LOCUS       XM_011529774            2544 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens cystathionine beta-synthase (CBS),
            transcript variant X2, mRNA.
ACCESSION   XM_011529774
VERSION     XM_011529774.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000021.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011529774.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2544
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
     gene            1..2544
                     /gene="CBS"
                     /gene_synonym="CBSL; HIP4"
                     /note="cystathionine beta-synthase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 26
                     ESTs, 177 long SRA reads, 2 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 8 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:875"
                     /db_xref="HGNC:HGNC:1550"
                     /db_xref="MIM:613381"
     CDS             321..2069
                     /gene="CBS"
                     /gene_synonym="CBSL; HIP4"
                     /codon_start=1
                     /product="cystathionine beta-synthase isoform X1"
                     /protein_id="XP_011528076.1"
                     /db_xref="GeneID:875"
                     /db_xref="HGNC:HGNC:1550"
                     /db_xref="MIM:613381"
                     /translation="MRQRMGIWRVCGWPRPGCAGGHLRCGLRPPGKGISLQDAVSRLK
                     NVEGIPKGRSSPRAQSPGRPQHRHRESCGCRGLGDKAGTEFRISDDQGQSCSAPCRTG
                     RMGCRGRSSDRLVPRCRCRGVAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTII
                     EPTSGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPE
                     SHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGG
                     TITGIARKLKEKCPGCRIIGVDPEGSILAEPEELNQTEQTTYEVEGIGYDFIPTVLDR
                     TVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVKAAQELQEGQRCVVILP
                     DSVRNYMTKFLSDRWMLQKGFLKEEDLTEKKPWWWHLRVQELGLSAPLTVLPTITCGH
                     TIEILREKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQPSDQVGKVIYKQFKQIR
                     LTDTLGRLSHILEMDHFALVVHEQIQSQDQAWAGVVGGPADHSTGKSSQRQMVFGVVT
                     AIDLLNFVAAQERDQK"
ORIGIN      
        1 tggccaagaa catatcagct taagtttggg aaaaacacac aacagggcat tgtgtcagag
       61 ggtgaccaaa gtgactcccc agcagatgga ccagggaacg aacaggtgac ctttgaactg
      121 aggccggagt ggaagcagcg agggtgtgaa gggccgggtg agggtcaaag gcagaagcaa
      181 gcaggtgggg agggttagcg tcatgcctgc taaggagcag tggacgggtc ctagcacgtg
      241 ctgtgagcca cccgctgtcc agggagcggt tacctctgtc ttgccagctt cgtggggaca
      301 gatagttcag ctcatcattt atgagacaga gaatgggaat ttggagggtc tgtggctggc
      361 ctcgtcctgg gtgcgcaggg ggtcacctga ggtgtggtct gaggcctccg gggaagggca
      421 tttctttgca ggacgcagtt tccaggctca agaacgtgga gggaattcct aagggtcgct
      481 cttcaccaag agcgcagagc cctggtagac ctcagcatcg tcacagagaa agctgtgggt
      541 gcagaggcct tggggacaag gcggggacgg aatttcgtat ttcagatgac caaggccaaa
      601 gttgctcagc gccctgcagg accggtagga tgggctgcag ggggagaagc tctgataggc
      661 tagtgcccag gtgcaggtgt aggggagtgg ccaagtgtga gttcttcaac gcgggcggga
      721 gcgtgaagga ccgcatcagc ctgcggatga ttgaggatgc tgagcgcgac gggacgctga
      781 agcccgggga cacgattatc gagccgacat ccgggaacac cgggatcggg ctggccctgg
      841 ctgcggcagt gaggggctat cgctgcatca tcgtgatgcc agagaagatg agctccgaga
      901 aggtggacgt gctgcgggca ctgggggctg agattgtgag gacgcccacc aatgccaggt
      961 tcgactcccc ggagtcacac gtgggggtgg cctggcggct gaagaacgaa atccccaatt
     1021 ctcacatcct agaccagtac cgcaacgcca gcaaccccct ggctcactac gacaccaccg
     1081 ctgatgagat cctgcagcag tgtgatggga agctggacat gctggtggct tcagtgggca
     1141 cgggcggcac catcacgggc attgccagga agctgaagga gaagtgtcct ggatgcagga
     1201 tcattggggt ggatcccgaa gggtccatcc tcgcagagcc ggaggagctg aaccagacgg
     1261 agcagacaac ctacgaggtg gaagggatcg gctacgactt catccccacg gtgctggaca
     1321 ggacggtggt ggacaagtgg ttcaagagca acgatgagga ggcgttcacc tttgcccgca
     1381 tgctgatcgc gcaagagggg ctgctgtgcg gtggcagtgc tggcagcacg gtggcggtgg
     1441 ccgtgaaggc cgcgcaggag ctgcaggagg gccagcgctg cgtggtcatt ctgcccgact
     1501 cagtgcggaa ctacatgacc aagttcctga gcgacaggtg gatgctgcag aagggctttc
     1561 tgaaggagga ggacctcacg gagaagaagc cctggtggtg gcacctccgt gttcaggagc
     1621 tgggcctgtc agccccgctg accgtgctcc cgaccatcac ctgtgggcac accatcgaga
     1681 tcctccggga gaagggcttc gaccaggcgc ccgtggtgga tgaggcgggg gtaatcctgg
     1741 gaatggtgac gcttgggaac atgctctcgt ccctgcttgc cgggaaggtg cagccgtcag
     1801 accaagttgg caaagtcatc tacaagcagt tcaaacagat ccgcctcacg gacacgctgg
     1861 gcaggctctc gcacatcctg gagatggacc acttcgccct ggtggtgcac gagcagatcc
     1921 agtcgcagga ccaggcctgg gcaggcgtgg tgggggggcc tgcagaccac agcaccggga
     1981 agtccagtca gcggcagatg gtgttcgggg tggtcaccgc cattgacttg ctgaacttcg
     2041 tggccgccca ggagcgggac cagaagtgaa gtccggagcg ctgggcggat gtttcaccaa
     2101 ggaaatattg agagagaagt cggccaggta ggatgaacac aggcaatgac tgcgcagagt
     2161 ggattaaagg caaaagagag aagagtccag gaaggggcgg ggagaagcct gggtggctca
     2221 gcatcctcca cgggctgcgc cgtctgctcg gggctgagct ggcgggagca gtttgcgtgt
     2281 ttgggttttt taattgagat gaaattcaaa taacctaaaa atcaatcact tgaaagtgaa
     2341 caatcagcgg catttagtac atccagaaag ttgtgtaggc accacctctg tcacgttctg
     2401 gaacattctg tcatcacccc gtgaagcaat catttcccct cccgtcttcc tcctcccctg
     2461 gcaactgctg atcgactttg tgtctctgtt gtctaaaata ggttttccct gttctggaca
     2521 tttcatataa atggaatcac acaa
//
