LOCUS       NM_018237               4658 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens cell division cycle and apoptosis regulator 1 (CCAR1),
            transcript variant 1, mRNA.
ACCESSION   NM_018237
VERSION     NM_018237.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4658)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4658)
  AUTHORS   Ji,Q., Tu,Z., Liu,J., Zhou,Z., Li,F., Zhu,X. and Huang,K.
  TITLE     RUNX1-PDIA5 Axis Promotes Malignant Progression of Glioblastoma by
            Regulating CCAR1 Protein Expression
  JOURNAL   Int J Biol Sci 20 (11), 4364-4381 (2024)
   PUBMED   39247813
  REMARK    GeneRIF: RUNX1-PDIA5 Axis Promotes Malignant Progression of
            Glioblastoma by Regulating CCAR1 Protein Expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4658)
  AUTHORS   Chen,S., Zhao,Q., Zhang,R., Liu,J., Peng,W., Xu,H., Li,X., Wang,X.,
            Wu,S., Li,G. and Nan,A.
  TITLE     A transcribed ultraconserved noncoding RNA, uc.285+, promotes
            colorectal cancer proliferation through dual targeting of CDC42 by
            directly binding mRNA and protein
  JOURNAL   Transl Res 270, 52-65 (2024)
   PUBMED   38552953
  REMARK    GeneRIF: A transcribed ultraconserved noncoding RNA, uc.285+,
            promotes colorectal cancer proliferation through dual targeting of
            CDC42 by directly binding mRNA and protein.
REFERENCE   4  (bases 1 to 4658)
  AUTHORS   Harada,N., Asada,S., Jiang,L., Nguyen,H., Moreau,L., Marina,R.J.,
            Adelman,K., Iyer,D.R. and D'Andrea,A.D.
  TITLE     The splicing factor CCAR1 regulates the Fanconi anemia/BRCA pathway
  JOURNAL   Mol Cell 84 (14), 2618-2633 (2024)
   PUBMED   39025073
  REMARK    GeneRIF: The splicing factor CCAR1 regulates the Fanconi
            anemia/BRCA pathway.
REFERENCE   5  (bases 1 to 4658)
  AUTHORS   Huang,C., Xu,R., Zhu,X. and Jiang,H.
  TITLE     m6A-modified circABCC4 promotes stemness and metastasis of prostate
            cancer by recruiting IGF2BP2 to increase stability of CCAR1
  JOURNAL   Cancer Gene Ther 30 (10), 1426-1440 (2023)
   PUBMED   37563361
  REMARK    GeneRIF: m6A-modified circABCC4 promotes stemness and metastasis of
            prostate cancer by recruiting IGF2BP2 to increase stability of
            CCAR1.
REFERENCE   6  (bases 1 to 4658)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   7  (bases 1 to 4658)
  AUTHORS   McDonald,E.R. 3rd and El-Deiry,W.S.
  TITLE     Suppression of caspase-8- and -10-associated RING proteins results
            in sensitization to death ligands and inhibition of tumor cell
            growth
  JOURNAL   Proc Natl Acad Sci U S A 101 (16), 6170-6175 (2004)
   PUBMED   15069192
REFERENCE   8  (bases 1 to 4658)
  AUTHORS   Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
            Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
            Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
            Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
            Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
            Superti-Furga,G.
  TITLE     A physical and functional map of the human TNF-alpha/NF-kappa B
            signal transduction pathway
  JOURNAL   Nat Cell Biol 6 (2), 97-105 (2004)
   PUBMED   14743216
  REMARK    Erratum:[Nat Cell Biol. 2004 May;6(5):465]
REFERENCE   9  (bases 1 to 4658)
  AUTHORS   Rishi,A.K., Zhang,L., Boyanapalli,M., Wali,A., Mohammad,R.M.,
            Yu,Y., Fontana,J.A., Hatfield,J.S., Dawson,M.I., Majumdar,A.P. and
            Reichert,U.
  TITLE     Identification and characterization of a cell cycle and apoptosis
            regulatory protein-1 as a novel mediator of apoptosis signaling by
            retinoid CD437
  JOURNAL   J Biol Chem 278 (35), 33422-33435 (2003)
   PUBMED   12816952
  REMARK    GeneRIF: cell cycle and apoptosis regulatory protein-1 is a novel
            mediator of apoptosis signaling by retinoid CD437
REFERENCE   10 (bases 1 to 4658)
  AUTHORS   Zhou,Z., Licklider,L.J., Gygi,S.P. and Reed,R.
