LOCUS       NM_001039771            2476 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens cerebellin 3 precursor (CBLN3), mRNA.
ACCESSION   NM_001039771 XM_927137 XM_940162
VERSION     NM_001039771.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2476)
  AUTHORS   Teslovich,T.M., Musunuru,K., Smith,A.V., Edmondson,A.C.,
            Stylianou,I.M., Koseki,M., Pirruccello,J.P., Ripatti,S.,
            Chasman,D.I., Willer,C.J., Johansen,C.T., Fouchier,S.W., Isaacs,A.,
            Peloso,G.M., Barbalic,M., Ricketts,S.L., Bis,J.C., Aulchenko,Y.S.,
            Thorleifsson,G., Feitosa,M.F., Chambers,J., Orho-Melander,M.,
            Melander,O., Johnson,T., Li,X., Guo,X., Li,M., Shin Cho,Y., Jin
            Go,M., Jin Kim,Y., Lee,J.Y., Park,T., Kim,K., Sim,X., Twee-Hee
            Ong,R., Croteau-Chonka,D.C., Lange,L.A., Smith,J.D., Song,K., Hua
            Zhao,J., Yuan,X., Luan,J., Lamina,C., Ziegler,A., Zhang,W.,
            Zee,R.Y., Wright,A.F., Witteman,J.C., Wilson,J.F., Willemsen,G.,
            Wichmann,H.E., Whitfield,J.B., Waterworth,D.M., Wareham,N.J.,
            Waeber,G., Vollenweider,P., Voight,B.F., Vitart,V.,
            Uitterlinden,A.G., Uda,M., Tuomilehto,J., Thompson,J.R., Tanaka,T.,
            Surakka,I., Stringham,H.M., Spector,T.D., Soranzo,N., Smit,J.H.,
            Sinisalo,J., Silander,K., Sijbrands,E.J., Scuteri,A., Scott,J.,
            Schlessinger,D., Sanna,S., Salomaa,V., Saharinen,J., Sabatti,C.,
            Ruokonen,A., Rudan,I., Rose,L.M., Roberts,R., Rieder,M.,
            Psaty,B.M., Pramstaller,P.P., Pichler,I., Perola,M., Penninx,B.W.,
            Pedersen,N.L., Pattaro,C., Parker,A.N., Pare,G., Oostra,B.A.,
            O'Donnell,C.J., Nieminen,M.S., Nickerson,D.A., Montgomery,G.W.,
            Meitinger,T., McPherson,R., McCarthy,M.I., McArdle,W., Masson,D.,
            Martin,N.G., Marroni,F., Mangino,M., Magnusson,P.K., Lucas,G.,
            Luben,R., Loos,R.J., Lokki,M.L., Lettre,G., Langenberg,C.,
            Launer,L.J., Lakatta,E.G., Laaksonen,R., Kyvik,K.O., Kronenberg,F.,
            Konig,I.R., Khaw,K.T., Kaprio,J., Kaplan,L.M., Johansson,A.,
            Jarvelin,M.R., Janssens,A.C., Ingelsson,E., Igl,W., Kees
            Hovingh,G., Hottenga,J.J., Hofman,A., Hicks,A.A., Hengstenberg,C.,
            Heid,I.M., Hayward,C., Havulinna,A.S., Hastie,N.D., Harris,T.B.,
            Haritunians,T., Hall,A.S., Gyllensten,U., Guiducci,C., Groop,L.C.,
            Gonzalez,E., Gieger,C., Freimer,N.B., Ferrucci,L., Erdmann,J.,
            Elliott,P., Ejebe,K.G., Doring,A., Dominiczak,A.F., Demissie,S.,
            Deloukas,P., de Geus,E.J., de Faire,U., Crawford,G., Collins,F.S.,
            Chen,Y.D., Caulfield,M.J., Campbell,H., Burtt,N.P.,
            Bonnycastle,L.L., Boomsma,D.I., Boekholdt,S.M., Bergman,R.N.,
            Barroso,I., Bandinelli,S., Ballantyne,C.M., Assimes,T.L.,
            Quertermous,T., Altshuler,D., Seielstad,M., Wong,T.Y., Tai,E.S.,
            Feranil,A.B., Kuzawa,C.W., Adair,L.S., Taylor,H.A. Jr.,
            Borecki,I.B., Gabriel,S.B., Wilson,J.G., Holm,H.,
            Thorsteinsdottir,U., Gudnason,V., Krauss,R.M., Mohlke,K.L.,
            Ordovas,J.M., Munroe,P.B., Kooner,J.S., Tall,A.R., Hegele,R.A.,
            Kastelein,J.J., Schadt,E.E., Rotter,J.I., Boerwinkle,E.,
            Strachan,D.P., Mooser,V., Stefansson,K., Reilly,M.P., Samani,N.J.,
            Schunkert,H., Cupples,L.A., Sandhu,M.S., Ridker,P.M., Rader,D.J.,
            van Duijn,C.M., Peltonen,L., Abecasis,G.R., Boehnke,M. and
            Kathiresan,S.
