LOCUS       NM_032449               5650 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens coiled-coil and C2 domain containing 1B (CC2D1B),
            transcript variant 1, mRNA.
ACCESSION   NM_032449 XM_114087
VERSION     NM_032449.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5650)
  AUTHORS   Reiff,T., Baeumers,M., Tibbe,C. and Klein,T.
  TITLE     Unravelling of Hidden Secrets: The Tumour Suppressor Lethal (2)
            Giant Discs (Lgd)/CC2D1, Notch Signalling and Cancer
  JOURNAL   Adv Exp Med Biol 1287, 31-46 (2021)
   PUBMED   33034024
  REMARK    GeneRIF: Unravelling of Hidden Secrets: The Tumour Suppressor
            Lethal (2) Giant Discs (Lgd)/CC2D1, Notch Signalling and Cancer.
            Review article
REFERENCE   2  (bases 1 to 5650)
  AUTHORS   Baeumers,M., Ruhnau,K., Breuer,T., Pannen,H., Goerlich,B.,
            Kniebel,A., Haensch,S., Weidtkamp-Peters,S., Schmitt,L. and
            Klein,T.
  TITLE     Lethal (2) giant discs (Lgd)/CC2D1 is required for the full
            activity of the ESCRT machinery
  JOURNAL   BMC Biol 18 (1), 200 (2020)
   PUBMED   33349255
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5650)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5650)
  AUTHORS   Ventimiglia,L.N., Cuesta-Geijo,M.A., Martinelli,N., Caballe,A.,
            Macheboeuf,P., Miguet,N., Parnham,I.M., Olmos,Y., Carlton,J.G.,
            Weissenhorn,W. and Martin-Serrano,J.
  TITLE     CC2D1B Coordinates ESCRT-III Activity during the Mitotic
            Reformation of the Nuclear Envelope
  JOURNAL   Dev Cell 47 (5), 547-563 (2018)
   PUBMED   30513301
  REMARK    GeneRIF: CC2D1B is essential for ESCRT-III activity during mitotic
            reformation of the nuclear envelope.
REFERENCE   5  (bases 1 to 5650)
  AUTHORS   Deshar,R., Cho,E.B., Yoon,S.K. and Yoon,J.B.
  TITLE     CC2D1A and CC2D1B regulate degradation and signaling of EGFR and
            TLR4
  JOURNAL   Biochem Biophys Res Commun 480 (2), 280-287 (2016)
   PUBMED   27769858
  REMARK    GeneRIF: CC2D1B regulates degradation and signaling of EGFR and
            TLR4.
REFERENCE   6  (bases 1 to 5650)
  AUTHORS   Hadjighassem,M.R., Austin,M.C., Szewczyk,B., Daigle,M.,
            Stockmeier,C.A. and Albert,P.R.
  TITLE     Human Freud-2/CC2D1B: a novel repressor of postsynaptic
            serotonin-1A receptor expression
  JOURNAL   Biol Psychiatry 66 (3), 214-222 (2009)
   PUBMED   19423080
  REMARK    GeneRIF: Human Freud-2/CC2D1B binds to the 5-HT1A dual repressor
            element and represses the human 5-HT1A receptor gene to regulate
            its expression in non-serotonergic cells and neurons.
REFERENCE   7  (bases 1 to 5650)
  AUTHORS   Rogaeva,A., Galaraga,K. and Albert,P.R.
  TITLE     The Freud-1/CC2D1A family: transcriptional regulators implicated in
            mental retardation
  JOURNAL   J Neurosci Res 85 (13), 2833-2838 (2007)
   PUBMED   17394259
  REMARK    Review article
REFERENCE   8  (bases 1 to 5650)
  AUTHORS   Jaekel,R. and Klein,T.
  TITLE     The Drosophila Notch inhibitor and tumor suppressor gene lethal (2)
            giant discs encodes a conserved regulator of endosomal trafficking
  JOURNAL   Dev Cell 11 (5), 655-669 (2006)
   PUBMED   17084358
  REMARK    GeneRIF: Paper describes a function of Cc2d1b/Cc2d1a and their
            Drosophila homologue l(2)gd in D.melanogaster in Notch trafficking.
REFERENCE   9  (bases 1 to 5650)
  AUTHORS   Gallagher,C.M. and Knoblich,J.A.
  TITLE     The conserved c2 domain protein lethal (2) giant discs regulates
            protein trafficking in Drosophila
  JOURNAL   Dev Cell 11 (5), 641-653 (2006)
   PUBMED   17084357
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB458797.1, BQ073406.1, AB058739.1, AL513218.27 and BM975102.1.
