LOCUS       NM_016587               2061 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens chromobox 3 (CBX3), transcript variant 2, mRNA.
ACCESSION   NM_016587
VERSION     NM_016587.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2061)
  AUTHORS   Chen,J., Lin,Y., Zheng,S., Chen,Q., Tang,S. and Zhong,X.
  TITLE     CBX3 promotes clear cell renal carcinoma through PI3K/AKT
            activation and aberrant immunity
  JOURNAL   J Transl Med 21 (1), 600 (2023)
   PUBMED   37674204
  REMARK    GeneRIF: CBX3 promotes clear cell renal carcinoma through PI3K/AKT
            activation and aberrant immunity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2061)
  AUTHORS   Liu,K., Zhang,S., Gong,Y., Zhu,P., Shen,W. and Zhang,Q.
  TITLE     PSMC4 promotes prostate carcinoma progression by regulating the
            CBX3-EGFR-PI3K-AKT-mTOR pathway
  JOURNAL   J Cell Mol Med 27 (16), 2437-2447 (2023)
   PUBMED   37436074
  REMARK    GeneRIF: PSMC4 promotes prostate carcinoma progression by
            regulating the CBX3-EGFR-PI3K-AKT-mTOR pathway.
REFERENCE   3  (bases 1 to 2061)
  AUTHORS   Yang,K., Wang,Y.L., Zhu,Z., Cao,X.H., Liang,M.X., Xu,D., Fei,Y.J.,
            Yang,S.Y., Zhou,H.L. and Tang,J.H.
  TITLE     CBX3 promotes breast cancer progression and high level of CBX3
            predicts poor prognosis in patients
  JOURNAL   Neoplasma 70 (1), 71-81 (2023)
   PUBMED   36620876
  REMARK    GeneRIF: CBX3 promotes breast cancer progression and high level of
            CBX3 predicts poor prognosis in patients.
REFERENCE   4  (bases 1 to 2061)
  AUTHORS   Pintacuda,G., Hsu,Y.H., Tsafou,K., Li,K.W., Martin,J.M.,
            Riseman,J., Biagini,J.C., Ching,J.K.T., Mena,D.,
            Gonzalez-Lozano,M.A., Egri,S.B., Jaffe,J., Smit,A.B., Fornelos,N.,
            Eggan,K.C. and Lage,K.
  TITLE     Protein interaction studies in human induced neurons indicate
            convergent biology underlying autism spectrum disorders
  JOURNAL   Cell Genom 3 (3), 100250 (2023)
   PUBMED   36950384
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2061)
  AUTHORS   Mata-Garrido,J., Xiang,Y., Chang-Marchand,Y., Reisacher,C.,
            Ageron,E., Guerrera,I.C., Casafont,I., Bruneau,A., Cherbuy,C.,
            Treton,X., Dumay,A., Ogier-Denis,E., Batsche,E., Costallat,M.,
            Revechon,G., Eriksson,M., Muchardt,C. and Arbibe,L.
  TITLE     The Heterochromatin protein 1 is a regulator in RNA splicing
            precision deficient in ulcerative colitis
  JOURNAL   Nat Commun 13 (1), 6834 (2022)
   PUBMED   36400769
  REMARK    GeneRIF: The Heterochromatin protein 1 is a regulator in RNA
            splicing precision deficient in ulcerative colitis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2061)
  AUTHORS   Lehming,N., Le Saux,A., Schuller,J. and Ptashne,M.
  TITLE     Chromatin components as part of a putative transcriptional
            repressing complex
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7322-7326 (1998)
   PUBMED   9636147
REFERENCE   7  (bases 1 to 2061)
  AUTHORS   Seeler,J.S., Marchio,A., Sitterlin,D., Transy,C. and Dejean,A.
  TITLE     Interaction of SP100 with HP1 proteins: a link between the
            promyelocytic leukemia-associated nuclear bodies and the chromatin
            compartment
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7316-7321 (1998)
   PUBMED   9636146
REFERENCE   8  (bases 1 to 2061)
  AUTHORS   Lessard,J., Baban,S. and Sauvageau,G.
  TITLE     Stage-specific expression of polycomb group genes in human bone
            marrow cells
  JOURNAL   Blood 91 (4), 1216-1224 (1998)
   PUBMED   9454751
REFERENCE   9  (bases 1 to 2061)
  AUTHORS   Ye,Q., Callebaut,I., Pezhman,A., Courvalin,J.C. and Worman,H.J.
  TITLE     Domain-specific interactions of human HP1-type chromodomain
            proteins and inner nuclear membrane protein LBR
  JOURNAL   J Biol Chem 272 (23), 14983-14989 (1997)
   PUBMED   9169472
REFERENCE   10 (bases 1 to 2061)
  AUTHORS   Ye,Q. and Worman,H.J.
