LOCUS       XM_011529777            2537 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens cystathionine beta-synthase (CBS),
            transcript variant X5, mRNA.
ACCESSION   XM_011529777
VERSION     XM_011529777.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000021.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Mar 26, 2018 this sequence version replaced XM_011529777.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2537
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
     gene            1..2537
                     /gene="CBS"
                     /gene_synonym="CBSL; HIP4"
                     /note="cystathionine beta-synthase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 61
                     ESTs, 742 long SRA reads, 7 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 21 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:875"
                     /db_xref="HGNC:HGNC:1550"
                     /db_xref="MIM:613381"
     CDS             151..1848
                     /gene="CBS"
                     /gene_synonym="CBSL; HIP4"
                     /codon_start=1
                     /product="cystathionine beta-synthase isoform X3"
                     /protein_id="XP_011528079.1"
                     /db_xref="GeneID:875"
                     /db_xref="HGNC:HGNC:1550"
                     /db_xref="MIM:613381"
                     /translation="MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWI
                     RPDAPSRCTWQLGRPASESPHHHTAPAKSPKILPDILKKIGDTPMVRINKIGKKFGLK
                     CELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAV
                     RGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSH
                     ILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCR
                     IIGVDPEGSILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTF
                     ARMLIAQEGLLCGGSAGSTVAVAVKAAQELQEGQRCVVILPDSVRNYMTKFLSDRWML
                     QKGFLKEEDLTEKKPWWWHLRVQELGLSAPLTVLPTITCGHTIEILREKGFDQAPVVD
                     EAGVILGMVTLGNMLSSLLAGKVQPSDQVGKVIYKQFKQIRLTDTLGRLSHILEMDHF
                     ALVVHEQIQSQDQAWAGVVGGPADHSTGKSSQRQMVFGVVTAIDLLNFVAAQERDQK"
ORIGIN      
        1 gtcgccgtct ccgcctcgcc gcagtcgggg cagccgctcg cccctctttt ccatgtatcc
       61 gtccaggatc ccatgacaga ttctgttgtc acgtctcctt acagagtttg agcggtgctg
      121 aactgtcagc accatctgtc cggtcccagc atgccttctg agacccccca ggcagaagtg
      181 gggcccacag gctgccccca ccgctcaggg ccacactcgg cgaaggggag cctggagaag
      241 gggtccccag aggataagga agccaaggag cccctgtgga tccggcccga tgctccgagc
      301 aggtgcacct ggcagctggg ccggcctgcc tccgagtccc cacatcacca cactgccccg
      361 gcaaaatctc caaaaatctt gccagatatt ctgaagaaaa tcggggacac ccctatggtc
      421 agaatcaaca agattgggaa gaagttcggc ctgaagtgtg agctcttggc caagtgtgag
      481 ttcttcaacg cgggcgggag cgtgaaggac cgcatcagcc tgcggatgat tgaggatgct
      541 gagcgcgacg ggacgctgaa gcccggggac acgattatcg agccgacatc cgggaacacc
      601 gggatcgggc tggccctggc tgcggcagtg aggggctatc gctgcatcat cgtgatgcca
      661 gagaagatga gctccgagaa ggtggacgtg ctgcgggcac tgggggctga gattgtgagg
      721 acgcccacca atgccaggtt cgactccccg gagtcacacg tgggggtggc ctggcggctg
      781 aagaacgaaa tccccaattc tcacatccta gaccagtacc gcaacgccag caaccccctg
      841 gctcactacg acaccaccgc tgatgagatc ctgcagcagt gtgatgggaa gctggacatg
      901 ctggtggctt cagtgggcac gggcggcacc atcacgggca ttgccaggaa gctgaaggag
      961 aagtgtcctg gatgcaggat cattggggtg gatcccgaag ggtccatcct cgcagagccg
     1021 gaggagctga accagacgga gcagacaacc tacgaggtgg aagggatcgg ctacgacttc
     1081 atccccacgg tgctggacag gacggtggtg gacaagtggt tcaagagcaa cgatgaggag
     1141 gcgttcacct ttgcccgcat gctgatcgcg caagaggggc tgctgtgcgg tggcagtgct
     1201 ggcagcacgg tggcggtggc cgtgaaggcc gcgcaggagc tgcaggaggg ccagcgctgc
     1261 gtggtcattc tgcccgactc agtgcggaac tacatgacca agttcctgag cgacaggtgg
     1321 atgctgcaga agggctttct gaaggaggag gacctcacgg agaagaagcc ctggtggtgg
     1381 cacctccgtg ttcaggagct gggcctgtca gccccgctga ccgtgctccc gaccatcacc
     1441 tgtgggcaca ccatcgagat cctccgggag aagggcttcg accaggcgcc cgtggtggat
     1501 gaggcggggg taatcctggg aatggtgacg cttgggaaca tgctctcgtc cctgcttgcc
     1561 gggaaggtgc agccgtcaga ccaagttggc aaagtcatct acaagcagtt caaacagatc
     1621 cgcctcacgg acacgctggg caggctctcg cacatcctgg agatggacca cttcgccctg
     1681 gtggtgcacg agcagatcca gtcgcaggac caggcctggg caggcgtggt gggggggcct
     1741 gcagaccaca gcaccgggaa gtccagtcag cggcagatgg tgttcggggt ggtcaccgcc
     1801 attgacttgc tgaacttcgt ggccgcccag gagcgggacc agaagtgaag tccggagcgc
     1861 tgggcggtgc ggagcgggcc cgccaccctt gcccacttct ccttcgcttt cctgagccct
     1921 aaacacacgc gtgattggta actgcctggc ctggcaccgt tatccctgca cacggcacag
     1981 agcatccgtc tcccctcgtt aacacatggc ttcctaaatg gccctgttta cggcctatga
     2041 gatgaaatat gtgattttct ctaatgtaac ttcctcttag gatgtttcac caaggaaata
     2101 ttgagagaga agtcggccag gtaggatgaa cacaggcaat gactgcgcag agtggattaa
     2161 aggcaaaaga gagaagagtc caggaagggg cggggagaag cctgggtggc tcagcatcct
     2221 ccacgggctg cgccgtctgc tcggggctga gctggcggga gcagtttgcg tgtttgggtt
     2281 ttttaattga gatgaaattc aaataaccta aaaatcaatc acttgaaagt gaacaatcag
     2341 cggcatttag tacatccaga aagttgtgta ggcaccacct ctgtcacgtt ctggaacatt
     2401 ctgtcatcac cccgtgaagc aatcatttcc cctcccgtct tcctcctccc ctggcaactg
     2461 ctgatcgact ttgtgtctct gttgtctaaa ataggttttc cctgttctgg acatttcata
     2521 taaatggaat cacacaa
//
