LOCUS       NM_012117              11546 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens chromobox 5 (CBX5), transcript variant 3, mRNA.
ACCESSION   NM_012117
VERSION     NM_012117.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11546)
  AUTHORS   Lou,J., Deng,Q., Zhang,X., Bell,C.C., Das,A.B., Bediaga,N.G.,
            Zlatic,C.O., Johanson,T.M., Allan,R.S., Griffin,M.D.W.,
            Paradkar,P., Harvey,K.F., Dawson,M.A. and Hinde,E.
  TITLE     Heterochromatin protein 1 alpha (HP1alpha) undergoes a monomer to
            dimer transition that opens and compacts live cell genome
            architecture
  JOURNAL   Nucleic Acids Res 52 (18), 10918-10933 (2024)
   PUBMED   39193905
  REMARK    GeneRIF: Heterochromatin protein 1 alpha (HP1alpha) undergoes a
            monomer to dimer transition that opens and compacts live cell
            genome architecture.
REFERENCE   2  (bases 1 to 11546)
  AUTHORS   Sako,K., Furukawa,A., Nozawa,R.S., Kurita,J.I., Nishimura,Y. and
            Hirota,T.
  TITLE     Bipartite binding interface recruiting HP1 to chromosomal passenger
            complex at inner centromeres
  JOURNAL   J Cell Biol 223 (9) (2024)
   PUBMED   38781028
  REMARK    GeneRIF: Bipartite binding interface recruiting HP1 to chromosomal
            passenger complex at inner centromeres.
REFERENCE   3  (bases 1 to 11546)
  AUTHORS   Ukmar-Godec,T., Yu,T., de Opakua,A.I., Pantoja,C.F., Munari,F. and
            Zweckstetter,M.
  TITLE     Conformational diversity of human HP1alpha
  JOURNAL   Protein Sci 33 (7), e5079 (2024)
   PUBMED   38895997
  REMARK    GeneRIF: Conformational diversity of human HP1alpha.
REFERENCE   4  (bases 1 to 11546)
  AUTHORS   Xiong,F., Wang,D., Xiong,W., Wang,X., Huang,W.H., Wu,G.H.,
            Liu,W.Z., Wang,Q., Chen,J.S., Kuai,Y.Y., Wang,B. and Chen,Y.J.
  TITLE     Unveiling the role of HP1alpha-HDAC1-STAT1 axis as a therapeutic
            target for HP1alpha-positive intrahepatic cholangiocarcinoma
  JOURNAL   J Exp Clin Cancer Res 43 (1), 152 (2024)
   PUBMED   38812060
  REMARK    GeneRIF: Unveiling the role of HP1alpha-HDAC1-STAT1 axis as a
            therapeutic target for HP1alpha-positive intrahepatic
            cholangiocarcinoma.
            Erratum:[J Exp Clin Cancer Res. 2024 Jul 5;43(1):186. doi:
            10.1186/s13046-024-03112-w.. PMID: 38965576]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11546)
  AUTHORS   Papamokos,G.V. and Kaxiras,E.
  TITLE     How to evict HP1 from H3: Using a complex salt bridge
  JOURNAL   Biophys Chem 300, 107062 (2023)
   PUBMED   37302360
  REMARK    GeneRIF: How to evict HP1 from H3: Using a complex salt bridge.
REFERENCE   6  (bases 1 to 11546)
  AUTHORS   Lessard,J., Baban,S. and Sauvageau,G.
  TITLE     Stage-specific expression of polycomb group genes in human bone
            marrow cells
  JOURNAL   Blood 91 (4), 1216-1224 (1998)
   PUBMED   9454751
REFERENCE   7  (bases 1 to 11546)
  AUTHORS   Ye,Q., Callebaut,I., Pezhman,A., Courvalin,J.C. and Worman,H.J.
