LOCUS       XM_017007400            6406 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens Cbl proto-oncogene B (CBLB), transcript
            variant X7, mRNA.
ACCESSION   XM_017007400
VERSION     XM_017007400.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000003.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017007400.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6406
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
     gene            1..6406
                     /gene="CBLB"
                     /gene_synonym="ADMIO3; Cbl-b; Nbla00127; RNF56"
                     /note="Cbl proto-oncogene B; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 4
                     mRNAs, 32 ESTs, 561 long SRA reads, 4 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 4 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:868"
                     /db_xref="HGNC:HGNC:1542"
                     /db_xref="MIM:604491"
     CDS             144..2897
                     /gene="CBLB"
                     /gene_synonym="ADMIO3; Cbl-b; Nbla00127; RNF56"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase CBL-B isoform X6"
                     /protein_id="XP_016862889.1"
                     /db_xref="GeneID:868"
                     /db_xref="HGNC:HGNC:1542"
                     /db_xref="MIM:604491"
                     /translation="MGYLCVNFIWFLGITTHRVDLKKELKFQMANSMNGRNPGGRGGN
                     PRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYI
                     LDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERM
                     YEEQSQDRTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRL
                     FQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAI
                     GYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKV
                     TQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRC
                     EIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCT
                     DRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGS
                     PKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPP
                     MPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRH
                     DLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVE
                     EDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLS
                     IYLKGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLA
                     SGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRK
                     PHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPR
                     LNL"
ORIGIN      
        1 ggggccggga aggggcctga gcagggaagg gacacaggcg tcctgaaaca aagctttggg
       61 ttgagggcag aggcgaggag ccagagaagt gaactcctcc tttccgtggc cgctcttgtc
      121 atttttctct tttctctttt caaatgggct atttgtgtgt taatttcatt tggttcttgg
      181 gaataacgac tcaccgcgtt gatttaaaga aagaactaaa attccagatg gcaaactcaa
      241 tgaatggcag aaaccctggt ggtcgaggag gaaatccccg aaaaggtcga attttgggta
      301 ttattgatgc tattcaggat gcagttggac cccctaagca agctgccgca gatcgcagga
      361 ccgtggagaa gacttggaag ctcatggaca aagtggtaag actgtgccaa aatcccaaac
      421 ttcagttgaa aaatagccca ccatatatac ttgatatttt gcctgataca tatcagcatt
      481 tacgacttat attgagtaaa tatgatgaca accagaaact tgcccaactc agtgagaatg
      541 agtactttaa aatctacatt gatagcctta tgaaaaagtc aaaacgggca ataagactct
      601 ttaaagaagg caaggagaga atgtatgaag aacagtcaca ggacagaact atcgtaccat
      661 ggaaagtatt cagacagtgc cttcatgagg tccaccagat tagctctggc ctggaagcaa
