LOCUS       NM_001393997            3685 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens cell cycle and apoptosis regulator 2 (CCAR2),
            transcript variant 2, mRNA.
ACCESSION   NM_001393997 NR_033902
VERSION     NM_001393997.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3685)
  AUTHORS   Wang,Y., Wang,J.M., Xiao,Y., Hu,X.B., Zheng,S.Y., Fu,J.L.,
            Zhang,L., Gan,Y.W., Liang,X.M. and Li,D.W.
  TITLE     SUMO1-regulated DBC1 promotes p53-dependent stress-induced
            apoptosis of lens epithelial cells
  JOURNAL   Aging (Albany NY) 15 (17), 8812-8832 (2023)
   PUBMED   37683133
  REMARK    GeneRIF: SUMO1-regulated DBC1 promotes p53-dependent stress-induced
            apoptosis of lens epithelial cells.
REFERENCE   2  (bases 1 to 3685)
  AUTHORS   Kim,H.J., Moon,S.J. and Kim,J.H.
  TITLE     Mechanistic insights into the dual role of CCAR2/DBC1 in cancer
  JOURNAL   Exp Mol Med 55 (8), 1691-1701 (2023)
   PUBMED   37524873
  REMARK    GeneRIF: Mechanistic insights into the dual role of CCAR2/DBC1 in
            cancer.
            Review article
REFERENCE   3  (bases 1 to 3685)
  AUTHORS   Sarwar,Z., Nabi,N., Bhat,S.A., Gillani,S.Q., Reshi,I., Un Nisa,M.,
            Adelmant,G., A Marto,J. and Andrabi,S.
  TITLE     Interaction of DBC1 with polyoma small T antigen promotes its
            degradation and negatively regulates tumorigenesis
  JOURNAL   J Biol Chem 298 (2), 101496 (2022)
   PUBMED   34921839
  REMARK    GeneRIF: Interaction of DBC1 with polyoma small T antigen promotes
            its degradation and negatively regulates tumorigenesis.
REFERENCE   4  (bases 1 to 3685)
  AUTHORS   Chen,L., Zhou,S.J., Xu,Y., Liao,Q.M., Zou,Y.S. and Pei,H.
  TITLE     CCAR2 promotes a malignant phenotype of osteosarcoma through
            Wnt/beta-catenin-dependent transcriptional activation of SPARC
  JOURNAL   Biochem Biophys Res Commun 580, 67-73 (2021)
   PUBMED   34624572
  REMARK    GeneRIF: CCAR2 promotes a malignant phenotype of osteosarcoma
            through Wnt/beta-catenin-dependent transcriptional activation of
            SPARC.
REFERENCE   5  (bases 1 to 3685)
  AUTHORS   Mannen,T., Goto,M., Yoshizawa,T., Yamashita,A., Hirose,T. and
            Hayano,T.
  TITLE     Distinct RNA polymerase transcripts direct the assembly of
            phase-separated DBC1 nuclear bodies in different cell lines
  JOURNAL   Mol Biol Cell 32 (21), ar33 (2021)
   PUBMED   34495685
  REMARK    GeneRIF: Distinct RNA polymerase transcripts direct the assembly of
            phase-separated DBC1 nuclear bodies in different cell lines.
REFERENCE   6  (bases 1 to 3685)
  AUTHORS   Hafler,D.A., Compston,A., Sawcer,S., Lander,E.S., Daly,M.J., De
            Jager,P.L., de Bakker,P.I., Gabriel,S.B., Mirel,D.B., Ivinson,A.J.,
            Pericak-Vance,M.A., Gregory,S.G., Rioux,J.D., McCauley,J.L.,
            Haines,J.L., Barcellos,L.F., Cree,B., Oksenberg,J.R. and
            Hauser,S.L.
  CONSRTM   International Multiple Sclerosis Genetics Consortium
  TITLE     Risk alleles for multiple sclerosis identified by a genomewide
            study
  JOURNAL   N Engl J Med 357 (9), 851-862 (2007)
   PUBMED   17660530
REFERENCE   7  (bases 1 to 3685)
  AUTHORS   Trauernicht,A.M., Kim,S.J., Kim,N.H. and Boyer,T.G.
  TITLE     Modulation of estrogen receptor alpha protein level and survival
            function by DBC-1
  JOURNAL   Mol Endocrinol 21 (7), 1526-1536 (2007)
   PUBMED   17473282
  REMARK    GeneRIF: biological function for DBC-1 in the modulation of ERalpha
            expression and hormone-independent breast cancer cell survival
            GeneRIF: DBC-1 functions to modulate ER alpha expression and
            hormone-independent breast cancer cell survival.
