LOCUS       XM_047441023            3059 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens cystathionine beta-synthase (CBS),
            transcript variant X9, mRNA.
ACCESSION   XM_047441023
VERSION     XM_047441023.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000021.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3059
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
     gene            1..3059
                     /gene="CBS"
                     /gene_synonym="CBSL; HIP4"
                     /note="cystathionine beta-synthase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 50
                     ESTs, 385 long SRA reads, 7 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 8 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:875"
                     /db_xref="HGNC:HGNC:1550"
                     /db_xref="MIM:613381"
     CDS             673..2370
                     /gene="CBS"
                     /gene_synonym="CBSL; HIP4"
                     /codon_start=1
                     /product="cystathionine beta-synthase isoform X3"
                     /protein_id="XP_047296979.1"
                     /db_xref="GeneID:875"
                     /db_xref="HGNC:HGNC:1550"
                     /db_xref="MIM:613381"
                     /translation="MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWI
                     RPDAPSRCTWQLGRPASESPHHHTAPAKSPKILPDILKKIGDTPMVRINKIGKKFGLK
                     CELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAV
                     RGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSH
                     ILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCR
                     IIGVDPEGSILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTF
                     ARMLIAQEGLLCGGSAGSTVAVAVKAAQELQEGQRCVVILPDSVRNYMTKFLSDRWML
                     QKGFLKEEDLTEKKPWWWHLRVQELGLSAPLTVLPTITCGHTIEILREKGFDQAPVVD
                     EAGVILGMVTLGNMLSSLLAGKVQPSDQVGKVIYKQFKQIRLTDTLGRLSHILEMDHF
                     ALVVHEQIQSQDQAWAGVVGGPADHSTGKSSQRQMVFGVVTAIDLLNFVAAQERDQK"
ORIGIN      
        1 cccgggcccg cgacacacgc cctcggggtc ggtcctcgag gacgcgcagg gccccccacc
       61 caccaggacg cacgtttcaa gctcatcagt aaaggttcct taaattcccg aagggcaaga
      121 agttaaccaa gtaaaacagc atcggaacac caggtgagat ccggccccac cgagactcgc
      181 tcccctctct ggacagagga tctcaactgg gtcccggttt ccctctccgc gcctccgccc
      241 agagttgcat catctgcacc gaaaggcggc gagacagggt ctcccaagac ccccgcccca
      301 ccggcgccca cgcctgcggt cttgaccgcc cagaagatgg gggctggccg tgcacgtggc
      361 cccgggctcc caccccagcc cccgcgccgg cggagtggac cccactggcg gcgagtcctg
      421 gagcgtggag cagggacgcg gggtgggaat ccgggggaga tgcacgtttc ggtgcccagc
      481 attgagttcg ctgcattgtg gatgggaaat ggctgtttgc aaatcgccct ttttggcgga
      541 ccgtgtgggg tggcggtaaa cgctgtcgtt gcgcgggcgg cacgcgagga tcccatgaca
      601 gattctgttg tcacgtctcc ttacagagtt tgagcggtgc tgaactgtca gcaccatctg
      661 tccggtccca gcatgccttc tgagaccccc caggcagaag tggggcccac aggctgcccc