  TITLE     Domain-specific interactions of human HP1-type chromodomain
            proteins and inner nuclear membrane protein LBR
  JOURNAL   J Biol Chem 272 (23), 14983-14989 (1997)
   PUBMED   9169472
REFERENCE   8  (bases 1 to 11546)
  AUTHORS   Sugimoto,K., Yamada,T., Muro,Y. and Himeno,M.
  TITLE     Human homolog of Drosophila heterochromatin-associated protein 1
            (HP1) is a DNA-binding protein which possesses a DNA-binding motif
            with weak similarity to that of human centromere protein C (CENP-C)
  JOURNAL   J Biochem 120 (1), 153-159 (1996)
   PUBMED   8864858
REFERENCE   9  (bases 1 to 11546)
  AUTHORS   Ye,Q. and Worman,H.J.
  TITLE     Interaction between an integral protein of the nuclear envelope
            inner membrane and human chromodomain proteins homologous to
            Drosophila HP1
  JOURNAL   J Biol Chem 271 (25), 14653-14656 (1996)
   PUBMED   8663349
REFERENCE   10 (bases 1 to 11546)
  AUTHORS   Saunders,W.S., Chue,C., Goebl,M., Craig,C., Clark,R.F.,
            Powers,J.A., Eissenberg,J.C., Elgin,S.C., Rothfield,N.F. and
            Earnshaw,W.C.
  TITLE     Molecular cloning of a human homologue of Drosophila
            heterochromatin protein HP1 using anti-centromere autoantibodies
            with anti-chromo specificity
  JOURNAL   J Cell Sci 104 (Pt 2), 573-582 (1993)
   PUBMED   8505380
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP336150.1, AC078778.34 and
            BC030149.2.
            
            On Nov 22, 2018 this sequence version replaced NM_012117.2.
            
            Summary: This gene encodes a highly conserved nonhistone protein,
            which is a member of the heterochromatin protein family. The
            protein is enriched in the heterochromatin and associated with
            centromeres. The protein has a single N-terminal chromodomain which
            can bind to histone proteins via methylated lysine residues, and a
            C-terminal chromo shadow-domain (CSD) which is responsible for the
            homodimerization and interaction with a number of
            chromatin-associated nonhistone proteins. The encoded product is
            involved in the formation of functional kinetochore through
            interaction with essential kinetochore proteins. The gene has a
            pseudogene located on chromosome 3. Multiple alternatively spliced
            variants, encoding the same protein, have been identified.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence and transcripts to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.150766.1,
                                           SRR1660809.238217.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000209875.9/ ENSP00000209875.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BP336150.1         10-29
            21-115              AC078778.34        89725-89819
            116-294             AC078778.34        112135-112313
            295-481             AC078778.34        117600-117786
