LOCUS       NM_020649               3752 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens chromobox 8 (CBX8), mRNA.
ACCESSION   NM_020649
VERSION     NM_020649.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3752)
  AUTHORS   Cai,X., Lv,Y., Pan,J., Cao,Z., Zhang,J., Li,Y. and Zheng,H.
  TITLE     CBX8 Promotes Epithelial-mesenchymal Transition, Migration, and
            Invasion of Lung Cancer through Wnt/beta-catenin Signaling Pathway
  JOURNAL   Curr Protein Pept Sci 25 (5), 386-393 (2024)
   PUBMED   38265409
  REMARK    GeneRIF: CBX8 Promotes Epithelial-mesenchymal Transition,
            Migration, and Invasion of Lung Cancer through Wnt/beta-catenin
            Signaling Pathway.
REFERENCE   2  (bases 1 to 3752)
  AUTHORS   Chen,H., Su,Y., Yang,L., Xi,L., Li,X., Lan,B., Liu,M. and Xuan,C.
  TITLE     CBX8 promotes lung adenocarcinoma growth and metastasis through
            transcriptional repression of CDKN2C and SCEL
  JOURNAL   J Cell Physiol 238 (11), 2710-2723 (2023)
   PUBMED   37733753
  REMARK    GeneRIF: CBX8 promotes lung adenocarcinoma growth and metastasis
            through transcriptional repression of CDKN2C and SCEL.
REFERENCE   3  (bases 1 to 3752)
  AUTHORS   Liu,Q., Li,X. and Gao,W.
  TITLE     CBX8 Promotes Cell Proliferation and Metastasis and Leads to
            Radiotherapy Tolerance of Glioma Cells
  JOURNAL   Turk Neurosurg 33 (1), 46-52 (2023)
   PUBMED   35713250
  REMARK    GeneRIF: CBX8 Promotes Cell Proliferation and Metastasis and Leads
            to Radiotherapy Tolerance of Glioma Cells.
REFERENCE   4  (bases 1 to 3752)
  AUTHORS   Wu,Y., Duan,Y., Li,X., Zhao,R., Lan,B., Zhang,X., Wang,X., Chen,H.,
            Feng,S., Liu,Z., Cheng,Y., Xi,L., Wang,Y., Xue,F. and Xuan,C.
  TITLE     CBX8 Together with SET Facilitates Ovarian Carcinoma Growth and
            Metastasis by Suppressing the Transcription of SUSD2
  JOURNAL   Mol Cancer Res 20 (11), 1611-1622 (2022)
   PUBMED   35894945
  REMARK    GeneRIF: CBX8 Together with SET Facilitates Ovarian Carcinoma
            Growth and Metastasis by Suppressing the Transcription of SUSD2.
REFERENCE   5  (bases 1 to 3752)
  AUTHORS   Ng,L., Li,H.S., Man,A.T., Chow,A.K., Foo,D.C., Lo,O.S., Pang,R.W.
            and Law,W.L.
  TITLE     High Expression of a Cancer Stemness-Related Gene, Chromobox 8
            (CBX8), in Normal Tissue Adjacent to the Tumor (NAT) Is Associated
            with Poor Prognosis of Colorectal Cancer Patients
  JOURNAL   Cells 11 (11), 1852 (2022)
   PUBMED   35681547
  REMARK    GeneRIF: High Expression of a Cancer Stemness-Related Gene,
            Chromobox 8 (CBX8), in Normal Tissue Adjacent to the Tumor (NAT) Is
            Associated with Poor Prognosis of Colorectal Cancer Patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3752)
  AUTHORS   Obuse,C., Yang,H., Nozaki,N., Goto,S., Okazaki,T. and Yoda,K.
  TITLE     Proteomics analysis of the centromere complex from HeLa interphase
            cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of
            the CEN-complex, while BMI-1 is transiently co-localized with the
            centromeric region in interphase
  JOURNAL   Genes Cells 9 (2), 105-120 (2004)
   PUBMED   15009096
REFERENCE   7  (bases 1 to 3752)
  AUTHORS   Levine,S.S., Weiss,A., Erdjument-Bromage,H., Shao,Z., Tempst,P. and
            Kingston,R.E.