REFERENCE   8  (bases 1 to 3685)
  AUTHORS   Koch,H.B., Zhang,R., Verdoodt,B., Bailey,A., Zhang,C.D., Yates,J.R.
            3rd, Menssen,A. and Hermeking,H.
  TITLE     Large-scale identification of c-MYC-associated proteins using a
            combined TAP/MudPIT approach
  JOURNAL   Cell Cycle 6 (2), 205-217 (2007)
   PUBMED   17314511
REFERENCE   9  (bases 1 to 3685)
  AUTHORS   Sundararajan,R., Chen,G., Mukherjee,C. and White,E.
  TITLE     Caspase-dependent processing activates the proapoptotic activity of
            deleted in breast cancer-1 during tumor necrosis
            factor-alpha-mediated death signaling
  JOURNAL   Oncogene 24 (31), 4908-4920 (2005)
   PUBMED   15824730
  REMARK    GeneRIF: Caspase-dependent processing of DBC-1 may act as a
            feed-forward mechanism to promote apoptosis and possibly also tumor
            suppression.
REFERENCE   10 (bases 1 to 3685)
  AUTHORS   Hamaguchi,M., Meth,J.L., von Klitzing,C., Wei,W., Esposito,D.,
            Rodgers,L., Walsh,T., Welcsh,P., King,M.C. and Wigler,M.H.
  TITLE     DBC2, a candidate for a tumor suppressor gene involved in breast
            cancer
  JOURNAL   Proc Natl Acad Sci U S A 99 (21), 13647-13652 (2002)
   PUBMED   12370419
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC037459.16.
            
            On Mar 26, 2021 this sequence version replaced NR_033902.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065495.1, AK314535.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308511.9/ ENSP00000310670.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AC037459.16        125559-125644
            87-182              AC037459.16        126538-126633
            183-274             AC037459.16        126887-126978
            275-366             AC037459.16        127409-127500
            367-481             AC037459.16        127712-127826
            482-611             AC037459.16        127998-128127
            612-708             AC037459.16        128771-128867
            709-828             AC037459.16        133819-133938
            829-1051            AC037459.16        134894-135116
            1052-1165           AC037459.16        135192-135305
            1166-1329           AC037459.16        135640-135803
            1330-1501           AC037459.16        136227-136398
            1502-1732           AC037459.16        136484-136714
            1733-1969           AC037459.16        136814-137050
            1970-2114           AC037459.16        138222-138366
            2115-2197           AC037459.16        138498-138580
            2198-2344           AC037459.16        139151-139297
            2345-2456           AC037459.16        139419-139530
            2457-2645           AC037459.16        139629-139817
            2646-2851           AC037459.16        139952-140157
            2852-3685           AC037459.16        140440-141273
FEATURES             Location/Qualifiers
     source          1..3685
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..3685
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /note="cell cycle and apoptosis regulator 2"
                     /db_xref="GeneID:57805"
                     /db_xref="HGNC:HGNC:23360"
                     /db_xref="MIM:607359"
     exon            1..86
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /inference="alignment:Splign:2.1.0"
     exon            87..182
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2896
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /note="isoform 1 is encoded by transcript variant 2;
                     deleted in breast cancer 1; cell division cycle and
                     apoptosis regulator protein 2; cell cycle and apoptosis
                     regulator protein 2"
                     /codon_start=1
                     /product="cell cycle and apoptosis regulator protein 2
                     isoform 1"
                     /protein_id="NP_001380926.1"
