LOCUS       NM_175709               4111 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens chromobox 7 (CBX7), transcript variant 1, mRNA.
ACCESSION   NM_175709
VERSION     NM_175709.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4111)
  AUTHORS   Wang,Q., Zhu,M., Li,W., Guo,Y., Lou,H., Zhang,J., Xu,Y., Zeng,B.,
            Wen,X., Ji,X. and Xie,L.
  TITLE     CBX7 promotes choroidal neovascularization by activating the
            HIF-1alpha/VEGF pathway in choroidal vascular endothelial cells
  JOURNAL   Exp Eye Res 247, 110057 (2024)
   PUBMED   39179168
  REMARK    GeneRIF: CBX7 promotes choroidal neovascularization by activating
            the HIF-1alpha/VEGF pathway in choroidal vascular endothelial
            cells.
REFERENCE   2  (bases 1 to 4111)
  AUTHORS   Qiu,C.J., Hu,L.Y., Yang,J., Cao,J.J., Pei,B.G., Dai,R.R. and
            Pan,S.J.
  TITLE     A novel nanoplatform-based circCSNK1G3 affects CBX7 protein and
            promotes glioma cell growth
  JOURNAL   Int J Biol Macromol 276 (Pt 2), 134025 (2024)
   PUBMED   39033888
  REMARK    GeneRIF: A novel nanoplatform-based circCSNK1G3 affects CBX7
            protein and promotes glioma cell growth.
REFERENCE   3  (bases 1 to 4111)
  AUTHORS   Cheng,H., Hua,L., Tang,H., Bao,Z., Xu,X., Zhu,H., Wang,S.,
            Jiapaer,Z., Bhatia,R., Dunn,I.F., Deng,J., Wang,D., Sun,S.,
            Luan,S., Ji,J., Xie,Q., Yang,X., Lei,J., Li,G., Wang,X. and Gong,Y.
  TITLE     CBX7 reprograms metabolic flux to protect against meningioma
            progression by modulating the USP44/c-MYC/LDHA axis
  JOURNAL   J Mol Cell Biol 15 (10) (2024)
   PUBMED   37791390
  REMARK    GeneRIF: CBX7 reprograms metabolic flux to protect against
            meningioma progression by modulating the USP44/c-MYC/LDHA axis.
REFERENCE   4  (bases 1 to 4111)
  AUTHORS   Zhang,Y., Tedja,R., Millman,M., Wong,T., Fox,A., Chehade,H.,
            Gershater,M., Adzibolosu,N., Gogoi,R., Anderson,M., Rutherford,T.,
            Zhang,Z., Chopp,M., Mor,G. and Alvero,A.B.
  TITLE     Adipose-derived exosomal miR-421 targets CBX7 and promotes
            metastatic potential in ovarian cancer cells
  JOURNAL   J Ovarian Res 16 (1), 233 (2023)
   PUBMED   38037081
  REMARK    GeneRIF: Adipose-derived exosomal miR-421 targets CBX7 and promotes
            metastatic potential in ovarian cancer cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4111)
  AUTHORS   Scott,C.L., Gil,J., Hernando,E., Teruya-Feldstein,J., Narita,M.,
            Martinez,D., Visakorpi,T., Mu,D., Cordon-Cardo,C., Peters,G.,
            Beach,D. and Lowe,S.W.
  TITLE     Role of the chromobox protein CBX7 in lymphomagenesis
  JOURNAL   Proc Natl Acad Sci U S A 104 (13), 5389-5394 (2007)
   PUBMED   17374722
  REMARK    GeneRIF: CBX7 is a chromobox protein causally linked to cancer
            development
REFERENCE   6  (bases 1 to 4111)
  AUTHORS   Dietrich,N., Bracken,A.P., Trinh,E., Schjerling,C.K., Koseki,H.,
            Rappsilber,J., Helin,K. and Hansen,K.H.
  TITLE     Bypass of senescence by the polycomb group protein CBX8 through
            direct binding to the INK4A-ARF locus
  JOURNAL   EMBO J 26 (6), 1637-1648 (2007)
   PUBMED   17332741
REFERENCE   7  (bases 1 to 4111)
  AUTHORS   Gil,J., Bernard,D., Martinez,D. and Beach,D.