  TITLE     The core of the polycomb repressive complex is compositionally and
            functionally conserved in flies and humans
  JOURNAL   Mol Cell Biol 22 (17), 6070-6078 (2002)
   PUBMED   12167701
REFERENCE   8  (bases 1 to 3752)
  AUTHORS   Hemenway,C.S., de Erkenez,A.C. and Gould,G.C.
  TITLE     The polycomb protein MPc3 interacts with AF9, an MLL fusion partner
            in t(9;11)(p22;q23) acute leukemias
  JOURNAL   Oncogene 20 (29), 3798-3805 (2001)
   PUBMED   11439343
REFERENCE   9  (bases 1 to 3752)
  AUTHORS   Garcia-Cuellar,M.P., Zilles,O., Schreiner,S.A., Birke,M.,
            Winkler,T.H. and Slany,R.K.
  TITLE     The ENL moiety of the childhood leukemia-associated MLL-ENL
            oncoprotein recruits human Polycomb 3
  JOURNAL   Oncogene 20 (4), 411-419 (2001)
   PUBMED   11313972
REFERENCE   10 (bases 1 to 3752)
  AUTHORS   Bardos,J.I., Saurin,A.J., Tissot,C., Duprez,E. and Freemont,P.S.
  TITLE     HPC3 is a new human polycomb orthologue that interacts and
            associates with RING1 and Bmi1 and has transcriptional repression
            properties
  JOURNAL   J Biol Chem 275 (37), 28785-28792 (2000)
   PUBMED   10825164
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK074560.1, AF174482.1, AC100791.15 and AC105337.7.
            
            On Nov 23, 2018 this sequence version replaced NM_020649.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF174482.1, BC009376.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269385.9/ ENSP00000269385.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1028              AK074560.1         40-1067
            1029-1507           AF174482.1         1043-1521
            1508-3666           AC100791.15        30442-32600         c
            3667-3752           AC105337.7         125998-126083       c
FEATURES             Location/Qualifiers
     source          1..3752
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..3752
                     /gene="CBX8"
                     /gene_synonym="PC3; RC1"
                     /note="chromobox 8"
                     /db_xref="GeneID:57332"
                     /db_xref="HGNC:HGNC:15962"
                     /db_xref="MIM:617354"
     exon            1..148
                     /gene="CBX8"
                     /gene_synonym="PC3; RC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1249
                     /gene="CBX8"
                     /gene_synonym="PC3; RC1"
                     /note="chromobox homolog 8 (Pc class homolog, Drosophila);
                     Pc class 3 homolog; rectachrome 1; polycomb 3"
                     /codon_start=1
                     /product="chromobox protein homolog 8"
                     /protein_id="NP_065700.1"
                     /db_xref="CCDS:CCDS11765.1"
                     /db_xref="GeneID:57332"
                     /db_xref="HGNC:HGNC:15962"
                     /db_xref="MIM:617354"
                     /translation="MELSAVGERVFAAEALLKRRIRKGRMEYLVKWKGWSQKYSTWEP
                     EENILDARLLAAFEEREREMELYGPKKRGPKPKTFLLKAQAKAKAKTYEFRSDSARGI
                     RIPYPGRSPQDLASTSRAREGLRNMGLSPPASSTSTSSTCRAEAPRDRDRDRDRDRER
