LOCUS       NM_152719               1605 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens chibby family member 2 (CBY2), transcript variant 1,
            mRNA.
ACCESSION   NM_152719
VERSION     NM_152719.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1605)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1605)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1605)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1605)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   5  (bases 1 to 1605)
  AUTHORS   McClure-Begley,T.D. and Klymkowsky,M.W.
  TITLE     Nuclear roles for cilia-associated proteins
  JOURNAL   Cilia 6, 8 (2017)
   PUBMED   28560031
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1605)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1605)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   8  (bases 1 to 1605)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   9  (bases 1 to 1605)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   10 (bases 1 to 1605)
  AUTHORS   Feige,E., Chen,A. and Motro,B.
  TITLE     Nurit, a novel leucine-zipper protein, expressed uniquely in the
            spermatid flower-like structure
  JOURNAL   Mech Dev 117 (1-2), 369-377 (2002)
   PUBMED   12204287
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY017873.1, AK093129.1 and BC027609.2.
            
            On Nov 22, 2018 this sequence version replaced NM_152719.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB031134.1, AK093129.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310521.6/ ENSP00000309189.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                HY017873.1         19-67
            50-1490             AK093129.1         59-1499
            1491-1605           BC027609.2         1326-1440
FEATURES             Location/Qualifiers
     source          1..1605
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.13"
     gene            1..1605
                     /gene="CBY2"
                     /gene_synonym="NURIT; SPERT"
                     /note="chibby family member 2"
                     /db_xref="GeneID:220082"
                     /db_xref="HGNC:HGNC:30720"
                     /db_xref="MIM:618614"
     exon            1..146
                     /gene="CBY2"
                     /gene_synonym="NURIT; SPERT"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1418
                     /gene="CBY2"
                     /gene_synonym="NURIT; SPERT"
                     /note="isoform 1 is encoded by transcript variant 1; novel
                     leucine zipper testicular protein; spermatid flower-like
                     structure protein; testis-specific leucine zipper protein
                     nurit; spermatid-associated protein; spermatid associated;
                     protein chibby homolog 2; testicular tissue protein Li
                     182"
                     /codon_start=1
                     /product="protein chibby homolog 2 isoform 1"
                     /protein_id="NP_689932.1"
                     /db_xref="CCDS:CCDS9399.1"
                     /db_xref="GeneID:220082"
                     /db_xref="HGNC:HGNC:30720"
                     /db_xref="MIM:618614"
                     /translation="MSPLECSECFGDQLLHRTYTWQLTLHSRPNYTRKRDTRSESLEI
                     PISVVLPQRGTAEPFPRLHNLYSTPRCAQQAALPRLSRRMASQHSYPLNRFSSVPLDP
                     MERPMSQADLELDYNPPRVQLSDEMFVFQDGRWVNENCRLQSPYFSPSASFHHKLHHK
                     RLAKECMLQEENKSLREENKALREENRMLSKENKILQVFWEEHKASLGREESRAPSPL
                     LHKDSASLEVVKKDHVALQVPRGKEDSTLQLLREENRALQQLLEQKQAYWAQAEDTAA
                     PAEESKPAPSPHEEPCSPGLLQDQGSGLSSRFEEPKGPPARQEDSKELRALRKMVSNM
                     SGPSGEEEAKVGPGLPDGCQPLQLLREMRQALQALLKENRLLQEENRTLQVLRAEHRG
                     FQEENKALWENNKLKLQQKLVIDTVTEVTARMEMLIEELYAFMPARSQDPKKPSRV"
     exon            147..227
                     /gene="CBY2"
                     /gene_synonym="NURIT; SPERT"
                     /inference="alignment:Splign:2.1.0"
     exon            228..1605
                     /gene="CBY2"
                     /gene_synonym="NURIT; SPERT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1569..1574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBY2"
                     /gene_synonym="NURIT; SPERT"
                     /note="hexamer: AATAAA"
     polyA_site      1605
                     /gene="CBY2"
                     /gene_synonym="NURIT; SPERT"
                     /note="major polyA site"
ORIGIN      
        1 agatgcctca ttcccacctg tgatgctcag agagaaacca tgagccctga aaaacaccat
       61 attgttttgt gatgtcacct ctggaatgtt ctgagtgttt tggtgaccaa cttctgcata
      121 ggacctatac ctggcaactc acattgcact caaggccaaa ttatacaaga aaaagagata
      181 ccagatctga aagcctagaa attccaatca gtgtggttct acctcagagg ggcacagccg
      241 aacccttccc gaggctccac aacttgtaca gcacccctcg ctgcgcgcag caggccgccc
      301 tgccccggct gagccgcagg atggcgagcc agcactccta tccactgaac cgcttctcct
      361 ccgtgccttt agaccccatg gagcgcccca tgtcccaggc cgacctggag ctggactaca
      421 acccgccgcg ggtgcagctc agcgacgaga tgttcgtgtt ccaggacggg cgctgggtaa
      481 atgagaactg ccgcctgcag tctccctact tctccccatc cgcctccttc caccacaagc
      541 tgcaccacaa gaggctggcc aaggagtgca tgctgcagga ggagaacaag tctctgcggg
      601 aggagaacaa ggccctgcgc gaggagaacc ggatgctcag caaggagaac aagatcctac
      661 aggtcttctg ggaggagcac aaggcctcgc tgggccgaga ggagagccgg gccccctcgc
      721 cactgctgca caaagacagc gcgtccctgg aggtggtgaa gaaggaccac gtcgccctgc
      781 aggtgccccg tggcaaggag gacagcaccc tgcagctcct ccgggaggag aatcgcgcgc
      841 tgcagcagct gctggagcag aaacaggcct actgggcgca ggcagaggac acggccgccc
      901 ctgccgagga aagcaagccc gccccctcac cccacgagga gccctgcagc cccgggctgc
      961 tgcaggacca gggctccggc ctctcctccc gcttcgagga gcccaaaggg cctccggccc
     1021 ggcaggagga ctccaaggag ctgcgcgccc tgcggaagat ggtcagcaac atgtccgggc
     1081 cctccgggga ggaggaggcc aaggtgggcc cgggcctgcc cgacggctgc cagcccctgc
     1141 agctgctgag agagatgagg caggcgctgc aggccctgct caaggagaac cggctcctgc
     1201 aggaggagaa caggaccctg caggtgctac gggcagagca caggggcttc caggaggaga
     1261 acaaggccct gtgggagaac aacaagctga agctgcagca gaagctggtc attgacaccg
     1321 tgaccgaggt caccgcgcgc atggaaatgc tcatcgagga gctctacgcc ttcatgccgg
     1381 ccaggagcca ggaccccaag aagcctagca gggtctgagg cctcggcctt gcaccgggac
     1441 gccgagtttg ggacaccgaa cactgggcaa aagagaatcc cctgccttcc tttgtcgtcc
     1501 tcgccttccc cagccagttc gtacctattg aaaagcagcg ttagcagcct tcctaaactc
     1561 agagttttaa taaaggtgtg aggaggctgg ggccagttga cacca
//
