LOCUS       NM_005189               4628 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens chromobox 2 (CBX2), transcript variant 1, mRNA.
ACCESSION   NM_005189
VERSION     NM_005189.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4628)
  AUTHORS   Chen,J., Shan,W., Jia,Q., Chen,Y., Jiang,W., Tian,Y., Huang,X.,
            Li,X., Wang,Z. and Xia,B.
  TITLE     USP33 facilitates the ovarian cancer progression via
            deubiquitinating and stabilizing CBX2
  JOURNAL   Oncogene 43 (43), 3170-3183 (2024)
   PUBMED   39256572
  REMARK    GeneRIF: USP33 facilitates the ovarian cancer progression via
            deubiquitinating and stabilizing CBX2.
REFERENCE   2  (bases 1 to 4628)
  AUTHORS   Wen,Z., Li,Q. and Hu,G.
  TITLE     Bioinformatics analysis reveals that CBX2 promotes enzalutamide
            resistance in prostate cancer
  JOURNAL   Eur J Med Res 29 (1), 430 (2024)
   PUBMED   39175037
  REMARK    GeneRIF: Bioinformatics analysis reveals that CBX2 promotes
            enzalutamide resistance in prostate cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4628)
  AUTHORS   Wu,J., Fu,G., Luo,C., Chen,L. and Liu,Q.
  TITLE     Cuproptosis-related ceRNA axis triggers cell proliferation and cell
            cycle through CBX2 in lung adenocarcinoma
  JOURNAL   BMC Pulm Med 24 (1), 85 (2024)
   PUBMED   38355480
  REMARK    GeneRIF: Cuproptosis-related ceRNA axis triggers cell proliferation
            and cell cycle through CBX2 in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4628)
  AUTHORS   Xing,Y., Ba-Tu,J., Dong,C., Cao,X., Li,B., Jia,X., Juan,Y., Lv,X.,
            Zhang,H., Qin,N., Han,W., Wang,D., Qi,X., Wang,Y., Hao,X.,
            Zhang,S., Du,X., Wang,H. and Wang,M.
  TITLE     Phosphorylation of USP27X by GSK3beta maintains the stability and
            oncogenic functions of CBX2
  JOURNAL   Cell Death Dis 14 (11), 782 (2023)
   PUBMED   38030604
  REMARK    GeneRIF: Phosphorylation of USP27X by GSK3beta maintains the
            stability and oncogenic functions of CBX2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4628)
  AUTHORS   Meng,Q., Zhou,Q., Chen,X. and Chen,J.
  TITLE     Prognostic hub gene CBX2 drives a cancer stem cell-like phenotype
            in HCC revealed by multi-omics and multi-cohorts
  JOURNAL   Aging (Albany NY) 15 (22), 12817-12851 (2023)
   PUBMED   37980163
  REMARK    GeneRIF: Prognostic hub gene CBX2 drives a cancer stem cell-like
            phenotype in HCC revealed by multi-omics and multi-cohorts.
REFERENCE   6  (bases 1 to 4628)
  AUTHORS   Pearce,J.J., Singh,P.B. and Gaunt,S.J.
  TITLE     The mouse has a Polycomb-like chromobox gene
  JOURNAL   Development 114 (4), 921-929 (1992)
   PUBMED   1352241
REFERENCE   7  (bases 1 to 4628)
  AUTHORS   Paro,R. and Hogness,D.S.
  TITLE     The Polycomb protein shares a homologous domain with a
            heterochromatin-associated protein of Drosophila
  JOURNAL   Proc Natl Acad Sci U S A 88 (1), 263-267 (1991)
   PUBMED   1898775
REFERENCE   8  (bases 1 to 4628)
  AUTHORS   Chodak,G.W.
  TITLE     Early detection and screening for prostatic cancer
  JOURNAL   Urology 34 (4 Suppl), 10-2 (1989)
   PUBMED   2477932
  REMARK    Review article
REFERENCE   9  (bases 1 to 4628)
  AUTHORS   Kuziora,M.A. and McGinnis,W.
  TITLE     Different transcripts of the Drosophila Abd-B gene correlate with
            distinct genetic sub-functions
  JOURNAL   EMBO J 7 (10), 3233-3244 (1988)
   PUBMED   2903050
REFERENCE   10 (bases 1 to 4628)
  AUTHORS   Wedeen,C., Harding,K. and Levine,M.
  TITLE     Spatial regulation of Antennapedia and bithorax gene expression by
            the Polycomb locus in Drosophila
  JOURNAL   Cell 44 (5), 739-748 (1986)
   PUBMED   3081265
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105337.7, DB452048.1,
            CV815254.1, CN367098.1 and AL157459.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005189.2.
