LOCUS       NM_001330585            5338 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens coiled-coil and C2 domain containing 1B (CC2D1B),
            transcript variant 2, mRNA.
ACCESSION   NM_001330585 XM_005270591
VERSION     NM_001330585.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5338)
  AUTHORS   Reiff,T., Baeumers,M., Tibbe,C. and Klein,T.
  TITLE     Unravelling of Hidden Secrets: The Tumour Suppressor Lethal (2)
            Giant Discs (Lgd)/CC2D1, Notch Signalling and Cancer
  JOURNAL   Adv Exp Med Biol 1287, 31-46 (2021)
   PUBMED   33034024
  REMARK    GeneRIF: Unravelling of Hidden Secrets: The Tumour Suppressor
            Lethal (2) Giant Discs (Lgd)/CC2D1, Notch Signalling and Cancer.
            Review article
REFERENCE   2  (bases 1 to 5338)
  AUTHORS   Baeumers,M., Ruhnau,K., Breuer,T., Pannen,H., Goerlich,B.,
            Kniebel,A., Haensch,S., Weidtkamp-Peters,S., Schmitt,L. and
            Klein,T.
  TITLE     Lethal (2) giant discs (Lgd)/CC2D1 is required for the full
            activity of the ESCRT machinery
  JOURNAL   BMC Biol 18 (1), 200 (2020)
   PUBMED   33349255
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5338)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5338)
  AUTHORS   Ventimiglia,L.N., Cuesta-Geijo,M.A., Martinelli,N., Caballe,A.,
            Macheboeuf,P., Miguet,N., Parnham,I.M., Olmos,Y., Carlton,J.G.,
            Weissenhorn,W. and Martin-Serrano,J.
  TITLE     CC2D1B Coordinates ESCRT-III Activity during the Mitotic
            Reformation of the Nuclear Envelope
  JOURNAL   Dev Cell 47 (5), 547-563 (2018)
   PUBMED   30513301
  REMARK    GeneRIF: CC2D1B is essential for ESCRT-III activity during mitotic
            reformation of the nuclear envelope.
REFERENCE   5  (bases 1 to 5338)
  AUTHORS   Deshar,R., Cho,E.B., Yoon,S.K. and Yoon,J.B.
  TITLE     CC2D1A and CC2D1B regulate degradation and signaling of EGFR and
            TLR4
  JOURNAL   Biochem Biophys Res Commun 480 (2), 280-287 (2016)
   PUBMED   27769858
  REMARK    GeneRIF: CC2D1B regulates degradation and signaling of EGFR and
            TLR4.
REFERENCE   6  (bases 1 to 5338)
  AUTHORS   Hadjighassem,M.R., Austin,M.C., Szewczyk,B., Daigle,M.,
            Stockmeier,C.A. and Albert,P.R.
  TITLE     Human Freud-2/CC2D1B: a novel repressor of postsynaptic
            serotonin-1A receptor expression
  JOURNAL   Biol Psychiatry 66 (3), 214-222 (2009)
   PUBMED   19423080
  REMARK    GeneRIF: Human Freud-2/CC2D1B binds to the 5-HT1A dual repressor
            element and represses the human 5-HT1A receptor gene to regulate
            its expression in non-serotonergic cells and neurons.
REFERENCE   7  (bases 1 to 5338)
  AUTHORS   Rogaeva,A., Galaraga,K. and Albert,P.R.
  TITLE     The Freud-1/CC2D1A family: transcriptional regulators implicated in
            mental retardation
  JOURNAL   J Neurosci Res 85 (13), 2833-2838 (2007)
   PUBMED   17394259
  REMARK    Review article
REFERENCE   8  (bases 1 to 5338)
  AUTHORS   Jaekel,R. and Klein,T.