                     DRERERERERERERERERERGTSRVDDKPSSPGDSSKKRGPKPRKELPDPSQRPLGEP
                     SAGLGEYLKGRKLDDTPSGAGKFPAGHSVIQLARRQDSDLVQCGVTSPSSAEATGKLA
                     VDTFPARVIKHRAAFLEAKGQGALDPNGTRVRHGSGPPSSGGGLYRDMGAQGGRPSLI
                     ARIPVARILGDPEEESWSPSLTNLEKVVVTDVTSNFLTVTIKESNTDQGFFKEKR"
     exon            149..192
                     /gene="CBX8"
                     /gene_synonym="PC3; RC1"
                     /inference="alignment:Splign:2.1.0"
     exon            193..258
                     /gene="CBX8"
                     /gene_synonym="PC3; RC1"
                     /inference="alignment:Splign:2.1.0"
     exon            259..325
                     /gene="CBX8"
                     /gene_synonym="PC3; RC1"
                     /inference="alignment:Splign:2.1.0"
     exon            326..3752
                     /gene="CBX8"
                     /gene_synonym="PC3; RC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1486..1491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBX8"
                     /gene_synonym="PC3; RC1"
                     /note="hexamer: AATATA"
     polyA_site      1507
                     /gene="CBX8"
                     /gene_synonym="PC3; RC1"
                     /note="major polyA site"
     regulatory      3732..3737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBX8"
                     /gene_synonym="PC3; RC1"
                     /note="hexamer: AATATA"
     polyA_site      3752
                     /gene="CBX8"
                     /gene_synonym="PC3; RC1"
                     /note="major polyA site"
ORIGIN      
        1 agagtattat ggtctgtcgt gcgctggctg ctgcttttct gctcctggaa gcggccaagg
       61 ggggaagcgg cgagtcaaca tggagctttc agcggtgggg gagcgggtgt tcgcggccga
      121 agccctcctg aagcggcgca tacggaaagg acgcatggaa tacctcgtga aatggaaggg
      181 atggtcgcag aagtacagca catgggaacc ggaggaaaac atcctggatg ctcgcttgct
      241 cgcagccttt gaggaaaggg aaagagagat ggagctctat ggccccaaaa agcgtggacc
      301 caagcccaaa accttcctcc tcaaagcgca ggccaaggca aaggccaaaa cttacgagtt
      361 tcgaagtgac tcagccaggg gcatccggat cccctaccct ggccgctcgc cccaggacct
      421 ggcctccact tcccgggccc gggagggcct tcgaaacatg ggtttgtccc cgccagcgag
      481 cagcaccagc accagcagca cctgccgcgc agaggcccct cgggaccggg accgagaccg
      541 ggatagggac cgggagcggg atcgagaaag ggagagggag cgagagaggg agcgggaacg
      601 tgagagggaa cgagagcggg gtaccagcag agtggatgac aagcccagct caccggggga
      661 cagctcgaag aagcgaggcc ccaagccccg gaaggagctc ccggacccct cacagaggcc
      721 cttaggcgaa cccagcgccg gcctcggaga gtacctcaag ggcaggaagc tggacgacac
      781 cccttccggg gcaggaaagt ttccagccgg ccacagtgtg atccagctgg cccgaagaca
      841 ggactcggac ctggtgcagt gtggtgtgac cagccctagc tcagctgagg ccacgggcaa
      901 actggctgtg gacaccttcc cggccagggt gataaagcac agggctgcct tcctggaggc
      961 caaaggccag ggtgccctag atcccaatgg cacccgggtc cgacatggct caggcccccc
     1021 cagctctggg gggggcctgt accgggacat gggggcccag gggggaaggc cctccctcat
     1081 cgccaggatc cctgtggcca gaatcctggg ggacccggag gaagagtcct ggagcccctc
     1141 cctgactaac ctggagaagg tggtggtcac ggacgtgacc tcaaactttt tgaccgtcac
     1201 cattaaggaa agtaacacgg accaaggctt ttttaaagag aaaagatgaa tgctgggtgg