            
            Summary: This gene encodes a component of the polycomb multiprotein
            complex, which is required to maintain the transcriptionally
            repressive state of many genes throughout development via chromatin
            remodeling and modification of histones. Disruption of this gene in
            mice results in male-to-female gonadal sex reversal. Mutations in
            this gene are also associated with gonadal dysgenesis in humans.
            Alternatively spliced transcript variants encoding different
            isoforms have been noted for this gene.[provided by RefSeq, Mar
            2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CN367087.1, CN367085.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310942.9/ ENSP00000308750.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AC105337.7         112014-112043
            31-36               DB452048.1         47-52
            37-37               AC105337.7         112050-112050
            38-338              DB452048.1         54-354
            339-818             CV815254.1         210-689
            819-1091            CN367098.1         202-474
            1092-2512           AC105337.7         118313-119733
            2513-4295           AL157459.1         252-2034
            4296-4628           AC105337.7         121517-121849
FEATURES             Location/Qualifiers
     source          1..4628
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..4628
                     /gene="CBX2"
                     /gene_synonym="CDCA6; M33; SRXY5"
                     /note="chromobox 2"
                     /db_xref="GeneID:84733"
                     /db_xref="HGNC:HGNC:1552"
                     /db_xref="MIM:602770"
     exon            1..160
                     /gene="CBX2"
                     /gene_synonym="CDCA6; M33; SRXY5"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1687
                     /gene="CBX2"
                     /gene_synonym="CDCA6; M33; SRXY5"
                     /note="isoform 1 is encoded by transcript variant 1; Pc
                     class homolog; modifier 3; cell division cycle associated
                     6; chromobox homolog 2 (Pc class homolog, Drosophila);
                     chromobox protein homolog 2"
                     /codon_start=1
                     /product="chromobox protein homolog 2 isoform 1"
                     /protein_id="NP_005180.1"
                     /db_xref="CCDS:CCDS32757.1"
                     /db_xref="GeneID:84733"
                     /db_xref="HGNC:HGNC:1552"
                     /db_xref="MIM:602770"
                     /translation="MEELSSVGEQVFAAECILSKRLRKGKLEYLVKWRGWSSKHNSWE
                     PEENILDPRLLLAFQKKEHEKEVQNRKRGKRPRGRPRKLTAMSSCSRRSKLKEPDAPS
                     KSKSSSSSSSSTSSSSSSDEEDDSDLDAKRGPRGRETHPVPQKKAQILVAKPELKDPI
                     RKKRGRKPLPPEQKATRRPVSLAKVLKTARKDLGAPASKLPPPLSAPVAGLAALKAHA
                     KEACGGPSAMATPENLASLMKGMASSPGRGGISWQSSIVHYMNRMTQSQAQAASRLAL
                     KAQATNKCGLGLDLKVRTQKGELGMSPPGSKIPKAPSGGAVEQKVGNTGGPPHTHGAS
                     RVPAGCPGPQPAPTQELSLQVLDLQSVKNGMPGVGLLARHATATKGVPATNPAPGKGT
                     GSGLIGASGATMPTDTSKSEKLASRAVAPPTPASKRDCVKGSATPSGQESRTAPGEAR
                     KAATLPEMSAGEESSSSDSDPDSASPPSTGQNPSVSVQTSQDWKPTRSLIEHVFVTDV
                     TANLITVTVKESPTSVGFFNLRHY"
     exon            161..204
                     /gene="CBX2"
                     /gene_synonym="CDCA6; M33; SRXY5"
