LOCUS       NM_145040               1028 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens caveolae associated protein 3 (CAVIN3), mRNA.
ACCESSION   NM_145040
VERSION     NM_145040.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1028)
  AUTHORS   Li,J., Qi,L., Zhang,M., Yao,C., Feng,J., Zheng,Z., Chen,C., Duan,S.
            and Qi,Y.
  TITLE     PRKCDBP Methylation is a Potential and Promising Candidate
            Biomarker for Non-small Cell Lung Cancer
  JOURNAL   Zhongguo Fei Ai Za Zhi 25 (2), 78-85 (2022)
   PUBMED   35224960
  REMARK    GeneRIF: PRKCDBP Methylation is a Potential and Promising Candidate
            Biomarker for Non-small Cell Lung Cancer.
REFERENCE   2  (bases 1 to 1028)
  AUTHORS   McMahon,K.A., Stroud,D.A., Gambin,Y., Tillu,V., Bastiani,M.,
            Sierecki,E., Polinkovsky,M.E., Hall,T.E., Gomez,G.A., Wu,Y.,
            Parat,M.O., Martel,N., Lo,H.P., Khanna,K.K., Alexandrov,K.,
            Daly,R., Yap,A., Ryan,M.T. and Parton,R.G.
  TITLE     Cavin3 released from caveolae interacts with BRCA1 to regulate the
            cellular stress response
  JOURNAL   Elife 10, e61407 (2021)
   PUBMED   34142659
  REMARK    GeneRIF: Cavin3 released from caveolae interacts with BRCA1 to
            regulate the cellular stress response.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1028)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1028)
  AUTHORS   Fu,J., Zhou,H., Chen,J. and Wang,Y.
  TITLE     Low expression of PRKCDBP promoted cisplatin resistance in lung
            adenocarcinoma by DNMT1 and TNF-alpha
  JOURNAL   Oncol Rep 44 (4), 1616-1626 (2020)
   PUBMED   32945503
  REMARK    GeneRIF: Low expression of PRKCDBP promoted cisplatin resistance in
            lung adenocarcinoma by DNMT1 and TNFalpha.
REFERENCE   5  (bases 1 to 1028)
  AUTHORS   Wan,Q., Du,Z., Fang,Z., Cheng,H., Li,C. and Zhou,X.
  TITLE     Matrine induces apoptosis and autophagy in human lung
            adenocarcinoma cells via upregulation of Cavin3 and suppression of
            PI3K/AKT pathway
  JOURNAL   J BUON 25 (3), 1512-1516 (2020)
   PUBMED   32862598
  REMARK    GeneRIF: Matrine induces apoptosis and autophagy in human lung
            adenocarcinoma cells via upregulation of Cavin3 and suppression of
            PI3K/AKT pathway.
REFERENCE   6  (bases 1 to 1028)
  AUTHORS   McMahon,K.A., Zajicek,H., Li,W.P., Peyton,M.J., Minna,J.D.,
            Hernandez,V.J., Luby-Phelps,K. and Anderson,R.G.
  TITLE     SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae
            function
  JOURNAL   EMBO J 28 (8), 1001-1015 (2009)
   PUBMED   19262564
  REMARK    GeneRIF: Results suggest that SRBC (sdr-related gene product that
            binds to c-kinase) and two other family members [PTRF (Pol I and
            transcription release factor) and SDPR] function as caveolin
            adapter molecules that regulate caveolae function.
REFERENCE   7  (bases 1 to 1028)
  AUTHORS   Lee,J.H., Byun,D.S., Lee,M.G., Ryu,B.K., Kang,M.J., Chae,K.S.,
            Lee,K.Y., Kim,H.J., Park,H. and Chi,S.G.
  TITLE     Frequent epigenetic inactivation of hSRBC in gastric cancer and its
            implication in attenuated p53 response to stresses
  JOURNAL   Int J Cancer 122 (7), 1573-1584 (2008)
   PUBMED   18059034
  REMARK    GeneRIF: hSRBC is a novel tumor suppressor whose epigenetic
            inactivation contributes to the malignant progression of gastric
            tumors, in part, through attenuated p53 response to stresses.
REFERENCE   8  (bases 1 to 1028)
  AUTHORS   Zochbauer-Muller,S., Fong,K.M., Geradts,J., Xu,X., Seidl,S.,
            End-Pfutzenreuter,A., Lang,G., Heller,G., Zielinski,C.C.,
            Gazdar,A.F. and Minna,J.D.
  TITLE     Expression of the candidate tumor suppressor gene hSRBC is
            frequently lost in primary lung cancers with and without DNA
            methylation
  JOURNAL   Oncogene 24 (41), 6249-6255 (2005)
   PUBMED   15940253
  REMARK    GeneRIF: hSRBC is a candidate tumor suppressor gene involved in
            lung cancer pathogenesis, where expression is frequently
            inactivated by methylation and other mechanisms
REFERENCE   9  (bases 1 to 1028)
  AUTHORS   Xu,X.L., Wu,L.C., Du,F., Davis,A., Peyton,M., Tomizawa,Y.,
            Maitra,A., Tomlinson,G., Gazdar,A.F., Weissman,B.E., Bowcock,A.M.,
            Baer,R. and Minna,J.D.
  TITLE     Inactivation of human SRBC, located within the 11p15.5-p15.4 tumor
            suppressor region, in breast and lung cancers
  JOURNAL   Cancer Res 61 (21), 7943-7949 (2001)
   PUBMED   11691816
  REMARK    GeneRIF: Human SRBC is located within the 11p15.5-p15.4 tumor
            suppressor region and is inactivated in breast and lung cancers.
