LOCUS       NM_015373               1146 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens chibby 1, beta catenin antagonist (CBY1), transcript
            variant 1, mRNA.
ACCESSION   NM_015373
VERSION     NM_015373.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1146)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1146)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1146)
  AUTHORS   Wen,S., Qin,Y., Wang,R., Yang,L., Zeng,H., Zhu,P., Li,Q., Qiu,Y.,
            Chen,S., Liu,Y., Hou,Y., Tang,X., Liu,M. and Tu,G.
  TITLE     A novel Lnc408 maintains breast cancer stem cell stemness by
            recruiting SP3 to suppress CBY1 transcription and increasing
            nuclear beta-catenin levels
  JOURNAL   Cell Death Dis 12 (5), 437 (2021)
   PUBMED   33934099
  REMARK    GeneRIF: A novel Lnc408 maintains breast cancer stem cell stemness
            by recruiting SP3 to suppress CBY1 transcription and increasing
            nuclear beta-catenin levels.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1146)
  AUTHORS   Epting,D., Senaratne,L.D.S., Ott,E., Holmgren,A., Sumathipala,D.,
            Larsen,S.M., Wallmeier,J., Bracht,D., Frikstad,K.M., Crowley,S.,
            Sikiric,A., Baroy,T., Kasmann-Kellner,B., Decker,E., Decker,C.,
            Bachmann,N., Patzke,S., Phelps,I.G., Katsanis,N., Giles,R.,
            Schmidts,M., Zucknick,M., Lienkamp,S.S., Omran,H., Davis,E.E.,
            Doherty,D., Stromme,P., Frengen,E., Bergmann,C. and Misceo,D.
  TITLE     Loss of CBY1 results in a ciliopathy characterized by features of
            Joubert syndrome
  JOURNAL   Hum Mutat 41 (12), 2179-2194 (2020)
   PUBMED   33131181
  REMARK    GeneRIF: Loss of CBY1 results in a ciliopathy characterized by
            features of Joubert syndrome.
REFERENCE   5  (bases 1 to 1146)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1146)
  AUTHORS   Hidaka,S., Konecke,V., Osten,L. and Witzgall,R.
  TITLE     PIGEA-14, a novel coiled-coil protein affecting the intracellular
            distribution of polycystin-2
  JOURNAL   J Biol Chem 279 (33), 35009-35016 (2004)
   PUBMED   15194699
  REMARK    GeneRIF: PIGEA-14 plays an important role in regulating the
            intracellular location of polycystin-2
REFERENCE   7  (bases 1 to 1146)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
REFERENCE   8  (bases 1 to 1146)
  AUTHORS   Takemaru,K., Yamaguchi,S., Lee,Y.S., Zhang,Y., Carthew,R.W. and
            Moon,R.T.
  TITLE     Chibby, a nuclear beta-catenin-associated antagonist of the
            Wnt/Wingless pathway
  JOURNAL   Nature 422 (6934), 905-909 (2003)
   PUBMED   12712206
  REMARK    GeneRIF: Chibby inhibits beta-catenin-mediated transcriptional
            activation by competing with Lef-1 to bind to beta-catenin
REFERENCE   9  (bases 1 to 1146)
  AUTHORS   Collins,J.E., Goward,M.E., Cole,C.G., Smink,L.J., Huckle,E.J.,
            Knowles,S., Bye,J.M., Beare,D.M. and Dunham,I.
  TITLE     Reevaluating human gene annotation: a second-generation analysis of
            chromosome 22
  JOURNAL   Genome Res 13 (1), 27-36 (2003)
   PUBMED   12529303
REFERENCE   10 (bases 1 to 1146)
  AUTHORS   Suzuki,Y., Tsunoda,T., Sese,J., Taira,H., Mizushima-Sugano,J.,
            Hata,H., Ota,T., Isogai,T., Tanaka,T., Nakamura,Y., Suyama,A.,
            Sakaki,Y., Morishita,S., Okubo,K. and Sugano,S.
  TITLE     Identification and characterization of the potential promoter
            regions of 1031 kinds of human genes
  JOURNAL   Genome Res 11 (5), 677-684 (2001)
   PUBMED   11337467
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL021707.2, CD702742.1,
            AL136686.1 and BC016139.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_015373.3.