  TITLE     Polycomb CBX7 has a unifying role in cellular lifespan
  JOURNAL   Nat Cell Biol 6 (1), 67-72 (2004)
   PUBMED   14647293
  REMARK    GeneRIF: controls cellular lifespan through regulation of both the
            p16(Ink4a)/Rb and the Arf/p53 pathways
            Erratum:[Nat Cell Biol. 2022 Sep;24(9):1445. doi:
            10.1038/s41556-022-00956-2.. PMID: 35941232]
REFERENCE   8  (bases 1 to 4111)
  AUTHORS   Tajul-Arifin,K., Teasdale,R., Ravasi,T., Hume,D.A. and Mattick,J.S.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Identification and analysis of chromodomain-containing proteins
            encoded in the mouse transcriptome
  JOURNAL   Genome Res 13 (6B), 1416-1429 (2003)
   PUBMED   12819141
REFERENCE   9  (bases 1 to 4111)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   10 (bases 1 to 4111)
  AUTHORS   Garcia,E., Marcos-Gutierrez,C., del Mar Lorente,M., Moreno,J.C. and
            Vidal,M.
  TITLE     RYBP, a new repressor protein that interacts with components of the
            mammalian Polycomb complex, and with the transcription factor YY1
  JOURNAL   EMBO J 18 (12), 3404-3418 (1999)
   PUBMED   10369680
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031846.2, BU584877.1,
            BC051773.1 and BU584870.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_175709.4.
            
            Summary: This gene encodes a protein that contains the CHROMO
            (CHRomatin Organization MOdifier) domain. The encoded protein is a
            component of the Polycomb repressive complex 1 (PRC1), and is
            thought to control the lifespan of several normal human cells.
            [provided by RefSeq, Oct 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051773.1, SRR1803616.273035.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153031 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216133.10/ ENSP00000216133.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AL031846.2         62867-62896         c
            31-196              BU584877.1         1-166
            197-465             BC051773.1         1-269
            466-466             AL031846.2         48868-48868         c
            467-950             BC051773.1         271-754
            951-951             AL031846.2         44148-44148         c
            952-1458            BC051773.1         756-1262
            1459-3305           AL031846.2         41794-43640         c
            3306-3905           BC051773.1         3110-3709
            3906-4111           BU584870.1         1-206
FEATURES             Location/Qualifiers
     source          1..4111
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..4111
                     /gene="CBX7"
                     /note="chromobox 7"
                     /db_xref="GeneID:23492"
                     /db_xref="HGNC:HGNC:1557"
                     /db_xref="MIM:608457"
     exon            1..305
                     /gene="CBX7"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..992
                     /gene="CBX7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     chromobox protein homolog 7"
                     /codon_start=1
                     /product="chromobox protein homolog 7 isoform 1"
                     /protein_id="NP_783640.1"
                     /db_xref="CCDS:CCDS13986.1"