  TITLE     The Drosophila Notch inhibitor and tumor suppressor gene lethal (2)
            giant discs encodes a conserved regulator of endosomal trafficking
  JOURNAL   Dev Cell 11 (5), 655-669 (2006)
   PUBMED   17084358
  REMARK    GeneRIF: Paper describes a function of Cc2d1b/Cc2d1a and their
            Drosophila homologue l(2)gd in D.melanogaster in Notch trafficking.
REFERENCE   9  (bases 1 to 5338)
  AUTHORS   Gallagher,C.M. and Knoblich,J.A.
  TITLE     The conserved c2 domain protein lethal (2) giant discs regulates
            protein trafficking in Drosophila
  JOURNAL   Dev Cell 11 (5), 641-653 (2006)
   PUBMED   17084357
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL513218.27.
            
            On Jun 2, 2019 this sequence version replaced NM_001330585.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction and differs in the 3' UTR compared to variant 1.
            The resulting isoform (2) has the same N- and C-termini but is
            shorter compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.1017.1,
                                           SRR14038196.1996325.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284376.8/ ENSP00000284376.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AL513218.27        56871-57007         c
            138-220             AL513218.27        55354-55436         c
            221-365             AL513218.27        53404-53548         c
            366-469             AL513218.27        52315-52418         c
            470-628             AL513218.27        51776-51934         c
            629-754             AL513218.27        51226-51351         c
            755-914             AL513218.27        50876-51035         c
            915-1093            AL513218.27        50507-50685         c
            1094-1169           AL513218.27        50261-50336         c
            1170-1277           AL513218.27        50052-50159         c
            1278-1408           AL513218.27        49829-49959         c
            1409-1481           AL513218.27        49488-49560         c
            1482-1612           AL513218.27        49133-49263         c
            1613-1730           AL513218.27        48583-48700         c
            1731-1903           AL513218.27        48328-48500         c
            1904-2029           AL513218.27        47803-47928         c
            2030-2088           AL513218.27        47186-47244         c
            2089-2205           AL513218.27        46988-47104         c
            2206-2279           AL513218.27        46573-46646         c
            2280-2338           AL513218.27        46410-46468         c
            2339-2390           AL513218.27        46200-46251         c
            2391-2490           AL513218.27        45642-45741         c
            2491-2581           AL513218.27        45410-45500         c
            2582-2711           AL513218.27        44320-44449         c
            2712-5338           AL513218.27        41399-44025         c
FEATURES             Location/Qualifiers
     source          1..5338
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..5338
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /note="coiled-coil and C2 domain containing 1B"
                     /db_xref="GeneID:200014"
                     /db_xref="HGNC:HGNC:29386"
     exon            1..137
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            138..220
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..2710