  TITLE     Biological, clinical and population relevance of 95 loci for blood
            lipids
  JOURNAL   Nature 466 (7307), 707-713 (2010)
   PUBMED   20686565
REFERENCE   2  (bases 1 to 2476)
  AUTHORS   Bao,D., Pang,Z., Morgan,M.A., Parris,J., Rong,Y., Li,L. and
            Morgan,J.I.
  TITLE     Cbln1 is essential for interaction-dependent secretion of Cbln3
  JOURNAL   Mol Cell Biol 26 (24), 9327-9337 (2006)
   PUBMED   17030622
REFERENCE   3  (bases 1 to 2476)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   4  (bases 1 to 2476)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   5  (bases 1 to 2476)
  AUTHORS   Pang,Z., Zuo,J. and Morgan,J.I.
  TITLE     Cbln3, a novel member of the precerebellin family that binds
            specifically to Cbln1
  JOURNAL   J Neurosci 20 (17), 6333-6339 (2000)
   PUBMED   10964938
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL132800.4 and CD368047.1.
            
            On May 17, 2019 this sequence version replaced NM_001039771.2.
            
            Summary: Members of the precerebellin family, such as CBLN3,
            contain a cerebellin motif (see CBLN1; MIM 600432) and a C-terminal
            C1q signature domain (see MIM 120550) that mediates trimeric
            assembly of atypical collagen complexes. However, precerebellins do
            not contain a collagen motif, suggesting that they are not
            conventional components of the extracellular matrix (Pang et al.,
            2000 [PubMed 10964938]).[supplied by OMIM, Aug 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1176661.1,
                                           SRR3476690.2973.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267406.11/ ENSP00000267406.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AL132800.4         138073-138215
            144-914             AL132800.4         138216-138986
            915-1034            AL132800.4         139336-139455
            1035-2057           AL132800.4         139755-140777
            2058-2476           CD368047.1         28-446              c
FEATURES             Location/Qualifiers
     source          1..2476
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..2476
                     /gene="CBLN3"
                     /gene_synonym="PRO1486"
                     /note="cerebellin 3 precursor"
                     /db_xref="GeneID:643866"
                     /db_xref="HGNC:HGNC:20146"
                     /db_xref="MIM:612978"
     exon            1..914
                     /gene="CBLN3"
                     /gene_synonym="PRO1486"
                     /inference="alignment:Splign:2.1.0"
     CDS             615..1232
                     /gene="CBLN3"
                     /gene_synonym="PRO1486"
                     /note="cerebellin-3"
                     /codon_start=1
                     /product="cerebellin-3 precursor"
                     /protein_id="NP_001034860.1"
                     /db_xref="CCDS:CCDS32057.1"
                     /db_xref="GeneID:643866"
                     /db_xref="HGNC:HGNC:20146"
                     /db_xref="MIM:612978"
                     /translation="MLGAKPHWLPGPLHSPGLPLVLVLLALGAGWAQEGSEPVLLEGE
                     CLVVCEPGRAAAGGPGGAALGEAPPGRVAFAAVRSHHHEPAGETGNGTSGAIYFDQVL
                     VNEGGGFDRASGSFVAPVRGVYSFRFHVVKVYNRQTVQVSLMLNTWPVISAFANDPDV
                     TREAATSSVLLPLDPGDRVSLRLRRGNLLGGWKYSSFSGFLIFPL"
     exon            915..1034
                     /gene="CBLN3"
                     /gene_synonym="PRO1486"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..2476
                     /gene="CBLN3"
                     /gene_synonym="PRO1486"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2337..2342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBLN3"