            
            On Aug 13, 2020 this sequence version replaced NM_032449.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.175948.1,
                                           SRR14038191.294486.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                DB458797.1         1-78
            79-754              BQ073406.1         1-676
            755-4384            AB058739.1         186-3815
            4385-5603           AL513218.27        41446-42664         c
            5604-5650           BM975102.1         21-67               c
FEATURES             Location/Qualifiers
     source          1..5650
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..5650
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /note="coiled-coil and C2 domain containing 1B"
                     /db_xref="GeneID:200014"
                     /db_xref="HGNC:HGNC:29386"
     exon            1..137
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            138..220
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..2728
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil and C2 domain-containing protein 1B; freud-2;
                     FRE under dual repression-binding protein 2; five prime
                     repressor element under dual repression-binding protein 2;
                     lethal (2) giant discs homolog 1"
                     /codon_start=1
                     /product="coiled-coil and C2 domain-containing protein 1B
                     isoform 1"
                     /protein_id="NP_115825.1"
                     /db_xref="CCDS:CCDS30714.1"
                     /db_xref="GeneID:200014"
                     /db_xref="HGNC:HGNC:29386"
                     /translation="MMPGPRPRKGPQARGQGVAAAKQMGLFMEFGPEDMLLGMDEAED
                     DEDLEAELLALTGEAQTTGKKPAPKGQAPLPMAHIEKLAADCMRDVEEEEEEEGLEED
                     AELLTELQEVLGVDEETEPLDGDEVADPGGSEEENGLEDTEPPVQTAVLTASAPAAQA
                     GASQGLHALLEERIHNYREAAASAKEAGEAAKARRCERGLKTLESQLASVRRGRKINE
                     DEIPPPVALGKRPLAPQEPANRSPETDPPAPPALESDNPSQPETSLPGISAQPVSDLD
                     PDPRALLSSRQREYKVAALSAKRAGELDRARELMRIGKRFGAVLEALEKGQPVDLSAM
                     PPAPEDLKPQQASQAPTAPSVIPPAVERVQPVMAPDVPATPVAPTESQTVLDALQQRL
                     NKYREAGIQARSGGDERKARMHERIAKQYQDAIRAHRAGRKVNFAELPVPPGFPPIPG
                     LESTMGVEEDAVAATLAAAEKLASAEDSAPADKDEDEPPGHLQGEPPAQAPVAKKPAR
                     PTVPSSQRLPEPRASSSKESPSPSVREQLALLEARKLQYQRAALQAKRSQDLEQAKAY
                     LRVAKWLEAQIIQARSGRPVDLSKVPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQ
                     KMLLEQQEKCLLFSKQFMHQGNVAETTRFEKLAQDRKKQLEILQLAQAQGLDPPTHHF
                     ELKTFQTVRIFSELNSTEMHLIIVRGMNLPAPPGVTPDDLDAFVRFEFHYPNSDQAQK
                     SKTAVVKNTNSPEFDQLFKLNINRNHRGFKRVIQSKGIKFEIFHKGSFFRSDKLVGTA
                     HLKLERLENECEIREIVEVLDGRKPTGGKLEVKVRLREPLSGQDVQMVTENWLVLEPR
                     GL"
     exon            221..365
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            366..469
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            470..628
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..754
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..914
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1093
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1169
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1277
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1408
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1481
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1612
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1748
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1921
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2047
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2106
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2223
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2297
