LOCUS       NM_017721               3581 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens coiled-coil and C2 domain containing 1A (CC2D1A),
            transcript variant 1, mRNA.
ACCESSION   NM_017721
VERSION     NM_017721.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3581)
  AUTHORS   Kim,A.H., Sakin,I., Viviano,S., Tuncel,G., Aguilera,S.M., Goles,G.,
            Jeffries,L., Ji,W., Lakhani,S.A., Kose,C.C., Silan,F., Oner,S.S.,
            Kaplan,O.I., Ergoren,M.C., Mishra-Gorur,K., Gunel,M., Sag,S.O.,
            Temel,S.G. and Deniz,E.
  CONSRTM   MarmaRare Group
  TITLE     CC2D1A causes ciliopathy, intellectual disability, heterotaxy,
            renal dysplasia, and abnormal CSF flow
  JOURNAL   Life Sci Alliance 7 (10), e202402708 (2024)
   PUBMED   39168639
  REMARK    GeneRIF: CC2D1A causes ciliopathy, intellectual disability,
            heterotaxy, renal dysplasia, and abnormal CSF flow.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3581)
  AUTHORS   Sener,E.F., Onal,M.G., Dal,F., Nalbantoglu,U., Ozkul,Y., Canatan,H.
            and Oztop,D.B.
  TITLE     Novel alterations of CC2D1A as a candidate gene in a Turkish sample
            of patients with autism spectrum disorder
  JOURNAL   Int J Neurosci 132 (11), 1072-1079 (2022)
   PUBMED   33287601
  REMARK    GeneRIF: Novel alterations of CC2D1A as a candidate gene in a
            Turkish sample of patients with autism spectrum disorder.
REFERENCE   3  (bases 1 to 3581)
  AUTHORS   Belokopytova,I.I., Kondaurova,E.M., Kulikova,E.A., Ilchibaeva,T.V.,
            Naumenko,V.S. and Popova,N.K.
  TITLE     Effects of the Cc2d1a/Freud-1 Knockdown in the Hippocampus of BTBR
            Mice on the Autistic-Like Behavior, Expression of Serotonin 5-HT1A
            and D2 Dopamine Receptors, and CREB and NF-kB Intracellular
            Signaling
  JOURNAL   Biochemistry (Mosc) 87 (10), 1206-1218 (2022)
   PUBMED   36273889
  REMARK    GeneRIF: Effects of the Cc2d1a/Freud-1 Knockdown in the Hippocampus
            of BTBR Mice on the Autistic-Like Behavior, Expression of Serotonin
            5-HT1A and D2 Dopamine Receptors, and CREB and NF-kB Intracellular
            Signaling.
REFERENCE   4  (bases 1 to 3581)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 3581)
  AUTHORS   Rogaeva,A. and Albert,P.R.
  TITLE     The mental retardation gene CC2D1A/Freud-1 encodes a long isoform
            that binds conserved DNA elements to repress gene transcription
  JOURNAL   Eur J Neurosci 26 (4), 965-974 (2007)
   PUBMED   17714190
  REMARK    GeneRIF: disruption of transcriptional regulation by mutation of
            Freud-1 may play a role in abnormal brain function leading to
            mental retardation
REFERENCE   6  (bases 1 to 3581)
  AUTHORS   Basel-Vanagaite,L., Attia,R., Yahav,M., Ferland,R.J., Anteki,L.,
            Walsh,C.A., Olender,T., Straussberg,R., Magal,N., Taub,E.,
            Drasinover,V., Alkelai,A., Bercovich,D., Rechavi,G., Simon,A.J. and
            Shohat,M.
  TITLE     The CC2D1A, a member of a new gene family with C2 domains, is
            involved in autosomal recessive non-syndromic mental retardation
  JOURNAL   J Med Genet 43 (3), 203-210 (2006)
   PUBMED   16033914
  REMARK    GeneRIF: A protein truncating mutation was identified in the gene
            CC2D1A in nine consanguineous families with severe autosomal
            recessive mental retardation.
REFERENCE   7  (bases 1 to 3581)
  AUTHORS   Albert,P.R. and Lemonde,S.
  TITLE     5-HT1A receptors, gene repression, and depression: guilt by
            association
  JOURNAL   Neuroscientist 10 (6), 575-593 (2004)
   PUBMED   15534042
  REMARK    GeneRIF: Review of Freud-1 as a repressor of serotonin 1A receptor
            gene.