                     /db_xref="GeneID:23492"
                     /db_xref="HGNC:HGNC:1557"
                     /db_xref="MIM:608457"
                     /translation="MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEP
                     EEHILDPRLVMAYEEKEERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLC
                     FSLTCPLGSGSPEGVVKAGAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRG
                     PNLESHSHRRELFLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSS
                     EVTVTDITANSITVTFREAQAAEGFFRDRSGKF"
     exon            306..349
                     /gene="CBX7"
                     /inference="alignment:Splign:2.1.0"
     exon            350..415
                     /gene="CBX7"
                     /inference="alignment:Splign:2.1.0"
     exon            416..482
                     /gene="CBX7"
                     /inference="alignment:Splign:2.1.0"
     exon            483..834
                     /gene="CBX7"
                     /inference="alignment:Splign:2.1.0"
     exon            835..4111
                     /gene="CBX7"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4071
                     /gene="CBX7"
     regulatory      4085..4090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBX7"
                     /note="hexamer: ATTAAA"
     polyA_site      4111
                     /gene="CBX7"
                     /note="major polyA site"
ORIGIN      
        1 cccctccttg cgcgcgctcg ctcgctggcg ccgaggaaaa cgttgcgcag gttcaaaaat
       61 ggaacgtcgg cggcgtgagg gagcgcgagg gggtgtgcgc gcgtgcgcgt gcgcgtgcgc
      121 gcccggacga gggtgacggg gaccccgcca gccccagcat cgcgcgccgc agccgcggcc
      181 ccgcagctcc gcccccggcc cggcccggcc ccgggcccgc tcgcccgccg ccccgcatgg
      241 agctgtcagc catcggcgag caggtgttcg ccgtggagag catccggaag aagcgcgtgc
      301 ggaagggtaa agtcgagtat ctggtgaagt ggaaaggatg gcccccaaag tacagcacgt
      361 gggagccaga agagcacatc ttggaccccc gcctcgtcat ggcctacgag gagaaggagg
      421 agagagaccg agcatcgggg tataggaaga gaggtccgaa acccaagcgg cttctgctgc
      481 agcggctgta cagcatggac ctgcggagct cccacaaggc caagggcaag gagaagctct
      541 gcttctccct gacgtgccca ctcggcagcg ggagccctga gggggtggtc aaggcggggg
      601 cacctgagct ggtggacaag ggccccttgg tgcccaccct gcccttcccg ctccgcaagc
      661 cccgaaaggc ccacaagtac ctgcggctct cgcgcaagaa gttcccgccc cgcgggccca
      721 acctggagag ccacagccat cgacgggagc tcttcctgca ggagccaccg gccccagacg
      781 tcctgcaggc ggctggcgag tgggagcctg ctgcgcagcc ccctgaagag gaggcagatg
      841 ccgacctggc cgaggggccc cctccctgga cacctgcgct cccctcaagt gaggtgaccg
      901 tgaccgacat caccgccaac tccatcaccg tcaccttccg cgaggcccag gcagctgagg
      961 gcttcttccg agaccgcagt gggaagttct gaatcaccgt ttttactctt cttaaactgt
     1021 tttcttttgg gcttggggtg ggacttccag agatagggat gggttggggg cggggtaatt
     1081 attttattta aaaaaatacc gagcagcaaa aggggagaag atcccactac tctcccacca
     1141 cctgcccttt ctctgaggga cgtttaccac gaggcctcag gctggggatg gagagagttg
     1201 ctctgggagt tggggtacca cccccagggc aggatgggga caggatcacc tgcccgggac
     1261 accaccatta tcattctcct ctagtgacgc agcagctggt tctgggagtt aaaggagcat
     1321 tggaaggccc aaaccctctc ccttgagtgg ccaccccagc ctggttggct ggttttcccc
     1381 ttttctcttg tttcaattgg gtctttacct tgaactctcc tctctggctt tgcggtgggc
     1441 tgtggaggct ggttttgacc aaaagtgagt ggggcgggag gaaggggcag gaggaagggt
