LOCUS       NM_001393918            3281 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens CACN subunit beta associated regulatory protein
            (CBARP), transcript variant 1, mRNA.
ACCESSION   NM_001393918
VERSION     NM_001393918.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3281)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3281)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3281)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 3281)
  AUTHORS   Beguin,P., Nagashima,K., Mahalakshmi,R.N., Vigot,R., Matsunaga,A.,
            Miki,T., Ng,M.Y., Ng,Y.J., Lim,C.H., Tay,H.S., Hwang,L.A.,
            Firsov,D., Tang,B.L., Inagaki,N., Mori,Y., Seino,S., Launey,T. and
            Hunziker,W.
  TITLE     BARP suppresses voltage-gated calcium channel activity and
            Ca2+-evoked exocytosis
  JOURNAL   J Cell Biol 205 (2), 233-249 (2014)
   PUBMED   24751537
REFERENCE   5  (bases 1 to 3281)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   6  (bases 1 to 3281)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004221.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000650044.2/ ENSP00000497208.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               AC004221.2         12527-12776         c
            251-376             AC004221.2         10767-10892         c
            377-516             AC004221.2         10550-10689         c
            517-581             AC004221.2         10272-10336         c
            582-726             AC004221.2         9772-9916           c
            727-898             AC004221.2         9342-9513           c
            899-1039            AC004221.2         8962-9102           c
            1040-1250           AC004221.2         8197-8407           c
            1251-1425           AC004221.2         5872-6046           c
            1426-3281           AC004221.2         3058-4913           c
FEATURES             Location/Qualifiers
     source          1..3281
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..3281
                     /gene="CBARP"
                     /gene_synonym="BARP; C19orf26; DOS"
                     /note="CACN subunit beta associated regulatory protein"
                     /db_xref="GeneID:255057"
                     /db_xref="HGNC:HGNC:28617"
     exon            1..250
                     /gene="CBARP"
                     /gene_synonym="BARP; C19orf26; DOS"
                     /inference="alignment:Splign:2.1.0"
     exon            251..376
                     /gene="CBARP"
                     /gene_synonym="BARP; C19orf26; DOS"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..2389
                     /gene="CBARP"
                     /gene_synonym="BARP; C19orf26; DOS"
                     /note="isoform 1 is encoded by transcript variant 1;
                     downstream of Stk11; protein Dos; calcium channel,
                     voltage-dependent, beta subunit associated regulatory
                     protein; VGCC beta-anchoring and -regulatory protein;
                     voltage-dependent calcium channel beta subunit-associated
                     regulatory protein; CACN beta subunit associated
                     regulatory protein"
                     /codon_start=1
                     /product="voltage-dependent calcium channel beta
                     subunit-associated regulatory protein isoform 1"
                     /protein_id="NP_001380847.1"