  TITLE     Comprehensive proteomic analysis of the human spliceosome
  JOURNAL   Nature 419 (6903), 182-185 (2002)
   PUBMED   12226669
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA511293.1, BC132725.1, AY249140.1, DB636717.1 and BU617955.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018237.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.250323.1,
                                           SRR1660805.194872.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265872.11/ ENSP00000265872.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DA511293.1         96-111
            17-3636             BC132725.1         1-3620
            3637-3836           AY249140.1         3640-3839
            3837-4358           DB636717.1         121-642
            4359-4658           BU617955.1         17-316              c
FEATURES             Location/Qualifiers
     source          1..4658
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.3"
     gene            1..4658
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /note="cell division cycle and apoptosis regulator 1"
                     /db_xref="GeneID:55749"
                     /db_xref="HGNC:HGNC:24236"
                     /db_xref="MIM:612569"
     exon            1..44
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     exon            45..167
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..3547
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /note="isoform a is encoded by transcript variant 1; cell
                     division cycle and apoptosis regulator protein 1; death
                     inducer with SAP domain; cell cycle and apoptosis
                     regulatory protein 1"
                     /codon_start=1
                     /product="cell division cycle and apoptosis regulator
                     protein 1 isoform a"
                     /protein_id="NP_060707.2"
                     /db_xref="CCDS:CCDS7282.1"
                     /db_xref="GeneID:55749"
                     /db_xref="HGNC:HGNC:24236"
                     /db_xref="MIM:612569"
                     /translation="MAQFGGQKNPPWATQFTATAVSQPAALGVQQPSLLGASPTIYTQ
                     QTALAAAGLTTQTPANYQLTQTAALQQQAAAAAAALQQQYSQPQQALYSVQQQLQQPQ
                     QTLLTQPAVALPTSLSLSTPQPTAQITVSYPTPRSSQQQTQPQKQRVFTGVVTKLHDT
                     FGFVDEDVFFQLSAVKGKTPQVGDRVLVEATYNPNMPFKWNAQRIQTLPNQNQSQTQP
                     LLKTPPAVLQPIAPQTTFGVQTQPQPQSLLQAQISAASITPLLQTQPQPLLQQPQQKA
                     GLLQPPVRIVSQPQPARRLDPPSRFSGRNDRGDQVPNRKDDRSRERERERRRSRERSP
                     QRKRSRERSPRRERERSPRRVRRVVPRYTVQFSKFSLDCPSCDMMELRRRYQNLYIPS
                     DFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNMAILDPPDADHLYSAKVM
                     LMASPSMEDLYHKSCALAEDPQELRDGFQHPARLVKFLVGMKGKDEAMAIGGHWSPSL
                     DGPDPEKDPSVLIKTAIRCCKALTGIDLSVCTQWYRFAEIRYHRPEETHKGRTVPAHV
                     ETVVLFFPDVWHCLPTRSEWETLSRGYKQQLVEKLQGERKEADGEQDEEEKDDGEAKE
                     ISTPTHWSKLDPKTMKVNDLRKELESRALSSKGLKSQLIARLTKQLKVEEQKEEQKEL
                     EKSEKEEDEDDDRKSEDDKEEEERKRQEEIERQRRERRYILPDEPAIIVHPNWAAKSG
                     KFDCSIMSLSVLLDYRLEDNKEHSFEVSLFAELFNEMLQRDFGVRIYKSLLSLPEKED
                     KKEKDKKSKKDERKDKKEERDDETDEPKPKRRKSGDDKDKKEDRDERKKEDKRKDDSK
                     DDDETEEDNNQDEYDPMEAEEAEDEEDDRDEEEMTKRDDKRDINRYCKERPSKDKEKE
                     KTQMITINRDLLMAFVYFDQSHCGYLLEKDLEEILYTLGLHLSRAQVKKLLNKVVLRE
                     SCFYRKLTDTSKDEENHEESESLQEDMLGNRLLLPTPTVKQESKDVEENVGLIVYNGA
                     MVDVGSLLQKLEKSEKVRAEVEQKLQLLEEKTDEDEKTILNLENSNKSLSGELREVKK
                     DLSQLQENLKISENMNLQFENQMNKTIRNLSTVMDEIHTVLKKDNVKNEDKDQKSKEN
                     GASV"
     exon            168..340
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     exon            341..385
