LOCUS       NM_001236                998 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens carbonyl reductase 3 (CBR3), mRNA.
ACCESSION   NM_001236
VERSION     NM_001236.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 998)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 998)
  AUTHORS   Guan,Y., Yang,J., Liu,X. and Chu,L.
  TITLE     Long noncoding RNA CBR3 antisense RNA 1 promotes the aggressive
            phenotypes of non-small-cell lung cancer by sponging
            microRNA-509-3p and competitively upregulating HDAC9 expression
  JOURNAL   Oncol Rep 44 (4), 1403-1414 (2020)
   PUBMED   32945466
  REMARK    GeneRIF: Long noncoding RNA CBR3 antisense RNA 1 promotes the
            aggressive phenotypes of nonsmallcell lung cancer by sponging
            microRNA5093p and competitively upregulating HDAC9 expression.
REFERENCE   3  (bases 1 to 998)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 998)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 998)
  AUTHORS   Zhou,Q., Ding,W., Weng,Y., Ding,G., Xia,G., Xu,J., Xu,K. and
            Ding,Q.
  TITLE     NOS3 895G&gt;T and CBR3 730G&gt;A Are Associated with Recurrence
            Risk in Non-Muscle-Invasive Bladder Cancer with Intravesical
            Instillations of THP
  JOURNAL   Chemotherapy 63 (4), 191-197 (2018)
   PUBMED   30125887
  REMARK    GeneRIF: CBR3 730G>A is significantly associated with recurrence-
            free survival in patients who received intravesical chemotherapy
            with pirarubicin after complete transurethral resection.
REFERENCE   6  (bases 1 to 998)
  AUTHORS   Umemoto,M., Yokoyama,Y., Sato,S., Tsuchida,S., Al-Mulla,F. and
            Saito,Y.
  TITLE     Carbonyl reductase as a significant predictor of survival and lymph
            node metastasis in epithelial ovarian cancer
  JOURNAL   Br J Cancer 85 (7), 1032-1036 (2001)
   PUBMED   11592776
  REMARK    GeneRIF: Decreased Carbonyl Reductase expression in epithelial
            ovarian cancer is associated with RLN metastasis and poor survival
REFERENCE   7  (bases 1 to 998)
  AUTHORS   Ismail,E., Al-Mulla,F., Tsuchida,S., Suto,K., Motley,P.,
            Harrison,P.R. and Birnie,G.D.
  TITLE     Carbonyl reductase: a novel metastasis-modulating function
  JOURNAL   Cancer Res 60 (5), 1173-1176 (2000)
   PUBMED   10728668
  REMARK    GeneRIF: carbonyl reductase has an important function in modifying
            the metastatic behavior of malignant tumors.
REFERENCE   8  (bases 1 to 998)
  AUTHORS   Watanabe,K., Sugawara,C., Ono,A., Fukuzumi,Y., Itakura,S.,
            Yamazaki,M., Tashiro,H., Osoegawa,K., Soeda,E. and Nomura,T.
  TITLE     Mapping of a novel human carbonyl reductase, CBR3, and ribosomal
            pseudogenes to human chromosome 21q22.2
  JOURNAL   Genomics 52 (1), 95-100 (1998)
   PUBMED   9740676
REFERENCE   9  (bases 1 to 998)
  AUTHORS   Dahmane,N., Ghezala,G.A., Gosset,P., Chamoun,Z.,
            Dufresne-Zacharia,M.C., Lopes,C., Rabatel,N.,
            Gassanova-Maugenre,S., Chettouh,Z., Abramowski,V., Fayet,E.,
            Yaspo,M.L., Korn,B., Blouin,J.L., Lehrach,H., Poutska,A.,
            Antonarakis,S.E., Sinet,P.M., Creau,N. and Delabar,J.M.
  TITLE     Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21
            involved in Down syndrome
  JOURNAL   Genomics 48 (1), 12-23 (1998)
   PUBMED   9503011
REFERENCE   10 (bases 1 to 998)
  AUTHORS   Wermuth,B., Mader-Heinemann,G. and Ernst,E.
  TITLE     Cloning and expression of carbonyl reductase from rat testis
  JOURNAL   Eur J Biochem 228 (2), 473-479 (1995)
   PUBMED   7705364
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB041012.1 and BC002812.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001236.3.