  TITLE     Interaction between an integral protein of the nuclear envelope
            inner membrane and human chromodomain proteins homologous to
            Drosophila HP1
  JOURNAL   J Biol Chem 271 (25), 14653-14656 (1996)
   PUBMED   8663349
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD514780.1, BX648807.1 and
            DB565723.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016587.3.
            
            Summary: At the nuclear envelope, the nuclear lamina and
            heterochromatin are adjacent to the inner nuclear membrane. The
            protein encoded by this gene binds DNA and is a component of
            heterochromatin. This protein also can bind lamin B receptor, an
            integral membrane protein found in the inner nuclear membrane. The
            dual binding functions of the encoded protein may explain the
            association of heterochromatin with the inner nuclear membrane.
            This protein binds histone H3 tails methylated at Lys-9 sites. This
            protein is also recruited to sites of ultraviolet-induced DNA
            damage and double-strand breaks. Two transcript variants encoding
            the same protein but differing in the 5' UTR, have been found for
            this gene.[provided by RefSeq, Mar 2011].
            
            Transcript Variant: This variant (2) contains an alternate 5' exon
            but encodes the same isoform (a) as transcript variant 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.451520.1,
                                           SRR1803615.245389.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396386.7/ ENSP00000379670.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 CD514780.1         53-56
            5-1805              BX648807.1         2-1802
            1806-2061           DB565723.1         209-464
FEATURES             Location/Qualifiers
     source          1..2061
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.2"
     gene            1..2061
                     /gene="CBX3"
                     /gene_synonym="HECH; HP1-GAMMA; HP1gamma; HP1Hs-gamma"
                     /note="chromobox 3"
                     /db_xref="GeneID:11335"
                     /db_xref="HGNC:HGNC:1553"
                     /db_xref="MIM:604477"
     exon            1..82
                     /gene="CBX3"
                     /gene_synonym="HECH; HP1-GAMMA; HP1gamma; HP1Hs-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            83..134
                     /gene="CBX3"
                     /gene_synonym="HECH; HP1-GAMMA; HP1gamma; HP1Hs-gamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..662
                     /gene="CBX3"
                     /gene_synonym="HECH; HP1-GAMMA; HP1gamma; HP1Hs-gamma"
                     /note="isoform a is encoded by transcript variant 2;
                     heterochromatin protein HP1 gamma; chromobox homolog 3
                     (HP1 gamma homolog, Drosophila); heterochromatin-like
                     protein 1; chromobox protein homolog 3; modifier 2
                     protein; heterochromatin protein 1 homolog gamma"
                     /codon_start=1
                     /product="chromobox protein homolog 3 isoform a"
                     /protein_id="NP_057671.2"
                     /db_xref="CCDS:CCDS5398.1"
                     /db_xref="GeneID:11335"
                     /db_xref="HGNC:HGNC:1553"
                     /db_xref="MIM:604477"
                     /translation="MASNKTTLQKMGKKQNGKSKKVEEAEPEEFVVEKVLDRRVVNGK
                     VEYFLKWKGFTDADNTWEPEENLDCPELIEAFLNSQKAGKEKDGTKRKSLSDSESDDS
                     KSKKKRDAADKPRGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEANMKC
                     PQIVIAFYEERLTWHSCPEDEAQ"
     exon            135..277
                     /gene="CBX3"
                     /gene_synonym="HECH; HP1-GAMMA; HP1gamma; HP1Hs-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            278..440
                     /gene="CBX3"
                     /gene_synonym="HECH; HP1-GAMMA; HP1gamma; HP1Hs-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            441..535
                     /gene="CBX3"
                     /gene_synonym="HECH; HP1-GAMMA; HP1gamma; HP1Hs-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            536..2061
                     /gene="CBX3"
                     /gene_synonym="HECH; HP1-GAMMA; HP1gamma; HP1Hs-gamma"
                     /inference="alignment:Splign:2.1.0"
