LOCUS       XM_047441030            2389 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens cystathionine beta-synthase (CBS),
            transcript variant X17, mRNA.
ACCESSION   XM_047441030
VERSION     XM_047441030.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000021.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2389
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
     gene            1..2389
                     /gene="CBS"
                     /gene_synonym="CBSL; HIP4"
                     /note="cystathionine beta-synthase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 2
                     mRNAs, 47 ESTs, 276 long SRA reads, 22 Proteins, and 98%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 9 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:875"
                     /db_xref="HGNC:HGNC:1550"
                     /db_xref="MIM:613381"
     CDS             259..1914
                     /gene="CBS"
                     /gene_synonym="CBSL; HIP4"
                     /codon_start=1
                     /product="cystathionine beta-synthase isoform X4"
                     /protein_id="XP_047296986.1"
                     /db_xref="GeneID:875"
                     /db_xref="HGNC:HGNC:1550"
                     /db_xref="MIM:613381"
                     /translation="MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWI
                     RPDAPSRCTWQLGRPASESPHHHTAPAKSPKILPDILKKIGDTPMVRINKIGKKFGLK
                     CELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAV
                     RGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSH
                     ILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCR
                     IIGVDPEGSILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTF
                     ARMLIAQEGLLCGGSAGSTVAVAVKAAQELQEGQRCVVILPDSVRNYMTKFLSDRWML
                     QKGFLKEEDLTEKKPWWWHLRVQELGLSAPLTVLPTITCGHTIEILREKGFDQAPVVD
                     EAGVILGMVTLGNMLSSLLAGKVQPSDQVGKVIYKQFKQIRLTDTLGRLSHILEMDHF
                     ALVVHEQIQYHSTGKSSQRQMVFGVVTAIDLLNFVAAQERDQK"
ORIGIN      
        1 agagaccgcg gcggagctgc gcgggccgga ggaggctgcg gagcatcgct ctgacctgag
       61 ccggggacgc tgcggaggcg cagcacgttc ctctgcccag agctgatggg caccgtccgt
      121 gtctttcgct gcagggcaag aagttaacca agtaaaacag catcggaaca ccaggatccc
      181 atgacagatt ctgttgtcac gtctccttac agagtttgag cggtgctgaa ctgtcagcac
      241 catctgtccg gtcccagcat gccttctgag accccccagg cagaagtggg gcccacaggc
      301 tgcccccacc gctcagggcc acactcggcg aaggggagcc tggagaaggg gtccccagag
      361 gataaggaag ccaaggagcc cctgtggatc cggcccgatg ctccgagcag gtgcacctgg
      421 cagctgggcc ggcctgcctc cgagtcccca catcaccaca ctgccccggc aaaatctcca
      481 aaaatcttgc cagatattct gaagaaaatc ggggacaccc ctatggtcag aatcaacaag
      541 attgggaaga agttcggcct gaagtgtgag ctcttggcca agtgtgagtt cttcaacgcg
      601 ggcgggagcg tgaaggaccg catcagcctg cggatgattg aggatgctga gcgcgacggg
      661 acgctgaagc ccggggacac gattatcgag ccgacatccg ggaacaccgg gatcgggctg
      721 gccctggctg cggcagtgag gggctatcgc tgcatcatcg tgatgccaga gaagatgagc
      781 tccgagaagg tggacgtgct gcgggcactg ggggctgaga ttgtgaggac gcccaccaat
      841 gccaggttcg actccccgga gtcacacgtg ggggtggcct ggcggctgaa gaacgaaatc
      901 cccaattctc acatcctaga ccagtaccgc aacgccagca accccctggc tcactacgac
      961 accaccgctg atgagatcct gcagcagtgt gatgggaagc tggacatgct ggtggcttca
     1021 gtgggcacgg gcggcaccat cacgggcatt gccaggaagc tgaaggagaa gtgtcctgga
     1081 tgcaggatca ttggggtgga tcccgaaggg tccatcctcg cagagccgga ggagctgaac
     1141 cagacggagc agacaaccta cgaggtggaa gggatcggct acgacttcat ccccacggtg
     1201 ctggacagga cggtggtgga caagtggttc aagagcaacg atgaggaggc gttcaccttt
     1261 gcccgcatgc tgatcgcgca agaggggctg ctgtgcggtg gcagtgctgg cagcacggtg
     1321 gcggtggccg tgaaggccgc gcaggagctg caggagggcc agcgctgcgt ggtcattctg
     1381 cccgactcag tgcggaacta catgaccaag ttcctgagcg acaggtggat gctgcagaag
     1441 ggctttctga aggaggagga cctcacggag aagaagccct ggtggtggca cctccgtgtt
     1501 caggagctgg gcctgtcagc cccgctgacc gtgctcccga ccatcacctg tgggcacacc
     1561 atcgagatcc tccgggagaa gggcttcgac caggcgcccg tggtggatga ggcgggggta
     1621 atcctgggaa tggtgacgct tgggaacatg ctctcgtccc tgcttgccgg gaaggtgcag
     1681 ccgtcagacc aagttggcaa agtcatctac aagcagttca aacagatccg cctcacggac
     1741 acgctgggca ggctctcgca catcctggag atggaccact tcgccctggt ggtgcacgag
     1801 cagatccagt accacagcac cgggaagtcc agtcagcggc agatggtgtt cggggtggtc
     1861 accgccattg acttgctgaa cttcgtggcc gcccaggagc gggaccagaa gtgaagtccg
     1921 gagcgctggg cggatgtttc accaaggaaa tattgagaga gaagtcggcc aggtaggatg
     1981 aacacaggca atgactgcgc agagtggatt aaaggcaaaa gagagaagag tccaggaagg
     2041 ggcggggaga agcctgggtg gctcagcatc ctccacgggc tgcgccgtct gctcggggct
     2101 gagctggcgg gagcagtttg cgtgtttggg ttttttaatt gagatgaaat tcaaataacc
     2161 taaaaatcaa tcacttgaaa gtgaacaatc agcggcattt agtacatcca gaaagttgtg
     2221 taggcaccac ctctgtcacg ttctggaaca ttctgtcatc accccgtgaa gcaatcattt
     2281 cccctcccgt cttcctcctc ccctggcaac tgctgatcga ctttgtgtct ctgttgtcta
     2341 aaataggttt tccctgttct ggacatttca tataaatgga atcacacaa
//