     1501 tgaggttact tggggcgagt cccttcccct tcagagaggc ttctatcctt cccagggagg
     1561 aggcgccgct gagacccttc tgctgagagc tctgccctcc cctcatcacc tggcctgtgc
     1621 agaaacgctc atgcacacct ggctgcacag gtgtgcacgc attacccttc gcgtgtacgt
     1681 tcccatgtgc cccgtgaaag catgtgtggc tgcagacgtg tccacatggg ccttgcgaac
     1741 ctgggttaga aaccctggcc aggcgaacgt ggggtgattc acagcacaaa agacctcacc
     1801 accacacctg cactcacccc accttgcatg caccttgcta cctgcttgcg gctttcagtg
     1861 gagggcaggg gtctggcaca ggtgcgatgg caccccatgc tccaggcata cagatgtggt
     1921 ttctcggctg caccgggcca ggctgcgggt gtgcaggcgt ctgctaagtt gtgtgatgta
     1981 tcagcacagg ctttgagacg tctggaccct gtccttcctc ccgtgagggg ttcttgttct
     2041 ttctgactca ggtgactttt cagcccttcc aattcccctc tttttctgcc ctcccctcca
     2101 actcagccaa cccaggtgtg ggcagtcagg gagggaggga gtgtcccacc acgttctcag
     2161 ggcagccctt gactcctaag ccccttcctc cttccattct gcatcccctc cccatccaac
     2221 ctaaatgcca cagctggggc tgagctgtat tcctgtggag ggacctctgc cgtgcctctc
     2281 tgaggtcagg ctgtgctgtg tgatgggcag gctttgcccc agcccacccc tggcaaggtg
     2341 cacttgtttt ctggtttgta caaggtgtcc tgggggcccg tggcttccct gccagtgagg
     2401 agtgacttct ccctctcttc cagtcctgta ggggagacaa aaccagattg gggggcccaa
     2461 ggggagcatg gaaaaggccg gctcccctgt ctttccttgg ctgtcagagt cagggtaaca
     2521 cacaccaaga gtggagtgcg gccagcaagt ttgagacctg cccgccctcc tcgcagctct
     2581 gctctgtgtc ctcaggaagt cacagagtct actgaggcaa ggagagggtg attctttccc
     2641 caaatccctt cttccctggt tcccaaacca aagacagcct gcagcccttt ctgcatgggg
     2701 tgctctgttg acaggcttcc cagatccctg agtctctctt tccttcctcc tcgatcttta
     2761 gttgtccacg gtcaattcag tgcttccatt gggggacagt cccctccggg atgacctgat
     2821 tcacctccag cccagggaat ggaatctaga ggaatacgtg gggtgggtct ggacaaggag
     2881 cggcaggaat caccacccat ctccagctgt ggagccctgt ggaggggaag gggaagcttg
     2941 gggttcagag gggactcttc caggagaggg gtgcccagcg gaggtaaaga tgatagaggg
     3001 ttgtgggggg tctctagttg aatgttttgg cccatgactt tggaacatgg ctggcagctt
     3061 ccagcagaag tcacgctccc catcccccag gggacatagg acctttttcc tgcttcctgg
     3121 tcactttcaa agaactattt gcgcaatctg tgggtctgtg gattcacggg gctttctgtg
     3181 tgggtgctgc agttgctttt gtctgcagca gcaggacaca tctttcctct tactcagccc
     3241 tttatggccc atggggaact ccgtggctca gggagagctg aactccaggg gtgtgacctg
     3301 ggacgggtgg gcctgaggtg cccagctcag ggcagccagg tggctcatgg gctgtagtga
     3361 gccagctccc tgggggaaaa ggctgtgggc cgttaggacc atcctccagg acaggtgacc
     3421 tctatgaggt cacctacggc tgtggccgtg caggcctcct tccagcccag agtggcccag
     3481 tagagcaagg cagacagtga cctccacccc cgcagccctc ttaaaaggcc agtactcttg
     3541 ggggtggggg gagggtttag aaagcatttg cccatctgcc tttctttccc ccagccccca
     3601 cccgctttga atgtagagac ccgtgggcac ttttcctttt gtggtggggg gtgcggagga
     3661 ggtaccccca cccctggcac agccgcctgg aatgcaggac tgtcactgct gttcgggtga
     3721 tgacctcgtt gccaagctcc tcctgtcccc ttgttctggg ggcaggcgct gtgcttctgt
     3781 gaggtggttt agcttttgct ttcgaagtgg ccagctgcgg ccaccaggtc tcagcacaag
     3841 agcgcttcct ttgcacagaa tgagcttcga gctttgttca gactaaatga atgtatctgg
     3901 gaggggtcgg gggcacgagt tgattccaag cacatgcctt tgctgagtgt gtgtgtgctg
     3961 ggagagtcag agtggatgta gagcgcggtt ttatttttgt actgacattg gtaagagact
     4021 gtatagcatc tatttattta gatgatttat ctggtaaatg aggcaaaaaa attattaaaa
     4081 atacattaaa gatgatttaa aaaaaagaaa a
//