                     /db_xref="CCDS:CCDS92477.1"
                     /db_xref="GeneID:255057"
                     /db_xref="HGNC:HGNC:28617"
                     /translation="MQPTATMATAATTTTTTTATVALTTSWDNATGRPTAEPDPILDN
                     YVLLVVVMSLFVGGTLVVLSGVLLLCKRCWDVHQRLNRAMEEAEKTTTTYLDNGTHPA
                     QDPDFRGEDPECQDAETERFLSTSSTGRRVSFNEAALFEQSRKTQDKGRRYTLTEGDF
                     HHLKNARLTHLHLPPLKIVTIHECDSGEASSATTPHPATSPKATLAIFQPPGKALTGR
                     SVGPSSALPGDPYNSAAGATDFAEISPSASSDSGEGTSLDAGTRSTKAGGPGAAAGPG
                     EAGPGSGAGTVLQFLTRLRRHASLDGASPYFKVKKWKLEPSQRAASLDTRGSPKRHHF
                     QRQRAASESTEQEEGDAPQEDFIQYIARAGDAVAFPHPRPFLASPPPALGRLEAAEAA
                     GGASPDSPPERGAGSAGPEQQQPPLEPDAERDAGPEQAQTSYRDLWSLRASLELHAAA
                     SDHSSSGNDRDSVRSGDSSGSGSGGAAPAFPPPSPPAPRPKDGEARRLLQMDSGYASI
                     EGRGAGDDTEPPAAPARPRSPRAWPRRPRRDYSIDEKTDALFHEFLRHDPHFDDTPAA
                     ARHRARAHPHARKQWQRGRQHSDPGARAAPALAGTPAPPAGAARPARAPLRRGDSVDG
                     PPDGRTLGGAGDDPAIPVIEEEPGGGGCPGSGLCVLPSGSVLDKLAAGLDERLFPPRL
                     AEPVVATPALVAAAPTSPDHSPA"
     exon            377..516
                     /gene="CBARP"
                     /gene_synonym="BARP; C19orf26; DOS"
                     /inference="alignment:Splign:2.1.0"
     exon            517..581
                     /gene="CBARP"
                     /gene_synonym="BARP; C19orf26; DOS"
                     /inference="alignment:Splign:2.1.0"
     exon            582..726
                     /gene="CBARP"
                     /gene_synonym="BARP; C19orf26; DOS"
                     /inference="alignment:Splign:2.1.0"
     exon            727..898
                     /gene="CBARP"
                     /gene_synonym="BARP; C19orf26; DOS"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1039
                     /gene="CBARP"
                     /gene_synonym="BARP; C19orf26; DOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1250
                     /gene="CBARP"
                     /gene_synonym="BARP; C19orf26; DOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1425
                     /gene="CBARP"
                     /gene_synonym="BARP; C19orf26; DOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..3281
                     /gene="CBARP"
                     /gene_synonym="BARP; C19orf26; DOS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3263..3268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CBARP"
                     /gene_synonym="BARP; C19orf26; DOS"
                     /note="hexamer: TATAAA"
     polyA_site      3281
                     /gene="CBARP"
                     /gene_synonym="BARP; C19orf26; DOS"
                     /note="major polyA site"
ORIGIN      
        1 agacccagcg gcgagcgcag cgggggcggc gggccgggga ccgggcagca ccgggcgcgc
       61 ggagcgggcg cgccgccaac gcggtcacgt gcgcggcccc tcctctcgcg ccggcctccc
      121 ccgcgccgcg ctctccattc ataaattctc cgcctgctcc gcggccaccg ggcgccggag
      181 ccagccgcga gcgccacgca gccgcccgcc gccagcccgc cgcccatggg ccgctcgtcc
      241 cggcgctgag ggccctcctc cccagttcag aatgcagccc acagccacca tggccacagc
      301 cgccaccacc accaccacca ccactgccac agtagccctg acgacgtcgt gggacaatgc
      361 cactggacgc cccacggcag agccagaccc catcctggac aactacgtgc tgctggtggt
      421 ggtgatgtcg ctgttcgtgg ggggcacgct ggtggtgttg tctggcgtcc tgctcctctg
      481 caagcgctgc tgggacgtcc accagcgcct caacagggcc atggaggaag cggagaagac