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     exon            386..418
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     exon            419..612
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     exon            613..727
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     exon            728..920
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1050
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1212
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1438
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1552
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1719
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1930
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2014
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2200
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2392
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2632
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2744
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2827
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..2974
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3095
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     exon            3096..3281
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..3487
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     exon            3488..4658
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3814..3819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /note="hexamer: AATAAA"
     polyA_site      3833
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /note="major polyA site"
     regulatory      4635..4640
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /note="hexamer: ATTAAA"
     polyA_site      4658
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /note="major polyA site"
ORIGIN      
        1 gacgggtttg aaatggcttc gatgttagcc gggacccgac tcagatcgat gctatagaag
       61 acaaacaagg gaaggttttt tttccttttg catcatggct caatttggag gacagaagaa
      121 tccgccatgg gctactcagt ttacagccac tgcagtatca cagccagctg cactgggtgt
      181 tcaacagcca tcactccttg gagcatctcc taccatttat acacagcaaa ctgcattggc
      241 agcagcaggc cttaccacac aaactccagc aaactatcag ttaacacaaa ctgctgcatt
      301 gcagcaacaa gccgcagctg cagcagctgc attacaacag caatattcac aacctcagca
      361 ggccctgtat agtgtgcaac aacagttaca gcaaccccag caaaccctct taacacagcc
      421 agctgttgca ctgcctacaa gccttagcct gtctactcct cagccaacag cacaaataac
      481 tgtatcatat ccaacaccaa ggtccagtca acagcaaacc cagcctcaga agcagcgtgt
      541 tttcacaggg gtggttacaa aactacatga tacgtttgga tttgtggatg aagatgtatt
      601 ctttcagctt agtgctgtca aagggaaaac cccccaagta ggtgacagag tattggttga
      661 agctacttat aatcctaata tgccttttaa atggaatgca cagagaattc aaacactacc
      721 aaatcagaat cagtcgcaaa cccagccatt actgaagact cctcctgctg tacttcagcc
      781 aattgcacca cagacaacat ttggtgttca gactcagccc cagccccagt cactgctgca
      841 ggcacagatt tcagcagctt ctattacacc actattgcag actcaaccac agcccttatt
      901 acagcagcct cagcaaaaag ctggtttatt gcagcctcct gttcgtatag tttcacagcc
      961 acaaccggca cgacgattag atcccccatc ccgattttca ggaagaaatg acagagggga
     1021 tcaagtgcct aacagaaaag atgatcgaag tcgtgagaga gagagagaaa gacgtagatc
     1081 gagagaaaga tcacctcaga ggaaacgttc ccgggaaaga tctccacgaa gagagcgaga
     1141 gcgatcacct cggagagttc gacgtgttgt tccacgttac acagttcagt tttcaaagtt
     1201 ttctttagat tgtcccagtt gtgacatgat ggaactaagg cgccgttatc aaaatttgta
     1261 tatacctagt gacttttttg atgctcaatt tacatgggtg gatgctttcc ctttgtcaag
     1321 accatttcag ctgggaaatt actgcaattt ttatgtaatg cacagagaag tagagtcctt
     1381 agaaaaaaat atggccattc ttgatccacc agatgctgac cacttataca gtgcaaaggt
     1441 aatgctgatg gctagcccta gtatggaaga tttatatcat aagtcatgtg ctcttgctga
     1501 ggacccacaa gaacttcgag atggattcca acatcctgct agacttgtta agtttttagt
     1561 gggcatgaaa ggcaaggatg aagctatggc cattggaggc cactggtctc cttcgttgga