     regulatory      854..859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBX3"
                     /gene_synonym="HECH; HP1-GAMMA; HP1gamma; HP1Hs-gamma"
                     /note="hexamer: AATAAA"
     polyA_site      894
                     /gene="CBX3"
                     /gene_synonym="HECH; HP1-GAMMA; HP1gamma; HP1Hs-gamma"
                     /note="major polyA site"
     regulatory      927..932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBX3"
                     /gene_synonym="HECH; HP1-GAMMA; HP1gamma; HP1Hs-gamma"
                     /note="hexamer: ATTAAA"
     polyA_site      948
                     /gene="CBX3"
                     /gene_synonym="HECH; HP1-GAMMA; HP1gamma; HP1Hs-gamma"
                     /note="major polyA site"
     regulatory      1782..1787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBX3"
                     /gene_synonym="HECH; HP1-GAMMA; HP1gamma; HP1Hs-gamma"
                     /note="hexamer: AATAAA"
     polyA_site      1810
                     /gene="CBX3"
                     /gene_synonym="HECH; HP1-GAMMA; HP1gamma; HP1Hs-gamma"
                     /note="major polyA site"
     regulatory      2000..2005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBX3"
                     /gene_synonym="HECH; HP1-GAMMA; HP1gamma; HP1Hs-gamma"
                     /note="hexamer: AATAAA"
     polyA_site      2017
                     /gene="CBX3"
                     /gene_synonym="HECH; HP1-GAMMA; HP1gamma; HP1Hs-gamma"
     regulatory      2038..2043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBX3"
                     /gene_synonym="HECH; HP1-GAMMA; HP1gamma; HP1Hs-gamma"
                     /note="hexamer: ATTAAA"
     polyA_site      2061
                     /gene="CBX3"
                     /gene_synonym="HECH; HP1-GAMMA; HP1gamma; HP1Hs-gamma"
                     /note="major polyA site"
ORIGIN      
        1 cttcggatgt ggcttgagct gtaggcgcgg agggccggag acgctgcaga cccgcgaccc
       61 ggagcagctc ggaggcggtg aataatagct cttcaagtct gcaataaaaa atggcctcca
      121 acaaaactac attgcaaaaa atgggaaaaa aacagaatgg aaagagtaaa aaagttgaag
      181 aggcagagcc tgaagaattt gtcgtggaaa aagtactaga tcgacgtgta gtgaatggga
      241 aagtggaata tttcctgaag tggaagggat ttacagatgc tgacaatact tgggaacctg
      301 aagaaaattt agattgtcca gaattgattg aagcgtttct taactctcag aaagctggca
      361 aagaaaaaga tggtacaaaa agaaaatctt tatctgacag tgaatctgat gacagcaaat
      421 caaagaagaa aagagatgct gctgacaaac caagaggatt tgccagaggt cttgatcctg
      481 aaagaataat tggtgccaca gacagcagtg gagaattgat gtttctcatg aaatggaaag
      541 attcagatga ggcagacttg gtgctggcga aagaggcaaa tatgaagtgt cctcaaattg
      601 taattgcttt ttatgaagag agactaactt ggcattcttg tccagaagat gaagctcaat
      661 aattgttcac attgttcttt tatatatatt tatatatata tataaaaatt gggtcttaga
      721 ttttgattta ctagtgtgac aaaataacta catcctaatg aaaatcaagt ttgatatgtt
      781 tgttttgaaa gtagcgttgg aagagttgtt gggggttttt tgcatccata gcactggtta
      841 ctttgaacaa ataaataaaa gctttctgta gttgcttcct ttatcagaaa agaacatttg
      901 ataccatggt atatcatttc ctcttcatta aagaacagct tttctaaatg ttgggggaaa
      961 tgtccatagt cattactcag tcaaaacttg tgttctcatg agcctaagga ccattctaga
     1021 tttattacgt gttttttgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtatc cataaaatgc
     1081 atatgtaaat ttttttttgt ttttaagcat tcacccaaac aaaaaaatca caggtaaacc
     1141 catgtttctg agatgccatt attccaagca aaataagaga taatcccttc aagttaaatt
     1201 gaaaattttc ctgaaaccat acatttcaag tgaaataagt aattctagat aggacaattt
     1261 aaattggata attttaaagt gtctataatt gcagtggttt atttgcaaaa ttcctaaaag
     1321 gaaaaatttt atcactgcca tcacagcagg tttcctcatc cagatgagga aactagacaa
     1381 atgctagtgt gttttaacta gctaaacaaa actaagttaa atgaacattt aaaagtttcc
     1441 ctagcgggcc attccttagc aaaatgttgg aatccctgtt gctacattga ctaaaaggtc
     1501 atgatgaatg gaatatgtaa gacttggctc atagaaacct aatcagatgg ttagaggtgt
     1561 tggcagttta ggacctgctg tcataaatgt gtgaacaacc ttttgtaacc taacctattg
     1621 acctgcatgt tttttcttta ccccaattca ttacatggag gctcaatctt gagtttgctt
     1681 tactggttca gcaaaagcca ggaagaacaa ctttgtagta atcaaaatgt tatccaactg
     1741 tatattgttt actttattgt aaatactggt gaacagtggt taataaatag ttttatattc
     1801 ctttatgcaa ttattagact tttttcttta tttgatatgc ctttacagta gaaatagaaa
     1861 tgcccacact cattggatta tctttgttta taagttagat gataccagta aggcattaca
     1921 gtacatatcc tagatctttt gagcttacga gttttaaact tgaatatgta tttccacagg
     1981 aatgtttcca cagttgggaa ataaaagttt catgtgatgc ctagggtcaa ttgtctcatt
     2041 aaaatgaggt tttaaattct g
//
