LOCUS       NM_001127228            2182 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens chromobox 1 (CBX1), transcript variant 2, mRNA.
ACCESSION   NM_001127228
VERSION     NM_001127228.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2182)
  AUTHORS   Zhao,Y., Huang,S., Tan,X., Long,L., He,Q., Liang,X., Bai,J., Li,Q.,
            Lin,J., Li,Y., Liu,N., Ma,J. and Chen,Y.
  TITLE     N6 -Methyladenosine-Modified CBX1 Regulates Nasopharyngeal
            Carcinoma Progression Through Heterochromatin Formation and STAT1
            Activation
  JOURNAL   Adv Sci (Weinh) 9 (36), e2205091 (2022)
   PUBMED   36310139
  REMARK    GeneRIF: N[6] -Methyladenosine-Modified CBX1 Regulates
            Nasopharyngeal Carcinoma Progression Through Heterochromatin
            Formation and STAT1 Activation.
REFERENCE   2  (bases 1 to 2182)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 2182)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2182)
  AUTHORS   Keenen,M.M., Brown,D., Brennan,L.D., Renger,R., Khoo,H.,
            Carlson,C.R., Huang,B., Grill,S.W., Narlikar,G.J. and Redding,S.
  TITLE     HP1 proteins compact DNA into mechanically and positionally stable
            phase separated domains
  JOURNAL   Elife 10, e64563 (2021)
   PUBMED   33661100
  REMARK    GeneRIF: HP1 proteins compact DNA into mechanically and
            positionally stable phase separated domains.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2182)
  AUTHORS   Huang,Y., Myers,M.P. and Xu,R.M.
  TITLE     Crystal structure of the HP1-EMSY complex reveals an unusual mode
            of HP1 binding
  JOURNAL   Structure 14 (4), 703-712 (2006)
   PUBMED   16615912
  REMARK    GeneRIF: HP1 binding as analyzed through the crystal structure of
            the HP1-EMSY complex
REFERENCE   6  (bases 1 to 2182)
  AUTHORS   Aagaard,L., Laible,G., Selenko,P., Schmid,M., Dorn,R., Schotta,G.,
            Kuhfittig,S., Wolf,A., Lebersorger,A., Singh,P.B., Reuter,G. and
            Jenuwein,T.
  TITLE     Functional mammalian homologues of the Drosophila PEV-modifier
            Su(var)3-9 encode centromere-associated proteins which complex with
            the heterochromatin component M31
  JOURNAL   EMBO J 18 (7), 1923-1938 (1999)
   PUBMED   10202156
REFERENCE   7  (bases 1 to 2182)
  AUTHORS   Seeler,J.S., Marchio,A., Sitterlin,D., Transy,C. and Dejean,A.
  TITLE     Interaction of SP100 with HP1 proteins: a link between the
            promyelocytic leukemia-associated nuclear bodies and the chromatin
            compartment
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7316-7321 (1998)
   PUBMED   9636146
REFERENCE   8  (bases 1 to 2182)
  AUTHORS   Lessard,J., Baban,S. and Sauvageau,G.
  TITLE     Stage-specific expression of polycomb group genes in human bone
            marrow cells
  JOURNAL   Blood 91 (4), 1216-1224 (1998)
   PUBMED   9454751
REFERENCE   9  (bases 1 to 2182)
  AUTHORS   Furuta,K., Chan,E.K., Kiyosawa,K., Reimer,G., Luderschmidt,C. and
            Tan,E.M.
  TITLE     Heterochromatin protein HP1Hsbeta (p25beta) and its localization
            with centromeres in mitosis
  JOURNAL   Chromosoma 106 (1), 11-19 (1997)
   PUBMED   9169582
REFERENCE   10 (bases 1 to 2182)
  AUTHORS   Wreggett,K.A., Hill,F., James,P.S., Hutchings,A., Butcher,G.W. and
            Singh,P.B.
  TITLE     A mammalian homologue of Drosophila heterochromatin protein 1 (HP1)
            is a component of constitutive heterochromatin
  JOURNAL   Cytogenet Cell Genet 66 (2), 99-103 (1994)
   PUBMED   8287692
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA020204.1, DB026977.1,
            BC002609.1 and BC021302.2.
