LOCUS       NM_001032999            7344 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens CBFA2/RUNX1 partner transcriptional co-repressor 2
            (CBFA2T2), transcript variant 3, mRNA.
ACCESSION   NM_001032999
VERSION     NM_001032999.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7344)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 7344)
  AUTHORS   Luo,J., Dou,L., Yang,Z., Zhou,Z. and Huang,H.
  TITLE     CBFA2T2 promotes adipogenic differentiation of mesenchymal stem
            cells by regulating CEBPA
  JOURNAL   Biochem Biophys Res Commun 529 (2), 133-139 (2020)
   PUBMED   32703401
  REMARK    GeneRIF: CBFA2T2 promotes adipogenic differentiation of mesenchymal
            stem cells by regulating CEBPA.
REFERENCE   3  (bases 1 to 7344)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 7344)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 7344)
  AUTHORS   Tu,S., Narendra,V., Yamaji,M., Vidal,S.E., Rojas,L.A., Wang,X.,
            Kim,S.Y., Garcia,B.A., Tuschl,T., Stadtfeld,M. and Reinberg,D.
  TITLE     Co-repressor CBFA2T2 regulates pluripotency and germline
            development
  JOURNAL   Nature 534 (7607), 387-390 (2016)
   PUBMED   27281218
  REMARK    GeneRIF: CBFA2T2 forms a biochemical complex with PRDM14, a
            germline-specific transcription factor; mechanistically, CBFA2T2
            oligomerizes to form a scaffold upon which PRDM14 and OCT4 are
            stabilized on chromatin
REFERENCE   6  (bases 1 to 7344)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   7  (bases 1 to 7344)
  AUTHORS   Morohoshi,F., Mitani,S., Mitsuhashi,N., Kitabayashi,I.,
            Takahashi,E., Suzuki,M., Munakata,N. and Ohki,M.
  TITLE     Structure and expression pattern of a human MTG8/ETO family gene,
            MTGR1
  JOURNAL   Gene 241 (2), 287-295 (2000)
   PUBMED   10675041
REFERENCE   8  (bases 1 to 7344)
  AUTHORS   Fracchiolla,N.S., Colombo,G., Finelli,P., Maiolo,A.T. and Neri,A.
  TITLE     EHT, a new member of the MTG8/ETO gene family, maps on 20q11 region
            and is deleted in acute myeloid leukemias
  JOURNAL   Blood 92 (9), 3481-3484 (1998)
   PUBMED   9787195
REFERENCE   9  (bases 1 to 7344)
  AUTHORS   Calabi,F. and Cilli,V.
  TITLE     CBFA2T1, a gene rearranged in human leukemia, is a member of a
            multigene family
  JOURNAL   Genomics 52 (3), 332-341 (1998)
   PUBMED   9790752
REFERENCE   10 (bases 1 to 7344)
  AUTHORS   Kitabayashi,I., Ida,K., Morohoshi,F., Yokoyama,A., Mitsuhashi,N.,
            Shimizu,K., Nomura,N., Hayashi,Y. and Ohki,M.
  TITLE     The AML1-MTG8 leukemic fusion protein forms a complex with a novel
            member of the MTG8(ETO/CDR) family, MTGR1
  JOURNAL   Mol Cell Biol 18 (2), 846-858 (1998)
   PUBMED   9447981
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162505.20, CB998035.1,
            BC016298.2 and AL121906.18.
            
            On Jun 2, 2019 this sequence version replaced NM_001032999.2.