            482-582             AC078778.34        123612-123712
            583-10286           AC078778.34        127922-137625
            10287-11542         BC030149.2         1-1256
            11543-11546         AC078778.34        138882-138885
FEATURES             Location/Qualifiers
     source          1..11546
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..11546
                     /gene="CBX5"
                     /gene_synonym="HEL25; HP1; HP1A; HP1alpha"
                     /note="chromobox 5"
                     /db_xref="GeneID:23468"
                     /db_xref="HGNC:HGNC:1555"
                     /db_xref="MIM:604478"
     exon            1..115
                     /gene="CBX5"
                     /gene_synonym="HEL25; HP1; HP1A; HP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            116..294
                     /gene="CBX5"
                     /gene_synonym="HEL25; HP1; HP1A; HP1alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..733
                     /gene="CBX5"
                     /gene_synonym="HEL25; HP1; HP1A; HP1alpha"
                     /note="chromobox homolog 5 (HP1 alpha homolog,
                     Drosophila); heterochromatin protein 1 homolog alpha;
                     antigen p25; HP1Hs alpha; HP1-ALPHA; epididymis luminal
                     protein 25; heterochromatin protein 1-alpha"
                     /codon_start=1
                     /product="chromobox protein homolog 5"
                     /protein_id="NP_036249.1"
                     /db_xref="CCDS:CCDS8875.1"
                     /db_xref="GeneID:23468"
                     /db_xref="HGNC:HGNC:1555"
                     /db_xref="MIM:604478"
                     /translation="MGKKTKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGF
                     SEEHNTWEPEKNLDCPELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSADDIK
                     SKKKREQSNDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKC
                     PQIVIAFYEERLTWHAYPEDAENKEKETAKS"
     exon            295..481
                     /gene="CBX5"
                     /gene_synonym="HEL25; HP1; HP1A; HP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            482..582
                     /gene="CBX5"
                     /gene_synonym="HEL25; HP1; HP1A; HP1alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            583..11546
                     /gene="CBX5"
                     /gene_synonym="HEL25; HP1; HP1A; HP1alpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      831..836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBX5"
                     /gene_synonym="HEL25; HP1; HP1A; HP1alpha"
                     /note="hexamer: CATAAA"
     polyA_site      865
                     /gene="CBX5"
                     /gene_synonym="HEL25; HP1; HP1A; HP1alpha"
     regulatory      5203..5208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBX5"
                     /gene_synonym="HEL25; HP1; HP1A; HP1alpha"
                     /note="hexamer: AGTAAA"