REFERENCE   10 (bases 1 to 1028)
  AUTHORS   Izumi,Y., Hirai,Si., Tamai,Y., Fujise-Matsuoka,A., Nishimura,Y. and
            Ohno,S.
  TITLE     A protein kinase Cdelta-binding protein SRBC whose expression is
            induced by serum starvation
  JOURNAL   J Biol Chem 272 (11), 7381-7389 (1997)
   PUBMED   9054438
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ434360.1 and BC011585.1.
            
            On Nov 22, 2018 this sequence version replaced NM_145040.2.
            
            Summary: The protein encoded by this gene was identified as a
            binding protein of the protein kinase C, delta (PRKCD). The
            expression of this gene in cultured cell lines is strongly induced
            by serum starvation. The expression of this protein was found to be
            down-regulated in various cancer cell lines, suggesting the
            possible tumor suppressor function of this protein. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011585.1, AF339881.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303927.4/ ENSP00000307292.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-409               BQ434360.1         147-555
            410-1028            BC011585.1         419-1037
FEATURES             Location/Qualifiers
     source          1..1028
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..1028
                     /gene="CAVIN3"
                     /gene_synonym="cavin-3; HSRBC; PRKCDBP; SRBC"
                     /note="caveolae associated protein 3"
                     /db_xref="GeneID:112464"
                     /db_xref="HGNC:HGNC:9400"
                     /db_xref="MIM:618303"
     exon            1..409
                     /gene="CAVIN3"
                     /gene_synonym="cavin-3; HSRBC; PRKCDBP; SRBC"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..811
                     /gene="CAVIN3"
                     /gene_synonym="cavin-3; HSRBC; PRKCDBP; SRBC"
                     /note="sdr-related gene product that binds to c-kinase;
                     serum deprivation response factor-related gene product
                     that binds to C-kinase; protein kinase C delta binding
                     protein"
                     /codon_start=1
                     /product="caveolae-associated protein 3"
                     /protein_id="NP_659477.2"
                     /db_xref="CCDS:CCDS7762.1"
                     /db_xref="GeneID:112464"
                     /db_xref="HGNC:HGNC:9400"
                     /db_xref="MIM:618303"
                     /translation="MRESALERGPVPEAPAGGPVHAVTVVTLLEKLASMLETLRERQG
                     GLARRQGGLAGSVRRIQSGLGALSRSHDTTSNTLAQLLAKAERVSSHANAAQERAVRR
                     AAQVQRLEANHGLLVARGKLHVLLFKEEGEVPASAFQKAPEPLGPADQSELGPEQLEA
                     EVGESSDEEPVESRAQRLRRTGLQKVQSLRRALSGRKGPAAPPPTPVKPPRLGPGRSA
                     EAQPEAQPALEPTLEPEPPQDTEEDPGRPGAAEEALLQMESVA"
     exon            410..1028
                     /gene="CAVIN3"
                     /gene_synonym="cavin-3; HSRBC; PRKCDBP; SRBC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1007..1012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CAVIN3"
                     /gene_synonym="cavin-3; HSRBC; PRKCDBP; SRBC"
                     /note="hexamer: AATAAA"
     polyA_site      1028
                     /gene="CAVIN3"
                     /gene_synonym="cavin-3; HSRBC; PRKCDBP; SRBC"
                     /note="major polyA site"
ORIGIN      
        1 agacggagca gagcggtcag ggatcatgag ggagagtgcg ttggagcggg ggcctgtgcc
       61 cgaggcgccg gcggggggtc ccgtgcacgc cgtgacggtg gtgaccctgc tggagaagct
      121 ggcctccatg ctggagactc tgcgggagcg gcagggaggc ctggctcgaa ggcagggagg
      181 cctggcaggg tccgtgcgcc gcatccagag cggcctgggc gctctgagtc gcagccacga
      241 caccaccagc aacaccttgg cgcagctgct ggccaaggcg gagcgcgtga gctcgcacgc
      301 caacgccgcc caagagcgcg cggtgcgccg cgcagcccag gtgcagcggc tggaggccaa
      361 ccacgggctg ctggtggcgc gcgggaagct ccacgttctg ctcttcaagg aggagggtga
      421 agtcccagcc agcgctttcc agaaggcacc agagcccttg ggcccggcgg accagtccga
      481 gctgggccca gagcagctgg aggccgaagt tggagagagc tcggacgagg agccggtgga
      541 gtccagggcc cagcggctgc ggcgcaccgg attgcagaag gtacagagcc tccgaagggc
      601 cctttcgggc cggaaaggcc ctgcagcgcc accgcccacc ccggtcaagc cgcctcgcct
      661 tgggcctggc cggagcgctg aagcccagcc ggaagcccag cctgcgctgg agcccacgct
      721 ggagccagag cctccgcagg acaccgagga agatcccggg agacctgggg ctgccgaaga
      781 agctctgctc caaatggaga gtgtagcctg agggctggtg ttgcctgcct cccctgtgct
      841 tgtgccttgt cccaaaataa atcctttcag aatgtagcac tcacgcccta ataaggagcg
      901 aatcctacat ccaccaaggc gggcgctctg gccctccctt ccttaagccc agtcctgtgt
      961 cctctgaaag aggtgcagtc actcacacct gcttgcgctc accatcaata aaagtaattt
     1021 cacccgaa
//
