agctcaggcc gccaggagcg cagccggcta ccctgggagg acacagctgc cacggaggag
      961 gaggcctcca agttgaccgc cctgcggcta cggctggatg agtcccagaa ggtgctgctc
     1021 aaggagcgag aggataaact ggcgttgagc aggaacattg agaagctaga gggggagctc
     1081 agccagtgga agatcaagta tgaggagctg agcaagacca agcaggagat gctcaagcag
     1141 ctcagcatcc tgaaggaggc gcaccaggac gagctgggcc gcatgtctga ggacctggaa
     1201 gatgagctcg gtgcacgctc cagcatggac cggaaaatgg ccgagctgag gggcgagatg
     1261 gagcggctgc aggccgaaaa cgctgcggag tggggccgcc gggagcggct ggagacagag
     1321 aaactgggcc ttgagcggga gaacaagaag ctgcgggcac aggtcggaga cctggaggag
     1381 gcgctggccc ggcggcggcg gcaaacagcc agcgcactgg actgcgacct gagggccagc
     1441 caggccgcgc tcttcgagaa gaacaaggag ctggcagacc tgaagcatgt gcatggcaag
     1501 ctgaagaagc agttccagga gaaggtggca gagctggcac atgccaaccg gcgggtggag
     1561 cagcacgagg ctgaggtgaa gaagctgcgg ctgcgggtgg aggagctcaa gaaggagctg
     1621 gcccaggctg aggacgagct ggacgaggcc cacaaccagg cacgtaagct gcagcggtcg
     1681 ctggacgagc agacggagca gagcgagaac ctgcaagtgc aactggagca cctgcagtcc
     1741 aggctccgca ggcagcagca gaacgctccc ctcttcggga agatccgcag tgctcgcttt
     1801 ggcaccgagg aggccgagga tggaaccagt gacctggacg aggacgagga cctgcaaatc
     1861 caggtggcct agagcttcct gtggctgggc aggatgggcc gccccatacc tgcccagggt
     1921 ccaggctaac cagccactca aactgatgca gtgcctaggc tcactctggg accagtccct
     1981 gccacagccg actttcttct ctcccaggga tggcgtcaac agtcccacct accaacgccc
     2041 tgtggaaagg aagcctatgt tttatatata tatatacaca cacgcgcgcg cgcgcgcgca
     2101 cacccagaag tctttggacc catttggttt tataaataca ggacagctcc aaggcccagt
     2161 ccagatgacc tcacccaccc aggacttcat gcagggctgg gcatgttggg ggcagttgtt
     2221 ggagccccac cctgggctgc ctctctaggc ttcgctgttc atcatacaat gcagtgaacc
     2281 cagttatttg taataaatga agttcaagtt cttggggcat ctgaaagtat ggcagatgtg
     2341 ggcgggggtt gtgggggacg gcatcggcct gcacctgacg ctgaaccaga gctcaggaat
     2401 gtcaagtaac ttaataaatg agtgaatgtg aa
//
