LOCUS       NM_152577               1549 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens Cbl proto-oncogene like 2 (CBLL2), mRNA.
ACCESSION   NM_152577
VERSION     NM_152577.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1549)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1549)
  AUTHORS   Liu,Y.Q., Bai,G., Zhang,H., Su,D., Tao,D.C., Yang,Y., Ma,Y.X. and
            Zhang,S.Z.
  TITLE     Human RING finger protein ZNF645 is a novel testis-specific E3
            ubiquitin ligase
  JOURNAL   Asian J Androl 12 (5), 658-666 (2010)
   PUBMED   20657603
  REMARK    GeneRIF: A novel RING finger protein, ZNF645, which is expressed
            specifically in human testis and sperm and has E3 ubiquitin ligase
            activity.
REFERENCE   3  (bases 1 to 1549)
  AUTHORS   Bai,G., Liu,Y., Zhang,H., Su,D., Tao,D., Yang,Y., Ma,Y. and
            Zhang,S.
  TITLE     Promoter demethylation mediates the expression of ZNF645, a novel
            cancer/testis gene
  JOURNAL   BMB Rep 43 (6), 400-406 (2010)
   PUBMED   20587329
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX293560.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 26, 2019 this sequence version replaced NM_152577.3.
            
            Summary: This gene encodes a member of the zinc finger
            domain-containing protein family. This family member contains both
            a RING-type and a C2H2-type of zinc finger domain, and it may
            function as an E3 ubiquitin-protein ligase. Protein localization
            suggests a role in human sperm production and quality control.
            [provided by RefSeq, Aug 2011].
            
            ##Evidence-Data-START##
            Transcript is intronless :: GQ355336.1, AK098601.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323684.4/ ENSP00000323348.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1549              BX293560.3         11105-12653
FEATURES             Location/Qualifiers
     source          1..1549
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.11"
     gene            1..1549
                     /gene="CBLL2"
                     /gene_synonym="CT138; HAKAIL; ZNF645"
                     /note="Cbl proto-oncogene like 2"
                     /db_xref="GeneID:158506"
                     /db_xref="HGNC:HGNC:26371"
     exon            1..1549
                     /gene="CBLL2"
                     /gene_synonym="CT138; HAKAIL; ZNF645"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1357
                     /gene="CBLL2"
                     /gene_synonym="CT138; HAKAIL; ZNF645"
                     /EC_number="2.3.2.27"
                     /note="E3 ubiquitin ligase; E3 ubiquitin-protein ligase
                     ZNF645; RING-type E3 ubiquitin transferase ZNF645; zinc
                     finger protein 645; c-Cbl-like protein 2; cbl
                     proto-oncogene-like protein 2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase CBLL2"
                     /protein_id="NP_689790.1"
                     /db_xref="CCDS:CCDS14205.1"
                     /db_xref="GeneID:158506"
                     /db_xref="HGNC:HGNC:26371"
                     /translation="MNKMPAGEQECEYNKEGKYYSKGVKLVRKKKKIPGYRWGDIKIN
                     IIGEKDDLPIHFCDKCDLPIKIYGRIIPCKHAFCYHCANLYDKVGYKVCPRCRYPVLR
                     IEAHKRGSVFMCSIVQQCKRTYLSQKSLQAHIKRRHKRARKQVTSASLEKVRPHIAPP
                     QTEISDIPKRLQDRDHLSYIPPEQHTMVSLPSVQHMLQEQHNQPHKDIQAPPPELSLS
                     LPFPIQWETVSIFTRKHGNLTVDHIQNNSDSGAKKPTPPDYYPECQSQPAVSSPHHII
                     PQKQHYAPPPSPSSPVNHQMPYPPQDVVTPNSVRSQVPALTTTYDPSSGYIIVKVPPD
                     MNSPPLRAPQSQNGNPSASEFASHHYNLNILPQFTENQETLSPQFTQTDAMDHRRWPA
                     WKRLSPCPPTRSPPPSTLHGRSHHSHQRRHRRY"
     regulatory      1521..1526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBLL2"
                     /gene_synonym="CT138; HAKAIL; ZNF645"
                     /note="hexamer: AATAAA"
     polyA_site      1549
                     /gene="CBLL2"
                     /gene_synonym="CT138; HAKAIL; ZNF645"
                     /note="major polyA site"
ORIGIN      
        1 acgttagcag aagaattcct ttaaacgtca tttttgagga agtagacaaa cctaaatatg
       61 tgtctgaact ccaaggaata tgaacaagat gcctgctggt gaacaagaat gtgaatataa
      121 caaagaaggg aagtactact ctaaaggagt taaactggtg agaaaaaaga aaaaaattcc
      181 tggttaccgt tggggggaca ttaagataaa catcataggt gaaaaggatg atttaccaat
      241 tcatttctgt gacaaatgtg atttgcctat taaaatctat gggcgaataa ttccgtgcaa
      301 gcatgctttt tgctatcact gtgctaattt atatgacaaa gtcggatata aagtatgtcc
      361 gcgctgtcgt tatcctgtgc tgagaattga ggcgcataaa cgaggttctg tcttcatgtg
      421 tagtattgtt cagcagtgca agagaacata cttgtctcag aaaagcttac aggctcatat
      481 caaacgccgc cataagagag ctcgaaaaca agttaccagc gcttcgcttg aaaaagttcg
      541 tcctcatatt gctccgccac aaactgaaat ctctgacatc cctaaaagac tgcaagacag
      601 ggaccatcta agctatattc caccagaaca gcacaccatg gtgtcactac cgtctgtgca
      661 acatatgcta caagagcaac ataatcagcc acataaggat atccaggctc ctcccccaga
      721 actatctcta agtctgcctt ttcccatcca gtgggaaacc gttagtattt ttacgagaaa
      781 acatggcaat ttaacagttg atcatattca gaataactca gattctggtg ctaagaagcc
      841 aacacctccc gactattatc ctgagtgtca aagtcaacca gcggtatcgt cccctcatca
      901 tattatacct cagaaacagc attatgcgcc acctccatct ccatcatcac cagtaaacca
      961 tcaaatgcca tatcctcctc aggatgtagt tactcctaac tcggttcgta gccaagtgcc
     1021 agctctaacc acgacctacg atccatcatc tggatatatt attgtaaagg tgccacctga
     1081 tatgaattct cctccactac gtgctcccca gtctcaaaat ggtaatccat ctgcaagtga
     1141 atttgcttct caccattata accttaacat tttacctcag ttcaccgaaa atcaagaaac
     1201 cttgagccct cagtttacac aaacagatgc aatggatcat agaaggtggc ctgcatggaa
     1261 acgactgtca ccttgtccac caacgcggag tccacctcct tcaaccctac atggtcgatc
     1321 acatcattca caccagagaa gacatagacg gtattaagga tgataacagt atttggaact
     1381 gaagacctga tgggaaaaaa accttcaagt tctatactgt actgtggata agcggctcag
     1441 ttcagcagag ctggagttga acaactttgt tcctctggtg tggtaaattg acctaaaggt
     1501 gacctctgac gatttcctga aataaatatg caatgttaca ttttcaaaa
//