            
            Summary: Beta-catenin is a transcriptional activator and
            oncoprotein involved in the development of several cancers. The
            protein encoded by this gene interacts directly with the C-terminal
            region of beta-catenin, inhibiting oncogenic beta-catenin-mediated
            transcriptional activation by competing with transcription factors
            for binding to beta-catenin. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016139.1, AF331041.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216029.8/ ENSP00000216029.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AL021707.2         29120-29134
            16-32               CD702742.1         39-55
            33-37               AL136686.1         1-5
            38-1146             BC016139.1         1-1109
FEATURES             Location/Qualifiers
     source          1..1146
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..1146
                     /gene="CBY1"
                     /gene_synonym="arb1; C22orf2; CBY; Chibby1; HS508I15A;
                     PGEA1; PIGEA-14; PIGEA14"
                     /note="chibby 1, beta catenin antagonist"
                     /db_xref="GeneID:25776"
                     /db_xref="HGNC:HGNC:1307"
                     /db_xref="MIM:607757"
     exon            1..113
                     /gene="CBY1"
                     /gene_synonym="arb1; C22orf2; CBY; Chibby1; HS508I15A;
                     PGEA1; PIGEA-14; PIGEA14"
                     /inference="alignment:Splign:2.1.0"
     exon            114..229
                     /gene="CBY1"
                     /gene_synonym="arb1; C22orf2; CBY; Chibby1; HS508I15A;
                     PGEA1; PIGEA-14; PIGEA14"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..532
                     /gene="CBY1"
                     /gene_synonym="arb1; C22orf2; CBY; Chibby1; HS508I15A;
                     PGEA1; PIGEA-14; PIGEA14"
                     /note="polycystin-2 interactor, Golgi- and endoplasmic
                     reticulum-associated protein, 14 kDa; chibby
                     CTNNB1-mediated transcription inhibitor; cytosolic
                     leucine-rich protein; ARPP-binding protein; chibby family
                     member 1, beta catenin antagonist; coiled-coil protein
                     PIGEA-14; PKD2 interactor, Golgi and endoplasmic
                     reticulum-associated 1; chibby homolog 1"
                     /codon_start=1
                     /product="protein chibby homolog 1"
                     /protein_id="NP_056188.1"
                     /db_xref="CCDS:CCDS13974.1"
                     /db_xref="GeneID:25776"
                     /db_xref="HGNC:HGNC:1307"
                     /db_xref="MIM:607757"
                     /translation="MPFFGNTFSPKKTPPRKSASLSNLHSLDRSTREVELGLEYGSPT
                     MNLAGQSLKFENGQWIAETGVSGGVDRREVQRLRRRNQQLEEENNLLRLKVDILLDML
                     SESTAESHLMEKELDELRISRKRK"
     exon            230..335
                     /gene="CBY1"
                     /gene_synonym="arb1; C22orf2; CBY; Chibby1; HS508I15A;
                     PGEA1; PIGEA-14; PIGEA14"
                     /inference="alignment:Splign:2.1.0"
     exon            336..454
                     /gene="CBY1"
                     /gene_synonym="arb1; C22orf2; CBY; Chibby1; HS508I15A;
                     PGEA1; PIGEA-14; PIGEA14"
                     /inference="alignment:Splign:2.1.0"
     exon            455..1146
                     /gene="CBY1"
                     /gene_synonym="arb1; C22orf2; CBY; Chibby1; HS508I15A;
                     PGEA1; PIGEA-14; PIGEA14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1128..1133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBY1"
                     /gene_synonym="arb1; C22orf2; CBY; Chibby1; HS508I15A;
                     PGEA1; PIGEA-14; PIGEA14"
                     /note="hexamer: ATTAAA"
     polyA_site      1146
                     /gene="CBY1"
                     /gene_synonym="arb1; C22orf2; CBY; Chibby1; HS508I15A;
                     PGEA1; PIGEA-14; PIGEA14"
                     /note="major polyA site"
ORIGIN      
        1 atgcgcgtgg cgggcaggcg gcaggaggcg ggtgggtcaa ggtaactctg ggctacagag
       61 tccttgctgg gggttcgggg agcgcttgga ccccggcttc tgggacgcgt caggagaagg
      121 gagcactggc tttgctttca tcaggccaaa gatgcctttc tttgggaata cgttcagtcc
      181 gaagaagaca cctcctcgga agtcggcatc tctctccaac ctgcattctt tggatcgatc
      241 aacccgggag gtggagctgg gcttggaata cggatccccg actatgaacc tggcagggca
      301 aagcctgaag tttgaaaatg gccagtggat agcagagaca ggggttagtg gcggtgtgga
      361 ccggagggag gttcagcgcc ttcgcaggcg gaaccagcag ttggaggaag agaacaatct
      421 cttgcggctg aaagtggaca tcttattaga catgctttca gagtccactg ctgaatccca
      481 cttaatggag aaggaactgg atgaactgag gatcagccgg aagagaaaat gaagacccca
      541 gagacattta ttggggagta ggatgtggct gagtgctttt tttttggcca gactagcgga
      601 ttcagtcctg gaagagagta tcatataatg agacccacag gcactggcac ccttgggttg
      661 gcaatagaag gtgacatgga atggagaaaa ccaagattcc agatggggat agtaactaga
      721 aggtgcttca gatgcactgc ctgcgggtgc cagtctgaaa accagaccgc acagaggcct
      781 ggggctgctg atgagctttt tggtgctctc cacacacaag ctcgcaaaca cacatgtccc
      841 agaatagctc tgttgggttg tgttgggaga agcggctgga gttcattctc tcaccccctt
      901 atgttggtgt ttggcgtgtg acagcagttc tacagagctc tgtgttgggg tcatggatga
      961 gcggctctct tggctcttaa aggcaggcct ctctcttctt gcctttaaag aatcctcctt
     1021 cctcacacct ggcctcctct ggcttcagct tctcagcagc aagcaccagc cttccacaac
     1081 aacactatat ttttatgcta ctttcctgtt tgcactacta cttttttatt aaacgatgtt
     1141 aaataa
//