            
            Summary: In acute myeloid leukemia, especially in the M2 subtype,
            the t(8;21)(q22;q22) translocation is one of the most frequent
            karyotypic abnormalities. The translocation produces a chimeric
            gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the
            3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is
            thought to associate with the nuclear corepressor/histone
            deacetylase complex to block hematopoietic differentiation. The
            protein encoded by this gene binds to the AML1-MTG8 complex and may
            be important in promoting leukemogenesis. Several transcript
            variants are thought to exist for this gene, but the full-length
            natures of only three have been described. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            coding region compared to variant 2. The resulting isoform (MTGR1c)
            has a shorter and distinct N-terminus compared to isoform MTGR1b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.14.1, SRR1660803.228731.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342704.11/ ENSP00000345810.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AL162505.20        36638-36663
            27-564              CB998035.1         36-573
            565-2855            BC016298.2         58-2348
            2856-7344           AL121906.18        21979-26467
FEATURES             Location/Qualifiers
     source          1..7344
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21-q11.22"
     gene            1..7344
                     /gene="CBFA2T2"
                     /gene_synonym="EHT; MTGR1; p85; ZMYND3"
                     /note="CBFA2/RUNX1 partner transcriptional co-repressor 2"
                     /db_xref="GeneID:9139"
                     /db_xref="HGNC:HGNC:1536"
                     /db_xref="MIM:603672"
     exon            1..206
                     /gene="CBFA2T2"
                     /gene_synonym="EHT; MTGR1; p85; ZMYND3"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1960
                     /gene="CBFA2T2"
                     /gene_synonym="EHT; MTGR1; p85; ZMYND3"
                     /note="isoform MTGR1c is encoded by transcript variant 3;
                     MTG8-like protein; ETO homolog on chromosome 20; protein
                     CBFA2T2; myeloid translocation gene-related protein 1;
                     MTG8-related protein 1; ETO homologous on chromosome 20;
                     myeloid translocation-related protein 1; core-binding
                     factor, runt domain, alpha subunit 2; translocated to, 2;
                     CBFA2/RUNX1 translocation partner 2"
                     /codon_start=1
                     /product="protein CBFA2T2 isoform MTGR1c"
                     /protein_id="NP_001028171.1"
                     /db_xref="CCDS:CCDS46590.1"
                     /db_xref="GeneID:9139"
                     /db_xref="HGNC:HGNC:1536"
                     /db_xref="MIM:603672"
                     /translation="MVGVPGAAAFQLGPEKRVPAMPGSPVEVKIQSRSSPPTMPPLPP
                     INPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATC
                     GARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFP
                     LRPFVIPFLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLM
                     EVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFH
                     PTPPPLQHYTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTERE
                     WADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREELNYWKRRYNENTELRKTGT
                     ELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKA
                     VAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASET
                     CSGCNIARYCGSFCQHKDWERHHRLCGQNLHGQSPHGQGRPLLPVGRGSSARSADCSV
