LOCUS       XM_047441033            2414 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens cystathionine beta-synthase (CBS),
            transcript variant X23, mRNA.
ACCESSION   XM_047441033
VERSION     XM_047441033.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000021.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2414
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
     gene            1..2414
                     /gene="CBS"
                     /gene_synonym="CBSL; HIP4"
                     /note="cystathionine beta-synthase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 26
                     ESTs, 214 long SRA reads, 6 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 30 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:875"
                     /db_xref="HGNC:HGNC:1550"
                     /db_xref="MIM:613381"
     CDS             599..1939
                     /gene="CBS"
                     /gene_synonym="CBSL; HIP4"
                     /codon_start=1
                     /product="cystathionine beta-synthase isoform X7"
                     /protein_id="XP_047296989.1"
                     /db_xref="GeneID:875"
                     /db_xref="HGNC:HGNC:1550"
                     /db_xref="MIM:613381"
                     /translation="MAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGN
                     TGIGLALAAAVRGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVA
                     WRLKNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIA
                     RKLKEKCPGCRIIGVDPEGSILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKW
                     FKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVKAAQELQEGQRCVVILPDSVRNY
                     MTKFLSDRWMLQKGFLKEEDLTEKKPWWWHLRVQELGLSAPLTVLPTITCGHTIEILR
                     EKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQPSDQVGKVIYKQFKQIRLTDTLG
                     RLSHILEMDHFALVVHEQIQYHSTGKSSQRQMVFGVVTAIDLLNFVAAQERDQK"
ORIGIN      
        1 tggccaagaa catatcagct taagtttggg aaaaacacac aacagggcat tgtgtcagag
       61 ggtgaccaaa gtgactcccc agcagatgga ccagggaacg aacaggtgac ctttgaactg
      121 aggccggagt ggaagcagcg agggtgtgaa gggccgggtg agggtcaaag gcagaagcaa
      181 gcaggtgggg agggttagcg tcatgcctgc taaggagcag tggacgggtc ctagcacgtg
      241 ctgtgagcca cccgctgtcc agggagcggt tacctctgtc ttgccagctt cgtggggaca
      301 gatagttcag ctcatcattt atgagacaga gaatgggaat ttggagggtc tgtggctggc
      361 ctcgtcctgg gtgcgcaggg ggtcacctga ggtgtggtct gaggcctccg gggaagggca
      421 tttctttgca ggacgcagtt tccaggctca agaacgtgga gggaattcct aagggtcgct
      481 cttcaccaag agcgcagagc cctggtagac ctcagcatcg tcacagagaa agctgtgggt
      541 gcagaggcct tggggacaag gcggggacgg aatttcgtat ttcagatgac caaggccaat
      601 ggccaagtgt gagttcttca acgcgggcgg gagcgtgaag gaccgcatca gcctgcggat
      661 gattgaggat gctgagcgcg acgggacgct gaagcccggg gacacgatta tcgagccgac
      721 atccgggaac accgggatcg ggctggccct ggctgcggca gtgaggggct atcgctgcat
      781 catcgtgatg ccagagaaga tgagctccga gaaggtggac gtgctgcggg cactgggggc
      841 tgagattgtg aggacgccca ccaatgccag gttcgactcc ccggagtcac acgtgggggt
      901 ggcctggcgg ctgaagaacg aaatccccaa ttctcacatc ctagaccagt accgcaacgc
      961 cagcaacccc ctggctcact acgacaccac cgctgatgag atcctgcagc agtgtgatgg
     1021 gaagctggac atgctggtgg cttcagtggg cacgggcggc accatcacgg gcattgccag
     1081 gaagctgaag gagaagtgtc ctggatgcag gatcattggg gtggatcccg aagggtccat
     1141 cctcgcagag ccggaggagc tgaaccagac ggagcagaca acctacgagg tggaagggat
     1201 cggctacgac ttcatcccca cggtgctgga caggacggtg gtggacaagt ggttcaagag
     1261 caacgatgag gaggcgttca cctttgcccg catgctgatc gcgcaagagg ggctgctgtg
     1321 cggtggcagt gctggcagca cggtggcggt ggccgtgaag gccgcgcagg agctgcagga
     1381 gggccagcgc tgcgtggtca ttctgcccga ctcagtgcgg aactacatga ccaagttcct
     1441 gagcgacagg tggatgctgc agaagggctt tctgaaggag gaggacctca cggagaagaa
     1501 gccctggtgg tggcacctcc gtgttcagga gctgggcctg tcagccccgc tgaccgtgct
     1561 cccgaccatc acctgtgggc acaccatcga gatcctccgg gagaagggct tcgaccaggc
     1621 gcccgtggtg gatgaggcgg gggtaatcct gggaatggtg acgcttggga acatgctctc
     1681 gtccctgctt gccgggaagg tgcagccgtc agaccaagtt ggcaaagtca tctacaagca
     1741 gttcaaacag atccgcctca cggacacgct gggcaggctc tcgcacatcc tggagatgga
     1801 ccacttcgcc ctggtggtgc acgagcagat ccagtaccac agcaccggga agtccagtca
     1861 gcggcagatg gtgttcgggg tggtcaccgc cattgacttg ctgaacttcg tggccgccca
     1921 ggagcgggac cagaagtgaa gtccggagcg ctgggcggat gtttcaccaa ggaaatattg
     1981 agagagaagt cggccaggta ggatgaacac aggcaatgac tgcgcagagt ggattaaagg
     2041 caaaagagag aagagtccag gaaggggcgg ggagaagcct gggtggctca gcatcctcca
     2101 cgggctgcgc cgtctgctcg gggctgagct ggcgggagca gtttgcgtgt ttgggttttt
     2161 taattgagat gaaattcaaa taacctaaaa atcaatcact tgaaagtgaa caatcagcgg
     2221 catttagtac atccagaaag ttgtgtaggc accacctctg tcacgttctg gaacattctg
     2281 tcatcacccc gtgaagcaat catttcccct cccgtcttcc tcctcccctg gcaactgctg
     2341 atcgactttg tgtctctgtt gtctaaaata ggttttccct gttctggaca tttcatataa
     2401 atggaatcac acaa
//
