LOCUS       NM_014292               6052 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens chromobox 6 (CBX6), transcript variant 1, mRNA.
ACCESSION   NM_014292
VERSION     NM_014292.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6052)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6052)
  AUTHORS   Freire-Beneitez,V., Pomella,N., Millner,T.O., Dumas,A.A.,
            Niklison-Chirou,M.V., Maniati,E., Wang,J., Rajeeve,V., Cutillas,P.
            and Marino,S.
  TITLE     Elucidation of the BMI1 interactome identifies novel regulatory
            roles in glioblastoma
  JOURNAL   NAR Cancer 3 (1), zcab009 (2021)
   PUBMED   34316702
  REMARK    Erratum:[NAR Cancer. 2021 May 25;3(2):zcab020. doi:
            10.1093/narcan/zcab020.. PMID: 34319293]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6052)
  AUTHORS   Sakai,K., Nishiuchi,T., Tange,S., Suzuki,Y., Yano,S., Terashima,M.,
            Suzuki,T. and Matsumoto,K.
  TITLE     Proteasomal degradation of polycomb-group protein CBX6 confers
            MMP-2 expression essential for mesothelioma invasion
  JOURNAL   Sci Rep 10 (1), 16678 (2020)
   PUBMED   33028834
  REMARK    GeneRIF: Proteasomal degradation of polycomb-group protein CBX6
            confers MMP-2 expression essential for mesothelioma invasion.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6052)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 6052)
  AUTHORS   Deng,H., Guan,X., Gong,L., Zeng,J., Zhang,H., Chen,M.Y. and Li,G.
  TITLE     CBX6 is negatively regulated by EZH2 and plays a potential tumor
            suppressor role in breast cancer
  JOURNAL   Sci Rep 9 (1), 197 (2019)
   PUBMED   30655550
  REMARK    GeneRIF: CBX6 is negatively regulated by EZH2 and plays a potential
            tumor suppressor role in breast cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6052)
  AUTHORS   Vandamme,J., Volkel,P., Rosnoblet,C., Le Faou,P. and Angrand,P.O.
  TITLE     Interaction proteomics analysis of polycomb proteins defines
            distinct PRC1 complexes in mammalian cells
  JOURNAL   Mol Cell Proteomics 10 (4), M110.002642 (2011)
   PUBMED   21282530
REFERENCE   7  (bases 1 to 6052)
  AUTHORS   Maertens,G.N., El Messaoudi-Aubert,S., Elderkin,S., Hiom,K. and
            Peters,G.
  TITLE     Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation
            of the INK4a tumour suppressor
  JOURNAL   EMBO J 29 (15), 2553-2565 (2010)
   PUBMED   20601937
REFERENCE   8  (bases 1 to 6052)
  AUTHORS   El Messaoudi-Aubert,S., Nicholls,J., Maertens,G.N., Brookes,S.,
            Bernstein,E. and Peters,G.
  TITLE     Role for the MOV10 RNA helicase in polycomb-mediated repression of
            the INK4a tumor suppressor
  JOURNAL   Nat Struct Mol Biol 17 (7), 862-868 (2010)
   PUBMED   20543829
REFERENCE   9  (bases 1 to 6052)
  AUTHORS   Vincenz,C. and Kerppola,T.K.
  TITLE     Different polycomb group CBX family proteins associate with
            distinct regions of chromatin using nonhomologous protein sequences
  JOURNAL   Proc Natl Acad Sci U S A 105 (43), 16572-16577 (2008)
   PUBMED   18927235
REFERENCE   10 (bases 1 to 6052)
  AUTHORS   Tajul-Arifin,K., Teasdale,R., Ravasi,T., Hume,D.A. and Mattick,J.S.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Identification and analysis of chromodomain-containing proteins
            encoded in the mouse transcriptome
  JOURNAL   Genome Res 13 (6B), 1416-1429 (2003)
   PUBMED   12819141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD625491.1, BC064900.1 and AL008583.1.