                     PSPALDKTSATTSRSSTPASVTAIDTNGL"
     exon            207..350
                     /gene="CBFA2T2"
                     /gene_synonym="EHT; MTGR1; p85; ZMYND3"
                     /inference="alignment:Splign:2.1.0"
     exon            351..592
                     /gene="CBFA2T2"
                     /gene_synonym="EHT; MTGR1; p85; ZMYND3"
                     /inference="alignment:Splign:2.1.0"
     exon            593..682
                     /gene="CBFA2T2"
                     /gene_synonym="EHT; MTGR1; p85; ZMYND3"
                     /inference="alignment:Splign:2.1.0"
     exon            683..864
                     /gene="CBFA2T2"
                     /gene_synonym="EHT; MTGR1; p85; ZMYND3"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1118
                     /gene="CBFA2T2"
                     /gene_synonym="EHT; MTGR1; p85; ZMYND3"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1204
                     /gene="CBFA2T2"
                     /gene_synonym="EHT; MTGR1; p85; ZMYND3"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1400
                     /gene="CBFA2T2"
                     /gene_synonym="EHT; MTGR1; p85; ZMYND3"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1469
                     /gene="CBFA2T2"
                     /gene_synonym="EHT; MTGR1; p85; ZMYND3"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1660
                     /gene="CBFA2T2"
                     /gene_synonym="EHT; MTGR1; p85; ZMYND3"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..7344
                     /gene="CBFA2T2"
                     /gene_synonym="EHT; MTGR1; p85; ZMYND3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2584..2589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBFA2T2"
                     /gene_synonym="EHT; MTGR1; p85; ZMYND3"
                     /note="hexamer: AATAAA"
     polyA_site      2606
                     /gene="CBFA2T2"
                     /gene_synonym="EHT; MTGR1; p85; ZMYND3"
     regulatory      7325..7330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBFA2T2"
                     /gene_synonym="EHT; MTGR1; p85; ZMYND3"
                     /note="hexamer: AATAAA"
     polyA_site      7344
                     /gene="CBFA2T2"
                     /gene_synonym="EHT; MTGR1; p85; ZMYND3"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcggcg gcgacggcga cagcagcggt ggtggtgtct ggttagctcg gcggctgcag
       61 atctcgcggc gacgcctgcg agggacccgg gccgcgggtc gaggcgggcg gcgcctgcga
      121 gggacccgtg tcgcgggtag aggcgggcgg cgcgcggcgg cggcgctcgg cgatggtagg
      181 cgtccctgga gcggccgcct tccagcttgg tcctgagaaa agggtgccag cgatgcctgg
      241 atcgcctgtg gaagtgaaga tacagtccag atcctcacct cccaccatgc cacccctccc
      301 accaataaat cctggaggac cgaggccagt gtccttcact cctactgcat taagcaatgg
      361 catcaaccat tctcctccta ccctgaatgg tgccccatca ccgccacaga gattcagcaa
      421 tggtcctgcc tcctccacat catctgcact cacaaatcag caattgccag ccacttgtgg
      481 tgctcgacaa ctcagcaagt tgaaacgctt tcttaccact ctgcaacagt ttggcaatga
      541 catctcccct gagattgggg agaaggtgcg gactcttgtt cttgcactgg tgaactcaac
      601 agtgacaatt gaggaattcc actgtaagct ccaagaagcc acaaactttc cccttcgtcc
      661 ttttgtgatt ccatttctca aggccaacct gcccctgctg cagcgggaac tgctgcactg
      721 cgctcgggcg gccaagcaga ccccatccca gtacctggct cagcacgaac accttctgct
      781 caacacaagc attgcatcgc ctgctgactc gtcagagttg ctcatggagg tgcacggaaa
      841 tgggaagagg cccagtccag agaggagaga agagaatagt tttgatagag acacaattgc
      901 tcctgagcct cctgccaaga gagtatgtac catcagccct gctcctcggc acagtcctgc
      961 tctcactgtg cccctcatga atcccggggg ccaattccat cctacccctc cacctcttca
     1021 gcattacacc ttagaggata ttgcaacttc tcacctgtat cgggaaccca acaagatgct
     1081 agagcatcga gaagttcgtg atagacacca cagtcttggt ctaaatggag gctatcaaga
     1141 tgagttggta gatcatcgtt tgacagaaag ggaatgggct gatgaatgga aacatcttga