                     /inference="alignment:Splign:2.1.0"
     exon            205..270
                     /gene="CBX2"
                     /gene_synonym="CDCA6; M33; SRXY5"
                     /inference="alignment:Splign:2.1.0"
     exon            271..376
                     /gene="CBX2"
                     /gene_synonym="CDCA6; M33; SRXY5"
                     /inference="alignment:Splign:2.1.0"
     exon            377..4628
                     /gene="CBX2"
                     /gene_synonym="CDCA6; M33; SRXY5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4189..4194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBX2"
                     /gene_synonym="CDCA6; M33; SRXY5"
                     /note="hexamer: AATAAA"
     polyA_site      4215
                     /gene="CBX2"
                     /gene_synonym="CDCA6; M33; SRXY5"
                     /note="major polyA site"
     regulatory      4593..4598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBX2"
                     /gene_synonym="CDCA6; M33; SRXY5"
                     /note="hexamer: ATTAAA"
     polyA_site      4628
                     /gene="CBX2"
                     /gene_synonym="CDCA6; M33; SRXY5"
ORIGIN      
        1 ggtgctttgt gtgctgccgg cggggcgcgc ggcggtccgg gcgggtgact ggcggcgggc
       61 gccgcggtcg ggctggctgc cgggcagcat ggaggagctg agcagcgtgg gcgagcaggt
      121 cttcgccgcc gagtgcatcc tgagcaagcg gctccgcaag ggcaagctgg agtacctggt
      181 caagtggcgc ggctggtcct ccaaacataa cagctgggag ccggaggaga acatcctgga
      241 cccgaggctg ctcctggcct tccagaagaa ggaacatgag aaggaggtgc agaaccggaa
      301 gagaggcaag aggccgagag gccggccaag gaagctcact gccatgtcct cctgcagccg
      361 gcgctccaag ctcaaggaac ccgatgctcc ctccaaatcc aagtccagca gttcctcctc
      421 ttcctccacg tcatcctcct cttcctcaga tgaagaggat gacagtgact tagatgctaa
      481 gaggggtccc cggggccgcg agacccaccc agtgccgcag aagaaggccc agatcctggt
      541 ggccaaaccc gagctgaagg atcccatccg gaagaagcgg ggacgaaagc ccctgccccc
      601 agagcaaaag gcaacccgaa gacccgtgag cctggccaag gtgctgaaga ccgcccggaa
      661 ggatctgggg gccccggcca gcaagctgcc ccctccactc agcgcccccg ttgcaggcct
      721 ggcagctctg aaggcccacg ccaaggaggc ctgtggcggc cccagtgcca tggccacccc
      781 agagaacctg gccagcctaa tgaagggcat ggccagtagc cccggccggg gtggcatcag
      841 ctggcagagc tccatcgtgc actacatgaa ccggatgacc cagagccagg cccaggctgc
      901 cagcaggttg gcgctgaagg cccaggccac caacaagtgc ggcctcgggc tggacctgaa
      961 ggtgaggacg cagaaagggg agctgggaat gagccctcca ggaagcaaaa tcccgaaggc
     1021 ccccagcggt ggggctgtgg agcagaaagt ggggaacaca gggggccccc cgcacaccca
     1081 tggtgccagc agggtgcctg ctgggtgccc aggcccccag ccagcaccca cccaggagct
     1141 gagcctccag gtcttggact tgcagagtgt caagaatggc atgcccgggg tgggtctcct
     1201 tgcccgccac gccaccgcca ccaagggtgt cccggccacc aacccagccc ctgggaaggg
     1261 cactgggagt ggcctcattg gggccagcgg ggccaccatg cccaccgaca caagcaaaag
     1321 tgagaagctg gcttccagag cagtggcgcc acccacccct gccagcaaga gggactgtgt
     1381 caagggcagt gctaccccca gtgggcagga gagccgcaca gcccccggag aagcccgcaa
     1441 ggcggccaca ctgccagaga tgagcgcagg tgaggagagt agcagctcgg actccgaccc
     1501 cgactccgcc tcgccgccca gcactggaca gaacccgtca gtgtccgttc agaccagcca
     1561 ggactggaag cccacccgca gcctcatcga gcacgtattt gtcaccgacg tcactgccaa
     1621 cctcatcacc gtcacagtga aggagtctcc caccagcgtg ggcttcttca acctgaggca
     1681 ttactgaagc cccggcgcca ccagctgcgc ggtcttactc cccttccctg cctatggtgt
     1741 cgcttggcta agtgactccc agcccaagcc ccctcaagag tctgggtcgg gggaggagga
     1801 gtgggtggcc tccttgatgg gcaggcttgg aagggacttc tcccgcaccc cactctgtcc