            
            On Nov 24, 2018 this sequence version replaced NM_001127228.1.
            
            Summary: This gene encodes a highly conserved nonhistone protein,
            which is a member of the heterochromatin protein family . The
            protein is enriched in the heterochromatin and associated with
            centromeres. The protein has a single N-terminal chromodomain which
            can bind to histone proteins via methylated lysine residues, and a
            C-terminal chromo shadow-domain (CSD) which is responsible for the
            homodimerization and interaction with a number of
            chromatin-associated nonhistone proteins. The protein may play an
            important role in the epigenetic control of chromatin structure and
            gene expression. Several related pseudogenes are located on
            chromosomes 1, 3, and X. Multiple alternatively spliced variants,
            encoding the same protein, have been identified. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.928687.1,
                                           SRR1803613.3220.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000225603.9/ ENSP00000225603.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                DA020204.1         44-79
            37-598              DB026977.1         1-562
            599-1447            BC002609.1         566-1414
            1448-1657           BC021302.2         1482-1691
            1658-2182           BC002609.1         1625-2149
FEATURES             Location/Qualifiers
     source          1..2182
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..2182
                     /gene="CBX1"
                     /gene_synonym="CBX; HP1-BETA; Hp1beta; HP1Hs-beta;
                     HP1Hsbeta; M31; MOD1; p25beta"
                     /note="chromobox 1"
                     /db_xref="GeneID:10951"
                     /db_xref="HGNC:HGNC:1551"
                     /db_xref="MIM:604511"
     exon            1..211
                     /gene="CBX1"
                     /gene_synonym="CBX; HP1-BETA; Hp1beta; HP1Hs-beta;
                     HP1Hsbeta; M31; MOD1; p25beta"
                     /inference="alignment:Splign:2.1.0"
     exon            212..388
                     /gene="CBX1"
                     /gene_synonym="CBX; HP1-BETA; Hp1beta; HP1Hs-beta;
                     HP1Hsbeta; M31; MOD1; p25beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..806
                     /gene="CBX1"
                     /gene_synonym="CBX; HP1-BETA; Hp1beta; HP1Hs-beta;
                     HP1Hsbeta; M31; MOD1; p25beta"
                     /note="heterochromatin protein p25 beta; chromobox homolog
                     1 (HP1 beta homolog Drosophila); modifier 1 protein;
                     heterochromatin protein 1-beta; heterochromatin protein 1
                     homolog beta"
                     /codon_start=1
                     /product="chromobox protein homolog 1"
                     /protein_id="NP_001120700.1"
                     /db_xref="CCDS:CCDS11525.1"
                     /db_xref="GeneID:10951"
                     /db_xref="HGNC:HGNC:1551"
                     /db_xref="MIM:604511"
                     /translation="MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKG
                     FSDEDNTWEPEENLDCPDLIAEFLQSQKTAHETDKSEGGKRKADSDSEDKGEESKPKK
                     KKEESEKPRGFARGLEPERIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVV
                     ISFYEERLTWHSYPSEDDDKKDDKN"
     exon            389..566
                     /gene="CBX1"
                     /gene_synonym="CBX; HP1-BETA; Hp1beta; HP1Hs-beta;
                     HP1Hsbeta; M31; MOD1; p25beta"