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     coiled-coil and C2 domain-containing protein 1B; freud-2;
                     FRE under dual repression-binding protein 2; five prime
                     repressor element under dual repression-binding protein 2;
                     lethal (2) giant discs homolog 1"
                     /codon_start=1
                     /product="coiled-coil and C2 domain-containing protein 1B
                     isoform 2"
                     /protein_id="NP_001317514.1"
                     /db_xref="CCDS:CCDS81323.1"
                     /db_xref="GeneID:200014"
                     /db_xref="HGNC:HGNC:29386"
                     /translation="MMPGPRPRKGPQARGQGVAAAKQMGLFMEFGPEDMLLGMDEAED
                     DEDLEAELLALTGEAQTTGKKPAPKGQAPLPMAHIEKLAADCMRDVEEEEEEEGLEED
                     AELLTELQEVLGVDEETEPLDGDEVADPGGSEEENGLEDTEPPVQTAVLTASAPAAQA
                     GASQGLHALLEERIHNYREAAASAKEAGEAAKARRCERGLKTLESQLASVRRGRKINE
                     DEIPPPVALGKRPLAPQEPANRSPETDPPAPPALESDNPSQPETSLPGISAQPVSDLD
                     PDPRALLSSRQREYKVAALSAKRAGELDRARELMRIGKRFGAVLEALEKGQPVDLSAM
                     PPAPEDLKPQQASQAPTAPSVIPPAVERVQPVMAPDVPATPVAPTESQTVLDALQQRL
                     NKYREAGIQARSGGDERKARMHERIAKQYQDAIRAHRAGRKVNFAELPVPPGFPPIPG
                     LESTMGVEEDAVAATLAAAEKLASAEDSAPADKDEDEGEPPAQAPVAKKPARPTVPSS
                     QRLPEPRASSSKESPSPSVREQLALLEARKLQYQRAALQAKRSQDLEQAKAYLRVAKW
                     LEAQIIQARSGRPVDLSKVPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKMLLEQ
                     QEKCLLFSKQFMHQGNVAETTRFEKLAQDRKKQLEILQLAQAQGLDPPTHHFELKTFQ
                     TVRIFSELNSTEMHLIIVRGMNLPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVV
                     KNTNSPEFDQLFKLNINRNHRGFKRVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLER
                     LENECEIREIVEVLDGRKPTGGKLEVKVRLREPLSGQDVQMVTENWLVLEPRGL"
     exon            221..365
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            366..469
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            470..628
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..754
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..914
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1093
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1169
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1277
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1408
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1481
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1612
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1730
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1903
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2029
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2088
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2205
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2279
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2338
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2390
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2490
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2581
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..2711
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..5338
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3380..3385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /note="hexamer: AATATA"
     polyA_site      3403
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