     1861 caggacatag ggcagggggc ctcactgcct tgttggtctc caccttgttc ctacctctgc
     1921 aggcctcttt gctctcccct cttgcctcag gaaacccggt ggcacctgtg gctccaggtg
     1981 actgtcttga acagagcggg cttcttcatg gctgcgttgt tgctgagttt gaactgctcc
     2041 tccctggcct gcgtgactga atcacagctt tggtccctgt cttgcagggg ctgaggtgtc
     2101 aggaggggac ttctggccca ccttgccttc agccctggag tgggcagaga gtattgtggg
     2161 gaggcatggc cagtgggact agtgttccct ccatctggcc acagcttttg ggagatgggg
     2221 tgggcagggg tggtcctggc tggcattgcc tgagccggca gtgatgaagt ggggagcttg
     2281 cccttgacag gtgggggctg gctggggcct taatgtgaaa agacagtggc aggcagctgg
     2341 agtagagcga gcccagcagc cctaaaaggc tgccttcatg gccatctagc cccagttcag
     2401 ggcagcatcc atagcccaca agccagcgtg ggtggggcgg gggtggtccc acagctgggt
     2461 tccacctgaa gagcctccgt gcctcggagc aggagaggca ggctatggct gccaccctcc
     2521 ctcctgcctg tgtcccagtg agaactgacc tgagtcccct tccaaaccca gacccacctc
     2581 ctgccccagg cccactgaag catgttccat ttctaaaaag cccagagttc agtgtgtccc
     2641 aaggaaaacc caaagtggag gtgctcaggt ccaggggagt ccagtgggca ggacccttgg
     2701 caggcaagcc cctcccttca ctcccaggac ctaccttctg ctagtaaagg actggcttca
     2761 ttctaattat ggcccacaga ctgccccgga gacctggagg acagcagtgc tggcacttgg
     2821 gtgtccatgg gcccgtctgc cggctctgcc tgtgctgcaa gtgttggccg tgggtccagc
     2881 caacaactcc ctacgtcctg tgtggggccc tgcccaagtg gatgaggcat tccttgagga
     2941 gtatcatttt ccctgacaat ccccatcacc tttaggggtt ccctgcttgg ctcctttcca
     3001 gctgaaaaac tagacctgtg ccattgggga agctggacaa agtctagggg gcccgcctgg
     3061 tagagggtcc cgggaagctg gatctgtcag cctcggccct gaggcccctg ttaactcaag
     3121 actgtgagct gcctctaggt ggtcacgtct gggagctagc ttgtatggct tctgaccagt
     3181 atcaggattt ctgttctgag agcagcgtgg gcagcaaggc agggcagccc agaggtggca
     3241 gcggcaggca atctggtcac taggtctttg tgatgccaaa aataaaagag ggtggggtgg
     3301 gtgctttctg ttcctctgat tggatggagt ccgccagcag gcatggggct acattccagt
     3361 gcctgactat agggaggcac tcctgattcc atggagcagc ccggactttg agaatgggct
     3421 ctggtttgcg gggggcaggc gtaccagact gcaagacccc ccagtacctc accgtgccaa
     3481 ataggaagag gtggccttgg tgtagccaaa tggatctttt taacagtgtg cctttgggga
     3541 gggacccatg tccatggctt cgttgagggc catccatatg ccagctgggg gccagcccac
     3601 agtggccata ttggctgcag caggaatggt gcccacctcg gcgaattgaa gggctaagag
     3661 tcccagatag ctaggccaga gctggaagca gacagtaagg ggaagagctg ctcccacagg
     3721 agagggagag attccagctc actgcgcagc ctgggaggag gcgtggatcc tggcacgctg
     3781 agcctcaggc accagcctcc ctgtgctcga cagcaaagtc ttgactcctt cctgctgagc
     3841 actgtgctac cttcactgct ccaaagccag actaacagct ctccaagccc ttggggtgac
     3901 tcggcttcca ggagctgttg gagaaatgag gatgtctgtc cctgtctgcc tgggcaggcc
     3961 agattcctcc ccagcagccg ggtctctcca gaccctgatt cggtgccttt ctgtttacca
     4021 gctacttcaa tcccaaagtt tgaatctgca gataccttac tcccagccac tttgccttct
     4081 tactgtgttg tgtgtttttc ctggtgcttc aagagcgtgt gcagggcaag tgccgtcact
     4141 gggaactgca ccagatgctc agacttggtt gtcttatgtt taccaataaa taaaagtaga
     4201 ctttttctat ttttatttgc tgctatttgt gtgtgtgttt gtgtttgtgt agctaggtat
     4261 ctggcacttc tgacgatgca ttgttgcttt tttcccgaag gtcccgcagg aactgtggca
     4321 atggtgtgtg tgtgaaatgg tgtgttaacc gcgttttgtt tgctcctgta ttgaatagga
     4381 agcagtggcc agtctgtctt ccttagagat gttagcatat ttttatatgt atatattttg
     4441 taccaaaaaa gagtgttcct tgttttggtt acactcgaaa ttctgaccta gctggagagg
     4501 gctctgggcc gagagctttc actaagggga gacttcaggg gaggatcaag ctttgaacca
     4561 aagccaatca ctggcttgat ttgtgttttt taattaaaaa aaaaatcatt catgtatgcc
     4621 acttctaa
//