     polyA_site      5223
                     /gene="CBX5"
                     /gene_synonym="HEL25; HP1; HP1A; HP1alpha"
     regulatory      11522..11527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBX5"
                     /gene_synonym="HEL25; HP1; HP1A; HP1alpha"
                     /note="hexamer: AATAAA"
     polyA_site      11546
                     /gene="CBX5"
                     /gene_synonym="HEL25; HP1; HP1A; HP1alpha"
                     /note="major polyA site"
ORIGIN      
        1 gttttggcgg gcggttggcg ttgcgcagaa ggcggcggcg gtggtggctt gtggtgcggc
       61 ctcaccatac aggaacaggg cagacgttag cgtgagtgat cactctcaat cccggggacc
      121 tggtggcctt agtctttcag gtggaacggt gtgcgacatg ggaaagaaaa ccaagcggac
      181 agctgacagt tcttcttcag aggatgagga ggagtatgtt gtggagaagg tgctagacag
      241 gcgcgtggtt aagggacaag tggaatatct actgaagtgg aaaggctttt ctgaggagca
      301 caatacttgg gaacctgaga aaaacttgga ttgccctgag ctaatttctg aatttatgaa
      361 aaagtataag aagatgaagg agggtgaaaa taataaaccc agggagaagt cagaaagtaa
      421 caagaggaaa tccaatttct caaacagtgc cgatgacatc aaatctaaaa aaaagagaga
      481 gcagagcaat gatatcgctc ggggctttga gagaggactg gaaccagaaa agatcattgg
      541 ggcaacagat tcctgtggtg atttaatgtt cctaatgaaa tggaaagaca cagatgaagc
      601 tgacctggtt cttgcaaaag aagctaatgt gaaatgtcca caaattgtga tagcatttta
      661 tgaagagaga ctgacatggc atgcatatcc tgaggatgcg gaaaacaaag agaaagaaac
      721 agcaaagagc taaaggaggg gatggtctct gtcatttctc tttgtacata atacattcac
      781 ctccctgcct cctctccttt ctacccaccc ctttctatcc taaacacatc cataaaaaat
      841 gtgcttatca ctgtgctcca caggagaaat gttggtattg gttctcttgt aacataactg
      901 atggtctgat taatgataag tgtctctctg tgaagaccag gcatttacat actgagtgta
      961 atacccacaa tttttttttc ctttgccctg atctcttcct tctgcttccc tgtgacctca
     1021 agatgagttt caacttttta atcaccttag agtcttgatc ttttcagggt tggtcgcttt
     1081 ttaggttggg ggattttgtt acaatgatgt tgaattttgg tttcttgctt tggttcttag
     1141 aacatgttgc tgactagctg gcctttgttc tgacatgttg agatggaaag gatgttgccc
     1201 atctgttaaa aagccaatag caactgccta cctgttgggg ctttcccaac cttgttcagc
     1261 tctacccagg agaatacagg gtttctggtg tggtcttctg ggccaccctc tgttgttcat
     1321 cctcactcat cctcccagaa ttactccatc ctttggaaga tttgaaattt tacactgaaa
     1381 tctgtcaaga cactcttttt agccccagga ctttcggtat tgcttttagc actccccact
     1441 tctgcttctg taaagtgata tcaatttgtg ataaaatgac aagattatta actgtgcaga
     1501 tttgtagcta tagtacatga ggatgatggg gtagggtaca attgtcttta ttatcatata
     1561 tggtatgtat gtatgatttc tttccattcc tcatatttag actgtatatt tatgtaggtg
     1621 tgagtgattg cctggtgctt gcttgtgcca aggtgctagg caccctccaa ccctgccaac
     1681 ttttgtggcc tcccaaagca ttcctgttac caaagaggct tcaaacctga ccctcacttc
     1741 tcagtggacc cgagtttccc ttccatgcca ttattttcag tggggaagtt ttagaggtga
     1801 gctgttggcc acaatatcaa ttttaagtgt tcatagcagt tatgtctcct gcattcttgg
     1861 ctcctggatt taccaccaag agtccccaaa atattaatgc tcttcccttt ttctaccctc
     1921 aaacttatag ttgtatctta ttttttaaaa tgaattttca tggccaggca cagtggctac