     1201 ccatgcgctg aattgcatta tggaaatggt agagaaaaca aggcgctcta tggcagttct
     1261 gcggcgctgt caggaatcag atcgtgaaga actcaactac tggaaaagac ggtacaatga
     1321 aaacacagag ctgaggaaaa cggggaccga gttggtctcc aggcagcaca gccctgggag
     1381 tgcagattct ctcagcaatg attctcagag agagttcaac agcaggccag gtacaggata
     1441 cgtacctgtg gagttttgga aaaaaacaga agaagctgtg aataaggtga aaattcaggc
     1501 catgtcagaa gtacagaagg ccgtcgctga ggcagagcag aaagcctttg aagtgattgc
     1561 aacagagaga gcacgaatgg agcaaaccat agcggatgtc aagcggcagg ccgcagagga
     1621 tgctttcctc gtcatcaatg agcaagagga gtccacggag aactgctgga actgtggccg
     1681 caaagccagc gagacatgca gtggctgcaa tatcgcgcga tactgtggct ctttctgcca
     1741 gcacaaggac tgggagcggc accaccgcct ctgtggtcag aacctgcatg gccagagccc
     1801 ccacggccag ggccggccgc tgcttcctgt aggcaggggc tcctctgcca ggtccgccga
     1861 ctgcagcgtg cccagcccag ccctcgacaa gacctcggca accacatcgc gttcctcaac
     1921 acctgcttct gtgacagcta tcgacaccaa cggactctga gccccggact ctgcttaccc
     1981 tgatggctgc tcagcaccac agagtgcttg ggctgaggga ctgactgttg gaacccgtgc
     2041 atgtagctgc cgggtcatca gcaagaaatg aattggaggc aggaagagtc caagcctgaa
     2101 taataacacc ccacagcctc tctgtgcact tgctgtctgc ggagccagtg tgccattctc
     2161 tgcacatggg cagccagcct gagctgcctc ctccatggct ttcctggttt gttcctctct
     2221 ccactgaagc tgacttagcc ggcccctttt cagtgtagac caccagctcc cctccccatc
     2281 tccttgagtc agcagactgt ccaatgtgct cagccaggct ggaggcggca ggcggcaggc
     2341 agcaggctgt ggaggaggcc cctcggtcag ggagcggcct gcctcacccc tgaatagctc
     2401 cttcggcccc atctccatcc tcagcagatg acactgattg gcctcacggg gacttgggta
     2461 agcaacaggc ggcattcagg actcttctca accctgctgt tcagacttga taagatctca
     2521 gagtccacag gaaagaagtc actgttgcaa taaaagcacc cgtagtagca aaaacataaa
     2581 acaaataaaa cttcccccac atcacagatg attttggaca agattttcca accttgctgg
     2641 ctactttagt ttgggacctg ttttttttct catttgattt tgcttgtgca gaaaatagtt
     2701 tccagcacat ggattgatct gagagagaat gaggctcagt tgtggatagt ctgttttctc
     2761 tgagcatgtt ggccaactag tatcgtcaaa ttattgagtg gatcatctct tggaaatgca
     2821 gaacttctgc caccacttgg ctatttgcac agtcatcttg ttctgtgtcc ttttatctct
     2881 cagaccacac acatctggaa cgctgtgggc atcttctgcc catgggctcc atttggcacc
     2941 tgctgagcca cagttgtcct gctggatgtg ctgtgcaggt tggtaggact tgcccccact
     3001 gtcaaggcct ggtctcatct gaaaagccct cctggacctc aaagaattct tcagacctca
     3061 tagttacagg tcattatatc tactatgttg atttatcatc aggcacacaa cttctgtttc
     3121 cttctcttgt gttatctgat agcgtccctc cttgagctca tcagaaaggt tttatgaaat
     3181 gtgaaccatt ttgggaaaag ctgatcaatt tttcttccta gcttcccatt ttcaaatggg
     3241 acatcactca tatccctttc agaatgttag gaactgcctc ccacattctt ccctgtcttt
     3301 ttgggttttg ttttttgttg ttgtggtggt tttttaacac aaagtctcac tctgttgccc
     3361 aggctggagt gcagtggcat gatcttggct cactgcaacc tctgccttcc aggttcaagc
     3421 aattctcctg cctcagcctc ccgagtagct gagattacag gcgcccacca ccacgcccag
     3481 ctaatttttg tatttttagt agagacaggg tttcaccatg ttggccaggc tgatctcgaa
     3541 ctcctgacct caggtgacct gccttggcct cccaaagtgc agggattaca agcgtgagcc
     3601 accatgcccg gcctgtcttt ttggttttga tgggagtctg aggaccccga cccctcctgc
     3661 tctccatctt tgagcctctg gcatcctctc acacccagaa atcagttgga gtaagtttaa
     3721 ttggccctgc tccagctggc ctttgaagca caagtttaaa tctccacctt ctgtgcactg
     3781 accagagtct aaaataaaag ttgtcagtac cataaaggaa aagggatcca cacaggtagc
     3841 cttctccttg gatacaggta catcttactg taagaatttc aagtcctggc tgggcgcagt
     3901 ggctcactcc tgtaatccca gcactttgag agaccgaggc aggcagatca cttgaggtca
     3961 ggaattcaag accaacctgg ccaacatggt gaaaccctgt ctctaataaa aaaaaaatag
     4021 aaaaatcagc cgggtgtggt ggcacacacc tgtaatccta gctactcagg aggctgaggc
     4081 aagagaatct cttgaacctg tgagccagag gttgcagtga gccgagattc caccactgca
     4141 ctccagcctg ggcaacagag caaaactctg tctcaaaaaa aaaaaaaaaa aggcaaaatt
     4201 aaagaatttc aagtccctaa tttactctaa ccaagcattt tcagtcttac aaagaaatct
