LOCUS       NM_032783               3440 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens carbonyl reductase 4 (CBR4), mRNA.
ACCESSION   NM_032783
VERSION     NM_032783.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3440)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3440)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3440)
  AUTHORS   Venkatesan,R., Sah-Teli,S.K., Awoniyi,L.O., Jiang,G., Prus,P.,
            Kastaniotis,A.J., Hiltunen,J.K., Wierenga,R.K. and Chen,Z.
  TITLE     Insights into mitochondrial fatty acid synthesis from the structure
            of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA
            dehydrogenase
  JOURNAL   Nat Commun 5, 4805 (2014)
   PUBMED   25203508
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3440)
  AUTHORS   Bains,O.S., Grigliatti,T.A., Reid,R.E. and Riggs,K.W.
  TITLE     Naturally occurring variants of human aldo-keto reductases with
            reduced in vitro metabolism of daunorubicin and doxorubicin
  JOURNAL   J Pharmacol Exp Ther 335 (3), 533-545 (2010)
   PUBMED   20837989
REFERENCE   5  (bases 1 to 3440)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3440)
  AUTHORS   Chen,Z., Kastaniotis,A.J., Miinalainen,I.J., Rajaram,V.,
            Wierenga,R.K. and Hiltunen,J.K.
  TITLE     17beta-hydroxysteroid dehydrogenase type 8 and carbonyl reductase
            type 4 assemble as a ketoacyl reductase of human mitochondrial FAS
  JOURNAL   FASEB J 23 (11), 3682-3691 (2009)
   PUBMED   19571038
  REMARK    GeneRIF: Hs17beta-HSD8 and HsCBR4 show a strong genetic interaction
            in vivo in yeast, where, only if they are expressed together, they
            rescue the respiratory deficiency and restore the lipoic acid
            content of oar1Delta cells.
REFERENCE   7  (bases 1 to 3440)
  AUTHORS   Persson,B., Kallberg,Y., Bray,J.E., Bruford,E., Dellaporta,S.L.,
            Favia,A.D., Duarte,R.G., Jornvall,H., Kavanagh,K.L., Kedishvili,N.,
            Kisiela,M., Maser,E., Mindnich,R., Orchard,S., Penning,T.M.,
            Thornton,J.M., Adamski,J. and Oppermann,U.
  TITLE     The SDR (short-chain dehydrogenase/reductase and related enzymes)
            nomenclature initiative
  JOURNAL   Chem Biol Interact 178 (1-3), 94-98 (2009)
   PUBMED   19027726
REFERENCE   8  (bases 1 to 3440)
  AUTHORS   Endo,S., Matsunaga,T., Kitade,Y., Ohno,S., Tajima,K., El-Kabbani,O.
            and Hara,A.
  TITLE     Human carbonyl reductase 4 is a mitochondrial NADPH-dependent
            quinone reductase
  JOURNAL   Biochem Biophys Res Commun 377 (4), 1326-1330 (2008)
   PUBMED   19000905
  REMARK    GeneRIF: CBR4 is a mitochondrial NADPH-dependent reductase for o-
            and p-quinones.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA217727.1, AC021151.8, BC033650.1 and AL833393.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032783.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL833393.1, SRR1803614.275197.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306193.8/ ENSP00000303525.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                DA217727.1         63-141
            80-139              AC021151.8         79277-79336         c
            140-1068            BC033650.1         132-1060
            1069-2208           AC021151.8         57982-59121         c
            2209-3440           AL833393.1         2212-3443
FEATURES             Location/Qualifiers
     source          1..3440
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.3"
     gene            1..3440
                     /gene="CBR4"
                     /gene_synonym="SDR45C1"