            
            Summary: Carbonyl reductase 3 catalyzes the reduction of a large
            number of biologically and pharmacologically active carbonyl
            compounds to their corresponding alcohols.  The enzyme is
            classified as a monomeric NADPH-dependent oxidoreductase.  CBR3
            contains three exons spanning 11.2 kilobases and is closely linked
            to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223429.1, AB041012.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290354.6/ ENSP00000290354.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-990               AB041012.1         168-1157
            991-998             BC002812.2         965-972
FEATURES             Location/Qualifiers
     source          1..998
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.12"
     gene            1..998
                     /gene="CBR3"
                     /gene_synonym="hCBR3; HEL-S-25; SDR21C2"
                     /note="carbonyl reductase 3"
                     /db_xref="GeneID:874"
                     /db_xref="HGNC:HGNC:1549"
                     /db_xref="MIM:603608"
     exon            1..403
                     /gene="CBR3"
                     /gene_synonym="hCBR3; HEL-S-25; SDR21C2"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..948
                     /gene="CBR3"
                     /gene_synonym="hCBR3; HEL-S-25; SDR21C2"
                     /EC_number="1.1.1.184"
                     /EC_number="1.6.5.10"
                     /note="carbonyl reductase (NADPH) 3; NADPH-dependent
                     carbonyl reductase 3; epididymis secretory protein Li 25;
                     short chain dehydrogenase/reductase family 21C member 2;
                     quinone reductase CBR3"
                     /codon_start=1
                     /product="carbonyl reductase [NADPH] 3"
                     /protein_id="NP_001227.1"
                     /db_xref="CCDS:CCDS13642.1"
                     /db_xref="GeneID:874"
                     /db_xref="HGNC:HGNC:1549"
                     /db_xref="MIM:603608"
                     /translation="MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQ
                     AAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMP
                     FDIKAEMTLKTNFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHS
                     ETLTEGDLVDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKA
                     DRILVNACCPGPVKTDMDGKDSIRTVEEGAETPVYLALLPPDATEPQGQLVHDKVVQN
                     W"
     exon            404..511
                     /gene="CBR3"
                     /gene_synonym="hCBR3; HEL-S-25; SDR21C2"
                     /inference="alignment:Splign:2.1.0"
     exon            512..998
                     /gene="CBR3"
                     /gene_synonym="hCBR3; HEL-S-25; SDR21C2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      974..979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBR3"
                     /gene_synonym="hCBR3; HEL-S-25; SDR21C2"
                     /note="hexamer: AATAAA"
     polyA_site      998
                     /gene="CBR3"
                     /gene_synonym="hCBR3; HEL-S-25; SDR21C2"
                     /note="major polyA site"
ORIGIN      
        1 agaacttagt ctgcgcggcg gcattgacac tagctgggct cctcggggcg cgccccaggt
       61 ggtccgaagc ccggtccgcc ctccacgcag gtgccccgcg ctccccgctc agccatgtcg
      121 tcctgcagcc gcgtggcgct ggtgaccggg gccaacaggg gcatcggctt ggccatcgcg
      181 cgcgaactgt gccgacagtt ctctggggat gtggtgctca ccgcgcggga cgtggcgcgg
      241 ggccaggcgg ccgtgcagca gctgcaggcg gagggcctga gcccgcgctt ccaccaactg
      301 gacatcgacg acttgcagag catccgcgcc ctgcgcgact tcctgcgcaa ggagtacggg
      361 gggctcaacg tactggtcaa caacgcggcc gtcgccttca agagtgatga tccaatgccc
      421 tttgacatta aagctgagat gacactgaag acaaattttt ttgccactag aaacatgtgc
      481 aacgagttac tgccgataat gaaacctcat gggagagtgg tgaatatcag tagtttgcag
      541 tgtttaaggg cttttgaaaa ctgcagtgaa gatctgcagg aaaggttcca cagtgagaca
      601 ctcacagaag gagacctggt ggatctcatg aaaaagtttg tggaggacac aaaaaatgag
      661 gtgcatgaga gggaaggctg gcccaactca ccttatgggg tgtccaagtt gggggtcacg
      721 gtcttatcga ggatcctggc caggcgtctg gatgagaaga ggaaagctga caggattctg
      781 gtgaatgcgt gctgcccagg accagtgaag acagacatgg atgggaaaga cagcatcagg
      841 actgtggagg agggggctga gacccctgtc tacttggccc tcttgcctcc agatgccact
      901 gagccacaag gccagttggt ccatgacaaa gttgtgcaaa actggtaaac gtctgcttcg
      961 gagcttgctg cttaataaat gttggtggaa tgaatgaa
//