                     /gene_synonym="PRO1486"
                     /note="hexamer: AATAAA"
     polyA_site      2363
                     /gene="CBLN3"
                     /gene_synonym="PRO1486"
                     /note="major polyA site"
     regulatory      2451..2456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBLN3"
                     /gene_synonym="PRO1486"
                     /note="hexamer: AATAAA"
     polyA_site      2476
                     /gene="CBLN3"
                     /gene_synonym="PRO1486"
ORIGIN      
        1 gtgactggcc cactggtgct ctaggcccaa gcactttcca ccaaagcaat cgtggcggag
       61 ggggtaggcg ggaggcggga ggcggagggt acccgtggtg gagtacccct ttcttccaac
      121 aaacggaaag atgccacgaa gaagggctgt tgatttgtgg gggattttga agagaggaag
      181 agtaggagga aggggttgag gggctgcctc tggcatatgc acacactcac acattctgtc
      241 acacccgtca cacacacata ccatgttctc catcccccca ggtccagccc tcagtgctgt
      301 cccatccagc agggctgccc tgaagctctg gctgcagccc tcccgtccag tgggcaggcg
      361 gcttcatccc tcctttctct cccaaagccc aactgctgtc actgcatgct ctgccaagga
      421 ggagggaact gcagtgacag caggagtaag agtgggaggc aggacagagc tgggacacag
      481 gtatggagag ggggttcagc gagcctagag agggcagacg atcagggtgc cggcggtgag
      541 aatccaggga gaggagcgga aacagaagag gggcagaaga ccggggcact tgtgggttgc
      601 agagcccctc agccatgttg ggagccaagc cacactggct accaggtccc ctacacagtc
      661 ccgggctgcc cttggttctg gtgcttctgg ccctgggggc cgggtgggcc caggaggggt
      721 cagagcccgt cctgctggag ggggagtgcc tggtggtctg tgagcctggc cgagctgctg
      781 caggggggcc cgggggagca gccctgggag aggcaccccc tgggcgagtg gcatttgctg
      841 cggtccgaag ccaccaccat gagccagcag gggaaaccgg caatggcacc agtggggcca
      901 tctacttcga ccaggtcctg gtgaacgagg gcggtggctt tgaccgggcc tctggctcct
      961 tcgtagcccc tgtccggggt gtctacagct tccggttcca tgtggtgaag gtgtacaacc
     1021 gccaaactgt ccaggtgagc ctgatgctga acacgtggcc tgtcatctca gcctttgcca
     1081 atgatcctga cgtgacccgg gaggcagcca ccagctctgt gctactgccc ttggaccctg
     1141 gggaccgagt gtctctgcgc ctgcgtcggg ggaatctact gggtggttgg aaatactcaa
     1201 gtttctctgg cttcctcatc ttccctctct gaggacccaa gtctttcaag cacaagaatc
     1261 cagcccctga caactttctt ctgccctctc ttgccccaga aacagcagag gcaggagaga
     1321 gactccctct ggctcctatc ccacctcttt gcatgggacc ctgtgccaaa cacccaagtt
     1381 taagagaaga gtagagctgt ggcatctcca gaccaggcct ttccacccac ccacccccag
     1441 ttaccctccc agccacctgc tgcatctgtt cctgcctgca gccctaggat cagggcaagg
     1501 tttggcaaga aggaagatct gcactacttt gcggcctctg ctcctccggt tcccccaccc
     1561 cagcttcctg ctcaatgctg atcagggaca ggtggcgcag gtgagcctga caggccccca
     1621 caggagccca gatggacaag cctcagcgta ccctgcaggc ttcttcctgt gaggaaagcc
     1681 agcatcacgg atctcagcca gcaccgtcag aagctgaacc agcaccgtat gggctagggt
     1741 gggaggctca gccacaggca gaagggtggg aagggcctgg agtctgtggc tggtgaggaa
     1801 ggaaggaggg tgtattgtct agactgaaca tggtacacat tctgcatgta tagcagagca
     1861 gccagcaggt agcaatcctg gctgtccttc tatgctggat cccagatgga ctctggccct
     1921 tacctcccca cctgagatta gggtgagtgt gtttgctctg gctgagagca gagctgagag
     1981 caggtataca gagctggaag tggaccatgg aaaacatcga taaccatgca tcctcttgct
     2041 tggccacctc ctgaaactgc tccacctttg aagtttgaac tttagtccct ccacactctg
     2101 actgctgcct ccttcctccc agctctctca ctgagttatc ttcactgtac ctgttccagc
     2161 atatccccac tatctctctt tctcctgatc tgtgctgtct tattctcctc cttaggcttc
     2221 ctattacctg ggattccatg attcattcct tcagaccctc tcctgccagt atgctaaacc
     2281 ctccctctct ctttcttatc ccgctgtccc attggcccag cctggatgaa tctatcaata
     2341 aaacaactag agaatggtgg tcagtgagac actatagaat tactaaggag aagatgcctc
     2401 tggagtttgg atcgggtgtt acaggtacaa gtaggtatgt tgcagaggaa aataaatatc
     2461 aaactgtata ctaaaa
//