                     /inference="alignment:Splign:2.1.0"
     exon            567..661
                     /gene="CBX1"
                     /gene_synonym="CBX; HP1-BETA; Hp1beta; HP1Hs-beta;
                     HP1Hsbeta; M31; MOD1; p25beta"
                     /inference="alignment:Splign:2.1.0"
     exon            662..2182
                     /gene="CBX1"
                     /gene_synonym="CBX; HP1-BETA; Hp1beta; HP1Hs-beta;
                     HP1Hsbeta; M31; MOD1; p25beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2162..2167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBX1"
                     /gene_synonym="CBX; HP1-BETA; Hp1beta; HP1Hs-beta;
                     HP1Hsbeta; M31; MOD1; p25beta"
                     /note="hexamer: AATAAA"
     polyA_site      2182
                     /gene="CBX1"
                     /gene_synonym="CBX; HP1-BETA; Hp1beta; HP1Hs-beta;
                     HP1Hsbeta; M31; MOD1; p25beta"
                     /note="major polyA site"
ORIGIN      
        1 gcgagcggcg ggcagcgcag actgcgaggc tcttttgttc ggctgagggg agggccgttg
       61 gccggggcct gcggtacgcc gcttcagtga gggacgccac tgcggccacc cggcttgctg
      121 ccttcctggg cgccactccc ccaggcgacc cgacgcgacg cgccagcagc gcagcaccga
      181 ttcctctcgg gctcttgggc gctgctctga gcagcgtcac cctttacacc agaaagctgg
      241 cgggcactat ggggaaaaaa caaaacaaga agaaagtgga ggaggtgcta gaagaggagg
      301 aagaggaata tgtggtggaa aaagttctcg accgtcgagt ggtaaagggc aaagtggagt
      361 acctcctaaa gtggaaggga ttctcagatg aggacaacac atgggagcca gaagagaacc
      421 tggattgccc cgacctcatt gctgagtttc tgcagtcaca gaaaacagca catgagacag
      481 ataaatcaga gggaggcaag cgcaaagctg attctgattc tgaagataag ggagaggaga
      541 gcaaaccaaa gaagaagaaa gaagagtcag aaaagccacg aggctttgct cgaggtttgg
      601 agccggagcg gattattgga gctacagact ccagtggaga gctcatgttc ctgatgaaat
      661 ggaaaaactc tgatgaggct gacctggtcc ctgccaagga agccaatgtc aagtgcccac
      721 aggttgtcat atccttctat gaggaaaggc tgacgtggca ttcctacccc tcggaggatg
      781 atgacaaaaa agatgacaag aactaacgct cctgagtacc agcccctgtc acatctgact
      841 gtgggtttca agtgggaagg gaaggagttc tacttgtctt gacaccatag aggtggcttg
      901 agaagatgtc ctttgaagag ccagtatagt ttctgtgccc tgcagcagcc caagtgcttt
      961 aaagccgttt caagctgtat agtttgcaca cccatcccag tggaggggaa aggggataag
     1021 tgtttcaagg caaccttttc tgcactttgc tgcgaaaagc aaagggcctt ctatgaagga
     1081 caaaacttgc agaattgggt gtgtgggaga gcaaaaaaat actgtagatc ttcaaagagc
     1141 atctccacaa cccacagcct tcttcccaat agtgttaact ctgcattttt acagcgtagc
     1201 atgtgtgtag tttttggcta ttactggtgt attatttggg ggagggaggg atggggaggg
     1261 gagaaaggga gatgggtagc atcattttga ttaacatttg gggcctgata ggggaaatgg
     1321 tgaagcaatg gaaaagaaca gacaactaat gatttgcttc tatgtccaga atattttacc
     1381 tttaaaaaaa tgtcattggc accataaata aggactgtga gagactgttt aaaagctgtg
     1441 aaagtctgaa acctataagc caaggtgttc cctgcctaaa cttattgctg ttcccacaaa
     1501 ggactaagcc tgttcataag ttaccaaagt tgccattttg gagatggaaa ttgacgagga
     1561 gggaaggtct tttattggag agtatacagt acaagcagat cattctgcct tagaggtgct
     1621 aattcccgaa attagaagac cctttctttt ccagtaacga agttataaat atcagcttgt
     1681 tcatccaagc cactggctga ggtgttagga agaggaagag ggtggtagag gaggtaagac
     1741 agtagggaaa gacaagggcc catgctctta gtggggaaaa ctcttggagc cgtttacttt
     1801 gagctttgaa cactgaaacc attgttggca gggttcagtc actgacagca caagtttcac
     1861 tgaattgatc caagagttta gtgatttcaa aagccttggt ctcaggagaa gattaaactt
     1921 tcatattggg cagtggttca ctttaaaaca cacacataca cacacaaaac aattttttaa
     1981 gaaatcctaa taagtaacat acccaaaatg ctctgtcttg agtcatgaga accatcagtt
     2041 cttgatattg tctagacttg catctagagc tacgttgtaa aattctttta ggcatgtgtt
     2101 agatttctgt gtaaactttg tttaaatgta aacttcatac tacattgtca gtttttgtct
     2161 taataaaact atagatttat aa
//