     regulatory      5314..5319
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /note="hexamer: AATAAA"
     polyA_site      5338
                     /gene="CC2D1B"
                     /gene_synonym="Lgd1"
                     /note="major polyA site"
ORIGIN      
        1 agtggggtca cgtgttgcgc gcgagccacc tcccctgctg gcgcttcctg tcgctaccgc
       61 tgcggcccag ggcccgcggg agcccagggc ggtgccgggt gagacaaggc cggggtttgg
      121 ctcggattca ccgcgaggta tctaggctgc catgatgcca gggccaagac ctcggaaggg
      181 ccctcaggcc agaggccaag gggtggccgc tgccaagcag atggggctct ttatggagtt
      241 tggccctgag gacatgctgc tgggcatgga tgaggctgaa gatgatgagg acctggaggc
      301 tgagctgctg gctctcacag gggaagcaca aaccacaggc aagaagccag cacccaaggg
      361 gcaggccccc ctgcccatgg cccacatcga gaagttggcg gcagactgta tgcgggatgt
      421 ggaggaggag gaggaggagg aagggctgga ggaagatgca gagctgctga cggagctgca
      481 ggaggtctta ggtgtggacg aggagactga gcccctggat ggtgatgagg tagctgaccc
      541 aggcggctct gaggaggaga acggcctaga agacactgaa cctccagtgc agacagccgt
      601 cctgacagct tcagccccag cagctcaggc cggagcatct caggggctac acgctttgct
      661 ggaggaacgg attcacaact accgagaggc tgcggccagt gccaaggagg caggcgaagc
      721 agccaaagcc aggcgctgcg agcgcggcct gaagaccttg gagtcgcagc tagcctctgt
      781 gaggagaggc agaaagatca atgaggatga gatcccacct ccagtggcct taggaaagcg
      841 gcccctggcc ccccaggaac cagccaacag gagccctgag acagaccctc cagctccccc
      901 tgccttggag tcagacaacc cctcccaacc tgagaccagc ctccctggca tttctgccca
      961 gcccgtttca gacttagacc cagacccgcg ggccctgctg tcatcccgac agagagagta
     1021 caaagtggct gccctcagtg ccaagcgggc tggagagcta gaccgtgccc gagagctcat
     1081 gaggattggg aagagattcg gtgctgtcct ggaggccctg gagaaggggc agcccgtgga
     1141 tctgagtgcc atgcccccgg cacctgagga tctgaagccc cagcaggctt ctcaggctcc
     1201 cacagcaccc tcagtcattc ccccagccgt ggagcgagtg cagccagtga tggcccctga
     1261 cgtcccagca accccagtgg cccctacaga gtcacagaca gtgctggatg ccctgcagca
     1321 gaggctgaac aagtaccgcg aggcgggcat ccaggcccgg agtggtgggg acgagcgcaa
     1381 ggctcggatg catgagcgca ttgccaagca atatcaagat gctattcgag cacaccgagc
     1441 aggacggaaa gtcaactttg ctgaattgcc tgttcctcca ggatttcccc ccatccctgg
     1501 cctggagtcc actatgggtg ttgaggagga cgcagtggca gcgacattgg cagctgcaga
     1561 gaaactggcc tctgcagagg attcagcccc ggctgataaa gacgaggacg agggtgagcc
     1621 cccagcacag gccccagtgg ccaagaaacc tgcacggccc acagtccctt catcccagcg
     1681 cctgcctgag cccagggcct caagttctaa ggagtcaccg agtccatctg tgcgggagca
     1741 gctggcactg ctggaggcac ggaaactgca gtatcagcgg gcagccctgc aggccaagcg
     1801 cagccaggac ctggagcagg ccaaagccta tctgcgggta gccaaatggc ttgaggctca
     1861 gatcatccag gcccgatctg gcagacctgt tgatctgtcc aaggtgcctt cgcccttgac
     1921 ggatgaggag ggtgacttca tcctcatcca ccatgaggac ctgcgactct cccagaaggc
     1981 ggaggaggtg tatgcccagc tgcaaaaaat gcttctggag caacaagaga agtgcctgct
     2041 gttctccaag cagttcatgc accagggcaa cgtggctgag accacccgat ttgagaagct
     2101 tgctcaggac cgcaagaaac agctggagat cctgcagctg gcccaggctc agggcctcga
     2161 ccctcccacc caccactttg agttgaagac attccagact gtgaggatct tctcagaact
     2221 caacagcaca gaaatgcatc tgatcattgt ccggggaatg aacctcccag cccctccagg
     2281 ggtgactccc gatgacctgg atgcttttgt gcggtttgag tttcactacc ctaactcgga
     2341 ccaggctcaa aaaagcaaaa cagctgtggt gaagaacaca aactctccag aatttgatca
     2401 actcttcaaa ctaaacatca accgaaacca ccggggcttc aagagggtga tccagagcaa
     2461 aggcatcaag tttgagatct tccacaaagg gtccttcttc agaagcgaca agctggttgg
     2521 cacagcacac ctgaaactgg agcggctgga gaatgagtgt gagatcagag aaattgtgga