     1981 cgcctgtaat cccagcactt tgggaggctg aggcaggaga attgcttgaa gccagaagtt
     2041 tgagaccagc ctgggcaatg tagtgagacc ccctgtctct aaaaaatata aataaaaata
     2101 aaggcatgtt cctgaaagac tgtcaccttg gaaagtgaca ggccctggca ttagcatgtt
     2161 gacacaccct tttcttctta ctcagcaaaa tacttcgttt tggtttcttc ttgtgttgct
     2221 attgagaaat ttgtctgatc atatccttct gcctttgtcc cccaagaaat gccctacttt
     2281 atccttttct ttttgtagtt gaggagggct agagaatcac aattaaaagt aaggaaatag
     2341 cagggttttg aggatccttg tcccagcccc aaagctgagg aaataagaat aaatgcttaa
     2401 tatagcctta attctagagc gcaccagcca tgaggctgct tttcttgttg tttttgattt
     2461 ttaaaacata cagctgtctg gccaggagca tctaccattt ctagattatt cagagtaatg
     2521 aggggaatgg atggattgct ccagtccaca gatgagccac ataatatgca aatcatatac
     2581 ccattcatag catttgttaa cattgcttcc ctgctcagct gctgattgaa ttctgtgtgc
     2641 ttatataaat tatgtcaaaa attatactgc ataattgagg tgacagctgt tgctgcagtg
     2701 acatgacaga ctggaacaat gaagcttttg gtttaagtca gccaggaaaa tccttctgaa
     2761 tggtaatgtg attgggcaag agctcataaa ccatacctca agtgggtggg agttttatct
     2821 ctatattcct tctctctctg aaggaattaa aggcctagat caagtgctgg ataattgaca
     2881 attgcttgta cttaatctga tcggtatcta aaagaaggaa aggatggtca ggaaacattt
     2941 atcataaatg tagccaagga tatcaattag ggtagacaag aataggacaa aaataggcca
     3001 gagctcctga ggaggtgata tgggtctctt gatttgcaga aaatgacagc ctatccaagt
     3061 ggcccagtgt atgcctccca gtagcagtgg gcatgtaaac tgcagcgacc ttatttttaa
     3121 aaccaaaaac ctagtatgtg gacaaagaac atgacaatat ttggtactga gattggttct
     3181 gagaaacctg gggcatgtgg ctgctgtggt tataggtaat atttaagaca ttcataaaaa
     3241 tctgatattc ttttaccgaa ataaccccag tatcatctac tacttaccat ctgttaatag
     3301 actttactct gtcttttttg tcttcggttt attgtactga gtgccgccaa aacaactttt
     3361 gttctcttcc tgcctacctg cagctggttc tataggaatg tagggagcca gaggccagta
     3421 ttgatttcag cccttagcac aaaggaaatc agatgcctgc ttccagcatt tgttagtgtt
     3481 gagtagatgt tcttgcccta gaagaattac agcctcaaac agaaacctgt ttcatggagc
     3541 tttctcccct cagaagagtt aatagttaag agctaagcac tcttaaacac ctaagtctca
     3601 aatgctaaaa atttattttt cttgtgttta gtcctctttc aagacatctt tctaagcctt
     3661 tcagtaatca acattaaaag atctcccttt cttcagagtt atagcacagc tttgcccagt
     3721 agaggctacc aaggacagct tagcagccct ttgattgctg ggctgggcag atggccttca
     3781 agttaagatc aaatgccggg aaaatcagcc tacatgggag cacccatttt aaacctggag
     3841 agaaccatga tgttttcttc ttcaaataac aatctagttt tttttccccc agtactaaaa
     3901 ttgtattgtc tttcagacaa tataattttt atttaaaatt ggaacatact atcttcatgc
     3961 tttctaagct aaatcttcat ttagatttca ctcctcagta gatcccagag aagaagctat
     4021 ataggatcca gattcaaatt taacagtgtc ttctactttt ttagttatgt tttctatcaa
     4081 ctcctgctgc cttttcaaat acggatattt ttcaggagac tcttctactt gtccactgac
     4141 tgtatttttt cctttttgat ccgtagccct ggttaaatgg ctgacatcct tccgtggatg
     4201 attcttggag gtagtctcag aattccaaag tgattgtctg tcttcttctt gtcttgatcc
     4261 taatgcagac attcacctct attatttatt tatttttttt agacagagtc tcgctctgtc
     4321 accaggctgg agtgcagtgg cacaatcttg gcttactgta ccctccacct cctgggttca