            Review article
REFERENCE   8  (bases 1 to 3581)
  AUTHORS   Lemonde,S., Rogaeva,A. and Albert,P.R.
  TITLE     Cell type-dependent recruitment of trichostatin A-sensitive
            repression of the human 5-HT1A receptor gene
  JOURNAL   J Neurochem 88 (4), 857-868 (2004)
   PUBMED   14756806
  REMARK    GeneRIF: Freud-1 mediates HDAC-independent repression of the 5-HT1A
            receptor promoter in neuronal 5-HT1A-positive cells.
REFERENCE   9  (bases 1 to 3581)
  AUTHORS   Basel-Vanagaite,L., Alkelai,A., Straussberg,R., Magal,N., Inbar,D.,
            Mahajna,M. and Shohat,M.
  TITLE     Mapping of a new locus for autosomal recessive non-syndromic mental
            retardation in the chromosomal region 19p13.12-p13.2: further
            genetic heterogeneity
  JOURNAL   J Med Genet 40 (10), 729-732 (2003)
   PUBMED   14569116
REFERENCE   10 (bases 1 to 3581)
  AUTHORS   Ou,X.M., Lemonde,S., Jafar-Nejad,H., Bown,C.D., Goto,A., Rogaeva,A.
            and Albert,P.R.
  TITLE     Freud-1: A neuronal calcium-regulated repressor of the 5-HT1A
            receptor gene
  JOURNAL   J Neurosci 23 (19), 7415-7425 (2003)
   PUBMED   12917378
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB065701.1 and BC064981.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_017721.4.
            
            Summary: This gene encodes a transcriptional repressor that binds
            to a conserved 14-bp 5'-repressor element and regulates expression
            of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal
            cells. The DNA binding and transcriptional repressor activities of
            the protein are inhibited by calcium. A mutation in this gene
            results in a nonsyndromic form of cognitive disability (MRT3).
            [provided by RefSeq, Jul 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB097002.1, AK315068.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318003.11/ ENSP00000313601.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                DB065701.1         59-96
            39-3581             BC064981.1         1-3543
FEATURES             Location/Qualifiers
     source          1..3581
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..3581
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /note="coiled-coil and C2 domain containing 1A"
                     /db_xref="GeneID:54862"
                     /db_xref="HGNC:HGNC:30237"
                     /db_xref="MIM:610055"
     exon            1..301
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..3097
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil and C2 domain-containing protein 1A; five
                     repressor element under dual repression-binding protein 1;
                     Akt kinase-interacting protein 1; putative NFkB activating
                     protein; FRE under dual repression-binding protein 1;
                     putative NF-kappa-B-activating protein 023N; five prime
                     repressor element under dual repression-binding protein 1;
                     TBK1-associated protein in endolysosomes; lethal (2) giant
                     discs homolog 2"
                     /codon_start=1
                     /product="coiled-coil and C2 domain-containing protein 1A
                     isoform 1"
                     /protein_id="NP_060191.3"
                     /db_xref="CCDS:CCDS42512.1"
                     /db_xref="GeneID:54862"
                     /db_xref="HGNC:HGNC:30237"
                     /db_xref="MIM:610055"
                     /translation="MHKRKGPPGPPGRGAAAARQLGLLVDLSPDGLMIPEDGANDEEL
                     EAEFLALVGGQPPALEKLKGKGPLPMEAIEKMASLCMRDPDEDEEEGTDEDDLEADDD
                     LLAELNEVLGEEQKASETPPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDS
                     AKMRRYDRGLKTLENLLASIRKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRI
                     ASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQ
                     QGDTTAAARHFRVAKSFDAVLEALSRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPAT
                     APSTTEVPPPPRTLLEALEQRMERYQVAAAQAKSKGDQRKARMHERIVKQYQDAIRAH
                     KAGRAVDVAELPVPPGFPPIQGLEATKPTQQSLVGVLETAMKLANQDEGPEDEEDEVP
                     KKQNSPVAPTAQPKAPPSRTPQSGSAPTAKAPPKATSTRAQQQLAFLEGRKKQLLQAA
                     LRAKQKNDVEGAKMHLRQAKGLEPMLEASRNGLPVDITKVPPAPVNKDDFALVQRPGP
                     GLSQEAARRYGELTKLIRQQHEMCLNHSNQFTQLGNITETTKFEKLAEDCKRSMDILK
                     QAFVRGLPTPTARFEQRTFSVIKIFPDLSSNDMLLFIVKGINLPTPPGLSPGDLDVFV
                     RFDFPYPNVEEAQKDKTSVIKNTDSPEFKEQFKLCINRSHRGFRRAIQTKGIKFEVVH
                     KGGLFKTDRVLGTAQLKLDALEIACEVREILEVLDGRRPTGGRLEVMVRIREPLTAQQ
                     LETTTERWLVIDPVPAAVPTQVAGPKGKAPPVPAPARESGNRSARPLHSLSVLAFDQE
                     RLERKILALRQARRPVPPEVAQQYQDIMQRSQWQRAQLEQGGVGIRREYAAQLERQLQ
                     FYTEAARRLGNDGSRDAAKEALYRRNLVESELQRLRR"
     exon            302..437
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            438..553
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            554..619
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            620..754
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            755..989
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1114
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1187
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1259
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1390
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1463
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1597
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1709
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1882
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2005
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2064
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2181
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2255
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2314
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2366
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2466
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2557
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2695
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            2696..2760
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..2824
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..2951
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            2952..3028
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            3029..3076
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..3581
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3557..3562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /note="hexamer: AATAAA"
     polyA_site      3581
                     /gene="CC2D1A"
                     /gene_synonym="Aki-1; FREUD-1; Freud-1/Aki1; Lgd2; MRT3;
                     TAPE"
                     /note="major polyA site"
ORIGIN      
        1 gtagtttcgg ctcggcagac ccggcgagcc cagtggccgc gctccggtgc ggcggcgccc
       61 gaggcccgag gcggaagtgg gacggccaag cagggaagcg agggctcggg atcgacggcc
      121 gcggggcgcc gacgaggagt gcaggactca ggaagggcga gtgcgcggcg acagagcccg
      181 gggaaggagg cagggcaagg ccgggcttgg gggcaggtgg tccgggcatc cagccttgaa
      241 gatgcacaag aggaaaggac ccccgggacc cccgggcaga ggcgccgcgg ccgcccgcca
      301 gctgggcctg ctggttgacc tctccccaga tggcctgatg atccctgagg acggggctaa
      361 cgatgaagaa ctggaggctg agttcttggc tttggtcggg ggccagcccc cagccctgga
      421 gaagctcaaa ggcaaaggtc ccttgccgat ggaggccatt gagaagatgg ccagcctgtg
      481 catgagagac ccggatgagg atgaggagga ggggacggat gaggacgact tggaggctga