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2356
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2408
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2508
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2599
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..5650
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3692..3697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /note="hexamer: AATATA"
     polyA_site      3715
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
     regulatory      5626..5631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /note="hexamer: AATAAA"
     polyA_site      5650
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /note="major polyA site"
ORIGIN      
        1 agtggggtca cgtgttgcgc gcgagccacc tcccctgctg gcgcttcctg tcgctaccgc
       61 tgcggcccag ggcccgcggg agcccagggc ggtgccgggt gagacaaggc cggggtttgg
      121 ctcggattca ccgcgaggta tctaggctgc catgatgcca gggccaagac ctcggaaggg
      181 ccctcaggcc agaggccaag gggtggccgc tgccaagcag atggggctct ttatggagtt
      241 tggccctgag gacatgctgc tgggcatgga tgaggctgaa gatgatgagg acctggaggc
      301 tgagctgctg gctctcacag gggaagcaca aaccacaggc aagaagccag cacccaaggg
      361 gcaggccccc ctgcccatgg cccacatcga gaagttggcg gcagactgta tgcgggatgt
      421 ggaggaggag gaggaggagg aagggctgga ggaagatgca gagctgctga cggagctgca
      481 ggaggtctta ggtgtggacg aggagactga gcccctggat ggtgatgagg tagctgaccc
      541 aggcggctct gaggaggaga acggcctaga agacactgaa cctccagtgc agacagccgt
      601 cctgacagct tcagccccag cagctcaggc cggagcatct caggggctac acgctttgct
      661 ggaggaacgg attcacaact accgagaggc tgcggccagt gccaaggagg caggcgaagc
      721 agccaaagcc aggcgctgcg agcgcggcct gaagaccttg gagtcgcagc tagcctctgt
      781 gaggagaggc agaaagatca atgaggatga gatcccacct ccagtggcct taggaaagcg
      841 gcccctggcc ccccaggaac cagccaacag gagccctgag acagaccctc cagctccccc
      901 tgccttggag tcagacaacc cctcccaacc tgagaccagc ctccctggca tttctgccca
      961 gcccgtttca gacttagacc cagacccgcg ggccctgctg tcatcccgac agagagagta
     1021 caaagtggct gccctcagtg ccaagcgggc tggagagcta gaccgtgccc gagagctcat
     1081 gaggattggg aagagattcg gtgctgtcct ggaggccctg gagaaggggc agcccgtgga
     1141 tctgagtgcc atgcccccgg cacctgagga tctgaagccc cagcaggctt ctcaggctcc
     1201 cacagcaccc tcagtcattc ccccagccgt ggagcgagtg cagccagtga tggcccctga
     1261 cgtcccagca accccagtgg cccctacaga gtcacagaca gtgctggatg ccctgcagca
     1321 gaggctgaac aagtaccgcg aggcgggcat ccaggcccgg agtggtgggg acgagcgcaa
     1381 ggctcggatg catgagcgca ttgccaagca atatcaagat gctattcgag cacaccgagc
     1441 aggacggaaa gtcaactttg ctgaattgcc tgttcctcca ggatttcccc ccatccctgg
     1501 cctggagtcc actatgggtg ttgaggagga cgcagtggca gcgacattgg cagctgcaga
     1561 gaaactggcc tctgcagagg attcagcccc ggctgataaa gacgaggacg agcctcctgg
     1621 gcacctgcag ggtgagcccc cagcacaggc cccagtggcc aagaaacctg cacggcccac
     1681 agtcccttca tcccagcgcc tgcctgagcc cagggcctca agttctaagg agtcaccgag
     1741 tccatctgtg cgggagcagc tggcactgct ggaggcacgg aaactgcagt atcagcgggc
     1801 agccctgcag gccaagcgca gccaggacct ggagcaggcc aaagcctatc tgcgggtagc
     1861 caaatggctt gaggctcaga tcatccaggc ccgatctggc agacctgttg atctgtccaa
     1921 ggtgccttcg cccttgacgg atgaggaggg tgacttcatc ctcatccacc atgaggacct
     1981 gcgactctcc cagaaggcgg aggaggtgta tgcccagctg caaaaaatgc ttctggagca
     2041 acaagagaag tgcctgctgt tctccaagca gttcatgcac cagggcaacg tggctgagac
     2101 cacccgattt gagaagcttg ctcaggaccg caagaaacag ctggagatcc tgcagctggc
     2161 ccaggctcag ggcctcgacc ctcccaccca ccactttgag ttgaagacat tccagactgt
     2221 gaggatcttc tcagaactca acagcacaga aatgcatctg atcattgtcc ggggaatgaa
     2281 cctcccagcc cctccagggg tgactcccga tgacctggat gcttttgtgc ggtttgagtt
     2341 tcactaccct aactcggacc aggctcaaaa aagcaaaaca gctgtggtga agaacacaaa
     2401 ctctccagaa tttgatcaac tcttcaaact aaacatcaac cgaaaccacc ggggcttcaa
     2461 gagggtgatc cagagcaaag gcatcaagtt tgagatcttc cacaaagggt ccttcttcag