     4381 agcgattctc ctgcctcagc ctctcgagta gctgggacta caggtgtgtg ccaccatgcc
     4441 cagctaattt ttgtattttt ggtagagatg gggttttacc atgtttgcca ggatggtctc
     4501 gatttcctga ccttgtgatc tgcccacctt ggcctcccaa agtgctggaa ttacaggcat
     4561 gagccaccgt gcctggccac ctctattaaa tttttgtgga caaaaataaa attgtcatta
     4621 tttgtttgct ctcatggagc actttcagta atacaatttt ttttaaattc cagttgccct
     4681 ctttgttgct ctgtcctctg taatacctga ctttgctaaa gacttgaggg gtggtttcag
     4741 aggagggtca ggtgatggga aggcaggatg agaaaagccc tggacttgca tgtttgagaa
     4801 ggcttccaac cacatcttca ctcagactct tggaattcct gtccccaaaa caagcttctg
     4861 ttttttgctc acaatgctat atttctaaat ttttcctgaa ttactgagaa gcagtcatta
     4921 gctttgttaa gtttggtttg gggacattgt tggtatcaaa aatcgaagtc ttattcattt
     4981 gatgtaggcc atgaatcatc aataactggt tgctggaaag cttgactacc atccactggg
     5041 gtgctatttt gagaaggatt tttgggtatc tttatagtct gcaattagtt gatgattgct
     5101 ttctagttta tcaactgcat ttatatttgc ttttctgttc atggaaaatc ctttatttgc
     5161 tggggttttt tgtttgtttg tttgtttttc ccacttacag caagtaaaag tggtctgagg
     5221 ttatccttgt ttttcttcgc ggtttgccat gtgtgaaagt agatttcctg ctattgatat
     5281 attctcatta tagacagaat agtggagaac agtgttgcca tggacaaaat ccagttttgg
     5341 tccactctgg ggagcatttg gacctgtggt gcttctaaca attaaaagtc tagatggtcc
     5401 ttgactgtcc cccagccata ctgcatacta ctttgtgcat tctactttgt gtcattaatg
     5461 aaagattggt tctgtccctg taacttaggc atttattatt cttaactctt cattcctgtt
     5521 ctgtagccac ccagcagtcc attttcccta tgttcaggcc aaaccacagg gcattgggga
     5581 aggtttttgg gattttctta ttgagatttt gttgaatctg tagtttaccc cagctttcct
     5641 aaggtacagt gaggggttgg agggatctgt gtttggcccg gggagcaatt gtctctacct
     5701 taaggttcag ttttgagggc ataaaatact actttgcaat gtcatgagaa caccgttaga
     5761 tctgaaatgt ggaaatggtt tctcacaatt taaaggaaaa acccactttg cacccatgat
     5821 cccatcattt tggttgagat tttagaataa aaaatatagt gttgagatcc gtacttttgt
     5881 aatcagacca ccaagcatgc ctgtggcaag gcagagagga aaggtctgga gccagtgtat
     5941 tgcagtttca tgctaccttt acctgctaat cataaaaatt atgttttcaa aagtagatga
     6001 tactagcctt acacccaaaa acatgttctg aattagatgc cccctcaccc aatttttatt
     6061 aagctttcta aattccagcc acattgctgt acatcaacat tggtttcatt caacagacat
     6121 ttttttggcc tgaagataca aggttcagaa agaggccatc cctgccctca aataactttc
     6181 atactggtgt atgatgaact gaccattaat agtttaagtg cttacaagct atgtttctgt
     6241 tcaaaaaaaa aatagtttgg tataataaat gctataaacc aatacacatt tctgacttgg
     6301 gggcagagac agactggctg atgttgtata gtttgtagcc ctggagtaag aagttgacat
     6361 taatttcggc ctatatgtgg aaaagaccta taacattggg tgaactgagc cagctggcca
     6421 tagaacacaa gaacatattc caggaaataa atatagctgg agggttggaa atgctgttat
     6481 tactgagaga gaaaacaggt gagttgggat tgagaactcc tgattttcat ccctggttta
     6541 gattcttggc caaagtagtg gtagagttaa tctttgcttg tggaaagcat taactatgtt
     6601 gcagattcag ttgtgttaca ttattgtggg ttctataaca acatattcct catggacact
     6661 ttaccagagt tgctcacacc tttttcaatt tctcatccct tttggaggaa tgaacatgag
     6721 acttaactgc ctttaagcct aaaacggaca tgctttccaa tgacaagaga ttttctaaag