      541 tgatgacctg ctggcggagc taaatgaggt ccttggagag gagcagaagg cttcagagac
      601 cccacctcct gtggcccagc cgaagcctga ggcccctcat ccggggctgg agaccacctt
      661 gcaggagagg ctggcgctct atcagacagc aattgaaagc gccagacaag ctggagacag
      721 cgccaagatg cggcgctacg atcgggggct taaaacactg gaaaacctgc tcgcctccat
      781 ccgtaagggc aatgccattg acgaagcgga catcccgccg ccagtggcca taggaaaagg
      841 cccggcgtcc acgcctacct acagccctgc acccacccag ccggccccta gaatcgcgtc
      901 agccccagag cccagggtca ccctggaggg accttctgcc accgccccag cctcatctcc
      961 aggcttggct aagccccaga tgcccccagg tccctgcagc cctggccctc tggcccagtt
     1021 gcagagccgc cagcgcgact acaagctggc tgccctccac gccaagcagc agggagatac
     1081 cactgctgcc gctagacact tccgcgtggc taagagcttt gatgctgtct tggaggccct
     1141 gagccggggt gagcccgtgg acctctcctg cctgccccct ccacccgacc agctgccccc
     1201 agacccaccg tcaccaccgt cgcagcctcc gacccccgct acggcgccct ccacaacaga
     1261 ggtgccccca cccccgagga ccctgctgga ggcgctggag cagcggatgg agcggtacca
     1321 ggtggccgca gcccaggcca agagcaaggg ggaccagcgg aaagctcgaa tgcacgagcg
     1381 catcgtcaag caataccaag atgccatccg agcccacaag gctggccgag ccgtggatgt
     1441 cgctgaattg cccgtgcccc caggcttccc cccaatccag ggcctggagg ccaccaagcc
     1501 cacccagcag agtctggtgg gtgtcctgga gactgccatg aagctggcca accaggatga
     1561 aggcccagag gatgaagagg atgaggtgcc taagaagcag aacagccctg tggcccccac
     1621 agcccagccc aaagccccac cctcaagaac tccccagtcg ggatcagccc caacagccaa
     1681 agcgcccccc aaagccacat ccaccagagc ccagcagcag ctggccttcc tagagggccg
     1741 caagaagcag ctcctgcagg ccgcactgcg agccaagcag aaaaacgacg tggagggtgc
     1801 caagatgcac ctgcgccaag ccaagggact ggagcctatg ctggaggcct cgcgcaatgg
     1861 gctgcctgtg gacatcacca aggtgccgcc tgcccctgtc aacaaggacg actttgccct
     1921 ggtccagcgg cctggcccgg gtctgtctca ggaggccgcc cggcgctatg gtgaactcac
     1981 caagctcata cggcagcagc acgagatgtg cctgaaccac tcaaaccaat tcacccagct
     2041 gggcaacatc actgaaacca ccaagtttga aaagttggcg gaggactgta agcggagcat
     2101 ggacattctg aagcaagcct tcgtccgggg tctccccacg cccaccgccc gctttgagca
     2161 aaggaccttc agcgtcatca agatcttccc tgacctcagc agcaacgaca tgctcctctt
     2221 catcgtgaag ggcatcaact tgcccacacc cccaggactg tcccctggcg atctggatgt
     2281 ctttgttcgg tttgacttcc cctatcccaa cgtggaagaa gctcagaaag acaagaccag
     2341 tgtgatcaag aacacagact cccctgagtt caaggagcag ttcaaactct gcatcaaccg
     2401 cagccaccgt ggcttccgaa gggccatcca gaccaagggc atcaagttcg aagtggttca
     2461 caaggggggg ctgttcaaga ctgaccgggt gctggggaca gcccagctga agctggatgc
     2521 actggagata gcatgtgagg tccgggagat ccttgaggtc ctggatggtc gccggcccac
     2581 aggggggcga ctggaggtaa tggtccggat tcgggagcca ctgacagccc agcagttgga
     2641 gacgacgaca gagaggtggc tggtcattga ccctgtgccg gcagctgtgc ccacacaggt
     2701 tgctgggccc aaagggaagg cccctcctgt gcctgcccct gcaagggagt cagggaacag
     2761 atcagcccgg cccctgcata gcctcagtgt gctggcgttt gaccaagagc gtctggagcg
     2821 gaagatcctg gccctcaggc aggcgcggcg gccggtgccc ccagaagtgg cccagcagta
     2881 ccaggacatc atgcaacgca gccagtggca gagggcacag ctggagcagg ggggtgtggg
     2941 catccgacgg gaatacgcag cccagctgga gcggcagctg cagttctaca cggaggctgc
     3001 ccggcgcctg ggcaacgatg gcagcaggga tgctgcaaag gaggcgctct ataggcggaa
     3061 tctggtagag agtgagctgc agcggctccg caggtgagga gcccatgggg cgggcagccc
     3121 ccagaaagcg ggcagcaggc cccgataccg ggaagagccg acacagccac gaaccagaca
     3181 agcagacaat cagcggacaa tcggttctgg actcacccct catccgggcc cccagccccg
     3241 ccagagcctc cgtggctgcg ggtgttggga accatgcctg ccagccagta tgtgcccctc
     3301 acccaggcct ggctgggccc tggagagtcc tgtttgcaca gcccaggggt gtccggcctc
     3361 tggcccgccc cggagcaggg agggtggctg gggccaagcc ccgagggccc ctgcaagcac
     3421 tttacttcct gttcctcccc agccttaacc ccaaagccct cctgcacccc aaagaagcca
     3481 ctgaggctgg ccgagccaca ctgtctcccc aggggcgtcg acctggccca gctgggtccc
     3541 cagggccagc acatggaata aaatagccag ggccacactc a
//