      541 caccaccacc tacctggaca acggcaccca cccagcccaa gaccccgact tccggggaga
      601 ggaccccgag tgccaggatg cggagaccga acgcttcctg tccaccagct ccacgggccg
      661 ccgggtctcc ttcaatgagg cggcgctgtt tgagcagagc cgcaagacgc aggacaaggg
      721 tcgccggtac acactgacgg agggggactt ccaccacctg aagaatgccc ggctcacgca
      781 cctgcacctg ccgcccctca agattgtcac catccacgag tgtgactcag gcgaggccag
      841 ctcagccacc acgccccacc cggccacctc tcccaaggcc actctggcca tcttccagcc
      901 cccggggaag gccctcaccg gccgctctgt gggccccagc tccgccctgc caggtgaccc
      961 ctacaactca gccgcgggcg ccactgactt cgcagagatc agcccctcgg catctagcga
     1021 ctctggggaa ggcacctcgt tggatgccgg taccaggagc accaaggctg gagggcccgg
     1081 ggctgcagca gggcctgggg aggcgggccc gggatccggg gcaggtaccg ttctgcagtt
     1141 cctcacccgc ctgcgccgcc atgccagcct ggatggggcc agcccctatt tcaaggtcaa
     1201 gaagtggaag ctggagccca gccagcgggc agccagtctg gacacgagag gttcccccaa
     1261 gcggcaccac ttccagcggc agcgggcagc cagtgagagc acggagcagg aggaggggga
     1321 tgccccccag gaggacttca tccagtacat tgcccgggcg ggcgacgccg tggccttccc
     1381 gcacccccgc ccctttctgg ccagcccgcc ccctgctctc ggcaggctag aggcggccga
     1441 ggcagcggga ggagcgagcc ccgattcccc cccggagcgc ggcgcgggca gcgcggggcc
     1501 tgagcagcag cagccgccac tggagccgga cgccgagcgg gacgcgggcc ccgagcaggc
     1561 ccagaccagc taccgcgacc tgtggagcct gcgcgcctcg cttgagctgc atgcggccgc
     1621 ctcggaccac agcagcagcg gcaacgaccg cgactcggtg cgcagcggcg acagctcggg
     1681 ctcaggctcc gggggcgcgg cgcccgcctt cccgccgccc tccccgcccg cgccgcggcc
     1741 caaggacggc gaggcgcgcc ggctgctgca gatggacagt ggctacgcca gcatcgaggg
     1801 ccgcggcgca ggcgacgaca ccgagccacc tgccgcgccc gcccggcccc gcagcccgcg
     1861 cgcctggccc cgccgcccgc gccgcgacta cagcatcgac gagaagacgg acgcgctgtt
     1921 ccacgagttc ctgcgccacg acccgcactt cgacgacacg ccggctgccg cgcgacaccg
     1981 cgcccgcgcg cacccgcacg cccgcaaaca gtggcagcgt ggccggcagc acagcgaccc
     2041 cggcgcccgc gcggccccgg ccctggccgg aaccccggca ccgcctgccg gcgcggcccg
     2101 acccgcgcgt gcgcccttgc ggcgcggcga cagcgtggac ggcccgcccg acggtcgcac
     2161 cctgggcggc gccggcgacg accccgccat ccccgtcatc gaggaggagc cgggcggcgg
     2221 ggggtgcccc ggctcgggcc tgtgcgtcct accatccggg tcggtgctgg acaagctggc
     2281 ggctggcctc gacgagagac tctttccgcc gcgcctcgcc gagcccgtcg tggcgactcc
     2341 cgcgttggtc gccgccgccc ccacgtcccc cgaccacagc ccggcctaag tcccgcgtcc
     2401 tgggcccatc tctctggcag cttctccggc gccgcacggg gcctcggcgg cgggagagac
     2461 gtgggggcgc gacgccccga cgcgaatgcg cggggaccgc gggcccttcg cgcacgcgcc
     2521 gggcgacgga ggcgcgctcg ccgcttcagg gcgcaggcgc agagccccgg ccgccctcgc
     2581 gccgccgaag tgtgcactgc tctttccggt gcttgccggg tgctgggcgt cgtgaggcgc
     2641 gggccgcgga gaccccggct gggcgggaag gaaggggcgt gaacggctct cagcttcggg
     2701 ctcctgagga caacgatcac tcgccctcag tcccggacgg ggcggccgct tagtcgcagg
     2761 gcccgccacc cgagggtcgc gcagcccact gggcccgatg gagccgccgc gtgccgggcg
     2821 cgtgcgcgag ctcgcccggg cgggggccgc ggggcgctaa cggtcgcaga cgagttcgcc
     2881 gccctgggcc gggaggcggc tcaacaccgt gactgccgac ctccgagacc gtttacctca
     2941 ctgcggcgtg tgctggcggc agcccgcgcc gcctccgagc aataaccgcg ccgccaccgc
     3001 tgctgccgcc ggccctgagg gagccggccc cggccctccc gcgccccgag tccccactgc
     3061 cctccgcatg tcaacggcgc ccgccccgct gccgccccat ccacgttgag acgcgaacaa
     3121 aacccagacg gccaggtcca agcttcccaa gctttattta ttgccaaatt tgggcggcct
     3181 cgcccgcacg gcaccctccg agtccccgcc gcgtctgcac catcccgcga tggcgtttct
     3241 cgtgtttttc ttttctggat gatataaata ttgaccgcac a
//
