LOCUS       NP_060707               1150 aa            linear   PRI 28-APR-2025
DEFINITION  cell division cycle and apoptosis regulator protein 1 isoform a
            [Homo sapiens].
ACCESSION   NP_060707
VERSION     NP_060707.2
DBSOURCE    REFSEQ: accession NM_018237.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1150)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1150)
  AUTHORS   Ji,Q., Tu,Z., Liu,J., Zhou,Z., Li,F., Zhu,X. and Huang,K.
  TITLE     RUNX1-PDIA5 Axis Promotes Malignant Progression of Glioblastoma by
            Regulating CCAR1 Protein Expression
  JOURNAL   Int J Biol Sci 20 (11), 4364-4381 (2024)
   PUBMED   39247813
  REMARK    GeneRIF: RUNX1-PDIA5 Axis Promotes Malignant Progression of
            Glioblastoma by Regulating CCAR1 Protein Expression.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1150)
  AUTHORS   Chen,S., Zhao,Q., Zhang,R., Liu,J., Peng,W., Xu,H., Li,X., Wang,X.,
            Wu,S., Li,G. and Nan,A.
  TITLE     A transcribed ultraconserved noncoding RNA, uc.285+, promotes
            colorectal cancer proliferation through dual targeting of CDC42 by
            directly binding mRNA and protein
  JOURNAL   Transl Res 270, 52-65 (2024)
   PUBMED   38552953
  REMARK    GeneRIF: A transcribed ultraconserved noncoding RNA, uc.285+,
            promotes colorectal cancer proliferation through dual targeting of
            CDC42 by directly binding mRNA and protein.
REFERENCE   4  (residues 1 to 1150)
  AUTHORS   Harada,N., Asada,S., Jiang,L., Nguyen,H., Moreau,L., Marina,R.J.,
            Adelman,K., Iyer,D.R. and D'Andrea,A.D.
  TITLE     The splicing factor CCAR1 regulates the Fanconi anemia/BRCA pathway
  JOURNAL   Mol Cell 84 (14), 2618-2633 (2024)
   PUBMED   39025073
  REMARK    GeneRIF: The splicing factor CCAR1 regulates the Fanconi
            anemia/BRCA pathway.
REFERENCE   5  (residues 1 to 1150)
  AUTHORS   Huang,C., Xu,R., Zhu,X. and Jiang,H.
  TITLE     m6A-modified circABCC4 promotes stemness and metastasis of prostate
            cancer by recruiting IGF2BP2 to increase stability of CCAR1
  JOURNAL   Cancer Gene Ther 30 (10), 1426-1440 (2023)
   PUBMED   37563361
  REMARK    GeneRIF: m6A-modified circABCC4 promotes stemness and metastasis of
            prostate cancer by recruiting IGF2BP2 to increase stability of
            CCAR1.
REFERENCE   6  (residues 1 to 1150)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   7  (residues 1 to 1150)
  AUTHORS   McDonald,E.R. 3rd and El-Deiry,W.S.
  TITLE     Suppression of caspase-8- and -10-associated RING proteins results
            in sensitization to death ligands and inhibition of tumor cell
            growth
  JOURNAL   Proc Natl Acad Sci U S A 101 (16), 6170-6175 (2004)
   PUBMED   15069192
REFERENCE   8  (residues 1 to 1150)
  AUTHORS   Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
            Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
            Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
            Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
            Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
            Superti-Furga,G.
  TITLE     A physical and functional map of the human TNF-alpha/NF-kappa B
            signal transduction pathway
  JOURNAL   Nat Cell Biol 6 (2), 97-105 (2004)
   PUBMED   14743216
  REMARK    Erratum:[Nat Cell Biol. 2004 May;6(5):465]
REFERENCE   9  (residues 1 to 1150)
  AUTHORS   Rishi,A.K., Zhang,L., Boyanapalli,M., Wali,A., Mohammad,R.M.,
            Yu,Y., Fontana,J.A., Hatfield,J.S., Dawson,M.I., Majumdar,A.P. and
            Reichert,U.
  TITLE     Identification and characterization of a cell cycle and apoptosis
            regulatory protein-1 as a novel mediator of apoptosis signaling by
            retinoid CD437
  JOURNAL   J Biol Chem 278 (35), 33422-33435 (2003)
   PUBMED   12816952
  REMARK    GeneRIF: cell cycle and apoptosis regulatory protein-1 is a novel
            mediator of apoptosis signaling by retinoid CD437
REFERENCE   10 (residues 1 to 1150)
  AUTHORS   Zhou,Z., Licklider,L.J., Gygi,S.P. and Reed,R.
  TITLE     Comprehensive proteomic analysis of the human spliceosome
  JOURNAL   Nature 419 (6903), 182-185 (2002)
   PUBMED   12226669
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA511293.1, BC132725.1, AY249140.1, DB636717.1 and BU617955.1.