      721 tggctctaaa atcaacaatt gatttaactt gcaatgatta catttcagtt tttgaatttg
      781 atatttttac caggctgttt cagccttggg gctctatttt gcggaattgg aatttcttag
      841 ctgtgacaca tccaggttac atggcatttc tcacatatga tgaagttaaa gcacgactac
      901 agaaatatag caccaaaccc ggaagctata ttttccggtt aagttgcact cgattgggac
      961 agtgggccat tggctatgtg actggggatg ggaatatctt acagaccata cctcataaca
     1021 agcccttatt tcaagccctg attgatggca gcagggaagg attttatctt tatcctgatg
     1081 ggaggagtta taatcctgat ttaactggat tatgtgaacc tacacctcat gaccatataa
     1141 aagttacaca ggaacaatat gaattatatt gtgaaatggg ctccactttt cagctctgta
     1201 agatttgtgc agagaatgac aaagatgtca agattgagcc ttgtgggcat ttgatgtgca
     1261 cctcttgcct tacggcatgg caggagtcgg atggtcaggg ctgccctttc tgtcgttgtg
     1321 aaataaaagg aactgagccc ataatcgtgg acccctttga tccaagagat gaaggctcca
     1381 ggtgttgcag catcattgac ccctttggca tgccgatgct agacttggac gacgatgatg
     1441 atcgtgagga gtccttgatg atgaatcggt tggcaaacgt ccgaaagtgc actgacaggc
     1501 agaactcacc agtcacatca ccaggatcct ctccccttgc ccagagaaga aagccacagc
     1561 ctgacccact ccagatccca catctaagcc tgccacccgt gcctcctcgc ctggatctaa
     1621 ttcagaaagg catagttaga tctccctgtg gcagcccaac gggttcacca aagtcttctc
     1681 cttgcatggt gagaaaacaa gataaaccac tcccagcacc acctcctccc ttaagagatc
     1741 ctcctccacc gccacctgaa agacctccac caatcccacc agacaataga ctgagtagac
     1801 acatccatca tgtggaaagc gtgccttcca gagacccgcc aatgcctctt gaagcatggt
     1861 gccctcggga tgtgtttggg actaatcagc ttgtgggatg tcgactccta ggggagggct
     1921 ctccaaaacc tggaatcaca gcgagttcaa atgtcaatgg aaggcacagt agagtgggct
     1981 ctgacccagt gcttatgcgg aaacacagac gccatgattt gcctttagaa ggagctaagg
     2041 tcttttccaa tggtcacctt ggaagtgaag aatatgatgt tcctccccgg ctttctcctc
     2101 ctcctccagt taccaccctc ctccctagca taaagtgtac tggtccgtta gcaaattctc
     2161 tttcagagaa aacaagagac ccagtagagg aagatgatga tgaatacaag attccttcat
     2221 cccaccctgt ttccctgaat tcacaaccat ctcattgtca taatgtaaaa cctcctgttc
     2281 ggtcttgtga taatggtcac tgtatgctga atggaacaca tggtccatct tcagagaaga
     2341 aatcaaacat ccctgactta agcatatatt taaagggtga agatgctttt gatgccctcc
     2401 ctccatctct cccacctccc ccacctcctg caaggcatag tctcattgaa cattcaaaac
     2461 ctcctggctc cagtagccgg ccatcctcag gacaggatct ttttcttctt ccttcagatc
     2521 cctttgttga tctagcaagt ggccaagttc ctttgcctcc tgctagaagg ttaccaggtg
     2581 aaaatgtcaa aactaacaga acatcacagg actatgatca gcttccttca tgttcagatg
     2641 gttcacaggc accagccaga ccccctaaac cacgaccgcg caggactgca ccagaaattc
     2701 accacagaaa accccatggg cctgaggcgg cattggaaaa tgtcgatgca aaaattgcaa
     2761 aactcatggg agagggttat gcctttgaag aggtgaagag agccttagag atagcccaga
     2821 ataatgtcga agttgcccgg agcatcctcc gagaatttgc cttccctcct ccagtatccc
     2881 cacgtctaaa tctatagcag ccagaactgt agacaccaaa atggaaagca atcgatgtat
     2941 tccaagagtg tggaaataaa gagaactgag atggaattca agagagaagt gtctcctcct
     3001 cgtgtagcag cttgagaaga ggcttgggag tgcagcttct caaaggagac cgatgcttgc
     3061 tcaggatgtc gacagctgtg gcttccttgt ttttgctagc catattttta aatcagggtt
     3121 gaactgacaa aaataattta aagacgttta cttcccttga actttgaacc tgtgaaatgc
     3181 tttaccttgt ttacagtttg gcaaagttgc agtttgttct tgtttttagt ttagttttgt
     3241 tttggtgttt tgatacctgt actgtgttct tcacagaccc tttgtagcgt ggtcaggtct
     3301 gctgtaacat ttcccaccaa ctctcttgct gtccacatca acagctaaat catttattca
     3361 tatggatctc taccatcccc atgccttgcc caggtccagt tccatttctc tcattcacaa
     3421 gatgctttga aggttctgat tttcaactga tcaaactaat gcaaaaaaaa aaaagtatgt
     3481 attcttcact actgagtttc ttctttggaa accatcacta ttgagagatg ggaaaaacct
     3541 gaatgtataa agcatttatt tgtcaataaa ctgccttttg taaggggttt tcacataaca