      721 caccgctcag ggccacactc ggcgaagggg agcctggaga aggggtcccc agaggataag
      781 gaagccaagg agcccctgtg gatccggccc gatgctccga gcaggtgcac ctggcagctg
      841 ggccggcctg cctccgagtc cccacatcac cacactgccc cggcaaaatc tccaaaaatc
      901 ttgccagata ttctgaagaa aatcggggac acccctatgg tcagaatcaa caagattggg
      961 aagaagttcg gcctgaagtg tgagctcttg gccaagtgtg agttcttcaa cgcgggcggg
     1021 agcgtgaagg accgcatcag cctgcggatg attgaggatg ctgagcgcga cgggacgctg
     1081 aagcccgggg acacgattat cgagccgaca tccgggaaca ccgggatcgg gctggccctg
     1141 gctgcggcag tgaggggcta tcgctgcatc atcgtgatgc cagagaagat gagctccgag
     1201 aaggtggacg tgctgcgggc actgggggct gagattgtga ggacgcccac caatgccagg
     1261 ttcgactccc cggagtcaca cgtgggggtg gcctggcggc tgaagaacga aatccccaat
     1321 tctcacatcc tagaccagta ccgcaacgcc agcaaccccc tggctcacta cgacaccacc
     1381 gctgatgaga tcctgcagca gtgtgatggg aagctggaca tgctggtggc ttcagtgggc
     1441 acgggcggca ccatcacggg cattgccagg aagctgaagg agaagtgtcc tggatgcagg
     1501 atcattgggg tggatcccga agggtccatc ctcgcagagc cggaggagct gaaccagacg
     1561 gagcagacaa cctacgaggt ggaagggatc ggctacgact tcatccccac ggtgctggac
     1621 aggacggtgg tggacaagtg gttcaagagc aacgatgagg aggcgttcac ctttgcccgc
     1681 atgctgatcg cgcaagaggg gctgctgtgc ggtggcagtg ctggcagcac ggtggcggtg
     1741 gccgtgaagg ccgcgcagga gctgcaggag ggccagcgct gcgtggtcat tctgcccgac
     1801 tcagtgcgga actacatgac caagttcctg agcgacaggt ggatgctgca gaagggcttt
     1861 ctgaaggagg aggacctcac ggagaagaag ccctggtggt ggcacctccg tgttcaggag
     1921 ctgggcctgt cagccccgct gaccgtgctc ccgaccatca cctgtgggca caccatcgag
     1981 atcctccggg agaagggctt cgaccaggcg cccgtggtgg atgaggcggg ggtaatcctg
     2041 ggaatggtga cgcttgggaa catgctctcg tccctgcttg ccgggaaggt gcagccgtca
     2101 gaccaagttg gcaaagtcat ctacaagcag ttcaaacaga tccgcctcac ggacacgctg
     2161 ggcaggctct cgcacatcct ggagatggac cacttcgccc tggtggtgca cgagcagatc
     2221 cagtcgcagg accaggcctg ggcaggcgtg gtgggggggc ctgcagacca cagcaccggg
     2281 aagtccagtc agcggcagat ggtgttcggg gtggtcaccg ccattgactt gctgaacttc
     2341 gtggccgccc aggagcggga ccagaagtga agtccggagc gctgggcggt gcggagcggg
     2401 cccgccaccc ttgcccactt ctccttcgct ttcctgagcc ctaaacacac gcgtgattgg
     2461 taactgcctg gcctggcacc gttatccctg cacacggcac agagcatccg tctcccctcg
     2521 ttaacacatg gcttcctaaa tggccctgtt tacggcctat gagatgaaat atgtgatttt
     2581 ctctaatgta acttcctctt aggatgtttc accaaggaaa tattgagaga gaagtcggcc
     2641 aggtaggatg aacacaggca atgactgcgc agagtggatt aaaggcaaaa gagagaagag
     2701 tccaggaagg ggcggggaga agcctgggtg gctcagcatc ctccacgggc tgcgccgtct
     2761 gctcggggct gagctggcgg gagcagtttg cgtgtttggg ttttttaatt gagatgaaat
     2821 tcaaataacc taaaaatcaa tcacttgaaa gtgaacaatc agcggcattt agtacatcca
     2881 gaaagttgtg taggcaccac ctctgtcacg ttctggaaca ttctgtcatc accccgtgaa
     2941 gcaatcattt cccctcccgt cttcctcctc ccctggcaac tgctgatcga ctttgtgtct
     3001 ctgttgtcta aaataggttt tccctgttct ggacatttca tataaatgga atcacacaa
//