     2521 aagcgacaag ctggttggca cagcacacct gaaactggag cggctggaga atgagtgtga
     2581 gatcagagaa attgtggagg tcctggatgg aaggaagccc accgggggga agctggaggt
     2641 gaaggtgagg ctgcgggagc ctctgagtgg ccaggatgtg cagatggtca ctgagaactg
     2701 gctggttctg gagcccaggg gcttgtgagg tgggcagctc tctgggcctt cagaaccttt
     2761 gccccctcct tttactcaac taactactca actcatatct ggagagaaaa cctaggagtt
     2821 tctcatctat gagaaagacc taccatgctg ggtagggctt atgggctgag tttctgatgt
     2881 tcctcagtag aactgggaag agaaggtaac cttccaaggt ttaactatct atctatctat
     2941 ctatcttcag gaaacccttt ctaaaatctt tgtgttttca ctgcagttta gactgacttc
     3001 ttgtgctttg cacccctgtg tagccgatgg ccagcaccag gagaggagtc aggccgcgac
     3061 tgtgcaggag atgactttcc cagctttgct ggcttcagaa gcctttgtac ataagagatg
     3121 ctgctaccca agcaccaaag acctgttaag catgtgcact actgaccacg actctggtct
     3181 ttcctgttgt tggcccctct ggggctctac agaaacaggc tgggttccag gagcccatct
     3241 ccccgctgtc tccccctgcc ccgagtctgg aagagggcaa ggacacttcc attcctctgt
     3301 accatggagt cctgcagccc cttaacccct gcgtggcaac tgtgtacagc ttacccctgc
     3361 ctccagttgc accacttcta gatgtgcctt taaaagatct aactatggga tgggagaact
     3421 tgagggtgat cgggaacctc ccctgctgag ggtggtgtca gggttccgtg actccagtgg
     3481 gccagtggta gcctgtccca gacaactccg tcaccccagc tctgcctgtg cctttatccc
     3541 tgacagctgc tgcactagcc ttcctgcttc cctaaggact tagtggaggg ggaaagttgt
     3601 ttttggtact acttggtggg aagtaagggg aaggttggat cttgggtttg gtctacccac
     3661 ccaagagaaa agactgttaa ctggaagaaa aaatatatat ataaaatttt atgtagacac
     3721 gtttatttat ctaggaaact aagtctaact cattgtaggg attttatact caactataca
     3781 gagtatccac caaagtccta atctaaagtc ctgctccctg tcacttttta aaagccaggg
     3841 tagcagtaac atgacaaacg gctgctgtgg cttcctcttg agagaggaca gggaaagcct
     3901 ttcctcttcg gctggttatg tggggaactt ccttagtttt tttccacaag aaattctcct
     3961 ttggctttgt ttttctgaat ggatggagac tatgaagggg tttgtagttg taagagattt
     4021 aatattcaaa actgaaatat tctgcatttc ttagaaatac cccatcttcc cccaccccct
     4081 ttttgaatta ttaattcaag atcaacaaag cattcctcaa gatcactttt aaaaaaggtt
     4141 agaagtgaag caaatacatt cagcttactg atcactatag tattgcataa gcacagctca
     4201 agaactgagc tttgtatgtg tccttttggg ggataacagg gctggaccat gcttccctgc
     4261 ccttaaacgc agagctttta gtgggtcaca gagcgggaac tacacacaag tgactttttt
     4321 ccccatgagc cctctggccg attttttttt tttttttttt tttgagacag agtagctctc
     4381 tgccagccag gctggagtgc agtggcatga tctcagctcg ctgcaacccc cacctcccag
     4441 gttcaagcga ttctcctgtg tcagtctcct gagtagctgg gattacaggc acccaccact
     4501 atgcccagct aattttttta tttttagtag agacggtgtt tcaccatgtt ggtcaggctg
     4561 gtctcgaact cctgacctca tgatccaccc acctcagcct cccaaagtgc tgggattaca
     4621 ggtgtgagcc accgcacccg gctggccaat cttatcagaa gtgagctacc aaaacttcca
     4681 cagatgtgag atttaacact taattgcagt cacgtgtatg caacacagca ataatctaga
     4741 atgaaaagga gggtgattag ccttcataag atgacctata gagcaaagaa aggtgactgg
     4801 aagggttcct aacccaacct actcccctta gggtgtgtat ccaacccagt gcttcctaag
     4861 agggttacgg accactgtgg ttatcctcta aagttccagc cagctctagg agtttctaaa
     4921 ttcaggcctc tgttggaaat ggcctatttc gatagataga aagttttcta tagctctaaa
     4981 ggtttctcct ttgcaaccca ttcaatttca gtctgctgct ttgctctttc aaaacagaac
     5041 ctccaggctg acgaggcaag acaaagcctc ccaccagact tggagattga agttcttaaa
     5101 aggcctttgt tgtagccaaa ggcatgcatg cgtcactggt agtaggagga gcctgtccca
     5161 gcttcatctt gtcctgagat ttatccacat acaggaaaca ggcgggacac agtggctcac
     5221 gcctgtaatc ccaccacttt ggaaagctga ggcaggtgga tcacctgagg tcaggaattc
     5281 aagaccagcc tggccaacat ggtgaaaccc cgtctccact aaaaacaaaa acaattagct
     5341 gggcatggtg gccggcgcct gtaatcccag ctactaggga ggctgagaca cacgaatccc
     5401 ttgagcccag gaagcagagg ttgcagtgag cctcgattgt accactgcac tccagcctgg
     5461 gcgacagagc aagactctgt ctcaaaacaa acacaaatac agtatccaaa cattggagat
     5521 tagtgactca cctgcagttg ggagccagct acaacccaaa tcattttaaa attttcaatt
     5581 ctttgatctc atgcaatgca cactttcttc tgaattagca aactgaataa actacagaaa
     5641 ttttttagaa
//