            
            On Apr 29, 2004 this sequence version replaced NP_060707.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.250323.1,
                                           SRR1660805.194872.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265872.11/ ENSP00000265872.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1150
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.3"
     Protein         1..1150
                     /product="cell division cycle and apoptosis regulator
                     protein 1 isoform a"
                     /note="cell division cycle and apoptosis regulator protein
                     1; death inducer with SAP domain; cell cycle and apoptosis
                     regulatory protein 1"
                     /calculated_mol_wt=132690
     Region          1..249
                     /region_name="Interaction with AR.
                     /evidence=ECO:0000269|PubMed:23887938"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IX12.2)"
     Region          124..146
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IX12.2)"
     Region          148..204
                     /region_name="S1-like"
                     /note="pfam14444"
                     /db_xref="CDD:464176"
     Region          203..660
                     /region_name="Interaction with GATA2.
                     /evidence=ECO:0000269|PubMed:23887938"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IX12.2)"
     Region          285..354
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IX12.2)"
     Region          372..454
                     /region_name="BURAN"
                     /note="BURAN domain; pfam19257"
                     /db_xref="CDD:466013"
     Site            456
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q8IX12.2)"
     Region          479..604
                     /region_name="DBC1"
                     /note="pfam14443"
                     /db_xref="CDD:464175"
     Region          600..638
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IX12.2)"
     Site            627
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q8IX12.2)"
     Region          637..670
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          643..1150
                     /region_name="Interaction with GATA1.
                     /evidence=ECO:0000269|PubMed:24245781"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IX12.2)"
     Site            667
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (Q8IX12.2)"
     Region          673..713
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IX12.2)"
     Site            685
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (Q8IX12.2)"
     Site            697
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (Q8IX12.2)"
     Region          723..790
                     /region_name="LAIKA"
                     /note="LAIKA domain; pfam19256"
                     /db_xref="CDD:466012"
     Region          796..915
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IX12.2)"
     Site            861
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q8IX12.2)"
     Region          <1010..>1145
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1150
                     /gene="CCAR1"
                     /gene_synonym="uc.285+"
                     /coded_by="NM_018237.4:95..3547"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS7282.1"
                     /db_xref="GeneID:55749"
                     /db_xref="HGNC:HGNC:24236"
                     /db_xref="MIM:612569"
ORIGIN      
        1 maqfggqknp pwatqftata vsqpaalgvq qpsllgaspt iytqqtalaa aglttqtpan
       61 yqltqtaalq qqaaaaaaal qqqysqpqqa lysvqqqlqq pqqtlltqpa valptslsls
      121 tpqptaqitv syptprssqq qtqpqkqrvf tgvvtklhdt fgfvdedvff qlsavkgktp
      181 qvgdrvlvea tynpnmpfkw naqriqtlpn qnqsqtqpll ktppavlqpi apqttfgvqt
      241 qpqpqsllqa qisaasitpl lqtqpqpllq qpqqkagllq ppvrivsqpq parrldppsr
      301 fsgrndrgdq vpnrkddrsr erererrrsr erspqrkrsr ersprrerer sprrvrrvvp
      361 rytvqfskfs ldcpscdmme lrrryqnlyi psdffdaqft wvdafplsrp fqlgnycnfy
      421 vmhrevesle knmaildppd adhlysakvm lmaspsmedl yhkscalaed pqelrdgfqh
      481 parlvkflvg mkgkdeamai gghwspsldg pdpekdpsvl iktairccka ltgidlsvct
      541 qwyrfaeiry hrpeethkgr tvpahvetvv lffpdvwhcl ptrsewetls rgykqqlvek
      601 lqgerkeadg eqdeeekddg eakeistpth wskldpktmk vndlrkeles ralsskglks
      661 qliarltkql kveeqkeeqk eleksekeed edddrksedd keeeerkrqe eierqrrerr
      721 yilpdepaii vhpnwaaksg kfdcsimsls vlldyrledn kehsfevslf aelfnemlqr
      781 dfgvriyksl lslpekedkk ekdkkskkde rkdkkeerdd etdepkpkrr ksgddkdkke
      841 drderkkedk rkddskddde teednnqdey dpmeaeeaed eeddrdeeem tkrddkrdin
      901 ryckerpskd kekektqmit inrdllmafv yfdqshcgyl lekdleeily tlglhlsraq
      961 vkkllnkvvl rescfyrklt dtskdeenhe eseslqedml gnrlllptpt vkqeskdvee
     1021 nvglivynga mvdvgsllqk leksekvrae veqklqllee ktdedektil nlensnksls
     1081 gelrevkkdl sqlqenlkis enmnlqfenq mnktirnlst vmdeihtvlk kdnvknedkd
     1141 qkskengasv
//