                     /db_xref="CCDS:CCDS34863.1"
                     /db_xref="GeneID:57805"
                     /db_xref="HGNC:HGNC:23360"
                     /db_xref="MIM:607359"
                     /translation="MSQFKRQRINPLPGGRNFSGTASTSLLGPPPGLLTPPVATELSQ
                     NARHLQGGEKQRVFTGIVTSLHDYFGVVDEEVFFQLSVVKGRLPQLGEKVLVKAAYNP
                     GQAVPWNAVKVQTLSNQPLLKSPAPPLLHVAALGQKQGILGAQPQLIFQPHRIPPLFP
                     QKPLSLFQTSHTLHLSHLNRFPARGPHGRLDQGRSDDYDSKKRKQRAGGEPWGAKKPR
                     HDLPPYRVHLTPYTVDSPICDFLELQRRYRSLLVPSDFLSVHLSWLSAFPLSQPFSLH
                     HPSRIQVSSEKEAAPDAGAEPITADSDPAYSSKVLLLSSPGLEELYRCCMLFVDDMAE
                     PRETPEHPLKQIKFLLGRKEEEAVLVGGEWSPSLDGLDPQADPQVLVRTAIRCAQAQT
                     GIDLSGCTKWWRFAEFQYLQPGPPRRLQTVVVYLPDVWTIMPTLEEWEALCQQKAAEA
                     APPTQEAQGETEPTEQAPDALEQAADTSRRNAETPEATTQQETDTDLPEAPPPPLEPA
                     VIARPGCVNLSLHGIVEDRRPKERISFEVMVLAELFLEMLQRDFGYRVYKMLLSLPEK
                     VVSPPEPEKEEAAKEEATKEEEAIKEEVVKEPKDEAQNEGPATESEAPLKEDGLLPKP
                     LSSGGEEEEKPRGEASEDLCEMALDPELLLLRDDGEEEFAGAKLEDSEVRSVASNQSE
                     MEFSSLQDMPKELDPSAVLPLDCLLAFVFFDANWCGYLHRRDLERILLTLGIRLSAEQ
                     AKQLVSRVVTQNICQYRSLQYSRQEGLDGGLPEEVLFGNLDLLPPPGKSTKPGAAPTE
                     HKALVSHNGSLINVGSLLQRAEQQDSGRLYLENKIHTLELKLEESHNRFSATEVTNKT
                     LAAEMQELRVRLAEAEETARTAERQKSQLQRLLQELRRRLTPLQLEIQRVVEKADSWV
                     EKEEPAPSN"
     exon            183..274
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /inference="alignment:Splign:2.1.0"
     exon            275..366
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /inference="alignment:Splign:2.1.0"
     exon            367..481
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /inference="alignment:Splign:2.1.0"
     exon            482..611
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /inference="alignment:Splign:2.1.0"
     exon            612..708
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /inference="alignment:Splign:2.1.0"
     exon            709..828
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1051
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1165
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1329
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1501
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1732
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1969
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2114
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2197
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2344
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2456
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2645
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2851
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..3685
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3663..3668
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /note="hexamer: AATAAA"
     polyA_site      3685
                     /gene="CCAR2"
                     /gene_synonym="DBC-1; DBC1; KIAA1967; NET35; p30 DBC;
                     p30DBC"
                     /note="major polyA site"
ORIGIN      
        1 agaggcgctt ccggtggcgg cggcagcagc ggctgtggtg gttccgggtg tctttgtccc
       61 cccggtgtcg ctgccctggc ccgcagcctt ttccccacga ctctgaaaga ggacagcgtt
      121 cccaatgtcc cagtttaagc gccagcggat caacccgctt ccagggggac gcaacttctc
      181 aggcacagct tcaacatctc ttctgggccc tcctcctggt ttgctcactc ctcctgtggc
      241 cacagaactg tcccagaatg ccaggcacct tcagggtggg gagaaacagc gggtcttcac
      301 tggtattgtt accagcttgc atgactactt tggggttgtg gatgaagagg tcttttttca
      361 gctaagtgtg gtgaagggcc gtctgcccca gctgggtgag aaggtgctgg tgaaggctgc
      421 atacaaccca ggccaggcag tgccctggaa tgctgtcaag gtgcaaacgc tctccaacca
      481 gcccctactg aagtccccag cacctcctct tctgcatgta gcagccctgg gccagaagca