            
            On May 17, 2019 this sequence version replaced NM_014292.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1114975.1, BC064900.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407418.8/ ENSP00000384490.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               CD625491.1         38-176
            140-2343            BC064900.1         125-2328
            2344-6052           AL008583.1         88875-92583         c
FEATURES             Location/Qualifiers
     source          1..6052
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..6052
                     /gene="CBX6"
                     /note="chromobox 6"
                     /db_xref="GeneID:23466"
                     /db_xref="HGNC:HGNC:1556"
                     /db_xref="MIM:617438"
     exon            1..95
                     /gene="CBX6"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1265
                     /gene="CBX6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     chromobox protein homolog 6; chromobox homolog 6"
                     /codon_start=1
                     /product="chromobox protein homolog 6 isoform 1"
                     /protein_id="NP_055107.3"
                     /db_xref="CCDS:CCDS13980.1"
                     /db_xref="GeneID:23466"
                     /db_xref="HGNC:HGNC:1556"
                     /db_xref="MIM:617438"
                     /translation="MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEP
                     EENILDSRLIAAFEQKERERELYGPKKRGPKPKTFLLKARAQAEALRISDVHFSVKPS
                     ASASSPKLHSSAAVHRLKKDIRRCHRMSRRPLPRPDPQGGSPGLRPPISPFSETVRII
                     NRKVKPREPKRNRIILNLKVIDKGAGGGGAGQGAGALARPKVPSRNRVIGKSKKFSES
                     VLRTQIRHMKFGAFALYKPPPAPLVAPSPGKAEASAPGPGLLLAAPAAPYDARSSGSS
                     GCPSPTPQSSDPDDTPPKLLPETVSPSAPSWREPEVLDLSLPPESAATSKRAPPEVTA
                     AAGPAPPTAPEPAGASSEPEAGDWRPEMSPCSNVVVTDVTSNLLTVTIKEFCNPEDFE
                     KVAAGVAGAAGGGGSIGASK"
     exon            96..139
                     /gene="CBX6"
                     /inference="alignment:Splign:2.1.0"
     exon            140..205
                     /gene="CBX6"
                     /inference="alignment:Splign:2.1.0"
     exon            206..272
                     /gene="CBX6"
                     /inference="alignment:Splign:2.1.0"
     exon            273..6052
                     /gene="CBX6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3221..3226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBX6"
                     /note="hexamer: AACAAA"
     polyA_site      3236
                     /gene="CBX6"
     regulatory      5986..5991
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBX6"
                     /note="hexamer: AATAAA"
     polyA_site      6011
                     /gene="CBX6"
                     /note="major polyA site"
ORIGIN      
        1 atgggctgtg ggtgccgctg agcaagatgg agctgtctgc agtgggcgag cgggtcttcg
       61 cggccgaatc catcatcaaa cggcggatcc gaaagggacg catcgagtac ctggtgaaat
      121 ggaaggggtg ggcgatcaag tacagcactt gggagcccga ggagaacatc ctggactcgc
      181 ggctcattgc agccttcgaa caaaaggaga gggagcgtga gctgtatggg cccaagaaga
      241 ggggacccaa acccaaaact ttcctcctga aggcgcgggc ccaggccgag gccctccgca
      301 tcagtgatgt gcatttctct gtcaagccga gcgccagtgc ctcctcgccc aagctgcact
      361 ccagcgcagc cgtgcaccgg ctcaagaagg acatccgccg ctgccaccgt atgtcccgcc
      421 gtcccctgcc ccgcccggac ccgcaggggg gcagccccgg actgcgcccg cccatttcgc