                     /note="carbonyl reductase 4"
                     /db_xref="GeneID:84869"
                     /db_xref="HGNC:HGNC:25891"
                     /db_xref="MIM:619394"
     exon            1..308
                     /gene="CBR4"
                     /gene_synonym="SDR45C1"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..880
                     /gene="CBR4"
                     /gene_synonym="SDR45C1"
                     /EC_number="1.1.1.100"
                     /EC_number="1.6.5.10"
                     /note="carbonic reductase 4; carbonyl reductase family
                     member 4; quinone reductase CBR4; KAR beta subunit; short
                     chain dehydrogenase/reductase family 45C member 1;
                     3-ketoacyl-[acyl-carrier-protein] reductase beta subunit"
                     /codon_start=1
                     /product="3-oxoacyl-[acyl-carrier-protein] reductase"
                     /protein_id="NP_116172.2"
                     /db_xref="CCDS:CCDS3812.1"
                     /db_xref="GeneID:84869"
                     /db_xref="HGNC:HGNC:25891"
                     /db_xref="MIM:619394"
                     /translation="MDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAG
                     DLGGDHLAFSCDVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVS
                     QLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSR
                     ALAKEVARKKIRVNVVAPGFVHTDMTKDLKEEHLKKNIPLGRFGETIEVAHAVVFLLE
                     SPYITGHVLVVDGGLQLIL"
     exon            309..429
                     /gene="CBR4"
                     /gene_synonym="SDR45C1"
                     /inference="alignment:Splign:2.1.0"
     exon            430..566
                     /gene="CBR4"
                     /gene_synonym="SDR45C1"
                     /inference="alignment:Splign:2.1.0"
     exon            567..701
                     /gene="CBR4"
                     /gene_synonym="SDR45C1"
                     /inference="alignment:Splign:2.1.0"
     exon            702..3440
                     /gene="CBR4"
                     /gene_synonym="SDR45C1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1013..1018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBR4"
                     /gene_synonym="SDR45C1"
                     /note="hexamer: TATAAA"
     polyA_site      1035
                     /gene="CBR4"
                     /gene_synonym="SDR45C1"
                     /note="major polyA site"
     regulatory      3417..3422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBR4"
                     /gene_synonym="SDR45C1"
                     /note="hexamer: AATAAA"
     polyA_site      3440
                     /gene="CBR4"
                     /gene_synonym="SDR45C1"
                     /note="major polyA site"
ORIGIN      
        1 actattgtgc ggctgcagga ggtgtcgagc ggcgttattt ttttttgcgg tttgcctttt
       61 tttttctttt tttttttttt ggaaccgcgg ttgtttaaaa gcctgaggga acctggagag
      121 gggctcccac tccctaccct ctttcctccg agtttgtgac tccgagatgg acaaagtgtg
      181 tgctgttttt ggaggctccc gaggcattgg cagagctgtg gcccagttaa tggcccggaa
      241 aggctaccga ctggcggtca ttgccagaaa cctggaaggg gccaaagccg ccgccggtga
      301 cctcggcgga gatcatttgg catttagctg tgatgttgct aaagaacatg atgttcaaaa
      361 tacatttgaa gagctggaga aacatttagg tcgagtaaat ttcttggtaa atgcagctgg
      421 tattaacagg gatggtcttt tagtaagaac aaaaactgaa gatatggtat ctcagcttca
      481 tactaacctc ttgggttcca tgctgacctg taaagctgcc atgaggacta tgattcaaca
      541 acagggaggg tctattgtta atgtaggaag cattgttggc ttaaaaggca actctggcca