     1261 gtgtgtccag gaggagagca ggggagagag tgagcgtgag cttggcatag tgatttttat
     1321 ttctgggtgg gatgtggcct tttggctggt cccgtccctg atgtcacccc caccccacca
     1381 gcccctttca tccctccttc ctccccctca gtttttgttg gaaagattat ctctagagtt
     1441 atattttcta ttagatgtaa atatgttatt taagaaaaat atctaaatat atatatttca
     1501 actcgaagtt gttttattta aaggagagag actctcattg tgctttagtt ggggcagccc
     1561 gaatgagctg gggcaggagg ggcccccttg ccccagagct ctagggaagt tgggccctgg
     1621 gtacaggttt ctgagagtgt ctggaggggc ttggcctgcc cacctcaccc ctcctccctt
     1681 ctcccacagc ccaatgccag actcctggca ccaaggcccg gcccagattt gctctctctt
     1741 cccattggcc aggcaggcca acaaaaggtt ggctccccaa tcagaaaaaa gggggggtgg
     1801 ggtcagtctg ttttcctttt ttctattttt ttttttttaa ggtaaagaag tctattaggg
     1861 aaaaaagtat taacttgaat aagcttttcg tgtgtgatgt tgaaggttaa aacgtcccca
     1921 gcaggcaggg acaggaggtt tctccccagg accacaccag gaaatgcact ttagggaggg
     1981 gtgtgtgtgt ggtacacgca gatcgtgtgt atgtcatgtg gataaaatct ccccgttccc
     2041 tcgttccttt ccttactccg cagaaagaaa agaaatccag cgaatctgtt tacattcccg
     2101 aaatgccagg ataaattggg aggattgcgt gtcagtgctg agagttcgag acagttgttt
     2161 tgcaagaaaa gtgttggggt ggacttttcc ttttcgcgtc ctctagcttt gccaggagaa
     2221 gagacggtgg cccccacctc ccaggaagag ttggacaagc ctccctgcct ggggagggcg
     2281 ggccgccagc tctgtggtgg acacatggcc agacaggccc accctgcggg acccacggag
     2341 ggaggcgcgg cggcgggcgc tgctaggagc agtggcttcg cacccagggc ctctccacgg
     2401 ccaggcttgg agtgtggctg aggaccacgg ctcggagctc ggagctgggg ctagactcac
     2461 ccccgcggct ccggccgggc acgggaagga ggggcgaggc ggggttttca tccaagaatg
     2521 cgcatcggaa cttttgcttt ttcctttttt ttcccccgtc cttcttaaaa gcaaaagcta
     2581 taatttatag gtcttttcga ttcgcagtgt tctctatttg aactcgacat tcaaactccg
     2641 ccaaaggggg agggaggagc gggagttggg agtggggacg gccgcggcgg ggaaggccgt
     2701 gcgaggcggc ggggcctggg acgcccctgc ccggcggact tgaccgctct gcgctccgag
     2761 gacgcagaat gcgcgcccct cttttgactc aaaagcacaa atcagtcccc tccactccac
     2821 ccccgtctct tggagcacgg atcccgcagc ctccctgccc tccccgccct taaagggcca
     2881 gcgaagatct aacttcccat tgcttgttga gggaggggcg cgggggccct gcacgccaga
     2941 ggaagcacag actcgggggg agcgaggcgg ggagtcgggg gtgggggagc ttcgcgtggg
     3001 gtggggggtg ctgggaggga accccagcct cgtcctccgc actcccggct tctcagcctc
     3061 tcctccagac tttcttgcct ttaaagagag aaaaggaggg aaacggtgta ctacatgatt
     3121 gtgtttgttt ttgaatatca aattgcgcct ataaagagaa gcccctggaa tggggatttt
     3181 tatctactca catttgtaaa actggtattt tagactttgt ataaagaagc gccgttgacc
     3241 gagtgtatct atttaaatgt cgatgctatt ttcagatgaa acttcactga aggggcatgt
     3301 ctgttaccta gtggacggga ctgggggata cgcgtcttca cctggccgcc gccttccctt
     3361 ctctcccgcc tgtcctttac tcccacctcc ctcccttcct gggggctgac tttgcccctt
     3421 cccttggacc ttctttccag ccagctctgt ccctgccgcc cctccgtcct gctgtttgtc
     3481 cgtggccgtg tgtgtatgtg tctccttctc tcgctcttgc gacgctgacc tggggggtgg
     3541 gtgggcaggg gccgggggcc acgtggctgg gagtctgcaa ccgcgcaggg tgtgtgcgct
     3601 gttgggttta tttaattcta agatttgtac aaatctccaa tcgatctccg cctcagctca
     3661 agagtgaagc ttcggtacct atcttctgcg gtcgtgaatg tctgtatcca ataccgcttt
     3721 ttacgtgttt aaatatatac tttgtaaata ga
//