      481 ccttctcgga gacggtgcgc atcatcaacc gcaaggtgaa gccgcgggag cccaagcgga
      541 accgcatcat cctgaacctg aaggtgatcg acaagggcgc tggcggcggg ggcgccgggc
      601 agggggccgg ggcgctggcc cgccccaaag tcccctcgcg gaaccgcgtt ataggcaaga
      661 gcaagaagtt cagcgagagc gtcctgcgta cacagatccg ccacatgaag ttcggcgcct
      721 ttgcgctgta caagcctccg cccgcccccc tggtagcccc gtcccccggc aaggctgagg
      781 cctcagcccc gggccctggg ctacttctgg ccgcccccgc cgccccctac gacgcccgca
      841 gctctggctc ctccggctgc ccctcgccta caccacagtc ctctgacccc gacgacacgc
      901 cccccaagct cctccccgag accgtgagcc catccgcccc cagctggcgc gagccggagg
      961 tgctcgacct gtccctccct cccgagtcgg cagccaccag caagcgggca ccgcctgagg
     1021 tcacagctgc tgccggcccg gcacctccca cggcccctga gcccgccggt gcctcctccg
     1081 agcccgaggc tggggactgg cgccccgaga tgtcaccctg ctccaatgtg gtcgtcaccg
     1141 atgtcaccag caacctcctg acggtcacaa tcaaggaatt ctgcaaccct gaggatttcg
     1201 agaaggtggc tgctggggta gcaggcgccg ctgggggcgg tggcagcatt ggggcgagca
     1261 agtgaggggg ctccaccaag gaggggggct tgggggggcc ctcctgcccg aagtcatact
     1321 cttgctccca ccccaccctt gcccccagcc ctctctccct gtgctttgct tgtctcaaat
     1381 ggctcggtgt tgacccaggg atggggctgg gtagttgggg tcccagaaag ccgggggtag
     1441 gggccaccct ggaatggggc aggggaaggg cacaccccct gcccatgcat ggtagcccac
     1501 tgggtggttt ctggaaagcc ctagaaacta gggttcctct gccccttcca catcccacct
     1561 gtctctctag cttgcttcct gctctcctgt gcggcgtctg atttctcggt gctaacctgg
     1621 cagctgtggg gcccttagga gccccccacc gagggtggac acagtccctt tccttcctgc
     1681 agatgcctag gcaggaggag ggcttcctgc ctgtttggca aagtcccagg cagaggccaa
     1741 ggatgaggcc tgactcggct cctccctcca catcagccag ggcatcagaa gttgggccag
     1801 ggcggggtct tccctgctcg attttggacg aggcctaagt agacccccta tgccctgccc
     1861 cagccctggc tctttcctaa ccccctcaac ggtgggagga actggcagag ggtgcgcctg
     1921 gccacagcct ccccgcatct aaaggcccct tcagttcttg accaaaggtg ctacgagaac
     1981 ctgccgtgga aacttccagt tgtgcgtctg ccccactcgc tgtgtttgtc cgtgggttca
     2041 tacatgcatt gggtgctagg ccccaggctg ccgggtggca ccctttacag ttcctttgaa
     2101 caggggcatt gaaggcctgg actgcctctc gcctcagtag gcctggggac caggcttggg
     2161 tctggaggtt tgctgtggaa gtcaccaggc ctcccctcct ggcccaggtg tgctgggggc
     2221 accgtgcccc ccacccccct gccctcctca gggtggtcag cccaacctgt cggaccttca
     2281 cttcacatca tggtggggac cgagatagag agggagaccc cattccaagc tccctcttcc
     2341 tccgggtgtt tggggaggat gctgaagaat ccattcccga gggcctcccg gcttgtccca
     2401 gcccctcttt tgcttctgac cacggaggct ttctcacagc ccagcctgcc tgaagcaaag
     2461 gaggctcccg tgtcctgggc agcttctgtt tccctctgct gcctgggagc tgaggcaccc
     2521 gtgccagtgg cagaggccac agccccagcc ttaggccagg ccctgggagg gcaggcaggc
     2581 aaaggggaga ccagagggtc tgtgttctcc aggagaatga gggtgttggt cccagaattg
     2641 ggaccggggc cccgctggcc agccctgggc cacttcccgg gtctccattg tgcgtgggtg
     2701 gcgtgttcca ggcgtggctg gagctggctt cctggctgtg ctgccatggg cccctccctc
     2761 agaagcacgt tggcaggagg ccgatcagaa ccctagcgcc tttggtccta agaatgggag
     2821 gctgccttcc ttcccaatct ccctgccagg gcccacagcg tggccctagc cctcccctcc
     2881 ccgggatgta gaacggggac cctcgcaggg ttggggcggg ggctgatact cctcggcccc
     2941 tccctaccct gccctgtgtg ttggctttgt ggccgtccaa gtgccaattg gcttttcgcc
     3001 caaataaggg ctggtatttc tcctctgtcc ttggaggtga tttccccctg accccctccc
     3061 ccaggtgagt gaccacctgg gtgccagtta caggtgtttc cagagaccat agaaatgtgt
     3121 tttcctgaga gttcgtgtca ttcgtgactt ttttgtaaag aagttgtgtt ttcagaggtg
     3181 attttatgac aggaaagtga aagaattagt tttgcaaaaa aacaaaaaca aaaaaagagg