     1621 tggaccagac ccagaaaaag atccctctgt gttgattaag actgctattc gttgttgtaa
     1681 ggctctgaca ggcattgatc taagtgtgtg cacacaatgg taccgttttg cagagattcg
     1741 ctaccatcgc cctgaggaga cccacaaggg gcgtacagtt ccagctcatg tggagacagt
     1801 ggttttattt ttcccggatg tttggcattg ccttcccacc cgctcagagt gggaaaccct
     1861 ctcccgagga tacaagcagc agctggtcga gaagcttcag ggtgaacgca aggaggctga
     1921 tggagaacag gatgaagaag agaaggatga tggtgaagct aaagaaattt ctacacctac
     1981 ccattggtct aaacttgatc caaagacaat gaaggtaaat gacctccgaa aagaattaga
     2041 aagtcgagct cttagttcca aaggattaaa atcccagtta atagcccgat tgacaaaaca
     2101 gcttaaagta gaggaacaaa aagaagaaca gaaggagtta gagaaatctg aaaaagaaga
     2161 ggatgaggat gatgatagga aatctgaaga cgataaagag gaagaagaaa ggaaacgtca
     2221 agaggaaata gaacgccagc gtcgagaaag aagatatatt ttgcctgatg aaccggccat
     2281 cattgtacat ccaaattggg ctgcaaaaag tggcaagttt gattgtagca tcatgtcttt
     2341 gagtgtccta ttggactaca gattagagga taataaagaa cattcatttg aggtttcatt
     2401 gtttgcggaa cttttcaacg aaatgcttca aagagatttt ggtgtccgta tatacaaatc
     2461 attactgtct cttcctgaga aagaggacaa aaaagaaaag gataaaaaaa gcaaaaaaga
     2521 tgagagaaaa gataaaaaag aagaaagaga tgatgaaact gatgaaccaa aacccaaacg
     2581 gagaaaatca ggcgatgata aagataaaaa agaagataga gatgaaagga agaaagaaga
     2641 taaaagaaaa gatgattcta aagatgatga tgaaactgaa gaagataaca atcaagatga
     2701 atatgaccct atggaagcag aagaagctga ggatgaagaa gatgataggg atgaggaaga
     2761 aatgaccaaa cgagatgaca aaagagatat caacagatac tgcaaggaga ggccctctaa
     2821 agataaggaa aaagaaaaga ctcaaatgat cacaattaac agagatctgt taatggcttt
     2881 tgtttatttt gatcaaagtc attgtggtta ccttcttgaa aaggatttgg aagaaatact
     2941 ttatactctt ggactacatc tttctcgggc tcaggtaaag aagcttctta ataaagtagt
     3001 gctccgtgaa tcttgctttt accggaaatt aacagacacc tcaaaagatg aagagaacca
     3061 tgaagagtct gagtcattgc aggaagatat gctaggaaac agattattac ttccaacacc
     3121 aacagtaaag caggaatcaa aggatgtgga agaaaatgtt ggcctcattg tgtacaatgg
     3181 tgcaatggta gatgtaggaa gcctcttgca aaaattggaa aagagcgaaa aagtaagagc
     3241 tgaggtagaa cagaagctgc agttactaga agaaaaaaca gatgaagatg aaaaaaccat
     3301 attaaatttg gagaattcca acaaaagcct ctctggtgaa ctcagagaag ttaaaaagga
     3361 ccttagtcag ttacaagaaa acttaaagat ttcggaaaac atgaatttac aatttgaaaa
     3421 ccaaatgaat aagacaatca gaaacttatc tacggtaatg gatgaaatcc acactgttct
     3481 caagaaggat aatgtaaaga atgaagacaa agatcaaaaa tccaaggaga atggtgccag
     3541 tgtatgataa aatccatgta gtgatgagga atggtgttaa ataatgtaat atataaaaat
     3601 catgatataa gaatgtttga aggtgatgca tgtttgattt tagtagtata aatgtatttt
     3661 agttcaaatg atgtataaag ttttatgaat gtgagtttct gcttttgaaa attgcttgta
     3721 attcctagcc ttcaaattat taaacactcc ttgagtgaaa taattttgca ttgcaaagtg
     3781 ttttaggatg aactttgtta tagttttaac tccaataaag ttcatcagtt taattgactg
     3841 tagtatttaa ttaccaaatt tcttttatta aaatgcctag aaatttttaa tttatagaat
     3901 tattaggttt taaaattttt agttcatctg ttaaaatttc agtcaaaatc ataaaatagc
     3961 atgatgctta atttttgcaa gttttttgaa actttttgtt ttttttactc atcaccaaaa
     4021 aatcccctct tgatcagtct ctaaaagcat tcattaaaaa ttcagttcag gccgggcacg
     4081 gtggctcaca cctgtaatcc caacactttg ggaggccgag gcaggtggat cacctgaggt
     4141 taggagttcg agaccagcct ggccaacatg gtgaaacccg gtctctacta aaaatataaa
     4201 aattagctgg gcatggtggt gggtgcctgt aatcccagct acttgggagg ctgaggcagg
     4261 agaatcgctt gaacccagga ggcggaggtt gcagtcactc aggatcatgc agctacactc
     4321 cagcctgggc gacaagagtg aaactccatc tcaaaaagaa aaaaaaaaaa aatcagttta
     4381 tttgaaagac agtatatcag aaagaaagaa gcaatagaga actagtattg ttctttatgg
     4441 gttagacttt acataatatt agttgtcctg atgtcaatgt tactgctttc aattaatttt
     4501 tctactttcc cagaatagca tctatattcc ttttaatttt gagggtttaa aaaaaaatgc
     4561 agtgtatgtc aaatttacag tttagtacca agccagtaga tgtcagtatg atgccttaaa
     4621 ttaagtcttc tttaattaaa gatatttttt taaattaa
//