      541 agggatcctg ggagctcagc ctcagttgat cttccagcct caccggattc ccccactctt
      601 tcctcagaag cctctgagtc tcttccaaac atcccacaca cttcacctga gccacctgaa
      661 cagatttcct gcccggggcc ctcatggacg gttggatcag ggccgaagtg atgactatga
      721 ctccaagaaa cgcaaacagc gggctggtgg agagccctgg ggtgctaaga agccaaggca
      781 tgacctgcct ccttaccggg tccacctcac tccttacact gtggacagcc ccatctgtga
      841 cttcctagaa ctccagcgcc gttaccgcag cctcctggtc ccctcagatt ttctgtccgt
      901 gcatctgagt tggctatcag ccttccccct gagccagccc ttttccctcc atcatccaag
      961 ccggatccag gtctcttctg aaaaggaggc agctccagac gctggtgctg agcccatcac
     1021 tgcagacagt gaccccgctt atagttcgaa ggtactgctg ctctcttccc cggggttgga
     1081 ggaattgtat cgttgttgca tgctctttgt ggatgacatg gctgagccaa gggagacgcc
     1141 agagcatcct ctgaagcaga ttaagttttt gctgggcagg aaagaagagg aggcagtgct
     1201 ggttgggggt gaatggtctc cttccctgga tggcctcgac ccccaggctg acccgcaggt
     1261 gctggtgcgt accgccatcc gctgtgcgca ggcccagact ggcattgatt tgagcggctg
     1321 taccaagtgg tggcgctttg ccgagtttca gtacctgcag ccgggacccc cccggcggct
     1381 tcagacagtg gtggtgtacc tgccggatgt ctggaccatc atgcctactt tggaggagtg
     1441 ggaggccctg tgccagcaga aagctgcaga ggcagctccc ccaacccagg aggcacaagg
     1501 ggaaacggag cctactgaac aggcacctga tgccttggag caagcagcag acacttctag
     1561 acggaacgca gaaactccag aggccaccac acagcaggaa acggacactg atctcccaga
     1621 ggcccctcca ccccccctag aacctgctgt catcgcacgc cctggctgtg taaacctgtc
     1681 cctccatggg attgtggagg atcggaggcc aaaggaaagg atctcttttg aggtgatggt
     1741 gctggccgag ctgtttctgg agatgctcca gagggatttt ggctatagag tttataagat
     1801 gctactgagc cttcctgaaa aggtcgtgtc cccacctgaa cctgagaagg aggaggcggc
     1861 caaggaagaa gccaccaagg aggaagaagc catcaaagag gaggtggtca aggagcccaa
     1921 ggatgaggca cagaatgagg gcccggctac agagtcagag gccccgctga aggaggatgg
     1981 gcttttgccc aaaccactct cttctggggg agaggaagaa gaaaaacccc ggggcgaggc
     2041 ttctgaggac ctgtgtgaga tggccctgga cccagaactg ttgcttctga gggatgatgg
     2101 agaggaggag tttgcaggag caaagctgga ggattcggag gtccggtccg ttgcctcaaa
     2161 ccagtcagag atggagttct cttcacttca ggacatgccc aaggagctgg atccctctgc
     2221 tgtgctcccc ttagactgtc tgcttgcttt tgtgttcttt gatgccaact ggtgtggcta
     2281 cttgcaccgg cgagacttag agaggatcct ccttaccctt gggatccggc tcagtgcaga
     2341 gcaggccaag cagctggtca gcagggtggt gacccagaac atctgccagt accggagcct
     2401 tcagtacagc cgccaggagg gcctggatgg tggccttccc gaggaggtgc tcttcggaaa
     2461 cctggacctg ctgccccctc ctgggaaaag cacgaagcca ggtgctgccc ccacagaaca
     2521 caaagccttg gtgtcccaca atggcagcct gattaacgtg gggagcctgc tgcagcgcgc
     2581 ggagcagcag gacagcggcc ggctctacct agagaacaag atccacacac tggagctgaa
     2641 gctggaggag agccataacc gtttctcagc cactgaagta accaataaga cgctggcggc
     2701 agagatgcag gagctgcgag tccggctggc ggaggccgag gagaccgccc ggacggcgga
     2761 gcgacagaag agccagctcc agcggctgct gcaggagctc cgcaggcgtc tgacccccct
     2821 gcagctggag atccagcggg tggtggaaaa ggctgacagc tgggtggaga aggaggagcc
     2881 ggcacctagc aactgacggc ctcgcacgga actgccatcc tgtgagggca gcggtggcgc
     2941 ccggcaaagt tggagccctt gcggtaccag aaagcagcga gagcgagacc tgggagccag
     3001 ggcaggggtg gctgacccca tgctcagcct ctaggggacg gcaggccatc aggctggggg
     3061 ctgtgctatg tgggatggat gtgtgaggaa ccccggttcc acttaacaac taaatacaac
     3121 atcttttgca cccctagaat gtcattttgc cctcaacctt ggtatttctc ctggggccct
     3181 tttagtcttg tgctgacttt ctcctgtcct cttccagttt agaataagac aggggagaaa
     3241 aaggcttttc gagtgtggga caaggtctga tgtcagtgaa cggaactgaa gagcaagaca
     3301 tggagcctgg ctggggctaa gcagccccct cctccggatg gcacaggctc tgctaggttc
     3361 cggacacagg cttctggggg aagggtctcc cttggccatc acgggaatgg agtccatgct
     3421 agaaagagct cagtgttggg ctgggtttgc cagtagaaca ctgcgttcca gtcaccccgg
     3481 tcttgccaga agaaaccagc acctctttcc cgtggctcct gtgttcagaa tgtggtattg
     3541 gctctggccc agccttctcc cctgttaccc ataattcttg cctctttcca taatccgtgg
     3601 tttcagtttg actttgtata taaagttggg gttttttttt tttttttttg gcttgttttt
     3661 taaataaacc aaagtcaaaa acaaa
//