     3241 aaaaaaaaaa gaaatagaaa aaaatattgt gggattccta tgggggggtg gcgggggaga
     3301 aagagctatt taagaaaaaa tagtaacgca gtgattgcac aggtgaggtg gcaatgtcag
     3361 gatggggcgg aggcctgggc ccagctggca ggtcccctgg catcgcaggc actgtggaga
     3421 gggcctggac ccagatctcc acacccgtgc ttgctcaaag ggaaggacaa cagcgggccc
     3481 ccgggagcta acccaagctg caggtcccgg caagctgagg tttgggaggg tgggggttgt
     3541 cactggtgat tttctccagg gggctggtga gtgggcagtt tggtttcttg cccccttctg
     3601 ttcctttccc agttgttggg ccatctggtc cccaccaccg ccaccctatg ggggagacct
     3661 ccctccccac gggtcaccct aaagcccaca acctctctga gcctccctgg cctgaaaggg
     3721 gatgcaggct tcaggaggca agaagctggg cccctggggg tggctgggga gagggaatgc
     3781 atttcccttg ccacaggtgg tctgcttctg ctggcctgag ctccaagtgg agcagcccgg
     3841 gccagccttg gtgcatgaag aggcaccagg cacaccgcct tgaggtgggc agtgcccatg
     3901 ggggcccgag tggatgggac cgagggtgag tggagcctcc ttcctcccct ctctagtacc
     3961 cccgcctccc acacacttgc acggatcggc ctcccttggg agatcagcct ccatgggccc
     4021 ctcgtccacc cttgctgctt tccatttgcc taattaccaa gcagaagttg caatctggtt
     4081 tgctttattt ttgtatgtga aataaccccc aaagcccaat ctcctcctac gttcaatatt
     4141 ggttggggca tccgtcatct ccccttaagt gcgccccctc cccacccaag tatcatagga
     4201 aaccggtgag gtctggtgtc tctggtttga gacggtaagt tgggacccat ccctgtctgg
     4261 gtgcccactc tgacctttag tttgcccttc tgtgaaatgg gtgtattggg tagcaagccc
     4321 tcttcagaaa gcgctgctgg tgtcagagca gctgcccagt accaggtggg gggtcaaggt
     4381 tgctggtact ggggccccca gctgcccaca acccctcttt gttctcaccc tgcaaagggg
     4441 tcaaggtcaa aatgagcctc atccttccta tgatctggga agaggtgatg atcaagtccc
     4501 caacttcagt gtgaggtgga cagagttggg gggatggccc ctttttgaag aggtgaaaat
     4561 ggttttggag aagcgcagct gcttcactgg gggaatgcgg cagggactgg ggcccaggat
     4621 gctttggcct atggggaaaa gccctttaaa aggcagggcc caggccctgg agccagcaca
     4681 agactggcct cgagcccctg agccaggagg tcctggagga gagccaggcc ggtgggcccg
     4741 cccaaggctg gagggtcagc cccaacaggg agctgggttg gccagggggc tggactgcta
     4801 ccagcctctc tggcctatgg ggacccaaga ggacacatcc cccttttgcc cactcttctg
     4861 tgtcattttg ttgttttggt ttgtggtggt ttttcttttt tcttttgttt ttcttttttc
     4921 tttctttctt tttttttttt tttttttttt tttttgcact tcgcccacac aggacagtgg
     4981 agccccacct ggtcagttcc acttccgggc tcccatgcac ttgcccaagg cggcctcttt
     5041 gggacgggga tggtttgagg aaacactttt aaagaaaaaa ggaagacatt gaaaggtttt
     5101 agtttcttcc ctatctgcat gtcctctcat atagaaagcc cagaattagg ggctagaact
     5161 ccaggagagg gtctccccga ctcatctctt gctgacggtc accaggatgc agaaataggg
     5221 agatggttag tgggggccaa agatgccccc tcccaggcct tcgtggttcc ctcctccgcc
     5281 ccctgcaatc tttggaggag tcagtgcctc actccagcag tgagtgccta ctgtatgcag
     5341 gtagtcagcc aggcaaagag agactaacgg tctcatgggg gaaccctctt gcgggaggcc
     5401 gggtagctgg agcgaagcgt tccggctgcc cttgctgctg ggtggagtgg agagggagac
     5461 ttctttttgt tggttttaat ttaaaaacac aaaggcctaa agaaatacgt atcttataat
     5521 ttttttaatt tttgagacgt tcatttaatg aattgtgcac gaatgaattc tatatatata
     5581 aaatatacat atatagctct atatttgggg aggggcactg tctctttttt ctctcatttt
     5641 taaaatgaag tgttgttgcc tttgtatgtg gttcaaccat ccagctccca gctggctaaa
     5701 ctttgcctcc agtggtcaaa gatgggaaaa gagtggggtt ggcaggagat ggaaaacgga
     5761 ggtgccgccc cagcatgggg ggcaggtccc ccagtccacc ctgcccctcc ccctgtggag
     5821 aagacgctta gttgggggtg tgggtttggg ctccattctg gattcggcgg ttccggggga
     5881 ggggtgggtc tgtgccgatt actctgtctt gtacgtttgt tctgctgctc ttcaatattg
     5941 tatcaacgcc aggaaagggg ggtgaaaagc ctcttttacc ccccaaataa attgtcacat
     6001 tccgaagctg aggcctagcc cctaggttgg ggtgtgtctg tgtcttcttc ca
//