     3601 tagaggagct tccctttttt gtttaagttt tgtaaccttt aatcctccat attctcatgt
     3661 ctgtcatccc aggggtgtca caactgtaaa aatctacaat attagaaagc agctactaca
     3721 gatgtggaag agagaacact tgtataagac aatgctgtac tgaagttata taacaaggtc
     3781 ccctgatact tatgcctgca ttactttgag ggatgctgaa tgagaggacc atctccctga
     3841 aatatattaa taattttcag ataaaattat gaacataaca taccttttct caagtggaat
     3901 tagagttcat ttcccattta agtgattaca ctctatctcc taagagctgt gggaaccagt
     3961 tcatattgca gtggaaacat taactcttcg ttgcactgtt gagtgtcaag gctactgtgg
     4021 caatgttttt tgcaaagttc tcagtaattt tctctctgca atcaaattag agttcatatt
     4081 taatttgcag attctctcat tcattgctcc acactgcttt atcaaatcag gtgaaagaaa
     4141 ttaatgtagt tttgcctatt ttacaaaatg gtggttggtt ctttaaacac catgttatta
     4201 ctcttaataa atctacaaat atttattgag catctatgat atgcttggtg ctgttaggca
     4261 ctgtgttttt aaagcacaaa ctctcaaaag ctgattccag cgtaatgttt tatttttgtt
     4321 tttctgtgtt ttttatgaca aagtctgtct gatagacaaa gcctggaagg tttcccccag
     4381 ggctttagaa tttagaatta gctggttttc atttcaaatg ggaaattaat ggagaaatga
     4441 gataaaatca tctctgtgta aatgcttgaa cccacagaaa gttttctaaa tatggactaa
     4501 ttgtgggttt gtgcatattt ctgtgtctcc tcttttcact tcacacccac catgatataa
     4561 aaagatgcat cagagagtga gcctgccttc aggacctgaa aggacatgac tgaacatcta
     4621 gtagatctgg tggaaattaa tgttatacaa aagacacgta gactaagttg accctgggag
     4681 aggagttaat acattccttt gcaaagtgac atgtgccctt tttttgacag tctggctttc
     4741 atggtatgag atgaggactc acaggccttg ggtaatttct gcttttgtat gaattttttc
     4801 agatggttct gagctggtta tgtccctgga ggggaatttt tcatttgcct tagatgttct
     4861 tcccatgagt aggtacatga gtgaagtttc ttacactttt aaaattgcat tggcaaattt
     4921 tcttttgctt tatgaacccc tgttttgtca ttatgatttt tcacttgttt taacagtttc
     4981 agatgtcacc ttggaatagc actgtttatt ttggcctttt tatgattgct gatgataggt
     5041 acagtctaaa ggccaaaagt tgccacttca ttgtgataac attgttgcaa cattcctaat
     5101 atattagaga atgatgtaaa ataagaatgt tagagaacat agcacattct cattcagttt
     5161 ataaacaata tttgaaaatt tccagtgaga attaaaaaag gactagtgat gatatagcaa
     5221 acctggacct gaaatttggg ggtggggggt ggggggatat ctgttttgca gagaaaattt
     5281 accagcctcc agcaaaatct ctgcatcttg tactcaatag caaccattag tattgtcatt
     5341 taaaaagaat gaatcaaaaa ttcatacgta atggaatgaa aagaggaaaa ctttctatta
     5401 aacactgtca agaaagaccc attgctatct atcacctatg aaattaaacc taaaaaaatt
     5461 tttttttatt gtaaaagcga ctgctcgttg atgtctggaa gtgatccaga ctttgtttca
     5521 ctgtgatcca aaaagttaga cattccttcc atttctcaag atttggtaac aatttttttt
     5581 taagtcagca tttcatataa tacataaaat taagacaaat taacttactg atatgtggcc
     5641 aatatcaacc cttctcaccc aacccaaaca tgttctggag atagaaggac ttatcctcaa
     5701 ttatattcca gtaaatttat ctccataatc tgttttatcc cctaatgtat gatatatctc
     5761 accaaatttt tctagaattg aataaaagca gtttttgctt aacttgaatt tccttccaca
     5821 aatacaacct tcagctcttc cctctctgtt tcccttttgc ccacattgca aatagtcttc
     5881 ataatagaac cctcactgca acttaaaagg gtcccatttc ttaactcagc atttcatata
     5941 ccaagaacac ttgcaaagat ttcttcataa tgtgattttt taatttttca gttccagaag
     6001 catttcctac agttcgaacg ttattttttc tctcagattt tcaacttgaa gctttgattt
     6061 gcactgaatt aacttggata aaattttagt ttctctcttc agctaacaga tttggaagca
     6121 aattacagta tacttgaata attcaggtac tacctgttga cctggaattt tagtgattct
     6181 gggaaagttt tccagacaaa gacaccaata gagtgaaggg ttttttcccc aattactatt
     6241 ttattgtttt ttaaaatgcc tttttaaaac ttgtgtgatg tggcaaaata gtcatatgtt
     6301 caattaattt atattttatt cattcctttt caattctggt tattatgtaa cctcaagtac
     6361 tttatctgtt cttttaaagt attttataaa atgaacgtta actaaa
//