     2581 ggtcctggat ggaaggaagc ccaccggggg gaagctggag gtgaaggtga ggctgcggga
     2641 gcctctgagt ggccaggatg tgcagatggt cactgagaac tggctggttc tggagcccag
     2701 gggcttgtga gccgatggcc agcaccagga gaggagtcag gccgcgactg tgcaggagat
     2761 gactttccca gctttgctgg cttcagaagc ctttgtacat aagagatgct gctacccaag
     2821 caccaaagac ctgttaagca tgtgcactac tgaccacgac tctggtcttt cctgttgttg
     2881 gcccctctgg ggctctacag aaacaggctg ggttccagga gcccatctcc ccgctgtctc
     2941 cccctgcccc gagtctggaa gagggcaagg acacttccat tcctctgtac catggagtcc
     3001 tgcagcccct taacccctgc gtggcaactg tgtacagctt acccctgcct ccagttgcac
     3061 cacttctaga tgtgccttta aaagatctaa ctatgggatg ggagaacttg agggtgatcg
     3121 ggaacctccc ctgctgaggg tggtgtcagg gttccgtgac tccagtgggc cagtggtagc
     3181 ctgtcccaga caactccgtc accccagctc tgcctgtgcc tttatccctg acagctgctg
     3241 cactagcctt cctgcttccc taaggactta gtggaggggg aaagttgttt ttggtactac
     3301 ttggtgggaa gtaaggggaa ggttggatct tgggtttggt ctacccaccc aagagaaaag
     3361 actgttaact ggaagaaaaa atatatatat aaaattttat gtagacacgt ttatttatct
     3421 aggaaactaa gtctaactca ttgtagggat tttatactca actatacaga gtatccacca
     3481 aagtcctaat ctaaagtcct gctccctgtc actttttaaa agccagggta gcagtaacat
     3541 gacaaacggc tgctgtggct tcctcttgag agaggacagg gaaagccttt cctcttcggc
     3601 tggttatgtg gggaacttcc ttagtttttt tccacaagaa attctccttt ggctttgttt
     3661 ttctgaatgg atggagacta tgaaggggtt tgtagttgta agagatttaa tattcaaaac
     3721 tgaaatattc tgcatttctt agaaataccc catcttcccc cacccccttt ttgaattatt
     3781 aattcaagat caacaaagca ttcctcaaga tcacttttaa aaaaggttag aagtgaagca
     3841 aatacattca gcttactgat cactatagta ttgcataagc acagctcaag aactgagctt
     3901 tgtatgtgtc cttttggggg ataacagggc tggaccatgc ttccctgccc ttaaacgcag
     3961 agcttttagt gggtcacaga gcgggaacta cacacaagtg acttttttcc ccatgagccc
     4021 tctggccgat tttttttttt tttttttttt tgagacagag tagctctctg ccagccaggc
     4081 tggagtgcag tggcatgatc tcagctcgct gcaaccccca cctcccaggt tcaagcgatt
     4141 ctcctgtgtc agtctcctga gtagctggga ttacaggcac ccaccactat gcccagctaa
     4201 tttttttatt tttagtagag acggtgtttc accatgttgg tcaggctggt ctcgaactcc
     4261 tgacctcatg atccacccac ctcagcctcc caaagtgctg ggattacagg tgtgagccac
     4321 cgcacccggc tggccaatct tatcagaagt gagctaccaa aacttccaca gatgtgagat
     4381 ttaacactta attgcagtca cgtgtatgca acacagcaat aatctagaat gaaaaggagg
     4441 gtgattagcc ttcataagat gacctataga gcaaagaaag gtgactggaa gggttcctaa
     4501 cccaacctac tccccttagg gtgtgtatcc aacccagtgc ttcctaagag ggttacggac
     4561 cactgtggtt atcctctaaa gttccagcca gctctaggag tttctaaatt caggcctctg
     4621 ttggaaatgg cctatttcga tagatagaaa gttttctata gctctaaagg tttctccttt
     4681 gcaacccatt caatttcagt ctgctgcttt gctctttcaa aacagaacct ccaggctgac
     4741 gaggcaagac aaagcctccc accagacttg gagattgaag ttcttaaaag gcctttgttg
     4801 tagccaaagg catgcatgcg tcactggtag taggaggagc ctgtcccagc ttcatcttgt
     4861 cctgagattt atccacatac aggaaacagg cgggacacag tggctcacgc ctgtaatccc
     4921 accactttgg aaagctgagg caggtggatc acctgaggtc aggaattcaa gaccagcctg
     4981 gccaacatgg tgaaaccccg tctccactaa aaacaaaaac aattagctgg gcatggtggc
     5041 cggcgcctgt aatcccagct actagggagg ctgagacaca cgaatccctt gagcccagga
     5101 agcagaggtt gcagtgagcc tcgattgtac cactgcactc cagcctgggc gacagagcaa
     5161 gactctgtct caaaacaaac acaaatacag tatccaaaca ttggagatta gtgactcacc
     5221 tgcagttggg agccagctac aacccaaatc attttaaaat tttcaattct ttgatctcat
     5281 gcaatgcaca ctttcttctg aattagcaaa ctgaataaac tacagaaatt ttttagaa
//