     4261 agtgcacgac acctttaaaa tgcctagatt tccattgcct aaagtaaggt gtgaccagtg
     4321 aaacaacagc agagaatcat gttcctttgc tgtggaacac ataagcccca cagttttcca
     4381 gtcagcctaa tacatgggta tcccccgacc ccatctgcct ccttaagcca cagtccttgg
     4441 tggggaactc taagggggac ggagtcagta ccccggacag ggccacattt gcatgagaca
     4501 tggctgtctc acaggtcaca gagccattac aacagcttac tagtttttca tggatttgtt
     4561 ggattaacac cttaagcagg ttttttattg ttattttgtt tgtttgtttg ttttgagacg
     4621 ggagtttctc tcttgtctcc caggctggag tgcaatcgcg caatctcggc tcacggtaac
     4681 ctctgcctcc caggttcaag cgagtctcct gcctcagcct tctgagtagc tgggattaca
     4741 ggcatgcgcc accacgccca actaattttg tatttttagt agagacgggg tttctccttg
     4801 ttggtcaggc tggtctcaaa ccccggacct caggtgatcc ccccaccttg gcctcccaaa
     4861 gtgccaggat tacaggcatg agccactgtg tccggtcttg agcaggtttt taaaatctcc
     4921 agtggccata aaactagcca gggtagctca tgcttttact ggttggaata aggagccaaa
     4981 accaacaaaa taatatttat tagggctcga tgcccatttc tgtggctaag gcttaggttt
     5041 ggtgtgcaga gcctggcctg ctcttgtggg ctgtggttgc tgtgacagtt tcgttttctg
     5101 aatctttgta atgctcttcc accctgctcg tgctgcccag aggctgatct gcaaacctgg
     5161 gcagtattcc acactgaagc tcagtttgca aaccttctgc tgtgttaatt ctggtcagtt
     5221 tcacacagaa gtcacgaggg cctctgccca ggaccttcta ttcacatttc aagaatccct
     5281 ttctgaaatt ctccaactct ctggtcagga ggaggagcac cattggggcg gggtaggcag
     5341 ctagaggcgc aggagcgaat ccaggttcct tgcgtggttc ccagcctctg ctgacagcac
     5401 ctcagctacc aggtggggag tggaaattca gcctgcttag aggactgacc tctacagttc
     5461 atatttgcag tgacataaaa ggcaaagagg agctggcatg gtggtacaga aggtatcagt
     5521 caagcgcagg ctcttcagaa acctagaaac taaaaagaga tgcaacatgt gactggccat
     5581 cagccagaca tgtctagggt gagaccagtg ctcagcacca cccgccaagg aacactgatg
     5641 agttgtggga cattatggtc ggccaagtga ggaatgattg cagggaccag agaagaccaa
     5701 agatgccaga tgtccccaga gtttcttgag ggctgggttt cacgtctttg cttgtccttt
     5761 ttgtccccac ttgcctgcac cgtgcctgac tcatccagtg gggaaggtga ctcaagaagt
     5821 tgtttaagcc taggcctagg cagtccactt cgggaggtgg gggcactcca cactgggggg
     5881 ccctgcagct ccagggctgg tgctctagca gatccgctca ggcacggttg ggtgaccgtg
     5941 gggtcaccga ttgcgtagat tatttctagg gcagtgctgg gttagaaatg tctgtctgga
     6001 aacaggacac atcttgccac cacaagtcca cacctggcct tggctgctgc ccgctctctg
     6061 cagcgtggat ttcctttgcc catttgggcc agaaggtcac caggagttca tcactgctta
     6121 gtgtcaactt gacatcttca gcttccagac agaaaaccca tgctttactt tgtacagccc
     6181 tgtcccagag ttagtaagcc tcggcttgtc acctgcttgc aaagggtata gacatcattc
     6241 tgggtagttc tagaggatat cgcaacaagt gcgtttgaag gttcagcaca gctggaattg
     6301 tacggtagtg agctcttcaa aatgaaaaca gaatgaccgg atggccatct gtcctggaaa
     6361 ctgtagaatt gaataaatca ctgaaaatag aacacttctt ggaggctttc ttcagaactg
     6421 aactagaaac aaggtttcca ggctcccagg tcagtagacc aaaccaactt ccttagattt
     6481 ttttttttaa gctgtttgca gaaaactggg tggtagcgtg tctgaaccaa acggaagaat
     6541 agccagcgga gcatggactg ttccagcacg ggccagatgg ccagctgtcg agagcagccc
     6601 tgcccagatt gcggtggggg ctgtgccagc ggctccgcag ggcccttcca actctggagt
     6661 gtctgtagtt cttgtgaaac caaaacgttg actacctgcc tctttcctcg ggcatcgacg
     6721 tgctcatttc caaagatgat ggtgcaggtg accttttcca tcgtgagcta agagaaggtt
     6781 aggaggcctg aggggcgggc cttgtgtccc ctcctccccc tccacagccc ctgaggtgga
     6841 gcttccctca cagaccccat ctggtcgagc ctacggctgc ccagtgtaca ctcagtgatg
     6901 cttataccaa atagggcatg tgcgctggtg tctgttgggg acagccccat ccctaccttg
     6961 gagtcggcag agaagcagca ataagcatta ggcgaatgat tgaaagggct gctgcgccaa
     7021 gaggccttca gtccccttaa cgtggctttc caacttcctg acgaggctac aaaggctccg
     7081 ctcacaaaag aaagccaata atgtaaataa atagaaaacg aagcctccac gcgtggtttt
     7141 taaaggggga tgatgaatgt gacaccaccc acagaatgca ttagaatctg gtttttctgt
     7201 gctttgtcat tttactctga taggaatttt tgttacctaa ctctgtgcat aacttattta
     7261 atgtactgta taaatgaacc aaaactgtta aatatgtatt tagtttgttc tacttaaagt
     7321 agtcaataaa aaggctatat tcct
//