     6781 agaagtcttg gagcacatct gttaatacct gagcatctac tctgagcagt gcagttttat
     6841 tcaatactgg agagagggtg atttcttttt ttttgagacg gagtcttgct ctgtctccca
     6901 ggctggagtg cagtggcgca atctcggctc actgcaagct ccacctcccg ggttcacgcc
     6961 attctcctgc ctcagcctcc cgaggagctg ggactacagg cgccggccac cacgcccggc
     7021 taattttttg tatttttagt agagacgggg tttcaccttg ttagccagga tggtctcaat
     7081 ctcctgacct catgatccac ccacctcggc ctcccagagt gctgggatta caggcgtgag
     7141 ccaccgccgg gccgagaggg tgatttctaa gcagagaatt gtatcagtta tgtggaaacc
     7201 tttgccagaa atacatatac cttgtatatt aaatctgagt ctcagattta atcatcgaag
     7261 cgtagctggg ttaagaaaca gtctgatcgt aaggatgttg tcgattctga cccatggatg
     7321 accacaagaa aaagatattt atttctgcct ggataattga gagttgacta actttggaag
     7381 tcagaattcc caggaattag agtaactgct ctggaaagtt aaagtgtgaa gttttttaga
     7441 tagtttcata aaaacaattc tggtttcttt ttgcttgtgc tgactttctt ggattttaat
     7501 ctacctcatc ttgtcttttt agagttactt caacttgtca ctttaacatt gtgcttgact
     7561 ttggttgttt tctaagatgg aatttttcct gttcattgac agcttgttct cttgcctttt
     7621 cattctgatc ctcatttcat ctaacatcat ctcatattgc tcctctgtca agagaaatgt
     7681 tttaaaatag tttaaagtct tgttttatgg gaagaaagtg atcctccaat gctatttgtt
     7741 tctgaggtca gtaagagaag gagttaaaac aaggcagtgg ggaagggaat gaatcctgca
     7801 ctggaggcaa aagctgacaa ggaaagagcc attaattaag acaatttcaa agtcaactga
     7861 ttgtgatcat taatgtcaca atagatcaaa acctaattat cacagcctag gtaagagcca
     7921 tcagtattaa tcggaaaatc taataggaaa ctattatcaa gaaattaggc caaattgaat
     7981 gcagtgaact ttttatcttg gcattctcta tttttttgtg atgtcccctg gcattggcag
     8041 gtgtgaccct aacagtcgat tcaaggccaa gtggtcagtt tgtcagcctt ttttaaggga
     8101 tttcttttta tttttaggaa ttccaaacag agttaaccta aactgtcatt gccaaaagat
     8161 cagtcttaaa ctttcttagc acctgtacct gtttaatgtg atcagctatc agtgaggaaa
     8221 aaaaaaaaaa tctatttagg tcttggaatg gttcctgtac ctagagtatc catattgaac
     8281 cttttttttt tttttttttt tttttttttg agatggaaac ttgctctttt gcccaggctg
     8341 gagtgcagtg gcgtgatctt ggctcactgc aacctccgcc tcccgggttc aagcagttct
     8401 ctgcctcagc ctcctgagca gctgggatta taggcgcctg ccaccatgcc cggctaattt
     8461 ttgtattttt agtagagaca gggttcacca tcttggccgt gctggtcttg aactcctgac
     8521 cttgtgatcc gcctgcctcg gccactcaaa gtgctgggat tgcaggcgtg agccagcacc
     8581 cggccacagt atctttatta cagctcactg cagcctcaat ctcctgggct caaatgatcc
     8641 tcctgcctca gcctcccaag cagctgggac tacaggcgca caccacggtg tctggctaat
     8701 tttattattt aaaaaatgtt ttgtagagac agtctccctg tgttgcccag gctggtctcc
     8761 aactcgtgag ctcaagtgat ccacgtgcct cagcctccca aagtgctggg attacaagca
     8821 taagccaccg cacccggccc ctagtgaaca ttttactgta tgtgttgata aatcatcttt
     8881 tgagtttctg ttgtatgtgg ggacttccta cactggctgc tgtgaagagg tatggaagaa
     8941 aggagaggct ttctgcctag aaattctttg agaacacctg aaaagacagt ttaatcatgt
     9001 cacaacactc ttaaggctca agtcagtgtt ctggtttccg gtagctttag gattggattc
     9061 taaacgaggg ctggtggtga gtttggtgtt tgtctcgtgt caccctcacc cctcacctcc
     9121 tcagtttagg ataagagaca taatgatttc taccagaatc caaagtaaat ccaaaggggg