      601 gtccgtttac agtgccagta aaggaggatt agttggattt tcacgtgctc ttgctaaaga
      661 ggtagcaaga aagaaaatta gagtgaatgt agttgcacca ggatttgtac acacagatat
      721 gacgaaagac ttgaaagaag aacatttaaa gaaaaatatt cctcttggga ggtttggaga
      781 aactattgag gtggcacatg cggttgtgtt tcttttagaa tcaccgtata ttacagggca
      841 tgttctggta gtggatgggg gattacaact cattttgtaa tttgcagatt attcagttat
      901 aggggtgatt agcatcaagg gcacactttg gctactgatt agacaattat acctacatgg
      961 gtaacatgtg ctaatcaaac ctgctgatgc tacaaatgtt aatttctgtc tttataaaaa
     1021 tatgtctcaa aagaacaatg tgtgacaaat tgtggttttt ttttttttgg tctaagttac
     1081 atcagtgttg ttttgtttaa aaagccttca tgagatacaa ttcacatacc atataatcac
     1141 acatttaaaa tacacaattc agtggtttta acatatttaa atacatgtgc aatcatcccc
     1201 ccagacaaat tgtgttttct aaaggatgtg tatcacttac ctttggttac ctcatagact
     1261 gtagcaatct tagtgtatag acattttgca agtcatataa acaagtattg atttatatat
     1321 tttgtctcaa aagtggaaaa attatattgt ctaattatga tgaattattt tcttgtatca
     1381 agctgaattt tctaaaagtt aaccttgtgg gctgttgcca aaataagagt atttagagga
     1441 cactgattag ttgtcaatac tttagcaagc ccactaaaga taactatatt ccttttgcat
     1501 gtgcttgggt gatcagtttt tatacaggtt gcaaaacata gtattcatta aagacatgaa
     1561 tttagaattg atttctttga gtggtatttc tcttgattga gcagctagac aaaataatct
     1621 gcaaatttaa atgtggcgca tttgactcat tcttgagaaa ttctcataag tgaagaggat
     1681 tagcccttaa ggttttaata cctggtacag tagtgaaccg cacagatttc atgaacttag
     1741 gatgtgtttt ttattcatga aaaacttaga atagtgaact attaatattt aaaaacgaga
     1801 aatacaacat ttaaaaaatt aagagtattt tgcattagtg attatgattc ttatcccaaa
     1861 attctagaaa gtaataaatt ctgtatgaat aagcataaaa aataaataaa tatgcaataa
     1921 cattaaatta aatgtcttta caagaagcag tgaaggcact ggtcttaagt gagaatattt
     1981 gcctgggagt agagataaag acacaaaccg aatgtgaaat accaggtaat aattattttg
     2041 cattaaactc tttttatcgg gaatagtatg atattttcag tgtcactcca ttcatgttga
     2101 tttggagctg acagttattt tgtgtaagca gagatttaat tttatattga aagtcagtgc
     2161 aaaattatga ataggatata ctaataaata caaagtaata acaaaagtca aagcagtgtt
     2221 ctaaataaaa attctgggtt ccttaaaaat tattttaaat ttatctttga aatagttttc
     2281 ttagattaat ctcaggatat gagaaagtca attaagtgtg agtaaagtta gtatcattaa
     2341 acaaattgtc tattaaatgc aagacgtggt aatatacaga atttatcagg cattaccaag
     2401 tctaggcaca tataggaaat gcagcactca gaatggtttc aatgtagtag ttgatgcttg
     2461 taaggtaggg gagcttattc agacatagta gatagtttct ctaatgctgt ctcaattgct
     2521 ggcctttggc tacctgtact tccccattat ggcagcccat tcagtcttga gttttcttct
     2581 ctggacacct tatgctctga aatcatgagc gaggctgatt caattggtga tttgggtaga
     2641 aagcagtatg ttttgctgac attaagatgt aggttataga taggtttagc ctttaagtgt
     2701 atgtttttat actttaaaat aagaaatata accttttaag ctattccacc tcctccccca
     2761 gcctatctca aactggtgga atatatggag agatcttgaa agaggtaaaa taaaccttca
     2821 ctgctccact ccaggtgaat ccgcccactc ccactgacct agtagaattt gtaatttaat
     2881 acttaccttc tatttctgaa atcagttgtg aactgttgcc ttatgttcag aggtttaaga
     2941 acctcagtga attcattttt taaaatctgc tattctgaga agcattgaat gaattcttaa
     3001 caagaagact catctgtagc tgtttgctga ctcctatgag cccataaggg ttctgtgctt
     3061 agcattaaca aaataaggtt tataggtaaa gccaatgtat taattttttt ttgcatggag
     3121 ggctttaaaa tttgtgctct ttttcatatt ttattcatat tcaatttatg gtttgtaact
     3181 gctttttagg gagataatta tatgttataa attagttttg gggggaataa ttgtgcaaag
     3241 aggataattt aatttacgtg cttctgttat tcagaataaa gagagaagac tacgctgcat
     3301 attcaagagt tgtaccttaa cattggtgaa acattttttc taagattttc aaaaggaata
     3361 tgtgtaaatt gagaaatcat aaccactgtc ctaacttggt aaacaaactg ttcttaaata
     3421 aagtatttaa tgattttaaa
//