     9181 agaaaagaca taactgtttt ttcttctacc ttttttttgt taaagagtta catctctcac
     9241 aggaggaaag aattcaagag tctatatgat tagttacaga gaatattttc atcccctctc
     9301 cctgaataga aaagcagggg tcaccatttg tatccttacc cttgaggtgt ttttgaagat
     9361 gctgtaactc ttgaagttga gctgaggcag aaaggttgga aaaatgcagc cctctgggta
     9421 ttgtggggag ggatgtgatg tagtaagagg gtgttttgtg gtgctaggat tcccacgcca
     9481 ccaacttgca gctttataag agcgctacca agaaccacca ctggggaaaa ggttcttatt
     9541 cattgtttct gttggaatgt gatcttgctt tctggatttt aggaattcag gttactcagt
     9601 ataaaactct gagaaatcag tgtgacttag tccttcacct cctaagataa agtgaatatt
     9661 tctttacaaa ataattcatg tccttaatgt taaagatgta attttatttt caaaacatct
     9721 ataacatgac tttcagaagc agttcatttt tccaagattc ctcacattat actagataaa
     9781 taataggccc tcagttaata cccttcagtt attgaattaa tctagtttgt ggaatgaggt
     9841 gtatcctgcc aacttccctc tgctcccaag tacactctga gaggtaaaat gctctgggaa
     9901 atggaacaag aatcgagtgg atgctgactc tgtgtgccca cctcctcaac tgattgataa
     9961 tggttgacct tgggcaagtc acttctttca atgcctcagt tccccatctg tcaaatgggg
    10021 ttaataatac tgacctacct cacaggggtg ttgttgtgag gcattgtaaa tcaaagttaa
    10081 tagaatactt cagggtcctc tgtggaggat gtcttgagcc agagtttaag cctgacacac
    10141 aggctttggt cctcactgag ctgtctccaa gactggaact acttagtgac tcggcaaatt
    10201 ttctgccccc cacccctcat caaagctgct agttcagatg ttgacagtgt tttcatgaat
    10261 gttggaatct tactagtcca gacttactta ggatgttgtt ggggaaggca cttgggattt
    10321 tctgtgtctt gcattcacag agggaggcca tttcagattc aagagcattg gattagggaa
    10381 tcgtgaggca gggatgctac tgcgtatttc tctctgcagg ttggggatta aagttccttt
    10441 ccccatgggt ttgaagcaga ctcagactgt ctcaggatca aagcaaccct caatggtttt
    10501 gatttatgtc attgcttacc actccccaac caatcccagg acagctgggt cactgtaccc
    10561 ctttgtggta tctgtacctg ggcctctcct tcctcatagg gaccagctga ttgaataaat
    10621 gtgaccacct tatttccacc ccccaccccc aaaagctaca ttggaattat ttttcctaga
    10681 aatgtgtata acactcagaa ttgggcattg atccttaaag cttcatccca ttcaccgtat
    10741 tcaacatctg tcatctctta gtgtctgcag tctgaaccta accttgacct tttttccctc
    10801 tggtttgaga aaactttgga cactatttct acttggccag gtgtgggctc aagagcctta
    10861 ctctttccat ctcagtttag gggcgcagcc agctcctctt cccaataggg ctctttctgc
    10921 tttccctctc cttggcccta gatttgtaat ccatgaaaaa gcacaaggtc ctggctcctt
    10981 gcggtcacat tctggttctc tgtgttttgt ggactctgct ctcactgttc acccagcact
    11041 agcagtacca gatggttctg tggagtcctg gggaatggag agagcacagt ctgactccct
    11101 gccaagtagc caggagttga cttgcccatg gtccgctggc tttcccacca cttcctacag
    11161 gatgggatct aagagactca agagctgggt ttctttcagc actctgtact gtcccaaata
    11221 gcaaacaaat cactttgtag ccagatttct gaatggaaat gagaaattga attctccatg
    11281 gacttttagg tttatggggg agttttagct gtgtttcttg gttttatttc agccaaacat
    11341 gtctgctttt gatttttttt ttaaagtata agtggtctat atatatgttc accttttaaa
    11401 tgtaaatgtt taaaaagtaa gcatttatgt gtttccataa ctgacatctg atgcagacct
    11461 cattctctcc ccctcttcta ccctcctctt ttcccccttt tcatactctt gtattggttc
    11521 taataaatgg ttgcttttca aatatg
//
